Navigation Links
Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
Date:7/6/2012

Bethesda, MDA new research report published online in the FASEB Journal reveals a connection among sugar, cancer, and dependence on breathing machines--microRNA-320a. In the report, Stanford scientists show that the molecule microRNA-320a is responsible for helping control glycolysis. Glycolysis is the process of converting sugar into energy, which fuels the growth of some cancers, and contributes to the wasting of unused muscles such as the diaphragm when people are using ventilators. Identifying ways to use microRNA-320a to starve tumors and keep unused muscles strong would represent a significant therapeutic leap for numerous diseases and health conditions.

"We hope that this discovery will yield a new avenue of molecular treatment for cancers, particularly lung cancer, which is the number one cause of cancer deaths worldwide," said Joseph B. Shrager, M.D., a researcher involved in the work who is a Professor of Cardiothoracic Surgery, and Chief of the Division of Thoracic Surgery at Stanford University School of Medicine, and VA Palo Alto Healthcare System in California. "We also hope it can lead to a treatment to be given to intensive care unit patients who require the breathing machine, reducing the length of time they require the machine, and thereby reducing complications and deaths."

To make this discovery, Shrager and colleagues studied lung cancer tissues from patients and tissue from the diaphragm (the primary muscle used for breathing) from patients who had been on a breathing machine for more than a few hours. They found that both types of tissue had increases in glycolysis, as well as reductions in a molecule that controls glycolysismicroRNA-320a. Test tube experiments then showed that microRNA-320a definitely controls how much energy these two very different tissues have available to them.

"Just as the discovery of angiogenesis opened new doors to find w
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stanford marine biologist Barbara Block wins Rolex Award for Enterprise
2. Stanford researchers help predict the oceans of the future with a mini-lab
3. Stanford scientists document fragile land-sea ecological chain
4. Support for climate change action drops, Stanford poll finds
5. Americas clean energy policies need a reality check, say Stanford researchers
6. Stanford and MIT scientists win Perl-UNC Neuroscience prize
7. Climate change may create price volatility in the corn market, say Stanford and Purdue researchers
8. Keck award enables Carnegie Mellon and Stanford to dramatically expand crowdsourced RNA design
9. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
10. Scripps Florida scientists identify critical quality control for cell growth
11. Gladstone scientists identify critical process in stem cell development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... , Oct. 15, 2014 Sandata Technologies, ... home and community-based care, today announced it released ... Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™)  for ... a home health company founded in 1996 and ... . The study details the ...
(Date:10/15/2014)... Researchers have linked increased resistance to bacterial pneumonia in ... sex hormone estrogen. , Females are naturally more resistant ... of scientists has shown that increased resistance to bacterial ... nitric oxide synthase 3 (NOS3). They also show that ... the female sex hormone estrogen. , The team, lead ...
(Date:10/14/2014)... Research shows SIRT6—a protein known to inhibit the ... of skin cancers by turning on an enzyme that ... , Previously considered protective, SIRT6 is part of a ... genomic stability and prevent some of the genetic flaws ... can lead to cancer. This study, in the journal,s ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... global warming is causing the worldwide declines of amphibians ... to biologists. The findings, which contradict two widely held ... and toads and aid in their conservation. "We ... extinction event," said Peter Hudson, the Willaman professor of ...
... Greenland,s ice sheet Studies have indicated that ... increasing average summer air temperatures in southern coastal regions. ... mass from 1958 through 2008, Rignot et al. study ... sensing techniques; and surface mass balance, which is derived ...
... of DNA sequence information resulting from deciphering the human ... technological developments that have been vital in the identification ... for the development of novel genetic therapies to treat ... new genomic era heralds earlier diagnoses, greatly improved prevention ...
Cached Biology News:Global warming link to amphibian declines in doubt 2Global warming link to amphibian declines in doubt 3AGU journal highlights: Nov. 11, 2008 2AGU journal highlights: Nov. 11, 2008 3AGU journal highlights: Nov. 11, 2008 4AGU journal highlights: Nov. 11, 2008 5AGU journal highlights: Nov. 11, 2008 6AGU journal highlights: Nov. 11, 2008 7AGU journal highlights: Nov. 11, 2008 8AGU journal highlights: Nov. 11, 2008 9AGU journal highlights: Nov. 11, 2008 10Personalized medicine: Innovative online journal leads the way 2
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/19/2014)... The Latin American hardware encryption display market report defines ... and forecast of revenue. This market was valued at ... $2,366.8 million by 2018, at a CAGR of 70.3% ... of the Latin American hardware encryption market report to ... also provides a glimpse of the segmentation of the ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
(Date:10/18/2014)... (PRWEB) October 19, 2014 The ... (Short Acting, Intermediate Acting, Premixed), Modern Human Insulin ... Apidra, Levemir, NovoRapid, Novomix, Tresiba, Others) - Forecast ... major drivers, restraints, challenges, opportunities, current market trends, ... along with the estimates and forecasts of the ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... 27 Carna Biosciences, Inc. ("Carna"),announced on October ... with,Shanghai Universal Biotech Company ("SUBC"). Under the terms ... of Carna,s Protein,Kinases within China., With China,s ... life sciences, major biopharmaceutical companies have now established,research ...
... 27 BioAtom Inc. (private) announced,today that it will ... October 28, 2008 at 2:30 PM PDT (5:30 PM ... California., Myron Karasik, M.B.A., C.M.C., Director of Finance, ... of Costa Mesa, CA, dedicated,to development and commercialization of ...
... CITY, Oct. 24 /PRNewswire-FirstCall/ - AEterna Zentaris Inc.,(NASDAQ: ... company focused on,endocrine therapy and oncology, today announced ... Market, notifying AEterna Zentaris that during the 30,consecutive ... bid price of the,Company,s common shares had closed ...
Cached Biology Technology:Carna Biosciences Signs Distribution Agreement with Shanghai Universal Biotech Company 2BioAtom Inc. To Present at BIOCOM Investor Conference 2008 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 2AEterna Zentaris Receives Notification from Nasdaq Relating to Minimum Bid Price 3
Packaging: package with 500 l Patent/trademark/license (electronic): (r) Registered trademark of Molecular Probes...
... Rotofor purification system, 100-120 V, is used ... isoelectric focusing (IEF). The system includes both ... ml) focusing chambers, chassis, harvesting apparatus, cooling ... (pH 3-10), 60 ml syringe, colored protein ...
...
... B-Phycoerythrin Labeling Kit - NH2 is primarily ... for immunostaining and cellular proteins for tracing. ... has succinimidyl group (NHS), and can easily ... of IgG or other proteins without any ...
Biology Products: