Navigation Links
Stem cell finding could advance immunotherapy for lung cancer
Date:11/13/2012

CINCINNATIA University of Cincinnati (UC) Cancer Institute lung cancer research team reports that lung cancer stem cells can be isolatedand then grownin a preclinical model, offering a new avenue for investigating immunotherapy treatment options that specifically target stem cells.

John C. Morris, MD, and his colleagues report their findings in the Nov. 13, 2012, issue of PLOS One, a peer-reviewed online publication that features original research from all disciplines within science and medicine.

Stem cells are unique cells that can divide and differentiate into specialized cells typesfor example cardiac muscle or liver tissue. These cells also have the ability to self-renew and produce more stem cells.

"Increasing evidence supports the idea that cancerous tumors have a population of stem cells, also called cancer-initiating cells, that continually regenerate and fuel cancer growth," explains Morris, senior author of the study and professor at the UC College of Medicine. "These cancer stem cells may also have the highest potential to spread to other organs."

Current models used to study cancer stem cells provide limited information on the interaction between cancer stem cells with the immune system, making the study of new therapies that utilize the body's immune system to fight off cancer virtually impossible.

In this study, the UC team set out to find a viable, consistent way to isolate lung cancer stem cells that could be used in a mouse model with full immune system function. The team was able to achieve this using a functional laboratory test known as "tumorsphere" assay.

The testwhich shows how cells grow in cultureallowed them to enrich for cancer stem cells.

"Studying these unique cells could greatly improve our understanding of lung cancer's origins and lead to the novel therapeutics targeting these cells and help to more effectively eradicate this disease," adds Morris. "Immuno
'/>"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Verinata Health Announces New Findings At The American Society Of Human Genetics
2. New findings on gene regulation and bone development
3. Finding triggers of birth defects in an embryo heart
4. One click away: Finding data on Floridas endangered species just got easier
5. New findings on protein misfolding
6. Finding new research frontiers in a single cell
7. Team discovers reason that male moths can keep finding females
8. BGI reports the latest finding on NMNAT1 mutations linked to Leber congenital amaurosis
9. Blue Ribbon Panel unveils findings on logistical improvements to support Antarctic science
10. ACRG and BGI report findings from genomics research on recurrent hepatitis B virus integration
11. UMD finding may hold key to Gaia hypothesis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... is a non-traditional biophysics textbook and it describes how ... journey of discovery into biological systems and provides an ... It is about how our genes make proteins that ... of cells in an organism. It quantifies the principles ... can be found on both large and small scales. ...
(Date:10/15/2014)... 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market releases photos and video of ... on Monday October 13 th . Gino ... and angel investor Mr. Chad A. Verdi rang ... NXT-ID thanked his investors and employees "for their work and dedication ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to ... the development of skin cancers by turning on an ... skin cells. , Previously considered protective, SIRT6 is part ... help regulate genomic stability and prevent some of the ... damage, which can lead to cancer. This study, in ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... New Haven, Conn.Paleontologists have discovered the oldest mammalian tooth ... several large dinosaurs. They report their findings in a ... Paleontology . Nicholas Longrich of Yale University ... Natural History came across several of the bones while ...
... COLLEGE STATION, June 14, 2010 - Haze, scientifically known ... Earth,s atmosphere - represents a major environmental problem because ... climate. Despite its profound impacts, how the haze is ... University professor of atmospheric sciences and chemistry who has ...
... Just as President Barack Obama called for in his ... BP and all other companies be responsible to both their ... University,s Jones Graduate School of Business. The rigorous ... spill in the Gulf of Mexico found that Republicans, Democrats ...
Cached Biology News:Dinosaur-chewing mammals leave behind oldest known tooth marks 2Research is getting closer to understanding critical nucleus in haze formation, prof says 2Consumer responses to Gulf oil spill reflect Americans' changing corporate expectations 2
(Date:10/22/2014)... -- Research and Markets has announced ... Market (Product types, Application, Technology, End User and ... Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation and ... offering. This new report titled, ... and Geography) Global Size, Industry Analysis, Trends, Opportunities, ...
(Date:10/22/2014)... Involution Studios , a healthcare software ... infographic, Understanding Ebola . The goal of ... to follow informative tool for anyone wanting to know ... prevention. , "As the news has spread in all ... represents not only a healthcare crisis with global impact, ...
(Date:10/22/2014)... 2014 According to new market ... Type (Consulting, Integration, Deployment & Support), by Service ... (Public, Private, Others (Hybrid & Community)) - Global ... segments the Cloud Professional Services Market into various ... revenues. It also identifies the drivers and restraints ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... 15, 2011 Delcath Systems, Inc. (NASDAQ: ... symposium at the Interventional Radiology and Endovascular Surgery Society ... PHP – A New Evidenced-Based Technology for the Treatment ... 2011, and featured a presentation by Delcath,s Executive Vice ...
... it is now imperative to redefine what makes a successful ... waste management is not thought out from the beginning, the ... energy choice, according to research that appears today in the ... According to Allison Macfarlane, associate professor of environmental science ...
... Institute of Molecular and Cell Biology (IMCB) has discovered ... deadly plant toxin Ricin, widely feared for its bioterrorism ... for the tens of thousands of hospital-acquired infections in ... this first ever genome-wide study to understand how the ...
Cached Biology Technology:Delcath Systems, Inc. Hosts Symposium on Chemosaturation at the SOBRICE Annual Meeting in Brazil 2Delcath Systems, Inc. Hosts Symposium on Chemosaturation at the SOBRICE Annual Meeting in Brazil 3Nuclear waste requires cradle-to-grave strategy 2Nuclear waste requires cradle-to-grave strategy 3A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins 2A*Star scientists discover how to combat hospital-acquired infections and life-threatening toxins 3