Navigation Links
Special issue of the EMBO Journal celebrates 30 years of Wnt research
Date:5/22/2012

HEIDELBERG, 22 May 2012 The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. "Three decades of Wnt signalling" summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in development and disease.

Eric Wieschaus, Professor of Molecular Biology at the University of Princeton, remarked: "30 years ago, in the early days of Wnt research, no one anticipated how broadly the pathway would be utilized during development. We now know that Wnt signalling and the components of the Wnt pathway play a central role in patterning and cell fate in organisms from sea urchins to humans and operate in processes as diverse as stem cell maintenance, tissue polarity and neuronal development. We should not be surprised therefore by the parallel importance of the Wnt pathway in cancer and human disease."

Wnt-components and the signals they elicit have roles in many biological processes that range from cell behavior to the determination of cell fate. The discovery of the close relationship between the first mammalian Wnt gene, the int1 proto-oncogene, and the wingless gene in Drosophila provided an important early link between cancer biology and developmental genetics. Multidisciplinary research involving Drosophila geneticists, cancer biologists and molecular biologists, has facilitated the molecular dissection of Wnt pathways, establishing them as one of the first and best understood evolutionary conserved signaling mechanisms.

Today, the Wnt research community is bigger than ever, providing new insight into how cells interact to form a developing organism. This research is leading to the emergence of therapeutic appr
'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. So-called sandfish could help materials handling and process technology specialists
2. HJF nursing specialist wins prestigious Celina Field Cargiver Award
3. Neuroinformatics special issue spotlights the Neuroscience Information Framework
4. Special issue of BMC Microbiology spotlights standardized language for describing microbes
5. Special issue Comparative Cognition in Context now published
6. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
7. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
8. Pest management specialist Charles Summers wins prestigious Woodworth Award
9. GSA special paper presents new studies of Western US earth motion
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... environmental impact recently scored a major win. In August, ... bags, and Governor Jerry Brown is expected to sign ... without a fight, according to an article in ... the American Chemical Society. , Alexander Tullo, a senior ... its first small victory in 1990 when Nantucket became ...
(Date:9/17/2014)... the human retinoblastoma protein gene are a leading cause ... turned to fruit fly eyes to unlock the secrets ... paper featured on the cover of the current issue ... State University researchers provide the first detailed examination of ... the human cancer gene, said Irina Pushel, MSU undergraduate ...
(Date:9/17/2014)... crime unit designed to fight food fraud in ... being passed off as beef scientists from Germany ... describe their approach, which represents a vast improvement over ... Food Chemistry . , Hans-Ulrich Humpf and colleagues note ... But they also say that adding, for example, horse ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2
... Detroit automaker, it appears that nature prefers to build its ... combining advanced computational modeling and cutting-edge experiments by molecular biologists ... the most stable parts of a protein are also the ... Sept. 13 issue of the journal Structure. , Nature refuses ...
... are miniature labs that can be swallowed like a ... Their function is to screen for, detect, and ... still at a single-cell size in early development stages. ... and water. , Engineering researchers at McMaster University will ...
... the event of a large-scale smallpox bioterrorist attack in ... researchers at Fred Hutchinson Cancer Research Center that appears ... Instead, the current U.S. government policy of post-release surveillance, ... and close contacts would be sufficient to thwart an ...
Cached Biology News:Protein folding: Building a strong foundation 2Nano-devices hold promise for early-stage cancer detection 2Nano-devices hold promise for early-stage cancer detection 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 2Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 3Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 4Mass vaccination unnecessary in the event of a large bioterrorist US smallpox attack 5
(Date:9/18/2014)... Sept. 18, 2014 Research and ... "Global N-acetylcysteine Industry Report 2014" report ... N-acetylcysteine Industry Report 2014 is a professional and ... global N-acetylcysteine industry. The report provides ... classifications, applications and industry chain structure. The N-acetylcysteine ...
(Date:9/18/2014)... Sept. 18, 2014  U.S. biotech company Kultevat ... exclusive license for technology developed by the Donald ... in plants, including for applications in production of natural ... The technology was developed under the direction of ... and former president of the Danforth Plant Science Center, ...
(Date:9/18/2014)... Pennsylvanie, 18 septembre 2014 Mapi, ... en 1974, a été depuis 40 ans ... évaluations cliniques traditionnelles par des évaluations recentrées ... sur les impacts économiques des traitements. ... A cours d,une récente conférence ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 21974 - 2014 - Mapi fĂȘte ses 40 ans 2Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3
... their voracious appetite for wood, rendering houses to dust and ... provide the biochemical means to a greener biofuel future. ... mine of microbes that have now been tapped as a ... or waste biomass to valuable biofuels. , The ...
... will utilise technologies not currently available. An example of ... as interconnects for computer chips. This is now a ... nanotechnology researchers within the Materials Ireland Polymer Research Centre ... develop such junction structure nanotubes used various different methods ...
... us, in us and for us. Imagine them seeking out ... place. Just as a car is a combination of a ... etc, nanomachines too need to be constructed from a range ... of actuator to open and close things, to absorb shock, ...
Cached Biology Technology:DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 2DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 3DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 4DOE JGI plumbs termite guts to yield novel enzymes for better biofuel production 5Understanding of actuator properties of carbon nanotubes bring micro machines closer 2
Human PDGF, CF...
... For the ultimate in utility and ... to meet the needs of the researcher. ... interior dimensions or as sheet material that ... enclosures. These isolators are autoclavable and non-cytotoxic ...
... The mycobacteria in Complete Freund's adjuvant ... injection site which enhances the immuneresponse. For ... used for the initial injections; Incomplete Freund's ... Antigens (preferably in saline) are typically mixed ...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
Biology Products: