Navigation Links
SlipChip counts molecules with chemistry and a cell phone
Date:11/18/2013

In developing nations, rural areas, and even one's own home, limited access to expensive equipment and trained medical professionals can impede the diagnosis and treatment of disease. Many qualitative tests that provide a simple "yes" or "no" answer (like an at-home pregnancy test) have been optimized for use in these resource-limited settings. But few quantitative teststhose able to measure the precise concentration of biomolecules, not just their presence or absencecan be done outside of a laboratory or clinical setting. By leveraging their discovery of the robustness of "digital," or single-molecule quantitative assays, researchers at the California Institute of Technology (Caltech) have demonstrated a method for using a lab-on-a-chip device and a cell phone to determine a concentration of molecules, such as HIV RNA molecules, in a sample. This digital approach can consistently provide accurate quantitative information despite changes in timing, temperature, and lighting conditions, a capability not previously possible using traditional measurements.

In a study published on November 7 in the journal Analytical Chemistry, researchers in the laboratory of Rustem Ismagilov, Ethel Wilson Bowles and Robert Bowles Professor of Chemistry and Chemical Engineering, used HIV as the context for testing the robustness of digital assays. In order to assess the progression of HIV and recommend appropriate therapies, doctors must know the concentration of HIV RNA viruses in a patient's bloodstream, called a viral load. The problem is that the viral load tests used in the United States, such as those that rely on amplification of RNA via polymerase chain reaction (PCR), require bulky and expensive equipment, trained personnel, and access to infrastructure such as electricity, all of which are often not available in resource-limited settings. Furthermore, because it is difficult to control the environment in these settings, viral load tests must be "robust,"
'/>"/>

Contact: Deborah Williams-Hedges
mr@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. EyeLock Appoints Michael Fiorito Vice President of Enterprise Accounts
2. Quantum communication: Each photon counts
3. Global Biotech and Pharmaceutical Conference Early Bird Registration Discounts End This Week
4. Early Bird Discounts Available on International Healthcare and Biotechnology Conferences, Save Up To $600 with Global Information
5. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
6. Lawrence Livermore researchers unveil carbon nanotube jungles to better detect molecules
7. Biomolecules for the production line
8. CCNY chemists devise new way to prepare molecules for drug testing
9. Facebook for molecules
10. Detecting mirror molecules
11. Natural keystone molecules punch over their weight in ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... WINSTON-SALEM, N.C. , March 12, 2015 ... afternoon at Brenner Children,s Hospital, part of Wake Forest ... an outreach initiative for the 2015 ACC Men,s Basketball ... taking pictures with them and getting their autographs. ... Wake Forest Baptist. It is the only children,s hospital ...
(Date:3/10/2015)... March 10, 2015  Continuing its 167-year history of ... Schlemmer introduces The Eye Scanning Password Authenticator , ... access to secure websites or sensitive data. ... at international borders, the device has a small camera ... of the iris, converting them into an encrypted ID ...
(Date:3/4/2015)... Mar. 04, 2015 Research and Markets ... of the "Global Biometrics Market Forecast and ... The market for biometric authentication systems is ... 14% till 2020 The driving forces ... security needs, government projects and constant development in ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3
... viruses or parasites attack, immune system cells unleash the ... trigger inflammation, which, if unchecked, can destroy tissue, induce ... let loose another protein compound to cool down the ... operates is unclear. The leading hypothesis is that these ...
... Research Institute (NHGRI), one of the National Institutes ... targets including the Northern white-cheeked gibbon (Nomascus leucogenys), ... sequence the genome of at least one non-human ... along the evolutionary primate tree and making available ...
... The brain's septum helps prevent epileptic seizures by ... another area of the brain known as the ... Journal of Neurophysiology. The researchers found that, by ... rats, they could reduce epileptic seizures by 86-97 ...
Cached Biology News:Research reveals inner workings of immune system 'thermostat' 2NHGRI announces latest sequencing targets 2NHGRI announces latest sequencing targets 3NHGRI announces latest sequencing targets 4NHGRI announces latest sequencing targets 5NHGRI announces latest sequencing targets 6Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 2Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent 3
(Date:4/1/2015)... NEW YORK , April 1, 2015 ... biopharmaceutical company advancing protein biologic therapies and oncology ... the Company,s 2014 achievements and a strategic update ... progress the Company has made in the areas ... its MuGard programs, the FDA clearance of the ...
(Date:4/1/2015)... 1, 2015  Spherix Incorporated (Nasdaq: SPEX ... fostering and monetization of intellectual property, today announced ... full service global investment bank specializing in micro, ... note featuring Spherix. The report, authored ... Analyst at Chardan, was published on March 31, ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 Earlier this ... a vibrant life sciences industry association that represents research-based ... members. , Jonathan Parker, AJO’s Vice President of ... Dinner in February, an event that attracted over 750 ... Don Wright, a 73 year old cancer survivor shared ...
(Date:3/31/2015)... -- CytoSorbents Corporation (NASDAQ CM: CTSO), a critical ... critically-ill and cardiac surgery patients in multiple countries ... results for the fiscal year ending December 31, ... were a record $3.1M, an increase of $2.3M ... $0.8M Highlights for the Year Ending December 31, ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 2PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 3PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 4PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 5PlasmaTech Biopharmaceuticals Provides Strategic Update for 2015 and Review of 2014 Acheivements 6Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3HR Consulting Firm, A.J. O'Connor Associates Joins BioNJ – The Vibrant 400 Member Strong Life Sciences Industry Association - and Attends its Annual Dinner 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11
... growth company of diversified businesses, ... Transportation Accessories Group has acquired ... zinc plating services. Chem-Chrome is ... has been a longtime processor ...
... Software, worldwide leader in e-document ... Fax and VSI-FAX(R) product families, ... 3.0. This new solution allows ... more efficiently, effectively, and economically ...
... nanoscale device developed by a University of Wisconsin-Madison Engineering ... electrons in such devices as laptop computers and provide ... This device will allow researchers to study ... heat dissipation on single electron transport in transistors. ...
Cached Biology Technology:Cool Computers 2Cool Computers 3
Consists of 4 separate 100mM solutions (ATP,GTP,CTP and UTP pH 7.5) as sodium salts. 98% Pure by HPLC...
Tracker Datamatrix TRxD reads any 1D and 2D barcodes within 0.5 seconds....
8 different frozen tissues are mounted on positively charged glass slides...
... T2-04 is an ultra-compact pump available in single ... and ideal for use in portable air and ... this pump works well in environments where DC ... compact size are critical., Offers ultra-compact size, ...
Biology Products: