Navigation Links
Specific brain protein required for nerve cell connections to form and function
Date:9/5/2007

for the production of certain neurexin proteins. Deleting just one of these genes causes no adverse effects in mouse models, while removing all three is fatal. But fruit flies have only one gene for neurexin, and when Bhat and colleagues deleted the gene, the flies survived barely.

"Knocking out neurexin basically resulted in a fly with defective nervous system said Bhat, also a member of the UNC Neuroscience Center and the UNC Neurodevelopmental Disorders Research Center.

First of all, the mutated fruit flies had trouble moving around. When the researchers examined the synapses in these flies, they found that half of them were gone. The synapses that remained were deformed, causing them to send out less chemical signals. The researchers, led by Jingjun Li, a graduate student in neurobiology in the UNC School of Medicine, concluded that neurexin is required for the growth of synapses, for the maintenance of their structure and for their function.

Currently, Bhat and other scientists are working to identify the proteins that neurexin binds to, how they interact, and what sequence of events ultimately results in the organization of synapses within nerve cells. The hope is that such studies in Drosophila will one day clarify the role neurexin plays in learning and memory, ultimately leading to a better understanding of how defects in this protein can lead to human disorders such as autism, Bhat said.


'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Products containing specific probes for detecting alternative splice forms protected
2. Scientists generate patient-specific stem cells, Science study says
3. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
4. Eating, body weight regulated by specific neurons
5. Tool developed to silence genes in specific tissues using RNAi
6. Gene-specific Ebola therapies protect non-human primates from lethal disease
7. Unique dual target specificity of kinase inhibitor key for success against cancer
8. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
9. A new male-specific gene in algae unveils an origin of male and female
10. Scientists identify specific enzymes that make meningitis hard to fight
11. Sun exposure early in life linked to specific skin cancer gene mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/10/2015)... The latest 364 page report from business intelligence provider ... border security market . Visiongain assesses that this ... Now: Border security is hard to achieve and harder to ... you need to know about - and more importantly, you ... this will impact your company and the border security industry ...
(Date:8/5/2015)... According to a new market ... Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, Education, ... to 2020", published by MarketsandMarkets, defines and segments the ... segments. The global PIAM Market is estimated to grow ... 2019, at a CAGR of 14.9 % from 2014 ...
(Date:8/4/2015)... ALBANY, N.Y., Aug. 4, 2015  AMRI (NASDAQ: AMRI ) ... June 30, 2015. Highlights: , Second quarter ... increase from 2014 , Adjusted contract margins of ... EPS of $0.22, including a $0.05 decrease in EPS from royalties ... of $16 million "We are very pleased to ...
Breaking Biology News(10 mins):Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... Alexander Graham Bell professor of medicine and chief of ... of Medicine, is the recipient of the Alton Ochsner ... presented to Spira today at the Opening Session of ... Physicians in Chicago. This award recognizes Spira,s seminal ...
... rodents known as Murinae (mice, rats, etc.), which first ... the entire Old World (Eurasia, Africa, Australia) in less ... have long suspected that one of the reasons for ... apparatus. Now, researchers have used the brilliant X-ray beams ...
... of October. The goal is to develop the production process ... tires made from dandelion rubber. This is why molecular biologists ... built a pilot facility in Mnster that is capable of ... they cultivate several hectares of a dandelion variety which is ...
Cached Biology News:Dr. Avrum Spira receives award for advancing research on tobacco smoke's effect on lungs 2Chewing their way to success 2Fraunhofer and Continental come together when the dandelion rubber meets the road 2Fraunhofer and Continental come together when the dandelion rubber meets the road 3
(Date:8/26/2015)... ... August 26, 2015 , ... PRC Clinical, a ... business relationships with local sponsors in southern California. The Clinical Trial Management Expert CRO ... processes and regulatory pathways., , Stem Cell Meeting on ...
(Date:8/25/2015)... ... August 25, 2015 , ... Vets Plus, ... Knapp, Wis. The company has added a AS16 Sharples centrifuge to harvest products ... during bacterial or fungal fermentation process development. , The new centrifuge greatly ...
(Date:8/25/2015)... PETERSBURG, Fla. , Aug. 25, 2015 /PRNewswire/ ... announced today that it has been awarded Certification ... Quality Assurance (NCQA). NCQA is ... quality. NCQA accredits and certifies a wide range of ... in key areas of performance. "Our ...
(Date:8/25/2015)... New Zealand , Aug. 25, 2015 /PRNewswire/ ... MitoQ, has just launched the latest addition to ... MitoQ Blood Sugar, a comprehensive and highly targeted ... to support balanced blood sugar and insulin levels, ... Mitoquinol, the novel ingredient in MitoQ, was developed ...
Breaking Biology Technology:PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3New centrifuge and fermentor expand product development capacity at Vets Plus 2InformedDNA Achieves NCQA Utilization Management Certification 2MitoQ Launches Revolutionary NZ-Developed Supplement to Support Blood Sugar Balance 2MitoQ Launches Revolutionary NZ-Developed Supplement to Support Blood Sugar Balance 3MitoQ Launches Revolutionary NZ-Developed Supplement to Support Blood Sugar Balance 4
... 2011 Cellular Dynamics International, Inc. (CDI), the world,s ... lines and tissue cells for drug discovery and safety, ... at the 29th Annual JPMorgan Healthcare Conference at 7:30 ... Francis Hotel in San Francisco. Robert Palay, chief executive ...
... science: Cornell University researchers have unveiled striking, atomic-resolution details ... between patches, and have uncovered key insights into graphene,s ... 5, 2010.) Researchers focused on graphene ... a crystal lattice like a honeycomb or chicken wire ...
... 5, 2011 Sangamo BioSciences, Inc. (Nasdaq: SGMO ... will provide an update on the progress of Sangamo,s ZFP ... strategy at 12:30 pm PT (3:30 pm ET) on Thursday, ... Conference which will be held in San Francisco. ...
Cached Biology Technology:Graphene grains make atom-thick patchwork 'quilts' 2Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference 2
Glutathione Agarose Beads 10 ml...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Rabbit monoclonal [EP881Y] to EEF2K ( Abpromise for all tested applications). Antigen: Synthetic peptide corresponding to residues in the C-terminal of human EEF2K. Entrez GeneID: 29904 S...
...
Biology Products: