Navigation Links
Spiral constriction -- how dynamin mediates cellular nutrient uptake
Date:9/20/2011

Dr. Katja Flber and Professor Oliver Daumke, structural biologists at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, together with researchers from Freie Universitt (FU) Berlin, have determined the molecular structure of dynamin, a 'wire-puller' that mediates nutrient uptake into the cell. Since pathogens such as HIV can also enter the body's cells in this way, understanding the underlying molecular mechanisms can potentially open up new approaches for medical applications (Nature, DOI: 10.1038/nature10369)*.

Many nutrients pass from the blood through cell membrane channels into the body cells. However, appropriate channels do not exist for all nutrients. For example, iron binds outside the cell to a large transport molecule and is imported by other means, via endocytosis, into the cell. The cargo-containing transport molecules bind to the cell membrane, which invaginates inward. The iron molecules along with their transporters are taken up in a small membrane bubble (vesicle) into the cell and released there.

An important 'wire-puller' of endocytosis is the protein molecule dynamin. And that in the most literal sense of the word: If a vesicle forms, the dynamin molecules self-assemble and form a spiral around the neck of the vesicle. Dynamin functions like a small motor: It uses the energy of the cell's GTP to pull the spiral together, constricting the neck of the vesicle so that it detaches from the cell membrane.

The molecular details of this 'pull' mechanism around the vesicle neck were previously unknown. In their present study, MDC structural biologists Professor Daumke and Dr. Flber, together with the endocytosis researcher Professor Volker Haucke and the bioinformatician Dr. Frank No of FU Berlin, provide fundamental insights into this process. Using X-ray diffraction analysis, they succeeded in building a structural model of dynamin. For this study it was necessary to produce protein crystals of dyn
'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. The cellular intricacies of cystic fibrosis
2. Cellular metabolism self-adapts to protect against free radicals
3. New cellular surprise may help scientists better understand human mitochondrial diseases
4. Cellular laser microsurgery illuminates research in vertebrate biology
5. Cellular stress can induce yeast to promote prion formation
6. Researchers provide means of monitoring cellular interactions
7. Development of a FRET sensor for real-time imaging of intracellular redox dynamics
8. How muscle develops: A dance of cellular skeletons
9. Harvard scientists see the early cellular cause of dry eye disease for the first time
10. Thalidomide shows efficacy as adjuvant therapy for hepatocellular carcinoma patients
11. WSU proves extracellular matrix tugging creates come hither stimulus for cancer migration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Law Enforcement Biometrics Market in North America ... About Biometrics Biometrics is a technology that ... their physical or behavioral patterns. It involves the ... as fingerprints, face recognition, DNA, palm print, hand ...
(Date:8/27/2014)... new skill is easier when it is related to ... pianist might learn a new melody more easily than ... engineers from the Center for the Neural Basis of ... and Carnegie Mellon Universityhave discovered a fundamental constraint in ... as the cover story in the Aug. 28, 2014, ...
(Date:8/27/2014)... risk to Europe based upon a proxy for impact ... a ,big data, approach to scientific research. , The ... Health ranked the top 100 pathogens affecting humans and ... which, they believe, will help governments across the continent ... diseases, including as a result of climate change, and ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... who spray insecticides against aphids as a preventative measure only ... term, their fields will end up with even more aphids ... the Biocenter of the University of Wrzburg in the scientific ... the biodiversity in differently managed triticale fields? This is what ...
... Carolina State University researchers have found that a subset of ... a global epidemic threatening a number of economically important trees, ... of ambrosia beetle are creating problems so far, but there ... which could be devastating to any number of tree species," ...
... approach for producing large quantities of human-derived gelatin that ... tons of animal-based gelatin produced annually for gelatin-type desserts, ... in ACS,s Journal of Agriculture and Food Chemistry ... gelatin, which is made most often from the bones ...
Cached Biology News:Fewer aphids in organic crop fields 2Spread of fungus-farming beetles is bad news for trees 2
(Date:8/27/2014)... 27, 2014  Lisa Kulik saw fireworks for the ... holiday, thanks to a groundbreaking retinal implant co-invented by ... clinician-researcher at the University of Southern California (USC) Eye ... Peoria, Ariz. resident who has retinitis pigmentosa, ... sight. On June 2, she became the first person ...
(Date:8/27/2014)... 27, 2014 Guggenheim Securities, the investment banking ... the hiring of veteran equity analyst Charles "Tony" Butler ... Butler will focus on the biotech/biopharma sector. ... of experience and a broad network of relationships in ... Director and Head of Equities at Guggenheim Securities. "His ...
(Date:8/27/2014)... , Aug. 27, 2014 Research ... "Global Enzyme for Pulp & Paper Industry Report ... The Global Enzyme for Pulp & Paper Industry Report ... current state of the global enzyme for pulp & ... overview of the industry including definitions, classifications, applications and ...
(Date:8/27/2014)... , Aug. 27, 2014 Tris Pharma, ... delivery technologies, today announced that it has been selected ... & Industry Association,s 2014 Awards for Excellence ... by an independent panel of judges from SCORE (Counselors ... Award winners will be honored at a gala event ...
Breaking Biology Technology:USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2Global Enzyme for Pulp & Paper Industry Report 2014 2Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2
... 1 Isis,Pharmaceuticals, Inc. (Nasdaq: ISIS ) ... million in Ibis Biosciences, Inc., an Isis,subsidiary. The ... Ibis,T5000(TM) Biosensor System, which offers a unique solution ... making this,investment, Abbott retains the exclusive option to ...
... through compelling stories at technology's leading edges. The latest science ... subdued background with simple tutorials and references. Selected books ... and study. , ... Tucson, AZ ...
... researchers has created the first complete high-resolution map of ... cortex -- the outer layer of the brain responsible ... groundbreaking work identified a single network core, or hub, ... hemispheres of the brain. , The work by ...
Cached Biology Technology:Abbott Invests Additional $20M in Isis' Subsidiary Ibis Biosciences 2Abbott Invests Additional $20M in Isis' Subsidiary Ibis Biosciences 3"Brave New Reality" Provides a Wide Spectrum of High Tech News and Easy Science. 2"Brave New Reality" Provides a Wide Spectrum of High Tech News and Easy Science. 3New map IDs the core of the human brain 2New map IDs the core of the human brain 3
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... - Neurosphere is a system designed for ... neurospheres in a serum free environment. The kit ... which has been optimized for neural stem cell ... Genes & Development 10 :3129). Two growth ...
Biology Products: