Navigation Links
Sleeping Beauty hooks up with herpes to fight brain disease
Date:1/8/2010

package of genes that cells pass from one to another. Simply put, herpes cannot integrate the new DNA into the host genome. Instead, the DNA is adrift in the nucleus, where it's silenced within a few weeks. The short time span spells trouble when scientists are trying to treat a disease that requires the genes to be active for months or years.

That's where Sleeping Beauty comes in.

In molecular biology, Sleeping Beauty is a mobile genetic element that jumps into and out of longer segments of DNA. It's normally silent, but years ago a team of scientists was able to activate or "awaken" the snippet hence, Sleeping Beauty. Since Sleeping Beauty actually integrates segments of DNA into mammalian genomes, it sidesteps the main difficulties that herpes encounters inside a cell: Genes integrated within the cell's chromosomes by Sleeping Beauty operate for much longer periods of time. The drawback: The molecule can insert only small snippets of DNA.

So the Rochester team brought herpes and Sleeping Beauty together in an attempt to get the best of both worlds: Delivery of the bigger genetic package made possible by herpes, and the integration of the DNA into the host genome made possible by Sleeping Beauty.

And that's exactly what happened. In the tag-team approach funded by the National Institute of Neurological Disorders and Stroke, herpes gets the genetic package into the right neighborhood, the cell's nucleus, and then Sleeping Beauty delivers the package precisely where it needs to go to be most effective into the cellular genome.

In the current experiments, the herpes virus carried into cell nuclei the gene for green fluorescent protein, which allows scientists to track where the gene is active. The team also outfitted the herpes package with special molecular signals that Sleeping Beauty would recognize. Separately, the team introduced Sleeping Beauty into the cells. When the two met, Sleeping Beauty transferred the gene
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Emotion and scent create lasting memories -- even in a sleeping brain
2. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
3. Scientists discover important beauty secret for balanced skin color and tone
4. Penn researchers shine the light of venus to learn how the herpes virus invades cells
5. Herpes virus link to complications in pregnancy
6. Herpes drug inhibits HIV in patients infected with both viruses
7. Potential new herpes therapy studied
8. Herpes virus: To vaccinate or not to vaccinate
9. Clemson chemists discover new way antioxidants fight debilitating diseases
10. Social habits of cells may hold key to fighting diseases
11. Advance in effort to fight malaria by tricking the mosquitos sense of smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Fred Alt will be awarded the 44th Rosenstiel Award ... for his pioneering research exploring the mechanisms of genomic ... cancer cells. Alt is the second alumnus to win ... Nobel Prize in 2003. , Alt is the Charles ... at Harvard Medical School and an investigator at the ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
(Date:10/14/2014)... of scientists led by researchers at the University ... of Miami Miller School of Medicine (UMMSM) have ... underlying bipolar (manic depressive) disorder, a breakthrough that ... affective disorder, as well as depression and other ... online this week in Nature Molecular Psychiatry ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2House fly genome reveals expanded immune system 2Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... the tools of physics to show how our circadian ... cellular environment. , In an article appearing March ... the Ecole Polytechnique Federale de Lausanne demonstrate that the ... reflecting recent association studies in families affected by advanced ...
... An important cancer-related gene may play a critical role in ... and oxygen exchange between a mother and her fetus during ... from a new study of the retinoblastoma (Rb) gene in ... of a rare cancer of the eye called retinoblastoma. Two ...
... of Health have discovered how a defect in a ... genes interact to create myelin, a fatty coating that ... of their electrical signals. , The discovery has ... disorders can affect the peripheral nervous system—the nerves outside ...
Cached Biology News:Keeping the body in sync -- The stability of cellular clocks 2Tumor-suppressor gene is critical for placenta development 2Tumor-suppressor gene is critical for placenta development 3Researchers discover gene crucial for nerve cell insulation 2Researchers discover gene crucial for nerve cell insulation 3
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Sidney Kimmel Cancer Center at Thomas Jefferson University ... , Through the Strategic Alliance Partnership program, the ... will collaborate to raise awareness of the Center’s ... and other projects. Clinicians and other health care ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 ... Industry Meeting (ABIM). ABIM will take ... More information about ABIM 2014 is now ... , Delegates representing companies and organizations from ... and obtain information on the latest products ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asia-Pacific ... Analytics market in Asia-Pacific with analysis and forecast of ... million in 2014 to $208 million by 2019, at ... 2014 to 2019. , Browse through the TOC of ... idea of the in-depth analysis provided. It also provides ...
(Date:10/19/2014)... 19, 2014 According to market ... Points; WLAN Controllers; Wireless gateways)]- Global Advancements, Forecasts ... the global Outdoor Wi-Fi market with analysis and ... MarketsandMarkets also identifies the drivers and the restrains ... trends, opportunities and challenges. , Browse 65 market ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4
... compound found in plants and food groups, notably red ... mitochondria, the cell,s energy supplier. "The results were ... at Harvard Medical School and the study,s senior author. ... The findings are to be published May ...
...  The Diagnostic Marketing Association ( DxMA ), serving marketing, ... device market segments, today presented its 2011 Marketer of ... ), a leading molecular diagnostics company. Presented at the ... recognizes innovation by marketers seeking to highlight their company ...
... SAN DIEGO, May 1, 2012 AnaptysBio, Inc., ... antibody discovery partnership with Gilead Sciences, Inc. to ... http://photos.prnewswire.com/prnh/20111205/SF16052LOGO ) Under this ... SHM-XEL platform will be transferred to Gilead for ...
Cached Biology Technology:More evidence for longevity pathway 2Diagnostic Marketing Association Names Cepheid 2011 Marketer of the Year 2AnaptysBio Announces Antibody Discovery Partnership With Gilead Sciences 2
... Detection of the yolk protein Vtg in plasma ... and sensitive biomarker for endocrine disrupting chemicals (EDCs) ... has become an accepted screening test for the ... (rainbow trout) EIA kit is a double-antibody immunometric ...
... Vtg in plasma from juvenile or male fish ... disrupting chemicals (EDCs) with estrogenic effects in fish. ... test for the estrogenic effects of EDCs in ... a double-antibody immunometric (sandwich) EIA for analyzing Vtg ...
... Research Scale (gram quantities of IgY) , After ... your Antigen), we segregate the appropriate number of ... 3 such eggs are collected (usually over a ... series. This involves a total of four injections ...
... Agilents G1979A multisignal output accessory lessens ... data systems in laboratories with multiple ... digital MS signals from Agilent 1100 ... analog format and transmits the analog ...
Biology Products: