Navigation Links
Stem cell focus for IBD wound healing
Date:4/28/2009

Scientists at The University of Nottingham are investigating whether stem cell markers could have a role to play in speeding up wound healing in patients suffering from inflammatory bowel disease (IBD).

The study could eventually lead to the development of new drugs which use natural molecules to spark the recovery of patients suffering from ulcerative colitis and Crohn's disease, reducing their risk of associated complications such as scarring, bowel obstructions and tumour growth.

Funded with a 118,500 grant from the National Association for Colitis and Crohn's Disease (NACC), the two-year project is being led by Professor Mohammad Ilyas in the University's Division of Pathology.

He said: "The study will focus on the molecule CD24 which is a stem cell marker and which plays a key role in cell proliferation and the migration of healthy cells to a damaged area to restore normal tissue.

"CD24 is a small molecule attached to the cell membrane which has been recently reported as a marker of stem cells in the colon. It occurred to us that CD24 might have a role to play in IBD and during further studies we found that it was indeed present in sections of diseased bowel."

IBD affects around one in 400 people in the UK. Common symptoms include inflammation and ulceration of the intestine and colon, pain, severe diarrhoea, tiredness and weight loss. The cause of the disease is yet to be definitively identified, although scientists believe it could be due to a combination of genetic predisposition and environmental factors. Currently, there is no cure and patients manage their condition with a mixture of lifestyle changes, anti-inflammatory drugs and, in severe cases, surgery.

Professor Ilyas added: "The power of the gut to heal the damage caused by acute episodes of inflammation is remarkable and frequently the gut lining reverts to normal. Anti-inflammatory drugs help this process along and allow the wound healing
'/>"/>

Contact: Professor Mohammad Ilyas
Mohammad.Ilyas@nottingham.ac.uk
44-011-582-30735
University of Nottingham
Source:Eurekalert

Page: 1 2

Related biology news :

1. Supply Chain Council Seminar Focuses on Defense and IT
2. Supply Chain Council Seminar Focuses on Defense and IT
3. Recession Puts Focus on Business Optimisation and Excellence to Strengthen Business Core
4. Human aspects of climate change to be focus of conference at Illinois
5. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
6. New text focuses on formidable opportunistic fungus
7. GEN reports growing focus on PI3-kinase pathway in cancer research
8. ESA satellites focusing on the Arctic
9. Endangered sawfish focus of national collection and recovery efforts
10. 15-state Southern obesity summit to focus on deadly epidemic
11. Research conference at UH to focus on US troops needs, homeland security
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... ST. PAUL, Minn. , Dec. 10, 2014 ... in wireless physiologic monitoring, has released a new ... changing needs of preclinical toxicology researchers. M series, ... to help toxicologists collect the best possible physiologic ... studies. Adding functional endpoints to toxicology ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader in ... seeing a staggering demand from its licensees for highly ... revealed, is not solely coming from fitness and health ... "A wearable is only as useful as ... is the ultimate driver in long-term mass consumer adoption ...
(Date:12/10/2014)... CIE San Diego has launched an innovative ... tissue that enhances care coordination among social service and ... information; earned a second $1 million grant from the ... aging in community and; will be recognized as a ... 4-6p. CIE San Diego today announced ...
Breaking Biology News(10 mins):New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... Austin researchers have discovered how to extract and use information ... from the focus distance, a feat only accomplished by human ... camera, the human eye has an auto-focusing system, but human ... not require trial and error to focus an object. ...
... Texas Advanced Computing Center (TACC) at the University of ... and support a world-class supercomputer with comprehensive computing and ... Made possible by a $27.5 million grant from the ... of the NSF "eXtreme Digital" (XD) program, an integrating ...
... some people with asthma do not respond well to inhaled ... Researchers found that asthma patients who have two copies of ... steroid inhalers as those with two copies of the regular ... National Heart, Lung, and Blood Institute (NHLBI), part of the ...
Cached Biology News:Researchers develop optimal algorithm for determining focus error in eyes and cameras 2Stampede charges computational science forward in tackling complex societal challenges 2Stampede charges computational science forward in tackling complex societal challenges 3Stampede charges computational science forward in tackling complex societal challenges 4NIH-funded study connects gene variant to response to asthma drugs 2
(Date:12/19/2014)... The empty capsules market is experiencing ... and technological innovations in the empty capsules market. ... the growth of the empty capsules market. , ... Scope of Report , The report will enrich ... firms to gauge the pulse of the market ...
(Date:12/19/2014)... -- Egenix, Inc. is pleased to announce that Lionel ... to succeed Donald Fresne ; Mr. Fresne has also ... member of the Board.  In recognition of the many contributions ... almost twenty years, the Board designated Mr. Fresne as Chairman ... a Search Committee to find a suitable replacement with Biotech ...
(Date:12/17/2014)... The Activated Carbon Manufacturing ... why IBISWorld updated its original industry research report. ... an intensified focus on environmental policy. Over the five ... for power plants and a range of other industrial ... Analyst Sarah Kahn, “a range of downstream industrial sectors ...
(Date:12/17/2014)... Achim Noack has been named global vice ... this position, Noack will assist Jerry Stoller, CEO and ... strategy and supervise global marketing management and implementation of ... knowledge and experience in the crop protection industry,” says ... innovative thinking will be a great asset for Stoller ...
Breaking Biology Technology:Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... June 5, 2011 Northwest Biotherapeutics (OTC.BB: NWBO) today ... of financing arrangements, including a $3 million investment already ... further funding on fixed, specified and favorable terms, at ... chooses.  This series of financing arrangements will provide a ...
... Recent biopharmaceutical product launches have produced both noteworthy failures ... with a continually evolving launch landscape, organizations are rethinking ... current launch environment. In a new ... and failure points facing new product launches, Best Practices, ...
... 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: ... financial results for the fourth quarter and full year of ... close in the US.   The Company will ... June 13, 2011 to discuss its financial performance and give ...
Cached Biology Technology:Northwest Biotherapeutics Announces Series of Financing Arrangements 2Northwest Biotherapeutics Announces Series of Financing Arrangements 3Northwest Biotherapeutics Announces Series of Financing Arrangements 4Creating a Road Map for Successful Cardiovascular New Product Launch 2China Cord Blood Corporation to Report Fourth Quarter and Full Year Fiscal 2011 Financial Results 2
Human PLUNC MAb (Clone 252512)...
... ( Abpromise for all tested ... Synthetic peptide corresponding to amino acid ... of rat GRASP1, conjugated to keyhole ... Entrez GeneID: 56850 ...
Homo sapiens CDC23 (cell division cycle 23, yeast, homolog),...
Terrific Broth, 1 kg. Mixture of casein peptone, yeast extract, K2HPO4, and KH2PO4.Used at 47 g/l for E. coli growth with higher cell densities. Category: Nucleotides & Enzymes & Biochemicals, Ultrap...
Biology Products: