Navigation Links
Specific brain protein required for nerve cell connections to form and function
Date:9/5/2007

for the production of certain neurexin proteins. Deleting just one of these genes causes no adverse effects in mouse models, while removing all three is fatal. But fruit flies have only one gene for neurexin, and when Bhat and colleagues deleted the gene, the flies survived barely.

"Knocking out neurexin basically resulted in a fly with defective nervous system said Bhat, also a member of the UNC Neuroscience Center and the UNC Neurodevelopmental Disorders Research Center.

First of all, the mutated fruit flies had trouble moving around. When the researchers examined the synapses in these flies, they found that half of them were gone. The synapses that remained were deformed, causing them to send out less chemical signals. The researchers, led by Jingjun Li, a graduate student in neurobiology in the UNC School of Medicine, concluded that neurexin is required for the growth of synapses, for the maintenance of their structure and for their function.

Currently, Bhat and other scientists are working to identify the proteins that neurexin binds to, how they interact, and what sequence of events ultimately results in the organization of synapses within nerve cells. The hope is that such studies in Drosophila will one day clarify the role neurexin plays in learning and memory, ultimately leading to a better understanding of how defects in this protein can lead to human disorders such as autism, Bhat said.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Products containing specific probes for detecting alternative splice forms protected
2. Scientists generate patient-specific stem cells, Science study says
3. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
4. Eating, body weight regulated by specific neurons
5. Tool developed to silence genes in specific tissues using RNAi
6. Gene-specific Ebola therapies protect non-human primates from lethal disease
7. Unique dual target specificity of kinase inhibitor key for success against cancer
8. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
9. A new male-specific gene in algae unveils an origin of male and female
10. Scientists identify specific enzymes that make meningitis hard to fight
11. Sun exposure early in life linked to specific skin cancer gene mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 22, 2014The story of cowpea (black-eyed peas) is a ... biggest problemseven more fascinating is the story of the ... Cowpea: The Food Legume of the 21st Century to ... and use. The book was recently published by the ... Institute of Tropical Agriculture (IITA). , Singh has devoted ...
(Date:9/21/2014)... and barnacles secrete very sticky proteins that help them ... by these natural adhesives, a team of MIT engineers ... repair ships or help heal wounds and surgical incisions. ... researchers engineered bacteria to produce a hybrid material that ... bacterial protein found in biofilms slimy layers formed ...
(Date:9/19/2014)... biology professor will study multifunctional and specialized spinal ... a National Science Foundation grant in the amount ... Berkowitz, professor in the Department of Biology, OU ... the differences between the multifunctional and specialized spinal ... use and what connections they make. Berkowitz ...
Breaking Biology News(10 mins):Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3
... new study looking at the structure of feathers in bird-like ... inventions how flight might have evolved. Academics ... that prehistoric birds had a much more primitive version of ... acting as simple airfoils for gliding. Close examination of ...
... Stretching across central Africa, the Congo Basin forest is ... and a lifeline for more than 60 million people ... storing huge amounts of carbon, supporting unique ecosystems and ... Africa. Yet the Congo,s forests are being cleared at ...
... developed a simple method for reducing the amount of ... method is called simultaneous precipitation using iron sulphate. A ... takes place simultaneously with the actual biological wastewater treatment. ... prior to the biological wastewater treatment process, and the ...
Cached Biology News:New evidence of dinosaurs' role in the evolution of bird flight 2Feature package of Congo Basin forest photos, stories & videos 2Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill 2
(Date:9/22/2014)... were treated with a statin in the hospital after ... to survive than those who were not, according to ... This study was conducted by the same researchers who ... improve survival in victims of ischemic stroke., Ischemic stroke ... blood vessel that blocks blood from reaching areas of ...
(Date:9/22/2014)... MA (PRWEB) September 22, 2014 Pearl's ... scientific breakthrough in drought tolerant grass seed this week ... grass seed. The announcement coincides with the fact that ... the Spring as many believe. , As of ... rave and favorable reviews by industry experts and the ...
(Date:9/22/2014)... SANTA CLARA, Calif. , Sept. 22, ... WBMD ), the leading source of health information, today ... that provide novel insights regarding physician and patient ... care.  Dr. Eric Topol , a leading authority ... serves as both Editor-in-Chief of Medscape and Chief Academic ...
(Date:9/22/2014)... 2014 Research and Markets ... the "Global Biotechnology Reagents Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769) Biotechnology reagents are chemical compounds ... to detect and examine another substance to provide ... laboratories to prepare, collect, and examine specimens from ...
Breaking Biology Technology:Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2Pearl's Premium Ultra Low Maintenance Lawn Seed Announces A Major Breakthrough In Drought Tolerant Grass Seed 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 2WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 3WebMD/Medscape Digital Technology Survey Reveals Unique Insights Into How Patients and Physicians Perceive the Role, Potential and Risks Associated with Digital Health Technologies 4Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... companies had to scramble to attract and retain high-caliber talent. ... so important that it was at the top of the ... as a critical business imperative. But all this suddenly changed ... morphed into a war ON talent. For the past-three plus ...
... Fusion SOS (Small Office Solutions), a new, Milwaukee-based ... initial client group this month. The program the ... outsourced network management solution set, affording the end-user ... data back-up, e-mail and Web site-hosting needs. This ...
... CHICAGOIf you buy into the concept that any ink is good ... the first step to sales, then its worth a couple minutes ... huge media department. Its almost an entire hanging file folder in ... both contain only what I wrote and said. They dont contain ...
Cached Biology Technology:Return of Retention 2Return of Retention 3Learning how far your message reaches by Googling yourself 2Learning how far your message reaches by Googling yourself 3Learning how far your message reaches by Googling yourself 4
...
Candida (IgG) -Ab EIA Sample Size: 5 l...
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
Biology Products: