Navigation Links
Solving the puzzle of the BK ion channel
Date:6/23/2010

In 2004, Washington University in St. Lous researcher Jianmin Cui was handed a puzzling clue to the structure of an ion channel his lab had been studying for five years.

Scientists at the Cleveland Clinic Foundation in Ohio had located a large family whose members suffered from epilepsy, sudden attacks of involuntary movement or both, a syndrome called generalized epilepsy and paroxysmal dyskinesia (GEPD).

By analyzing the DNA of the 16 family members who had inherited the syndrome, the Cleveland Clinic scientists identified a mutation in the study family in the gene that encodes the big-conductance potassium ion channel (also known as the BK or MaxiK channel). This was one of the ion channels Cui, PhD, the Spencer T. Olin Associate Professor of Biomedical Engineering in the School of Engineering & Applied Science, had long studied.

Ion channels are small, highly selective pores in the cell membrane that allow specific ions (charged atoms) to enter or leave the cell. They are not continuously open but instead have gates, which open briefly and then close again in response to electrical, mechanical or chemical signals.

The mutation changes a single amino acid, or protein building block, in the BK channel.

The scientists thought that the mutation led to an increase in channel activity and thus nerve-cell excitability, causing epilepsy or involuntary movement, depending on which parts of the central nervous system were affected by the mutation.

But there was a problem. The altered amino acid was not part of the gate that opens and closes the channel.

Cui and his colleagues were thus faced with the problem of action at a distance. How did the mutation that apparently didn't interfere with the channel's gate nevertheless alter how often it was open?

Meticulous work that involved mutating other amino acids and testing the electrical properties of the mutated channels in frog eggs finally led to
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Brains problem-solving function at work when we daydream
2. Bowman Global Change says public engagement critical to solving climate crisis
3. Fossils and layers: Solving the terrane puzzle of the North American cordillera
4. Solving an avian scourge could also provide benefits to human health
5. New tool for resolving fisheries conflicts
6. Magnetic snakes control fluids, gravity-defying droplets, and solving a dragonfly mystery
7. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
8. Key piece of puzzle sheds light on function of ribosomes
9. CSHL scientists harness logic of Sudoku math puzzle to vastly enhance genome-sequencing capability
10. New piece found in the puzzle of epigenetics
11. Biologists devise unifying framework to explain evolutionary puzzles
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Solving the puzzle of the BK ion channel
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... 2012 -- It,s time to economically value the greenhouse gas-trapping ... says mining engineer and geologist Michael Hitch of the University ... mine waste rock for its CO 2 -sequestration potential, or ... be able to offset CO 2 emissions with so-named ...
... GAINESVILLE, Fla. --- The great white shark is one of ... sensationalism, yet its evolutionary history is as misunderstood as its ... relative of megatooth sharks, the white shark,s evolutionary history has ... a study appearing in print and online today in the ...
... microbial hitchhikers we all harbor, the largest dam-removal project ... era of personal genomics are among the winners of ... administered by the American Association for the Advancement of ... professional journalists for distinguished reporting for a general audience. ...
Cached Biology News:Researchers tap into CO2 storage potential of mine waste 2Researchers tap into CO2 storage potential of mine waste 3New ancient shark species gives insight into origin of great white 2New ancient shark species gives insight into origin of great white 3Winners named in 2012 AAAS Kavli Science Journalism Award Competition 2Winners named in 2012 AAAS Kavli Science Journalism Award Competition 3Winners named in 2012 AAAS Kavli Science Journalism Award Competition 4Winners named in 2012 AAAS Kavli Science Journalism Award Competition 5Winners named in 2012 AAAS Kavli Science Journalism Award Competition 6Winners named in 2012 AAAS Kavli Science Journalism Award Competition 7Winners named in 2012 AAAS Kavli Science Journalism Award Competition 8
(Date:11/22/2014)... Grand Rapids, MI (PRWEB) November 22, 2014 ... the opportunity to simulate the proper management of ... training and test lung devices . Grand Rapids-based, ... Lung” plans to donate two of the respiratory ... $12,000 to $15,000 each. Grand Valley and Muskegon ...
(Date:11/21/2014)... 2014 The science of light and ... with more than 200 primary students in a traveling ... University of Otago Physics Department and funded by an ... members of the university’s OSA/SPIE Student Chapter visited six ... giving children from small, rural schools hands-on lessons in ...
(Date:11/21/2014)... 20, 2014 The November 2014 issue ... an open access journal featuring the following articles:, ... to preserve photoresponsiveness in the retina , ... situ hybridization using chromogenic substrates in zebrafish , ... and protein electrophoresis , Nuclear LC3-positive puncta ...
(Date:11/21/2014)... DIEGO , Nov. 20, 2014 ... has been dosed in its Phase 1 trial ... cisplatin for the treatment of malignant pleural mesothelioma ... Group is conducting clinical trials on ADI-PEG 20, ... agents, for the treatment of several other indications, ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2
... A new,analysis of a landmark weight loss survey ... whites to use unproven dietary,supplements for weight loss. The ... NAASO, The Obesity Society, adds to the growing body,of ... the associated health risks of overweight and obesity is ...
... - New Interactive and Intuitive Tools ... Elsevier, leading publisher of scientific, technical and ... added more,development-partner-tested features on its ScienceDirect platform. ... development partners,involvement has ensured that the new ...
... Cases of Chagas, Disease ... Blood Transfusions, ANAHEIM, Calif., Oct. 20 In the ... first blood-screening test,for Chagas, disease, some 241 blood donations in ... parasite known to cause,this serious and potentially fatal parasitic infection, ...
Cached Biology Technology:New Data Reveal Ethnicity May Play Role in Weight Loss Decisions 2New Data Reveal Ethnicity May Play Role in Weight Loss Decisions 3ScienceDirect Maximizes Research Capabilities, Enhances the Research Process 2ScienceDirect Maximizes Research Capabilities, Enhances the Research Process 3Blood Donations in U.S. Testing Positive for Chagas' Disease 2Blood Donations in U.S. Testing Positive for Chagas' Disease 3Blood Donations in U.S. Testing Positive for Chagas' Disease 4
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
RAT ANTI MOUSE JAM-2 Immunogen: Recombinant soluble JAM-2...
...
Biology Products: