Navigation Links
Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Date:3/5/2009

An experimental procedure that dramatically strengthens stem cells' ability to regenerate damaged tissue could offer new hope to sufferers of muscle-wasting diseases such as myopathy and muscular dystrophy, according to researchers from the University of New South Wales (UNSW).

The world-first procedure has been successfully used to regrow muscles in a mouse model, but it could be applied to all tissue-based illnesses in humans such as in the liver, pancreas or brain, the researchers say.

The research team, which is based at UNSW and formerly from Sydney's Westmead Children's Hospital, adapted a technique currently being trialled in bone marrow transplantation. Adult stem cells are given a gene that makes them resistant to chemotherapy, which is used to clean out damaged cells and allow the new stem cells to take hold.

A paper detailing the breakthrough appears in the prestigious journal Stem Cells this week.

The ability of adult stem cells to regenerate whole tissues opens up a world of new possibilities for many human diseases, according to the lead authors of the paper, Professor Peter Gunning, Professor Edna Hardeman and Dr Antonio Lee, from UNSW's School of Medical Sciences.

"The beauty of this technique is that chemotherapy makes space for stem cells coming into muscle and also gives the stem cells an advantage over the locals. It's the first strategy that gives the good guys the edge in the battle to cure sick tissues," Professor Gunning said.

"What has been the realm of science fiction is looking more and more like the medicine of the future," he said.

The procedure solves one of the major hurdles involving stem cell therapy getting the cells to survive for more than an hour or so after inserting them into damaged tissue.

"In muscle, most stem cells die in the first hour or are present in such low numbers that they are not much help," Professor Gunning said. "Until now, the new healthy cells had no advantage over the existing damaged tissue and were getting out-competed.

While trials of the procedure are at the pre-clinical stage, researchers are looking to launch human trials treating specific forms of muscular dystrophy such as oculopharyngeal dystrophy within the next three to five years.


'/>"/>

Contact: Steve Offner
s.offner@unsw.edu.au
61-293-858-107
University of New South Wales
Source:Eurekalert

Related biology news :

1. Mount Sinai Hospital researcher makes stem cell breakthrough
2. World breakthrough in treating premature babies
3. Key to future medical breakthroughs is systems biology, say leading European scientists
4. Researchers make breakthrough in the production of double-walled carbon nanotubes
5. Fly guy makes memory breakthrough
6. A scientific breakthrough on the control of the bad cholesterol
7. Adult stem cell breakthrough
8. NC State finds new nanomaterial could be breakthrough for implantable medical devices
9. Sandia, SES win Popular Mechanics Breakthrough Innovator Award
10. Breakthrough optical technology to assess colon cancer risk, accuracy
11. Chips are down as Manchester makes protein scanning breakthrough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/11/2016)... Synaptics Incorporated (NASDAQ: SYNA ), the ... its ClearPad ® TouchView ™ 4300 touch ... categories in the 8 th Annual Mobile Excellence ... The Synaptics ® TDDI solution enables faster time-to-market, ... devices, brighter displays and borderless designs. ...
(Date:1/8/2016)... Kingdom , Jan. 8, 2016   Bruin Biometrics, ... today announced the closing of a $9 million financing. The ... the financing will be used to accelerate the commercialization of ... early-stage pressure ulcers. United Kingdom ... Mark approval. The device,s introduction has been met with enthusiasm ...
(Date:1/7/2016)... , Jan. 7, 2016 This BCC ... markets for biometric technologies and devices, identifying newer markets ... for various types of biometric devices. Includes forecast from ... Identify newer markets and explore the expansion of ... devices. Examine each type of biometric technology, determine its ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... 2016 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... for clean technology companies in the TSX Venture 50 TM ... listed on the TSX Venture Exchange, in each of five ... technology & life sciences, diversified industries and technology – ... return on investment, market cap growth, trading volume and analyst ...
(Date:2/8/2016)... Feb. 8, 2016  CytRx Corporation (NASDAQ: ... specializing in oncology, today announced that it has ... with Hercules Technology Growth Capital, Inc. and Hercules ... in financing. --> ... million of financing under the loan and security ...
(Date:2/8/2016)... , Feb. 8, 2016 Novan, Inc. today announced that ... the Board of Directors of Novan. In addition, Robert Keegan ... North Carolina . --> ... announced that it received a total of $32.8 million of net ... its private investor network originating throughout the Research Triangle area of ...
(Date:2/8/2016)... , Feb. 8, 2016  BioElectronics Corporation (OTC ... devices, announced today that it is responding to ... from the Securities and Exchange Commission posted on ... , Chairman of the Board of BioElectronics Corporation ... Business Administration at The Fuqua School of Business, ...
Breaking Biology Technology: