Navigation Links
Source identification of H7N9 influenza virus causing human infections
Date:4/24/2013

enza viruses, sharing 95.2󈟋.8% homology at the nucleotide level. The NA gene of the novel H7N9 virus isolates shared highest homology (97.3󈟍.9%) with NA genes from H4N9 or H11N9 influenza viruses isolated from ducks, and environmental samples from duck farms, located in the Dongting Lake region. It is clear that the novel H7N9 viruses are the product of gene reassortment, with the internal genes from one donor, and HA and NA genes from one or several other donors.

HA receptor-binding specificity is a major molecular determinant for the host range of influenza viruses. Amino acids at positions 226 and 228 of HA are critical for specificity of receptor-binding in influenza viruses. Within the HA protein of novel H7N9 viruses, there was a leucine residue at position 226, which is characteristic of the HA gene in human influenza viruses. This finding implies that H7N9 viruses have partially acquired human receptor-binding specificity. All of the H7N9 human isolates examined contained a lysine residue at position 627 in the PB2 protein. It is well known that this lysine residue contributes to the replication and transmission of avian influenza viruses in mammalian hosts. It is likely that the acquisition of this lysine in H7N9 viruses during their replication in human hosts has significantly contributed to their virulence and lethality in humans.

Tracing the source of these novel H7N9 influenza viruses, and their subsequent characterization, was a collaborative effort involving researchers from the National Avian Influenza Reference Laboratory at the Harbin Veterinary Research Institute, and Shanghai Animal Disease Control Center. This research project was partially supported by the National Basic Research Program of China (2011CB505000), the China Agriculture Research System (CARS-42-G08), and the National Science and Technology Major Project (2012ZX10004214). We suggest that strong measures, such as continued surveillance of avian and
'/>"/>

Contact: YAN Bei
yanbei@scichina.org
86-106-400-8316
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Collaboration to establish new computational resources for metabolomics
2. Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment
3. Microalgae could be a profitable source of biodiesel
4. Education resource focuses on teaching population genetics using current research
5. Pesticide application as potential source of noroviruses in fresh food supply chains
6. Assembling the transcriptome of a noxious weed: New resources for studying how plants invade
7. Report: Water and Agriculture in Canada: Towards Sustainable Management of Water Resources
8. Stem cell source an important factor, impacting ability to treat myocardial infarction
9. Hastings Center resources chart progress in debate over medical research with animals
10. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
11. Marginal lands are prime fuel source for alternative energy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... The German Gauß-Allianz has admitted Johannes Gutenberg University ... the Rhineland-Palatinate science hub continues to maintain a ... computing. , "The acceptance of Johannes Gutenberg ... Gauß-Allianz is a milestone in the national and ... support. The state of Rhineland-Palatinate can be proud ...
(Date:10/15/2014)... Geneticist Fred Alt will be awarded the 44th Rosenstiel ... University for his pioneering research exploring the mechanisms of ... and cancer cells. Alt is the second alumnus to ... the Nobel Prize in 2003. , Alt is the ... Genetics at Harvard Medical School and an investigator at ...
(Date:10/14/2014)... ATHENS, Ohio (Oct. 14, 2014)—It,s been millions of years ... but a team led by Ohio University scientists is ... to model airflow through dinosaur snouts. The research has ... not only breathe but to enhance the sense of ... pretty ,nosy, animals," said Ohio University doctoral student Jason ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... daily recommended dosages of ibuprofen and acetaminophen caused a ... quadriceps muscle mass and muscle strength gained during three ... physiologists at the Human Performance Laboratory, Ball State University. ... working with Dr. Todd Trappe, reported study results at ...
... Laboratory will host the inaugural conference of the ... create a virtual center in cyberspace for plant ... "Bringing Plant and Computing Scientists Together to Solve ... 7-9, 2008, will take the first steps in ...
... As the saying goes, some people are born with ... at least one species of the animal world, according ... Alberta. A study of female red squirrels in ... as food availability and spring temperature experienced between birth ...
Cached Biology News:Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength 2iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 2iPlant Kickoff Conference at CSHL begins tackling plant biology's grand challenges 3
(Date:10/25/2014)... (PRWEB) October 24, 2014 SonaCare ... focused ultrasound (HIFU) technology, announced that its Board ... as Chief Executive Officer, President and member of ... Dr. Carol will take-on expanded responsibilities within the ... as well as overseeing commercialization, manufacturing and finance. ...
(Date:10/25/2014)... 25, 2014 Berkshire Corporation, the ... to announce the release of the ValuSeal® IonX™ ... of contamination containment in critical processing applications. , ... higher cleanroom environments, ValuSeal® IonX™ is a laser ... wiper that continues Berkshire’s innovative focus on meeting ...
(Date:10/25/2014)... and NEW YORK ... Inc. (OTCQB: ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), ... areas, announced it has implemented a 1-for-50 reverse ... opening of trading on Friday, October 24, 2014. ... basis under new CUSIP number 72754H109 and temporary ...
(Date:10/25/2014)... LONDON , October 24, 2014 ... CytRx Corporation (NASDAQ: CYTR ), Vertex Pharmaceuticals ... (NASDAQ: ALXN ), Peregrine Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... on Thursday, October 23, 2014, ended on a positive ...
Breaking Biology Technology:SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 2SonaCare Medical Board of Directors Appoints Dr. Mark Carol as CEO and President 3Ions Are Bygones, Berkshire Announces the Release of New Innovative Cleanroom Wipers 2PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5
MAb to Vasopressin Preservative: NaN3...
... Anti-AP-2 α, clone 8G8/5 GenBank Accession ... made human AP-2alpha/gamma fusion protein corresponding to ... 278-450 of human AP-2γ Formulation: 0.1M Tris-glycine, ... before the addition of glycerol to 30% ...
Mouse monoclonal [1C6/2] to Rad17 ( Abpromise for all tested applications). entrezGeneID: 5884 SwissProtID: Q9UPF5...
MMP-2 / MMP-9 Inhibitor IV is a potent, selective, slow binding and mechanism based inhibitor of human gelatinases. • Molecular weight: 306.4 • Molecular Formula: C(15)H(14)O(3)S(2). &bul...
Biology Products: