Navigation Links
Special issue of the EMBO Journal celebrates 30 years of Wnt research
Date:5/22/2012

HEIDELBERG, 22 May 2012 The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. "Three decades of Wnt signalling" summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in development and disease.

Eric Wieschaus, Professor of Molecular Biology at the University of Princeton, remarked: "30 years ago, in the early days of Wnt research, no one anticipated how broadly the pathway would be utilized during development. We now know that Wnt signalling and the components of the Wnt pathway play a central role in patterning and cell fate in organisms from sea urchins to humans and operate in processes as diverse as stem cell maintenance, tissue polarity and neuronal development. We should not be surprised therefore by the parallel importance of the Wnt pathway in cancer and human disease."

Wnt-components and the signals they elicit have roles in many biological processes that range from cell behavior to the determination of cell fate. The discovery of the close relationship between the first mammalian Wnt gene, the int1 proto-oncogene, and the wingless gene in Drosophila provided an important early link between cancer biology and developmental genetics. Multidisciplinary research involving Drosophila geneticists, cancer biologists and molecular biologists, has facilitated the molecular dissection of Wnt pathways, establishing them as one of the first and best understood evolutionary conserved signaling mechanisms.

Today, the Wnt research community is bigger than ever, providing new insight into how cells interact to form a developing organism. This research is leading to the emergence of therapeutic appr
'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. So-called sandfish could help materials handling and process technology specialists
2. HJF nursing specialist wins prestigious Celina Field Cargiver Award
3. Neuroinformatics special issue spotlights the Neuroscience Information Framework
4. Special issue of BMC Microbiology spotlights standardized language for describing microbes
5. Special issue Comparative Cognition in Context now published
6. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
7. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
8. Pest management specialist Charles Summers wins prestigious Woodworth Award
9. GSA special paper presents new studies of Western US earth motion
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... examining only marketing directed at children on the ... found that the majority of black, middle-income and ... tactics. , Authored by Arizona State University researcher ... the first to examine the use of child-directed ... food restaurants and its relationship to demographics. It ...
(Date:11/4/2014)... – (Nov. 4, 2014) – A majority of Madagascar,s ... that could have serious consequences for the rainforests they ... shows the positive impacts lemurs can have on rainforest ... their disappearance could have on the region,s rich biodiversity. ... have fruits eaten by lemurs. Lemurs in turn ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... calls for policymakers to reduce both nitrogen and phosphorus ... problems in fresh and coastal waters. In the ... argue that dual-nutrient reduction strategies are likely to be ... phosphorus in fresh and coastal water ecosystems. "If ...
... 2009 ― Protecting drinking water and preventing harmful ... many lakes, will require reducing both nitrogen and ... to the sea, management strategies should be implemented ... that focus only on one nutrient will fail. ...
... be exhausting. When fruit flies mate, the females, genes ... an immune reaction starts. This is shown in a ... the scientific publication, Journal of Evolutionary Biology .* ... genomic technology, so-called microarrays, researchers at Uppsala University can ...
Cached Biology News:Nutrient pollution chokes marine and freshwater ecosystems 2
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/18/2014)... , Nov. 18, 2014 Cord Blood Registry® ... of the 10th Annual World Stem Cell Summit, the largest ... The 2014 World Stem Cell Summit will be held December ... Texas . The World Stem ... of lifesaving cures and therapies, convening the most prominent figures ...
(Date:11/18/2014)... 17, 2014 Athena Signature Series: Turning Cancer ... Beverly Emerson, a professor in the Regulatory Biology Laboratory at ... recent discovery points to an “off switch” for drug resistance ... how her local research is making a global impact in ... and then join host Cheryl K. Goodman, CEO of Social ...
(Date:11/18/2014)... Texas (PRWEB) November 18, 2014 ... Polytetrahydrofuran (PTMEG) Industry is professional and in-depth ... gives Polytetrahydrofuran basic information, including its definition, ... also industry outline. This exploration covers the ... and worldwide industry examination covering macroeconomic environment ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 2PTMEG Market: 2019 Global Polytetrahydrofuran Industry Development Trends & Analysis Now at DeepResearchReports.com 3
... Multiporator , , , , , , , , ... Protocol No. 4308 915.029 11/1999 , , , , , ... , Cell line , 293 T, human embryonal kidney, ... Plasmid pEGFP-N1 (in bidistilled H 2 O), , ...
... , , , , Multiporator / Electroporator 2510 , , , , ... Transformation Protocol , Protocol No. 4308 915.541 03/2002 , ... , , , , ... , Cell type , Bacteria, gram positive, ...
... Electroporator 2510 , , , , , , , , ... Protocol No. 4308 915.534 01/2002 , , , , ... , Microorganism , Staphylococcus epidermidis, ... Bacteria, gram positive, , , ...
Cached Biology Technology:293 T 2Streptococcus salivarius 2Staphylococcus epidermidis 2
... sufficient materials for 1,464 array sample elements. , , ... , Blocker BSA in PBS (10X): 50 ml ... BupH Phosphate Buffered Saline: 8 packs , 10% ... Pico Luminol Enhancer: 2 x 25 ml , SuperSignal ...
... The Partec Cell Counter Analyser counts cells ... the CCA detects only cells, so that ... the results.,While passing through a 250 m ... fluorescence light signal which is used as ...
... Obtain Clean and Accurate Results ... dramatically increase the sensitivity and accuracy of ... homogeneous cell types and multi-cellular structures isolated ... unique approach to microdissection-developed in 1996 at ...
Mouse monoclonal antibody raised against a partial recombinant DHX8. NCBI Entrez Gene ID = DHX8...
Biology Products: