Navigation Links
Source identification of H7N9 influenza virus causing human infections
Date:4/24/2013

enza viruses, sharing 95.2󈟋.8% homology at the nucleotide level. The NA gene of the novel H7N9 virus isolates shared highest homology (97.3󈟍.9%) with NA genes from H4N9 or H11N9 influenza viruses isolated from ducks, and environmental samples from duck farms, located in the Dongting Lake region. It is clear that the novel H7N9 viruses are the product of gene reassortment, with the internal genes from one donor, and HA and NA genes from one or several other donors.

HA receptor-binding specificity is a major molecular determinant for the host range of influenza viruses. Amino acids at positions 226 and 228 of HA are critical for specificity of receptor-binding in influenza viruses. Within the HA protein of novel H7N9 viruses, there was a leucine residue at position 226, which is characteristic of the HA gene in human influenza viruses. This finding implies that H7N9 viruses have partially acquired human receptor-binding specificity. All of the H7N9 human isolates examined contained a lysine residue at position 627 in the PB2 protein. It is well known that this lysine residue contributes to the replication and transmission of avian influenza viruses in mammalian hosts. It is likely that the acquisition of this lysine in H7N9 viruses during their replication in human hosts has significantly contributed to their virulence and lethality in humans.

Tracing the source of these novel H7N9 influenza viruses, and their subsequent characterization, was a collaborative effort involving researchers from the National Avian Influenza Reference Laboratory at the Harbin Veterinary Research Institute, and Shanghai Animal Disease Control Center. This research project was partially supported by the National Basic Research Program of China (2011CB505000), the China Agriculture Research System (CARS-42-G08), and the National Science and Technology Major Project (2012ZX10004214). We suggest that strong measures, such as continued surveillance of avian and
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Collaboration to establish new computational resources for metabolomics
2. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
3. Microalgae could be a profitable source of biodiesel
4. Education resource focuses on teaching population genetics using current research
5. Pesticide application as potential source of noroviruses in fresh food supply chains
6. Assembling the transcriptome of a noxious weed: New resources for studying how plants invade
7. Report: Water and Agriculture in Canada: Towards Sustainable Management of Water Resources
8. Stem cell source an important factor, impacting ability to treat myocardial infarction
9. Hastings Center resources chart progress in debate over medical research with animals
10. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
11. Marginal lands are prime fuel source for alternative energy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its launch in ... of people to eliminate the pain of trying to remember ... their own biometrics fused to their smartphones. To assist people ... Labs , the company that created 1U and focuses on ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the brightest ever ... that the long anticipated floodgates for consumer biometrics may ... smart phones, tablets, and wearable mobile devices that incorporate ... users with nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Institute of Marine Science continue to monitor the algal blooms ... few weeks. These "red tides" occur in the lower Bay ... area than in years past, likely due to last winter,s ... by dense blooms of tiny marine plants called algae that ...
... , PROVIDENCE, R.I. [Brown University] Policymakers struggling to ... questions on the scale of millions of people and ... the impact of many potential interventions, alone or in ... 2012 International AIDS Society Conference in Washington, D.C., Brandon ...
... Ethical Treatment of Animals (PETA) Foundation UK has submitted ... the European Chemicals Agency (ECHA) is failing to fulfil ... which animal testing could be avoided under the rules ... in EU institutions and agencies, and PETA maintains that ...
Cached Biology News:Researchers monitor 'red tides' in Chesapeake Bay 2Computers can predict effects of HIV policies 2Computers can predict effects of HIV policies 3PETA files complaint with European ombudsman over animal testing for REACH 2
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... December 23, 2014 Earlier this year in ... director of the Adult Stem Cell Technology Center, LLC ( ... appreciated unique property of adult tissue stem cells. His ... Past, Important for the Future,” embodied the essence of his ...
Breaking Biology Technology:United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... Novel system is the first to use rapid, automated DNA ... ... Inc., a leader in the,development of state of the art ... the United States Patent,and Trademark Office (USPTO) recently issued U.S. ...
... Expression Genetics, Inc.,(EGEN) announced today that ... selected as one of the Top 10 ... strategic partnering. The selection was made by,an ... leading,provider of business information products and services ...
... Bio-,Pharmaceutical Technology, Inc (OTC Bulletin Board: HFGB) (the ... and pharmaceutical raw,materials for use in pharmaceutical, nutraceutical ... announce a Letter of Intent to enter into ... ("Qinba").,Under the proposed terms of this arrangement, Huifeng ...
Cached Biology Technology:eGenomics Awarded First U.S. Patent Covering Rapid DNA Sequencing Technology Platform to Control Hospital-Acquired Infections 2eGenomics Awarded First U.S. Patent Covering Rapid DNA Sequencing Technology Platform to Control Hospital-Acquired Infections 3Expression Genetics' EGEN-001 Named One of 10 Most Promising Oncology Products by Windhover 2Expression Genetics' EGEN-001 Named One of 10 Most Promising Oncology Products by Windhover 3Huifeng Bio-Pharmaceutical (HFGB) Enters into Letter of Intent with Xi'an Qinba Xintong Medical Ltd. 2
... Caspase-9 Pan-Caspase In Situ Assay Kit, Fluorescein ... active caspases in cells undergoing apoptosis. The ... for use in diagnostic or therapeutic procedures. ... use a novel approach to detect active ...
... silencing experiments often call for critical, ... Transfection Agent refines siRNA transfection protocols ... lipid-based formulation can be used to ... are subcultured without increased cytotoxicity. ...
... as well as other yeasts, has become ... laboratories. The ability to transform whole cells ... DNAs using lithium based buffers and polyethylene ... library screening easy and reliable, especially when ...
...
Biology Products: