Navigation Links
Special issue of the EMBO Journal celebrates 30 years of Wnt research
Date:5/22/2012

HEIDELBERG, 22 May 2012 The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. "Three decades of Wnt signalling" summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in development and disease.

Eric Wieschaus, Professor of Molecular Biology at the University of Princeton, remarked: "30 years ago, in the early days of Wnt research, no one anticipated how broadly the pathway would be utilized during development. We now know that Wnt signalling and the components of the Wnt pathway play a central role in patterning and cell fate in organisms from sea urchins to humans and operate in processes as diverse as stem cell maintenance, tissue polarity and neuronal development. We should not be surprised therefore by the parallel importance of the Wnt pathway in cancer and human disease."

Wnt-components and the signals they elicit have roles in many biological processes that range from cell behavior to the determination of cell fate. The discovery of the close relationship between the first mammalian Wnt gene, the int1 proto-oncogene, and the wingless gene in Drosophila provided an important early link between cancer biology and developmental genetics. Multidisciplinary research involving Drosophila geneticists, cancer biologists and molecular biologists, has facilitated the molecular dissection of Wnt pathways, establishing them as one of the first and best understood evolutionary conserved signaling mechanisms.

Today, the Wnt research community is bigger than ever, providing new insight into how cells interact to form a developing organism. This research is leading to the emergence of therapeutic appr
'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. So-called sandfish could help materials handling and process technology specialists
2. HJF nursing specialist wins prestigious Celina Field Cargiver Award
3. Neuroinformatics special issue spotlights the Neuroscience Information Framework
4. Special issue of BMC Microbiology spotlights standardized language for describing microbes
5. Special issue Comparative Cognition in Context now published
6. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
7. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
8. Pest management specialist Charles Summers wins prestigious Woodworth Award
9. GSA special paper presents new studies of Western US earth motion
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the publication ... 3 study of Zerenex (ferric citrate), the Company,s investigational ... hyperphosphatemia in patients with end-stage renal disease (ESRD) on ... with FErric CiTrate in EsrD) was published online today ... Nephrology ( JASN ). , This ...
(Date:7/24/2014)... species of fish, according to a new study ... tested fish anti-predator behaviour. , Three-spined sticklebacks ... when exposed to additional noise, whereas no effects ... author Dr Irene Voellmy of Bristol,s School of ... environments have increased substantially during the last few ...
(Date:7/24/2014)... A sake brewery has its own microbial terroir, meaning ... resemble those found in the product, creating the final ... the journal Applied and Environmental Microbiology . This ... census of a sake brewery. , Many sake ... author David A. Mills of the University of California, ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4The microbes make the sake brewery 2
... Baylor College of Medicine (BCM) and the Puget Sound Blood ... small blood vessels of the heart and brain could cause ... clots. The scientists were surprised to find that the proteins ... five hours before returning to their normal, healthy shape. ...
... are the origins of life on Earth? A new ... building blocks of life could have been created on icy ... Chemists from the University of California, Berkeley, and the University ... of creating complex dipeptides linked pairs of amino acids ...
... discovered that deleting a specific gene in mice prevents them ... finding they believe may be replicated in humans. "When ... fat," said Prof. James McManaman, Ph.D., lead author of the ... the University of Colorado School of Medicine. "It may be ...
Cached Biology News:Stressed proteins can cause blood clots for hours 2Stressed proteins can cause blood clots for hours 3New evidence that comets could have seeded life on Earth 2Researchers discover gene that causes obesity in mice 2
(Date:7/25/2014)... 2014 At the request of the ... 60-day extension for the public comment period (Docket No. ... Model Aircraft established by Congress as part of the ... extension establishes the new deadline for comments as September ... Transportation/FAA notice published in the Federal Register on July ...
(Date:7/24/2014)... 24, 2014 Gain recognition for ... Chain of the biotech industry. Nominations are now ... brought to you by the Bio Supply ... supply chain management professionals for the past 7 ... of the Biotech industry – Manufacturers, Service Providers, ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... to settle into equilibriuma state of unchanging balance ... of non-equilibrium conditions where new possibilities lie. Non-equilibrium ... such as temperature fluctuations, freezing and melting, or ... body temperature, airplanes to fly, and the Earth ... even though these conditions exist naturally and are ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... American Stock Exchange(R),(Amex(R)) today listed the common ... symbol RNN., Rexahn Pharmaceuticals is a ... discover, develop and commercialize,innovative treatments for cancer, ... unmet medical needs. Rexahn,s compounds are designed,to ...
... Judges for Nikon Small World, MELVILLE, N.Y., ... received a record number of entries for the ... by over 300,images. The oldest and most respected ... world,s best photomicrographers who create beautiful,imagery while showing ...
... Informed Medical Communications,(IMC), a leading provider of peer-to-peer ... appointment of Bert,Marchio to the position of Executive ... ), Marchio brings to IMC over 20 ... both the public and private sectors, with the ...
Cached Biology Technology:American Stock Exchange Lists the Common Stock of Rexahn Pharmaceuticals, Inc. 2Nikon Instruments Receives Record Number of Entries for Nikon Small World 2Informed Medical Communications Appoints New Chief Financial Officer 2
Mouse monoclonal [M7-PB-E9] to pan alpha Sodium Potassium ATPase ( Abpromise for all tested applications)....
Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: +4C...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
E2F2 protein...
Biology Products: