Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

as easier to toggle the channel open and closed.

What it all means

As far as he knows, Cui says, this is the first study to focus on the dynamics of ion channels and to show that dynamics matter to function.

He suspects, however, that dynamics might be generally important to ion-channel function. A class of ion channels called TRP channels, Cui says, respond to heat or cold and also to menthol, which is why menthol is a "cool" taste. At colder temperatures, proteins would move more sluggishly, so in this case, too, it is possible that dynamics influence function.

Understanding ion channels is also important to medicine. Many poorly understood diseases, such as epilepsy, migraine, cardiac arrhythmias and some autoimmune diseases, are being revealed to be disorders of the ion channels, or channelopathies, as they are called.

Based on what is known of the BK channel's roles in the body, work on the channel might lead to the identification of several more channelopathies.

The BK channel is implicated not just in epilepsy and movement disorders but also in hypertension (it regulates the tone of smooth muscles like those that line the blood vessels). It is a suspect in schizophrenia because some antipsychotic drugs function much as BK does to increase outflows of potassium, and it may also play a role in autism and mental retardation.

In short, the basic research now underway in Cui's lab may one day have an impact far beyond its walls.


'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:9/21/2014)... to what was previously thought, newborn immune T cells ... to bacteria, according to a new study led by ... differently to that of adults, babies may still be ... study published in the journal Nature Medicine . ... different types of immune cells, including neutrophils which play ...
(Date:9/21/2014)... has developed a protein therapy that disrupts the process ... tumor sites, travel through the blood stream and start ... process, known as metastasis, can cause cancer to spread ... who succumb to cancer fall prey to metastatic forms ... of bioengineering who describes a new therapeutic approach in ...
(Date:9/19/2014)... from several Harvard University labs in collaboration with ... researchers with the intellectual raw materials needed to ... flexible materials. , With the advent of low-cost ... manufacturing technology, soft robotics is emerging as an ... rigid robot design, but working with pliable materials, ...
Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4Soft robotics 'toolkit' features everything a robot-maker needs 2
... physicians and scientists to study brain function and to ... whether the electrodes on the head give an exact ... at the Max Planck Institute for Biological Cybernetics in ... the activity generated within the brain to that measured ...
... thinking about amyloids the fibrous protein deposits associated with ... up a potential new area for therapeutics. It was ... proteins sometimes known as fibres - are inert, but that ... damage cells and cause disease. But in a ...
... to changes in our daily environment, as well as to ... where nerve cells communicate, according to a new study by ... this week in the journal Nature . ... physiology and neuroscience at NYU School of Medicine, discovered that ...
Cached Biology News:How to read brain activity? 2New therapy targets for amyloid disease 2Lifelong memories linked to stable nerve connections 2
(Date:9/19/2014)... 2014 Biotech companies make announcements ... drug systems and advanced Laboratory Instrumentation. Companies in focus ... BDX ), Thermo Fisher Scientific Inc. (NYSE: ... RGDO ), Sangamo Biosciences Inc. (NASDAQ: ... Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" or the "Company") ...
(Date:9/19/2014)... Barnhardt Manufacturing Company has ... Organic Cotton . The USDA Certified Biobased Product ... ingredients meets or exceeds levels set by USDA. Biobased ... or in significant part of agricultural, forestry, or marine ... cotton to be immediately identified as a USDA certified ...
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review ... PharmaBoardroom.com for free download , looks beyond ... economy in 2009, and the austerity measures that followed, to ... times of trouble. "Despite the crisis, ... and the general conditions to invest are favorable to the ...
(Date:9/18/2014)... -- DeepResearchReports.com adds "2014 Deep Research Report on ... Deep Research Report on Global and China Sodium ... Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... China Acetic Acid Industry" is a professional and ... and Global Acetic Acid Market. The report ...
Breaking Biology Technology:Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4
... GeneGo, Inc., the leading systems biology tools company, ... GeneGo Center of Excellence. Burnham researchers will have ... training and advanced support. The Burnham institute ... OMICs experimental studies throughout many departments, including research ...
... 2 NicOx S.A.,(NYSE Euronext Paris: COX) ... with,DSM for the commercial manufacture and supply ... ingredient). Naproxcinod is NicOx, lead,investigational product and ... (CINOD) class of,anti-inflammatory agents, which recently achieved ...
... 2 Cardiogenesis Corporation (Pink Sheets: CGCP), a leading developer ... from severe angina, today announced the addition of veteran medical ... Cohen as a member of the Company,s Board of Directors, ... , Mr. Cohen, 49, has over ...
Cached Biology Technology:The Burnham Institute for Medical Research Becomes a GeneGo Center of Excellence Using MetaCore for Stem Cell Research and Neurology 2NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 2NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 3NicOx Signs Agreement With DSM for the Commercial Manufacture of Naproxcinod Drug Substance 4Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 2Cardiogenesis Announces Addition of Raymond W. Cohen to Board of Directors 3
... Ascent is the first nephelometer ... microplates. Nepheloskan measures light scattering ... for particle quantification. This makes ... in drug discovery, immunoprecipitation, and ...
Anti-VDAC (Voltage-Dependent Anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
6 x Blend of rTth DNA Polymerase and Tli to provide optimized amounts of both 5-3 and 3-5 proofreading activity...
... Rotarods are used to assess the effect of ... on mice and rats using one unit in ... the animals are placed on textured drums to ... individual sensing platforms below, its test results are ...
Biology Products: