Navigation Links
Special issue of the EMBO Journal celebrates 30 years of Wnt research
Date:5/22/2012

HEIDELBERG, 22 May 2012 The impact and influence of thirty years of research into the Wnt/beta-catenin signaling pathway are highlighted in a special issue of The EMBO Journal. "Three decades of Wnt signalling" summarizes many of the crucial scientific developments that have taken place since the discovery of the first mammalian Wnt gene in 1982. The reviews also describe many of the crucial research findings that have established the pathway as one of the fundamental signal transduction mechanisms in development and disease.

Eric Wieschaus, Professor of Molecular Biology at the University of Princeton, remarked: "30 years ago, in the early days of Wnt research, no one anticipated how broadly the pathway would be utilized during development. We now know that Wnt signalling and the components of the Wnt pathway play a central role in patterning and cell fate in organisms from sea urchins to humans and operate in processes as diverse as stem cell maintenance, tissue polarity and neuronal development. We should not be surprised therefore by the parallel importance of the Wnt pathway in cancer and human disease."

Wnt-components and the signals they elicit have roles in many biological processes that range from cell behavior to the determination of cell fate. The discovery of the close relationship between the first mammalian Wnt gene, the int1 proto-oncogene, and the wingless gene in Drosophila provided an important early link between cancer biology and developmental genetics. Multidisciplinary research involving Drosophila geneticists, cancer biologists and molecular biologists, has facilitated the molecular dissection of Wnt pathways, establishing them as one of the first and best understood evolutionary conserved signaling mechanisms.

Today, the Wnt research community is bigger than ever, providing new insight into how cells interact to form a developing organism. This research is leading to the emergence of therapeutic appr
'/>"/>

Contact: Barry Whyte
barry.whyte@embo.org
49-622-188-91108
European Molecular Biology Organization
Source:Eurekalert

Page: 1 2

Related biology news :

1. So-called sandfish could help materials handling and process technology specialists
2. HJF nursing specialist wins prestigious Celina Field Cargiver Award
3. Neuroinformatics special issue spotlights the Neuroscience Information Framework
4. Special issue of BMC Microbiology spotlights standardized language for describing microbes
5. Special issue Comparative Cognition in Context now published
6. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
7. Explorations Group Announces Letter of Intent to Acquire Specialty Lighting Company
8. Pest management specialist Charles Summers wins prestigious Woodworth Award
9. GSA special paper presents new studies of Western US earth motion
10. Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
11. Women with endometriosis need special care during pregnancy to avoid risk of premature birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... , May 21, 2015 The Sync ... of music for health, today announced a collaborative partnership ... The partnership will center on collaboration on original research, ... first step in the collaboration, The Sync Project and ... "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... LLC, a company engaged in biometric identification is an ... portion of the recently awarded TIES (Technical Information Engineering ... Army. 3D-ID LLC has a suite of ... and security agencies. Gino Pereira , ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... report released today by the University of Victoria ranks ... to the environment. It is the first study to ... unlabeled options in the marketplace. "How Green ... sort through competing sustainability claims and better identify those ...
... bane of picky eaters everywhere, broccoli,s taste is not just ... easily taste a bitter compound in the vegetable that others ... helped uncover the evolutionary history of one of the genes ... the gene, the researchers discovered something unexpected: something other than ...
... of additional radioactive leaks from Fukushima nuclear power plants, ... from the plants remains unclear. But a new study ... radioactivity discharged from the facility in the first four ... about the history of contaminant releases to the ocean., ...
Cached Biology News:New study puts eco-labels to the test 2Penn geneticists help show bitter taste perception is not just about flavors 2Penn geneticists help show bitter taste perception is not just about flavors 3Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 2Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 3
(Date:5/21/2015)... YORK , May 21, 2015  Susan ... Research (FPWR), a nonprofit organization dedicated to supporting ... Prader-Willi syndrome (PWS), announced today that FPWR has ... and Irina Shaulov contributed $1 million ... clinical initiatives.  ...
(Date:5/21/2015)... uBiome, the leading startup focused ... PicnicHealth, a healthcare company that collects and consolidates ... Bowel Disease (IBD) will receive a complementary PicnicHealth ... kit. Both companies were funded by Y Combinator ... more information on this partnership and how to ...
(Date:5/21/2015)... 2015 Imagine being able to ... those of others. Being able to read faces and ... people to anticipate their thoughts and actions like never ... feelings to create unique abstract paintings and video, or, ... inside a first-person-shooter as it creates action, dialog, and ...
(Date:5/21/2015)... NJ (PRWEB) May 21, 2015 Patent ... a method for diagnostic or therapeutic imaging within a ... apparatus uses an endoscope having a low cost, single-use ... USPTO filing date was October 18, 2013 and the ... The technology enables the physician to customize the lighting ...
Breaking Biology Technology:The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 35 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... 2011  MacroGenics, Inc., a privately held biotechnology company ... that it will receive a milestone payment from ... part of an agreement executed in October 2010 ... on MacroGenics, Dual-Affinity Re-Targeting (DART) platform.  The amount ...
... in everyday materials, polymers and the field of ... U.S. economy. Polymers possess unique properties and processing ... For these reasons, advances in polymer science ... 21st century challenges of energy, sustainability, clean water, ...
... /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: CO ) ... blood banking operator in China, today announced the results of ... 19, 2011, in Hong Kong. At the Annual ... and Dr. Yungang (Ken) Lu to serve on the Board ...
Cached Biology Technology:MacroGenics Receives Milestone Payment as Part of Its Global DART™ Alliance with Boehringer Ingelheim 2Research and education success earns more NSF funding 2Research and education success earns more NSF funding 3China Cord Blood Corporation Announces Results of 2011 Annual General Meeting 2
... control for microbiology and cell culture. The ... suitable for DASGIP bioreactors from 150 mL ... ranges from approximately 10 °C to 60 ... an individual electrical heating element with integrated ...
... The software records analyzes and reports the ... The software replaces the a chart recorder. The ... the software program. The end-point selection is automatic ... values are automatically computed. The user is always ...
... Custom DNA microarrays designed for your specific ... powerful Paraflo microfluidic synthesis platform. Thousands of ... and LC Sciences can provide assistance with ... as part of our comprehensive Custom DNA ...
... Microarrays designed for RNA aptamer screening ... flexible and powerful Paraflo microfluidic on-chip synthesis ... of our comprehensive DNA/RNA Aptamer Microarray Service. ... 2-F RNA Aptamer Microarray contains greater than ...
Biology Products: