Navigation Links
Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
Date:1/29/2012

A team of UCLA scientists has found that the pathogen that causes leprosy has a remarkable ability to avoid the human immune system by inhibiting the antimicrobial responses important to our defenses.

In one of the first laboratory studies of its kind, researchers discovered that the leprosy pathogen Mycobacterium leprae was able to reduce and evade immune activity that is dependent on vitamin D, a natural hormone that plays an essential role in the body's fight against infections.

The pathogen manipulated micro-RNAs, tiny molecules made of ribonucleic acids that carry information and that help regulate genes to direct cell activity, including immune system defenses. Micro-RNAs are short RNAs that do not code information for proteins, which carry out all cell activity; rather, they bind to the RNAs that do code for proteins and block them.

Published in the Jan. 29 online edition of the journal Nature Medicine, the findings demonstrate how an infectious disease pathogen like M. leprae can use micro-RNAs to impact the immune system's fight response.

"We may find that these tiny micro-RNAs can be exploited by pathogens to weaken our immune response," said the study's first author, Dr. Philip T. Liu, an assistant professor of medicine at the Orthopaedic Hospital Research Center and in the department of dermatology at the David Geffen School of Medicine at UCLA. "By better understanding how pathogens can escape our immune cells, we can design more effective therapies to boost our immune responses to these difficult to treat infections like leprosy."

Leprosy, one of the world's oldest known diseases, is a chronic infectious disease that affects the skin, the peripheral nerves, the upper respiratory tract and the eyes and can lead to disfigurement of the hands, face and feet. In 2008, approximately 249,000 new cases of leprosy were reported worldwide, according to the World Health Organization
'/>"/>

Contact: Rachel Champeau
rchampeau@mednet.ucla.edu
310-794-2270
University of California - Los Angeles Health Sciences
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Massive gene loss linked to pathogens stealthy plant-dependent lifestyle
2. Tuberculosis strain spread by the fur trade reveals stealthy approach of epidemics
3. UD research study to shed light on emerging seaborne pathogen
4. Comparative genomics reveals molecular evolution of Q fever pathogen
5. UGA licenses invention that kills food-borne pathogens in minutes
6. Plant microbe shares features with drug-resistant pathogen
7. Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms
8. Flexible neck in cell-receptor DC-SIGN targets more pathogens
9. Designing probiotics that ambush gut pathogens
10. Genome of Irish potato famine pathogen decoded
11. Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
(Date:4/17/2015)... , April 17, 2015 ... concerns, and technological advancement to drive biometric systems ... until 2020   According to a ... Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems market in ... to register growth at CAGR of over 22% ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... URBANA Speculation about how animals will respond to ... Illinois researcher Patrick Weatherhead and his students to conduct ... and Texas. His findings suggest that ratsnakes will be ... more active at night. "Ratsnakes are a species ...
... male wasp lays claim to his harem, according to new research ... former PhD graduate student Kelly Ablard, found that when a male ... side, and once in range, uses the tip of his antenna ... a yet unidentified specimen-specific pheromone onto the female,s antenna that marks ...
... of fireflies has inspired scientists to modify a light-emitting ... a half times as efficient as the original. Researchers ... of firefly lanterns, the organs on the bioluminescent insects, ... an unexpected pattern of jagged scales that enhanced the ...
Cached Biology News:Global warming beneficial to ratsnakes 2Global warming beneficial to ratsnakes 3Global warming beneficial to ratsnakes 4Scientists mimic fireflies to make brighter LEDs 2Scientists mimic fireflies to make brighter LEDs 3
(Date:4/18/2015)... -- Aurigene and its partner Curis, ... data at the poster sessions from two programs ... Meeting (April 18-22 in Philadelphia, PA ... ) , Aurigene will present data ... inhibitors program, which is currently in preclinical development. ...
(Date:4/17/2015)... Calif. , April 17, 2015 /PRNewswire/ ... received a SBIR grant from the National ... National Institutes of Health (NIH). The grant ... efforts in the development of breakthrough genomic ... using specially fabricated substrates. Centrillion has been ...
(Date:4/17/2015)... 2015 Reed Technology and Information ... data management, preparation, and submission to the U.S. Food ... a new Lot Distribution Report (LDR) service for manufacturers ... compliant with the FDA’s new rule on electronic submission ... monitor the volume and timing of particular biologics introduced ...
(Date:4/17/2015)... CA (PRWEB) April 17, 2015 CIO ... ) for its 20 Most Promising Pharma and Life ... on MMIS’s MediSpend global compliance software platform for life ... is selected by a panel of experts and members ... technology entrepreneurship. “MMIS’s MediSpend Platform has been on our ...
Breaking Biology Technology:Aurigene to Present its NAMPT and IRAK-4 Inhibitors Programs at AACR 2015 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2
... Nominated Actress Shares Her Personal Story and Tips for Better Blood ... ... of the more,than 20 million Americans living with diabetes, Emmy nominated actress ... diabetes care, to urge other Americans with diabetes to reach,better levels of ...
... Mass. -- By activating multiple fluorescent proteins in neurons, neuroscientists ... as never before, rendering their cells in a riotous spray ... in the cover story of the Nov. 1 issue of ... Livet, Joshua R. Sanes, and Jeff W. Lichtman. , Brainbow ...
... California, Berkeley, have built the smallest radio yet - a ... hair that requires only a battery and earphones to tune ... their first FM broadcast last year - Derek & The ... across the room. In homage to last year,s 100th anniversary ...
Cached Biology Technology:Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 2Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 3Actress Aida Turturro Tells Americans to Start Now to Talk With Their Healthcare Provider About Taking Control of Their Diabetes 4Scientists create colorful 'brainbow' images of the nervous system 2World's smallest radio uses single nanotube to pick up good vibrations 2World's smallest radio uses single nanotube to pick up good vibrations 3World's smallest radio uses single nanotube to pick up good vibrations 4
... Zero Blunt TOPO PCR Cloning Kit ... for high-efficiency (>=95%) cloning of blunt-end ... polymerases. The kit includes the linearized ... for 5-minute bench-top ligations without ligase ...
... The Zero Blunt TOPO ... the fastest and easiest ... than or equal to95%) ... products amplified with proofreading ...
Carp Vitellogenin ELISA System, 96 wells. ELISARange: 5.0-225 ng/ml.Sensitivity: 5.0 ng/ml.Sample volume: 100 ul.Suitable for use with Carp plasma samples.3-h protocol.Store at 2-8 C. Category: Drug ...
Blot Paper 7 x 8.5cm semi-dry western blots (order number RB-400)...
Biology Products: