Navigation Links
Stem cell finding could advance immunotherapy for lung cancer
Date:11/13/2012

CINCINNATIA University of Cincinnati (UC) Cancer Institute lung cancer research team reports that lung cancer stem cells can be isolatedand then grownin a preclinical model, offering a new avenue for investigating immunotherapy treatment options that specifically target stem cells.

John C. Morris, MD, and his colleagues report their findings in the Nov. 13, 2012, issue of PLOS One, a peer-reviewed online publication that features original research from all disciplines within science and medicine.

Stem cells are unique cells that can divide and differentiate into specialized cells typesfor example cardiac muscle or liver tissue. These cells also have the ability to self-renew and produce more stem cells.

"Increasing evidence supports the idea that cancerous tumors have a population of stem cells, also called cancer-initiating cells, that continually regenerate and fuel cancer growth," explains Morris, senior author of the study and professor at the UC College of Medicine. "These cancer stem cells may also have the highest potential to spread to other organs."

Current models used to study cancer stem cells provide limited information on the interaction between cancer stem cells with the immune system, making the study of new therapies that utilize the body's immune system to fight off cancer virtually impossible.

In this study, the UC team set out to find a viable, consistent way to isolate lung cancer stem cells that could be used in a mouse model with full immune system function. The team was able to achieve this using a functional laboratory test known as "tumorsphere" assay.

The testwhich shows how cells grow in cultureallowed them to enrich for cancer stem cells.

"Studying these unique cells could greatly improve our understanding of lung cancer's origins and lead to the novel therapeutics targeting these cells and help to more effectively eradicate this disease," adds Morris. "Immuno
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Verinata Health Announces New Findings At The American Society Of Human Genetics
2. New findings on gene regulation and bone development
3. Finding triggers of birth defects in an embryo heart
4. One click away: Finding data on Floridas endangered species just got easier
5. New findings on protein misfolding
6. Finding new research frontiers in a single cell
7. Team discovers reason that male moths can keep finding females
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
10. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
11. UMD finding may hold key to Gaia hypothesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , Chine, 31 juillet 2015 La ... www.icg-10.org ) sera organisée par le BGI du ... Shenzhen en Chine. La ... son inauguration en 2006, l,ICG est devenue l,une ... le domaine des « omiques » et c,est aussi la ...
(Date:7/30/2015)... , July 30, 2015 Cellecta, ... for gene function analysis and biomarker discovery, announced ... (sgRNA) Knockout Library targeting all human protein coding ... permanently "knock out" a gene,s function. Cellecta,s new ... high throughput screening tool so that researchers can ...
(Date:7/21/2015)... Sweden , July 21, 2015 Today, ... FPC1025. Already received as well as expected revenues in 2015 that ... in FPC,s communicated revenue guidance of approximately 2,200 MSEK for 2015. ... is a leading smartphone manufacturer in China ... selected FPC1 02 5 for Axon ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... helps prevent epileptic seizures by inducing rhythmical electrical ... the brain known as the hippocampus, according to ... The researchers found that, by imposing a normal ... reduce epileptic seizures by 86-97 percent. , The ...
... plants and are critical to the health of our planet. ... Earth and Biosphere Institute is looking at the impact of ... we may be at the start of a vicious cycle, ... the amount of carbon in the atmosphere, raising the earth's ...
... African scientists working at the epicenter of the AIDS ... immunodeficiency virus (HIV) "exhausts" killer T cells that would ... can simply "turn off" fully functional T cells by ... tube studies, however, the scientists showed that they could ...
Cached Biology News:Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 2Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 3The vicious cycle of rainforest destruction 2A new tool against brain disease 2A new tool against brain disease 3A new tool against brain disease 4
(Date:7/30/2015)... ... 31, 2015 , ... Ralco is honored to announce that it is the ... be held August 5-9 in Marshall. The Ralco Enrichment Center is an interactive experience ... agriculture impacts their daily lives. This unique exhibit also features a birthing center for ...
(Date:7/30/2015)... 30, 2015   GenoSpace , a leading ... and analysis of genomic and other biomedical data, ... joined the company as Vice President of Sales ... "GenoSpace partners with its ... analyze and explore complex sets of genomic, phenotypic ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report on ... current state of the global Propanol market with a focus on the Chinese situation. ... Carboclor, Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang ...
(Date:7/30/2015)... CA (PRWEB) , ... July 30, 2015 , ... ... successful completion of a field clinical study of its canine osteoarthritis stem cell ... with Aratana Therapeutics (Kansas City, KS) and will be marketed in the US ...
Breaking Biology Technology:Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3
... annual SBIR/STTR Conference will be held in conjunction with ... in Madison, 4402 E. Washington. The afternoon conference will ... and Small Business Technology Transfer (STTR) grant programs, and ... to small businesses for technological innovation. ...
... leader in e-document delivery solutions, ... VSI-FAX(R) product families, announces Esker ... new solution allows Lotus Notes ... effectively, and economically with customers, ...
... announced today that it has developed a new SARS ... is now in the hands of USAMRIID (US Army Medical ... WHO Central Public Health Laboratory (UK) and the British Columbia ... the SARS genome, EraGen went to work immediately to develop ...
Cached Biology Technology:Annual Conference Honors Tech Grant Winners 2EraGen Biosciences Ships SARS Diagnostic Test in Record Time 2
... screening and binding optimization and built on ... synthesis platform. These microarrays are available as ... Service. Probe Content Our ... 1500 known aptamer sequences. Add up to ...
... LC Sciences provides a comprehensive service ... high density peptide microarrays synthesized on ... using recombinant proteins/antibodies or serum samples. ... your sequence designs, binding assays using ...
... a comprehensive epitope analysis service utilizing ... Paraflo microfluidic chips for immunological studies, ... comprehensive service includes assistance with your ... provided by you, single or dual ...
... aptamer screening and binding optimization and built ... on-chip synthesis platform. Thousands of customer specified ... LC Sciences can provide assistance with custom ... part of our comprehensive DNA/RNA Aptamer Microarray ...
Biology Products: