Navigation Links
Sleeping Beauty hooks up with herpes to fight brain disease
Date:1/8/2010

field of gene therapy is just beginning to yield some successes for patients. Improvements like this are crucial for increasing the number of patients who might benefit from such an approach," said Bowers, who is an associate professor of Neurology, Microbiology and Immunology, and of Pharmacology and Physiology.

The research is part of a decades-long endeavor by scientists trying to get the right genes into the right cells at the right time to improve human health.

In the new work, scientists dramatically increased the size of the "genetic payload" they can deliver to brain cells compared to some conventional techniques, nearly tripling the amount of genetic material by some measures. They hope to deliver even bigger genes in the future.

The team did this by bringing together in a new way two molecular players, herpes and Sleeping Beauty, which are commonly used in molecular technology.

For years Bowers' team has been using the herpes virus HSV-1, the type that causes cold sores to shuttle genes into cells. Viruses like herpes are adept at infecting human cells, and scientists like Bowers use such viruses to carry into cells genes that would help people who are sick. Bowers and colleagues modify the viruses extensively, removing the portions that could make a person sick and using the portions that the virus uses to gain access to human cells.

Many scientists use other viruses, such as lentiviruses or a cold-related virus known as adeno-associated virus (AAV), to do a similar job. Each virus has its strengths and weaknesses when it comes to gene therapy. Herpes, for instance, readily infects cells, and it can carry a huge amount of genetic material, typically 15 to 30 times the amount of DNA that other viruses can carry into a cell.

But herpes as a genetic tool has a couple of big weaknesses. While the virus can deliver DNA into the nucleus of a cell, the genetic payload it carries does not become part of the
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Emotion and scent create lasting memories -- even in a sleeping brain
2. Dog owners more likely to share germs with pets by not washing hands than by sleeping with dog
3. Scientists discover important beauty secret for balanced skin color and tone
4. Penn researchers shine the light of venus to learn how the herpes virus invades cells
5. Herpes virus link to complications in pregnancy
6. Herpes drug inhibits HIV in patients infected with both viruses
7. Potential new herpes therapy studied
8. Herpes virus: To vaccinate or not to vaccinate
9. Clemson chemists discover new way antioxidants fight debilitating diseases
10. Social habits of cells may hold key to fighting diseases
11. Advance in effort to fight malaria by tricking the mosquitos sense of smell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... begins a trip to Asia to coordinate with ... Pacific, officials at the Office of Naval Research ... Partnership (APTEP) as an example of strong and ... allies in the region. , The APTEP program, ... region, supports the development of alternative energy technologies. ...
(Date:4/22/2014)... available in French . ... sequencing of the complete genome and subsequent phylogenetic analysis ... clade (variant) that is distinct from strains previously identified ... Epidemiological investigations also linked the laboratory confirmed cases with ... , Ebola virus is a lethal, highly contagious virus ...
(Date:4/22/2014)... studies have shown that exposure to environmental ... region, thus improving learning and memory. Previous ... exist predominantly in the superficial layer of ... as guinea pigs, and these neurons exhibit ... under physiological conditions. Whether environmental enrichment has ...
Breaking Biology News(10 mins):Full power: Alternative energy partnerships flourish in Asia 2Full power: Alternative energy partnerships flourish in Asia 3Inserm and the Institut Pasteur identify a new variant of Ebola virus in Guinea 2
... Mars or any planet, there is much more than the ... cycles as a reference point, elements like nitrogen, iron and ... in studies published in February,s open-access Special Issue of Frontiers ... together to support an extraordinary diversity of life. ...
... SAN ANTONIO (Feb. 2, 2011) Obesity among ... of obese mothers are themselves predisposed to obesity, society ... people to continue through future generations. In ... San Antonio obstetrics researchers are studying the question: If ...
... , The same properties that make engineered nanoparticles attractive ... stabile, and water-solublealso cause concern about their long-term impacts ... the tendency for nanoparticles to clump together in solution, ... clusters may be key to whether or not they ...
Cached Biology News:Earth's life support systems discussed in an open-access special issue 2Losing body fat before pregnancy can be beneficial for the baby 2NIST technique controls sizes of nanoparticle clusters for EHS studies 2
(Date:1/15/2014)... OXFORD, England and SAN JOSE, California ... an international biotechnology company developing antibody-drug conjugates for cancer, today ... its Board of Directors. Dr Reynolds has over 20 years, ... Chief Medical Officer at Seattle Genetics. "I am ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... CA (PRWEB) January 15, 2014 ... research solutions, today announced that Lupin Limited, one of ... Freeslate’s CM Protégé PharmD System for high ... Mumbai, India, is focused on a wide range of ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... Eden Prairie-,based molecular diagnostics service and technology company, announced ... CFO, and Elizabeth A. Skinner,as VP - Legal, Quality ... Edwin Watts Golf, and has previously,served as VP of ... Signal,Aerospace, and corporate controller of NCR Corporation. He holds ...
... Inc. (Amex:,ADL), headquartered in Tustin, California, with ... its wholly owned subsidiary Jade,Pharmaceutical Inc. (JPI), ... the development, manufacture and marketing of proprietary,pharmaceutical ... JPI has,signed an agreement with Heze Mudan ...
... surface addresses key factors in the prevention and treatment ... pressure ulcers to enhance patient safety and comfort, ... HB ) today announced its Hill-Rom subsidiary has,introduced a ... patients with pressure ulcers. The Hill-Rom(R) E700 Wound Surface ...
Cached Biology Technology:Access Genetics Announces New Executive Appointments 2AMDL Expands Drug Distribution in China With Additional Agreement, Valued at $2.3 Million Annually 2Hill-Rom Introduces New Wound Therapy Surface With Innovative Safety and Treatment Features 2Hill-Rom Introduces New Wound Therapy Surface With Innovative Safety and Treatment Features 3Hill-Rom Introduces New Wound Therapy Surface With Innovative Safety and Treatment Features 4Hill-Rom Introduces New Wound Therapy Surface With Innovative Safety and Treatment Features 5
Physical Form: powder Color: white Removes FLAG peptide from N-terminal and Met-N-terminal fusion proteins. Supplied with optimized enterokinase buffer....
This antibody detects ubiquitinated proteins on SDS-PAGE immunoblots. It does not detect free ubiquitin....
... The Jouan B4i ventilated and BR4i refrigerated multifunction ... low speed operation at a low sound level ... certified for biocontainment. Their AUTO-LOCK rotor exchange system ... ready for use within seconds. Instant ...
... BR4i refrigerated multifunction centrifuges are equally capable of ... low sound level with a large range of ... rotor exchange system without tools ensures that the ... Instant rotor exchange (5 sec.) ...
Biology Products: