Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

an answer, published in the June 24 issue of the journal Neuron.

It turns out that the mutation makes part of the channel more rigid, altering its dynamics in a way that makes it easier to toggle it open. This is the first time, says Cui, that protein dynamics have been implicated in the functioning of an ion channel.

Ion channels

Life itself depends on ion channels, the tiny pores in our cells that open on cue, letting charged atoms rush in or out. These influxes and effluxes create the electrical signals that make our eyes blink or our ribs expand to draw breath.

But because the channels are tiny and stuck in the greasy cell membrane, they are hard to study. Their existence wasn't even confirmed until the 1970s. Working out the structure and function of a single ion channel (there are more than 300 types) earned researchers a Nobel Prize as recently as 2003.

Nerve impulses are actually changes in the electrical potential across a nerve cell's membrane. The traveling wave of electrical excitation, known as an action potential, is orchestrated by the synchronized opening and closing of ion channels.

At rest, cells are slightly more negative (a matter of millivolts) inside than they are outside. An action potential starts when sodium channels open, allowing positively charged sodium atoms to rush into the cell, reversing the polarization of the membrane.

The sodium channels then automatically close and potassium channels open, repolarizing the membrane by allowing positively charged potassium ions to flood out of the cell.

What the BK channel does

One of the BK channel's functions is to allow a nerve to adapt to constant stimulation by becoming less responsive. This loss of sensitivity is what allows us, for example, to ignore the constant pressure of our clothing.

Ion channels are gated, or triggered, in a variety of ways. Voltage-gated channels respond to the vol
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:8/26/2015)... The report "Multi-Factor Authentication (MFA) Market ... (Travel & Immigration, Government, Banking, Defense, Commercial Security, Consumer ... published by MarketsandMarkets, Multi-Factor Authentication Market is expected to ... CAGR of 17.7% between 2015 and 2020. ... spread through 169 P ages and ...
(Date:8/20/2015)... 2015   Sensory, Inc ., a Silicon ... experience and security of consumer electronics through state-of-the-art ... its TrulySecure™ is the first multimodal ... FIDO Certified™. The FIDO (Fast Identification ... FIDO UAF (Universal Authentication Framework) 1.0 specifications, which ...
(Date:8/17/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Q4 2015. The new marketing campaign is being spearheaded ... Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ... in retail driven marketing and brand awareness and has ...
Breaking Biology News(10 mins):Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... up its current session, the Federation of American Societies ... to urge their Senators and Representatives to pass a ... $1 billion funding increase for the National Institutes of ... from across the country sent nearly 9,400 messages to ...
... The Sainsbury Laboratory, and Virginia Polytechnic Institute and State ... plant disease causing organism revealing that it acts like ... uncovered the tactics used to sneak past the plant,s ... researchers to identify the components of the plant immune ...
... nothing about the comprehensiveness of the genetic information it contains. ... with its fine fungal threads, is a good example of ... and therefore one of the largest genomes of the sac ... than that of comparable species. It has lost many of ...
Cached Biology News:Plant disease 'stealth bomber' tactics subverted to tackle hundreds of plant pathogens 2Plant disease 'stealth bomber' tactics subverted to tackle hundreds of plant pathogens 3Powdery mildew at an evolutionary dead end 2
(Date:9/2/2015)... Sept. 2, 2015 Axovant Sciences Ltd. (NYSE:  AXON), ... dementia, today announced upcoming presentations at three investor conferences: ... Baird 2015 Healthcare Conference in New York ... September 10 at 2:00 PM at the BioCentury NewsMakers Conference ... Broadway Hotel & Conference Center , Thursday, September 17 ...
(Date:9/2/2015)... Sept. 2, 2015 Research and ... addition of Jain PharmaBiotech,s new report ... their offering. An increasing ... biotechnology industries is anticipated. Nanotechnology will be ... - from formulations for optimal delivery to ...
(Date:9/2/2015)... ANN ARBOR, Mich. and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... NSF International, a leading provider of regulatory compliance, quality systems, ... acquired Avarent LLC, a consulting firm with expertise in medical device products/processes ...
(Date:9/2/2015)... 02, 2015 Research ... addition of Jain PharmaBiotech,s new report "DNA ... their offering. This report briefly reviews ... technologies, and their applications. Current large and small ... them. Various applications of sequencing are described including ...
Breaking Biology Technology:Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... Launch of First Three Diagnostic Tests Based on Company,s microRNA ... Technology on Schedule for ... Rosetta Genomics, Ltd. (NASDAQ: ROSG ), a leading,molecular diagnostics company, ... quarter of 2007 compared with corresponding,period of 2006, and said it ...
... presented at national conference provides important insight into ... treatments is jeopardizing quit attempts, PORTLAND, Ore., ... smoking cessation are gathering at the annual meeting ... (SRNT) to present the,latest research on smoking cessation, ...
... Continued year over year growth driven by Loestrin 24 ... Warner Chilcott,Limited (Nasdaq: WCRX ) today announced ... 2007. Revenue in the quarter ended December 31, 2007,totaled ... year quarter.,Revenue for the year ended December 31, 2007 ...
Cached Biology Technology:Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 2Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 3Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 4Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 5Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 6Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 7Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 8Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 9Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 10Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 11Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results 12Misperceptions About Smoking Cessation Aids May Hinder Smokers From Using Effective Treatment for Quitting 2Misperceptions About Smoking Cessation Aids May Hinder Smokers From Using Effective Treatment for Quitting 3Misperceptions About Smoking Cessation Aids May Hinder Smokers From Using Effective Treatment for Quitting 4Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 2Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 3Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 4Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 5Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 6Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 7Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 8Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 9Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 10Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 11Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 12Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 13Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 14Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 15Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 16Warner Chilcott Reports Operating Results for the Quarter and Year ended December 31, 2007 17
... DeCypher combines enterprise-scale sequence analysis software with ... bioinformatics analyses. With DeCypher, you can perform searches ... ESTs vs NCBI NT database in under 6 ... to genomic DNA Use HMM analysis ...
...
Mouse polyclonal antibody to ALS2CR8 - amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8...
...
Biology Products: