Navigation Links
Slice, stack, and roll: A new way to build collagen scaffolds
Date:12/27/2012

MEDFORD/SOMERVILLE, Mass. (December, 26 2012) Tufts University School of Engineering researchers have developed a novel method for fabricating collagen structures that maintains the collagen's natural strength and fiber structure, making it useful for a number of biomedical applications.

Collagen, the most abundant protein in the body, is widely used to build scaffolds for tissue engineering because it is biocompatible and biodegradable. Collagen is, however, hard to work with in its natural form because it is largely insoluble in water, and common processing techniques reduce its strength and disrupt its fibrous structure.

The Tufts engineers' new technique, called bioskiving, creates collagen structures from thin sheets of decellularized tendon stacked with alternating fiber directions that maintain much of collagen's natural strength.

Bioskiving does not dilute collagen's natural properties, says Qiaobing Xu, assistant professor of biomedical engineering, and inventor of the new technique. "Our method leverages collagen's native attributes to take advantage of the well-organized micro/nanostructures that nature already provides," he says.

Xu and Kyle Alberti, a Ph.D. student in Xu's lab, describe their technology in the paper "Slicing, Stacking and Rolling: Fabrication of Nanostructured Collagen Constructs from Tendon Sections" published online in Advanced Healthcare Materials on December 12, 2012.

Slice, Stack, and Roll

In their research, Xu and Albert cut small sections of collagen from bovine tendons. Using a specialized detergent, the researchers decellularized the sections, leaving intact only the extracellular collagen matrix made of bundles of aligned collagen nanofibers.

Xu and Alberti sliced the sections into ultra-thin sheets using a microtome, and then stacked 10 slices, crisscrossing the sheets so that the fibers in one ran perpendicular to those above and below it. T
'/>"/>

Contact: Alex Reid
Alexander.Reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Building the European Unions Natura 2000 -- the largest ever network of protected areas
2. Newly found protein helps cells build tissues
3. New study finds a protein combination is best to consume post-workout for building muscle
4. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
5. Light weights are just as good for building muscle, getting stronger, researchers find
6. UC Santa Cruz builds national data center for cancer genome research
7. CUNY Energy Institute battery system could reduce buildings electric bills
8. A cells first steps: Building a model to explain how cells grow
9. Stealing lifes building blocks
10. Blood-brain barrier building blocks forged from human stem cells
11. Building global collaboration for biodiversity intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slice, stack, and roll: A new way to build collagen scaffolds
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Arabia Biomedical Sensors market is estimated at $0.23 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:8/25/2015)... and BELLEVUE, Wash. , ... in advanced robotic systems, announced today it will unveil ... ground vehicle (UGV), at the National Tactical Officers Association ... The Guardian S is the first-ever commercially ... of years of research and in-field trials and is ...
(Date:8/20/2015)... Aug. 20, 2015 The wearable technology ... are active and healthy. However, wearable technology has ... environment to help improve diagnostic capabilities and therapeutic ... the Wearable Technologies Conference 2015 , where ... for wearables in healthcare.    "Over ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3
... research from the University of Adelaide are a ... life-saving blood transfusions for preterm babies, by reducing the likelihood ... are among the most common medical procedures experienced by preterm ... Researchers from the University of Adelaide,s Robinson Institute ...
... causes of dementia. In Germany and Switzerland alone, around ... doubling of the number of patients worldwide within the ... including amyloid- (Aβ) among others, in patients, brains plays ... from the Department of Neuropathology at Charit and his ...
... Harbor, NY -- The cerebral cortex of the human brain ... it is so complex that even our greatest minds and ... it organizes itself in early development, and how its many ... major step toward this great goal in neuroscience has been ...
Cached Biology News:Better blood transfusions for preterm babies 2Alzheimer's disease in mice alleviated promising therapeutic approach for humans 2Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells 2Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells 3Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells 4
(Date:9/2/2015)... 2015 Axovant Sciences Ltd. (NYSE:  AXON), a leading ... announced upcoming presentations at three investor conferences: , ... Healthcare Conference in New York at ... at 2:00 PM at the BioCentury NewsMakers Conference in ... & Conference Center , Thursday, September 17 at 9:30 ...
(Date:9/2/2015)... DUBLIN , Sept. 2, 2015 /PRNewswire/ ... has announced the addition of Jain PharmaBiotech,s ... Companies" to their offering. ... the pharmaceutical and biotechnology industries is anticipated. ... of drug development - from formulations for ...
(Date:9/2/2015)... ARBOR, Mich. and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... NSF International, a leading provider of regulatory compliance, quality systems, analytical ... Avarent LLC, a consulting firm with expertise in medical device products/processes development, ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... ) has announced the addition of Jain PharmaBiotech,s ... and Companies" to their offering. ... variations, development of sequencing technologies, and their applications. ... well as companies developing them. Various applications of ...
Breaking Biology Technology:Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2
... share improvements from automating their environmental monitoring processes using MODA-EM™ ... ... April 16, 2009 -- The Parenteral Drug Association (PDA) is ... 20-24, 2009 at Red Rock Casino and Resort. During this ...
... XTLB , TASE: XTL) today announced that on ... Nasdaq Stock Market ("Nasdaq") that the Nasdaq Listing ... Depository Shares ("ADRs") will be delisted. ... the opening of trading on April 17, 2009. Nasdaq,s ...
... Bioscience Inc have successfully implemented Amphora,s PatentSafe solution ... using PatentSafe as a fully electronic lab notebook, ... more efficiently into today,s laboratories but it also ... simply and effectively, saving significant time previously spent ...
Cached Biology Technology:ImClone Systems and Lonza Walkersville to Discuss Paperless QC Micro at PDA Annual Meeting 2ImClone Systems and Lonza Walkersville to Discuss Paperless QC Micro at PDA Annual Meeting 3XTL Biopharmaceuticals Ltd. Receives Notification of Delisting Determination by NASDAQ Listing Qualifications Panel 2Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution 2Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution 3
BD Primaria 35 mm Cell Culture Dish with Easy-Grip design, surface-modified polystyrene for enhanced cell culture. (20/sp, 200/ca) Packaging: 20 / sleeve, 500 / case ...
... premium quality recombinant form of Thermus aquaticus ... for a wide range of PCR applications. ... performance, each preparation is extensively tested in ... DNA Polymerase possesses an integral 5′→3′ exonuclease ...
... a direct antibiotic-based selection system for recombinant ... survival, eliminating the need for costly color ... close to 100% accuracy in recombinant selection. ... robot colony picking. This cloning kit can ...
AVOID FREEZE/THAW CYCLES. Recognizes the ~32 kDa DNase IIα chain and the ~40 kDa proenzyme. DNase II causes both DNA condensation and DNA fragmentation. ...
Biology Products: