Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

as easier to toggle the channel open and closed.

What it all means

As far as he knows, Cui says, this is the first study to focus on the dynamics of ion channels and to show that dynamics matter to function.

He suspects, however, that dynamics might be generally important to ion-channel function. A class of ion channels called TRP channels, Cui says, respond to heat or cold and also to menthol, which is why menthol is a "cool" taste. At colder temperatures, proteins would move more sluggishly, so in this case, too, it is possible that dynamics influence function.

Understanding ion channels is also important to medicine. Many poorly understood diseases, such as epilepsy, migraine, cardiac arrhythmias and some autoimmune diseases, are being revealed to be disorders of the ion channels, or channelopathies, as they are called.

Based on what is known of the BK channel's roles in the body, work on the channel might lead to the identification of several more channelopathies.

The BK channel is implicated not just in epilepsy and movement disorders but also in hypertension (it regulates the tone of smooth muscles like those that line the blood vessels). It is a suspect in schizophrenia because some antipsychotic drugs function much as BK does to increase outflows of potassium, and it may also play a role in autism and mental retardation.

In short, the basic research now underway in Cui's lab may one day have an impact far beyond its walls.


'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:7/22/2014)... by researchers in modifying properties of nanomaterials for application ... thanks to recent innovative studies conducted by scientists from ... use of a simple, efficient and low cost technique ... led by Professor Sow Chorng Haur from the Department ... that the properties of two different types of materials ...
(Date:7/22/2014)... a cost-effectiveness analysis of commercial diet programs and pills, ... the best value for the money. The Jenny Craig ... the most expensive option tested, according to researchers at ... The findings, published in the June issue of the ... health and weight-loss benefits per dollar spent as insurance ...
(Date:7/22/2014)... multinational, collaborative effort, researchers from the Icahn School of ... locations in the human genome associated with the risk ... on any psychiatric disorder to date, conducted with 80,000 ... point to biological mechanisms and pathways that may underlie ... the disorder, which has seen little innovation in drug ...
Breaking Biology News(10 mins):NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3Study compares cost-effectiveness of weight-loss programs and drugs 2Study compares cost-effectiveness of weight-loss programs and drugs 3Mount Sinai scientists and international team shed new light on schizophrenia 2Mount Sinai scientists and international team shed new light on schizophrenia 3
... have determined the fine-scale genetic structure of the first ... change. , They used a high-throughput sequencing technique called ... , Their results, which focus on the pitcher ... the journal Proceedings of the National Academy of ...
... of the High Arctic climate roughly 50 million years ago ... explain how ancient alligators and giant tortoises were able to ... as they endured six months of darkness each year. ... Eocene period 52 to 53 million years ago, also has ...
... Male infertility is a common medical problem, affecting millions ... include an inability to make productive sperm. Now, using ... of Pennsylvania School of Medicine are beginning to identify ... problem. Shelley Berger PhD, the Daniel S. ...
Cached Biology News:Genetic structure of first animal to show evolutionary response to climate change determined 2Genetic structure of first animal to show evolutionary response to climate change determined 3New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 2New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 3New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago 4Swimming upstream: Molecular approaches to better understand male infertility 2Swimming upstream: Molecular approaches to better understand male infertility 3
(Date:7/22/2014)... Hussey Copper , a leader in ... copper announces Pullman Regional Hospital,s conversion of more than ... touch surface, at a nominal cost.  This reasonably priced ... other bacteria within 2 hours of exposure 1 and ... infectious diseases in its facilities. Pullman Regional ...
(Date:7/22/2014)... Quorum Review IRB, the industry leader in central ... called Quick Step™ . The offering went live on ... industry’s need for seamless study start-up with a large volume ... planning 50 or more North American investigator sites, as well ... count of 80 or more. Qualifying studies may also enroll ...
(Date:7/22/2014)... July 22, 2014 Biofeedback ... disorder (ADHD) is diagnosed, selecting medication to best treat ... Analyzing brain patterns by using electroencephalography (EEG) can help ... thus lower the risk of adverse drug events. , ... Biomarkers” in the current issue of the journal ...
(Date:7/21/2014)... Hills, IL (PRWEB) July 21, 2014 ... control, and simple programming, the new Cole-Parmer® ... Head is easy to operate for automated ... cycles for hands-free dispensing. The batch count function ... cumulative volume or totalizer tracks amount dispensed across ...
Breaking Biology Technology:Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 2Pullman Regional Hospital changes more than 1,100 touch points to Hussey Copper's MD-Cu29 antimicrobial copper to help protect against bacteria 3Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 2Quorum Review IRB Launches New Quick Step™ Service for Large Clinical Trials 3Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 2Analyzing Brain Patterns with EEG Can Help Predict Effective Use of Medication 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2
... E May Help,Prevent, Cardiovascular Events in Hp2-2 Diabetes, ... SYI ) today announced new data demonstrating that,discontinuation ... may result,in an increased risk of heart attack and ... at the Annual Scientific,Sessions of the American Heart Association, ...
... First laboratory to be certified for A1c testing using ... Heritage Labs,International LLC, a division of Hooper Holmes ... A1c testing methods by the National,Glycohemoglobin Standardization Program (NGSP)., ... hemoglobin A1c, one,for testing whole blood specimens and the ...
... 11 Amicus Therapeutics,(Nasdaq: FOLD ), today announced ... at the 5th Annual Lazard Capital Markets Healthcare,Conference in ... p.m. EST., A webcast and audio archive of ... at http://www.amicustherapeutics.com . Participants,should allow approximately five to ...
Cached Biology Technology:Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 2Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 3Synvista Therapeutics Announces Data Further Demonstrating the Value of Haptoglobin Genotyping in Diabetic Patients During AHA Meeting 4Heritage Labs Announces A1c Test Certification Milestone 2Heritage Labs Announces A1c Test Certification Milestone 3
... GeneBLAzer cell-based assays utilize the membrane-permeant ... the negatively charged fluorescent beta-lactamase substrates, ... readily enter the cell, where cleavage ... them into their negatively charged forms, ...
Chlorine-36, 3.7 MBq, 100 uCi. 0.1-0.3 HCl.< 111 MBq/g Cl, < 3 mCi/g Cl.Dispensed to order. Please inquire for alternative pack sizes. Category: Radiochemicals &Radiation Safety, Radiochemicals....
Src cDNA Expression Kit (wild type)...
... Detection Kit is intended for quantitative detection ... peptides, which can result from the gradual, ... aspartic acid residues during storage or handling. ... the monitoring of charge differences for detection, ...
Biology Products: