Navigation Links
Specific brain protein required for nerve cell connections to form and function
Date:9/5/2007

CHAPEL HILL Neurons, or nerve cells, communicate with each other through contact points called synapses. When these connections are damaged, communication breaks down, causing the messages that would normally help our feet push our bike pedals or our mind locate our car keys to fall short.

Now scientists at the University of North Carolina at Chapel Hill School of Medicine have shown that a protein called neurexin is required for these nerve cell connections to form and function correctly.

The discovery, made in Drosophila fruit flies may lead to advances in understanding autism spectrum disorders, as recently, human neurexins have been identified as a genetic risk factor for autism.

"This finding now gives us the opportunity to see what job neurexin performs within the cell, so that we can gain a better insight into what can go wrong in the nervous system when neurexin function is lost said Dr. Manzoor Bhat, associate professor of cell and molecular physiology in the UNC School of Medicine and senior author of the study.

The study, published online September 6, 2007, in the journal Neuron, is the first to successfully demonstrate in a Drosophila model the consequences that mutating this important protein may have on synapses.

The research was supported in part by grants from the National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke and the National Institute of Mental Health and funds from the state of North Carolina.

During the last decade, scientists have learned that neurexins are integral to the transmission of chemical signals within the nervous system. Neurexins interact with binding partners called neuroligins to link neighboring nerve cells together so that signals can be sent and received correctly.

Previous attempts to study these proteins in animal models have been challenging. In vertebrates such as mice, three different genes code
'/>"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Products containing specific probes for detecting alternative splice forms protected
2. Scientists generate patient-specific stem cells, Science study says
3. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
4. Eating, body weight regulated by specific neurons
5. Tool developed to silence genes in specific tissues using RNAi
6. Gene-specific Ebola therapies protect non-human primates from lethal disease
7. Unique dual target specificity of kinase inhibitor key for success against cancer
8. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
9. A new male-specific gene in algae unveils an origin of male and female
10. Scientists identify specific enzymes that make meningitis hard to fight
11. Sun exposure early in life linked to specific skin cancer gene mutation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2
... neuroscience research programme that spans basic science all the ... tertiary hospitals and medical schools, and a national organisation ... Singapore. These are some of the new initiatives ... Council (BMS IAC) at their annual meeting today. ...
... An international team of Australian and Israeli researchers has ... moonlight sex event on Earth., An ancient light-sensitive gene ... of Excellence for Coral Reef Studies (CoECRS) that appears ... spawning of corals across a third of a million ...
... method of constructing artificial plant chromosomes from small rings ... transport multiple genes at once into embryonic plants where ... passed on to the next generation -- a long-term ... In the October 19, 2007, issue of PLoS-Genetics, ...
Cached Biology News:Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research 2Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research 3Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research 4Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research 5Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research 6Key found to moonlight romance 2Key found to moonlight romance 3Transgenics transformed 2Transgenics transformed 3
(Date:11/22/2014)...  The element of surprise has been a major ... without warning. Until now, epidemiologists had nothing to measure ... resulting in suboptimal responses to both the H1N1 pandemic ... Photo - http://photos.prnewswire.com/prnh/20141121/160242 That ... virus gene structural changes have been found that invariably ...
(Date:11/21/2014)... England , Nov. 21, 2014   TRU-D SmartUVC ... will feature their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, ... this week from Nov. 23 to 26 at Stand 23. ... is the United Kingdom,s largest infection-related ... infection prevention societies to one of the leading events of ...
(Date:11/21/2014)... CA (PRWEB) November 20, 2014 Author ... Short Walk to the Other Side” published as ... “Award-Winning Finalist in the “Fiction: Short Story” category of ... Jeffrey Keen, President and CEO of USA Book News, ... mainstream and independent publishers, including Simon & Schuster, Penguin, ...
(Date:11/21/2014)... New York, NY (PRWEB) November 20, 2014 ... ) is now available as an open access journal ... cells with infrared fluorescent proteins to preserve photoresponsiveness in ... Two-color fluorescent in situ hybridization using chromogenic ... microfluidics chips for DNA, RNA, and protein electrophoresis , ...
Breaking Biology Technology:Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... SUNNYVALE, Calif., Aug. 5 Pharmacyclics, Inc. (Nasdaq: PCYC ... up to 22,500,000 shares of the Company,s common stock at a subscription ... on July 31, 2009. The Company increased the offering size on July ... to 22,500,000 shares. , , The subscription ...
... JEFFERSON, N.C., Aug. 5 Next Safety, Inc. (NSI) ... work in a pandemic environment. Next Safety is releasing for sale ... flu influenza A subtype H5N1. , , The ... became contagious. The Next Safety respirators are now being sold to ...
... , SANTA MONICA, Calif., Aug. 5 Cord ... stem cell preservation company ( http://www.cordblood-america.com ) ... families nationwide and internationally, said today it has retired $2.53M of ... in February and March of 2007 respectively, between CBAI and the ...
Cached Biology Technology:Pharmacyclics, Inc. Rights Offering Oversubscribed 2Pharmacyclics, Inc. Rights Offering Oversubscribed 3Next Safety Releases Advanced Respirator for Infectious Diseases 2Next Safety Releases Advanced Respirator for Infectious Diseases 3Cord Blood America Retires $2.53M Obligation 2Cord Blood America Retires $2.53M Obligation 3
MOUSE ANTI RAT KAPPA/LAMBDA:HRP Immunogen: MARK-1: Rat kappa light chains (IR202 and IR968)MARL-15: Rat lambda light chains (RH58, IR31)...
Request Info...
Request Info...
Non-Protein Peroxidase Stabilizer , 1 L...
Biology Products: