Navigation Links
Stem cells + nanofibers = Promising nerve research
Date:11/7/2012

ANN ARBOR, Mich. Every week in his clinic at the University of Michigan, neurologist Joseph Corey, M.D., Ph.D., treats patients whose nerves are dying or shrinking due to disease or injury.

He sees the pain, the loss of ability and the other effects that nerve-destroying conditions cause and wishes he could give patients more effective treatments than what's available, or regenerate their nerves. Then he heads to his research lab at the VA Ann Arbor Healthcare System, where his team is working toward that exact goal.

In new research published in several recent papers, Corey and his colleagues from the U-M Medical School, VAAAHS and the University of California, San Francisco report success in developing polymer nanofiber technologies for understanding how nerves form, why they don't reconnect after injury, and what can be done to prevent or slow damage.

Using polymer nanofibers thinner than human hairs as scaffolds, researchers coaxed a particular type of brain cell to wrap around nanofibers that mimic the shape and size of nerves found in the body.

They've even managed to encourage the process of myelination the formation of a protective coating that guards larger nerve fibers from damage. They began to see multiple concentric layers of the protective substance called myelin start to form, just as they do in the body. Together with the laboratory team of their collaborator Jonah Chan at UCSF, the authors reported the findings in Nature Methods.

The research involves oligodendrocytes, which are the supporting actors to neurons -- the "stars" of the central nervous system. Without oligodendrocytes, central nervous system neurons can't effectively transmit the electrical signals that control everything from muscle movement to brain function.

Oligodendrocytes are the type of cells typically affected by multiple sclerosis, and loss of myelin is a hallmark of that debilitating disease.

Th
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
2. Stem cells can repair a damaged cornea
3. Scientists produce eye structures from human blood-derived stem cells
4. Study demonstrates cells can acquire new functions through transcriptional regulatory network
5. Epigenetic signatures direct the repair potential of reprogrammed cells
6. Researchers print live cells with a standard inkjet printer
7. Nanopills release drugs directly from the inside of cells
8. Protein jailbreak helps breast cancer cells live
9. Newly found protein helps cells build tissues
10. BU researchers derive purified lung and thyroid progenitors from embryonic stem cells
11. Housekeeping mechanism for brain stem cells discovered
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells + nanofibers = Promising nerve research
(Date:4/13/2015)... , April 13, 2015  higi, a leading cloud-based ... to more fully engage with their communities around health ... privacy protected and secure API.  ... the most accessible, affordable, and convenient vehicle to receive ... The API will allow higi,s ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
(Date:4/2/2015)... April 2, 2015 At its 2015 ACMG ... City , the American College of Medical Genetics ... directors to its Board.  Members of the ACMG Board ... for forming and advancing its policies and programs. ACMG ... "It,s an eventful time in medical genetics ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... than two-thirds of adults considered overweight and more than ... gain, loss and maintenance is a major national goal. ... is an important and growing subfield of obesity research, ... The National Institute for Mathematical and Biological Synthesis (NIMBioS) ...
... a postdoctoral researcher and sea slug expert at the ... 16 Rubenstein Fellows by the Encyclopedia of Life (EOL). ... platform for sharing their biodiversity research with colleagues and ... ) is an international collaboration that aims to provide ...
... 2003, the year a complete draft of the human genome ... the ENCODE project (ENCyclopedia of DNA Elements), to develop an ... many factors that can change the expression of the genes ... Institutes of Health funded modENCODE (the Model Organism ENCylopedia of ...
Cached Biology News:Body weight regulation and metabolism focus of workshop 2Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow 2Encyclopedia of Life names Dr. Rebecca Johnson a 2011 Rubenstein Fellow 3Deep genomics 2Deep genomics 3Deep genomics 4Deep genomics 5Deep genomics 6Deep genomics 7
(Date:4/25/2015)... Join us for a webinar at ... Residence Times using the Transcreener® ADP Assay , ... is increasingly being incorporated into lead development efforts because ... efficacy, increased therapeutic window and reduced side effects. ... methods such surface plasmon resonance, conjugation of drugs can ...
(Date:4/24/2015)... and Tempe, AZ (PRWEB) April 24, 2015 ... and Arizona State University (ASU) have entered into an ... projects. , A memorandum of agreement signed by the ... distance learning, student success and other services particularly, though ... , “We have complementary strengths and a similar ...
(Date:4/24/2015)... Texas (PRWEB) April 24, 2015 ... for use in applications such as animal waste ... and oil reduction in wastewater treatment plants and ... an exhibitor at the National Restaurant Association’s NRA ... , Representatives of the company will be ...
(Date:4/24/2015)... SAN DIEGO , April 24, 2015  Pfenex ... in the development of biosimilar therapeutics including high value ... of its follow-on public offering of 6,000,000 shares of ... of $15.50 per share. Of the shares being offered, ... 3,390,000 shares are being offered by existing stockholders. Pfenex ...
Breaking Biology Technology:BellBrook Labs Webinar: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ADP Assay 2South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2DryLet to Showcase Bio-React at the National Restaurant Association’s NRA Show 2015 May 16-19, 2015 in Chicago, Illinois 2Pfenex Inc. Announces Pricing Of Follow-on Offering 2
... 22 IMPAC Medical Systems,Inc., an Elekta ... for anatomic pathology and oncology care, today ... Year, Anatomic Pathology award to,Judith Thompson, Manager ... Jefferson Hills, Pennsylvania and the 2008 IMPAC,Laboratory ...
... April 22 SuperGen Inc.,(Nasdaq: SUPG ), a ... of therapies for solid tumors and,hematological malignancies, invites all ... its 3rd Annual Analyst Day beginning at 9:30 a.m. ... a.m. PT) on Tuesday,April 29, 2008., Investors and ...
... ... Presence in China, CAMBRIDGE, Mass., April 22 Genzyme ... major new research and,development center in Beijing. The initiative is an ... presence in China., The new facility will be used for ...
Cached Biology Technology:IMPAC Medical Systems Announces 2008 Laboratory Professionals of the Year 2IMPAC Medical Systems Announces 2008 Laboratory Professionals of the Year 3Genzyme to Build New R&D Center in Beijing 2Genzyme to Build New R&D Center in Beijing 3Genzyme to Build New R&D Center in Beijing 4Genzyme to Build New R&D Center in Beijing 5
... experimental process of determining the nucleotide sequence ... Sequencing is based on Sangers enzymatic method ... cycle sequencing reactions. The resulting fluorescent products ... instrument controlled by a computer and the ...
... Anti-phospho-Lck (pTyr 192 ) The antibody is preadsorbed ... affinity isolated antibody buffered aqueous glycerol solution ... saline (without Mg 2+ and Ca 2+ ... 1.0 mg/mL BSA (IgG, protease free) and 0.05% ...
... calibration, and validation (MCV) plate ... used for hands-free startup, shutdown, ... the Bio-Plex suspension array system. ... use with Bio-Plex Manager software ...
High-throughput DNA sequencing of any library. Just give us your transformation mixture, and we'll do the rest. ABI 3730xl's yield the longest read lengths available. LIMS tracking utilizing Geospiza...
Biology Products: