Navigation Links
Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests
Date:11/11/2013

SAN DIEGO A father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience.

The study, led by Mathieu Wimmer, PhD, a post-doctoral researcher in the laboratory of R. Christopher Pierce, PhD, associate professor of Neuroscience in Psychiatry at the Perelman School of Medicine at the University of Pennsylvania, found that sons, but not females, of male rats on cocaine were not only less likely to want the drug, but also resistant to effects of it. This suggests cocaine causes epigenetic changesthat is alterations to DNA that do not involve changing the sequencein sperm in which reprogrammed information is transmitted down to the next generation of men.

Last year, Dr. Pierce and colleagues found that cocaine abuse in a male rat rendered the next generation of animals resistant to the rewarding properties of the drugthose offspring were less likely to take cocaine. They found changes in the brain-derived neurotrophic factor (BDNF), which is a molecule known to be important for the rewarding efficacy of cocaine, but only by looking at molecular signaling pathways in progeny that had never experienced cocaine.

In the current study, the authors focused on the physiology of neurons before and after taking cocaine in the offspring of cocaine-experienced fathers, and found that they were less sensitive to the drug and less likely to succumb to addictive behaviors.

In short, not only are rat offspring of cocaine-abusing fathers less likely to take the drug on their own volition, they are less likely to become addicted to it if they are administered it.

In male rats whose fathers used cocaine, the neurons in the nucleus accumbens were less sensitive to cocaine. That is, repeated cocaine use in the sons of cocaine-e
'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. First paternity study of southern right whales finds local fathers most successful
2. The old primates club: Even male monkeys ride their fathers coattails to success
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. BRG1 mutations confer resistance to hormones in lung cancer
5. Genetic variation in East Asians found to explain resistance to cancer drugs
6. Team discovers how bacteria resist a Trojan horse antibiotic
7. New paper examines poison resistance in snakes around the world
8. Hot on the trail of metabolic diseases and resistance to antibiotics
9. Notre Dame researchers using novel method to combat malaria drug resistance
10. MicroRNA controls malignancy and resistance of breast cancer cells
11. Scientists discover new type of cell with a key role in treatment-resistant asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... and stress-related psychiatric disorders are associated with ... molecular mechanisms underlying this relation are unknown. ... development of targeted preventive strategies and new ... This work is presented at the European ... an international group of researchers from Germany ...
(Date:10/17/2014)... Copenhagen have shown for the first time how bacteria ... patients, giving them the opportunity to get tremendous insights ... The study also discovered the bacterial growth in chronic ... or slowed down by the immune cells. The researchers ... helped "suffocate" the bacteria, forcing the bacteria to switch ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... Va. -- The USDA,s National Institute of Food and ... of Agriculture and Life Sciences at Virginia Tech to ... wine quality in the eastern United States. According ... the five-year project seeks to create, refine, and encourage ...
... REDWOOD SHORES, Calif., Oct. 27 ... ... lpUnit=,PRN,; --> ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... New Delhi, India, October 27, 2010 -- Research teams ... on two continents have come together to form the ... classes of antimalarials. This bold initiative will develop ... in desperate need of new treatments. Malaria ...
Cached Biology News:USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry 2CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 2CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 3CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 4CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 5CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 6CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 7CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 8CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 9CIC Announces Upcoming Webinar: Insurance Consumer Expectations; Customer Experience & Self-Service Will Hit New Highs in 2011! The Role eSignatures Will Play in Meeting that Demand 10International malaria research consortium tackles deadly disease 2International malaria research consortium tackles deadly disease 3
(Date:10/20/2014)... Richardson, Texas (PRWEB) October 20, 2014 ... today announced that a team from Iowa State University ... * design contest. Using a Convey HC-2ex, the team’s ... than 14 times faster than the second place finisher. ... academic world embarked upon the month long challenge, using ...
(Date:10/20/2014)...  GenVec, Inc. (NASDAQ: GNVC ) today announced ... its board of directors effective on October 24, 2014.   Dr. ... as its chairman from June 2006 to November 2013.  During ... Governance and Audit Committees of the board.  ... dedicated service to GenVec, and its stockholders," said Wayne ...
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The ... bromine market in Asia-Pacific with analysis and forecast ... the Asia Pacific Bromine Market report, to get ... also provides a glimpse of the segmentation in ... various tables and figures. , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3
... Galenea Corp. and,Otsuka Pharmaceutical Co., Ltd. announced ... development collaboration. The two companies have,been working together ... for schizophrenia and other central nervous system (CNS),diseases. ... extension of the initial,five-year alliance and brings the ...
... PRINCETON, N.J., Oct. 3 Covance Inc. (NYSE:,CVD), ... drug development,services companies, today announced that it has ... provide a broad-range of drug development services,over the ... early drug,development campus in Greenfield, Indiana. Effective midnight ...
... AUSTIN, Texas and TORONTO, Oct. 3 Two ... to integrate vibration,therapy into the stem cell harvesting ... company based in Austin,Texas, has signed an exclusive ... of Toronto, Ontario. The partnership,between the two companies ...
Cached Biology Technology:Galenea and Otsuka Pharmaceutical Extend & Expand Schizophrenia Research Collaboration 2Galenea and Otsuka Pharmaceutical Extend & Expand Schizophrenia Research Collaboration 3New Partnership Integrates Vibration Therapy Into Stem Cell Procedures 2New Partnership Integrates Vibration Therapy Into Stem Cell Procedures 3
assays for phosphatase, lipase, nucleoside triphosphatases (ATPase, GTPase etc). HTS and follow up studies for phosphatase inhibitors. Quantitation of phosphate content in protein, lipids, and DNA....
... with Purpose -- The Varian ... the highest level of flexibility ... an affordable, easy-to-use system. The ... workstation guarantees success with today's ...
Homo sapiens 4-aminobutyrate aminotransferase Antigen: Recombinant Protein...
Human DCIR/CLEC4A Phycoerythrin MAb (Clone 216110)...
Biology Products: