Navigation Links
Skin care: new research into scar-free healing
Date:1/20/2008

New research from the University of Bristol shows that by suppressing one of the genes that normally switches on in wound cells, wounds can heal faster and reduce scarring. This has major implications not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery.

When skin is damaged a blood clot forms and cells underneath the wound start to repair the damage, leading to scarring. Scarring is a natural part of tissue repair and is most obvious where skin has healed after a cut or burn. It ranges from trivial (a grazed knee) to chronic (diabetic leg ulcers) and is not limited to the skin. All tissues scar as they repair; for example, alcohol-induced liver damage leads to fibrosis and liver failure, and after most abdominal surgeries scars can often lead to major complications.

Tissue damage triggers an inflammatory response by white cells to protect skin from infection by killing microbes. The same white cells guide the production of layers of collagen. These layers of collagen help the wound heal but they stand out from the surrounding skin and result in scarring. Research by Professor Paul Martin and colleagues at the University of Bristol shows that osteopontin (OPN) is one of the genes that triggers scarring and that applying a gel, which suppresses OPN to the wound, can accelerate healing and reduces scarring. It does this in part by increasing the regeneration of blood vessels around the wound and speeding up tissue reconstruction.

The findings will be published by the Journal of Experimental Medicine on 26 January in a paper entitled Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. The paper is available online now.

Speaking of the discovery, Professor Martin said: White blood cells (macrophages), and the chemical signals (PDGF) delivered to the wound cells, and osteopontin itself ar
'/>"/>

Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... (Nov. 4, 2014) – A majority of Madagascar,s 101 ... could have serious consequences for the rainforests they call ... the positive impacts lemurs can have on rainforest tree ... disappearance could have on the region,s rich biodiversity. , ... fruits eaten by lemurs. Lemurs in turn disperse ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... Amgen TM Oncology Assistance (AOA), a comprehensive, ... "cap" on out-of-pocket co-payments for cancer patients receiving ... who are uninsured, underinsured, or unable to afford ... support for Amgen's cancer medicines. , "We recognize ...
... small segment of DNA in the genome of a primeval ... animals from sea to land, or to later key evolutionary ... copied DNA elements known as retroposons could be an important ... Howard Hughes Medical Institute investigator David Haussler. , "The ...
... of G&D, Dr. Marie-Louise Hammarskjold (UVA) and colleagues lend ... 1 tumor suppressor. The Wilms' Tumor 1 (WT1) protein ... with known roles in kidney and urogenital formation as ... and colleagues reveal that WT1 works not only at ...
Cached Biology News:Amgen introduces comprehensive financial assistance programs for cancer patients 2Mobile DNA part of evolution's toolbox 2Mobile DNA part of evolution's toolbox 3Mobile DNA part of evolution's toolbox 4
(Date:11/22/2014)... (PRWEB) November 21, 2014 On November ... at the 2014 Emerging Medical Technologies Summit in San ... Awards. Widely regarded among Silicon Valley investors and ... device innovation, the win also positions Briteseed to ... Innovator competition in 2015 and compete with other elite ...
(Date:11/22/2014)... -- The element of surprise has been a major advantage ... warning. Until now, epidemiologists had nothing to measure that ... in suboptimal responses to both the H1N1 pandemic of ... - http://photos.prnewswire.com/prnh/20141121/160242 That virus ... gene structural changes have been found that invariably to ...
(Date:11/21/2014)... TRU-D SmartUVC LLC and its UK partners, Rapid Disinfection ... TRU-D SmartUVC, at FIS 2014 in Harrogate, England ... Stand 23. The conference, hosted by Federation of ... largest infection-related event of its kind and brings together more ... events of its type throughout the world. This annual event ...
(Date:11/21/2014)... Angeles, CA (PRWEB) November 20, 2014 ... “A Short Walk to the Other Side” published ... an “Award-Winning Finalist in the “Fiction: Short Story” category ... , Jeffrey Keen, President and CEO of USA Book ... from mainstream and independent publishers, including Simon & Schuster, ...
Breaking Biology Technology:Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 2Insight Product Development Accelerator Member Wins MedTech Innovator Award Competition 3Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4
... , Compatible with GeneChip , ... little as 100 , ng RNA in a single round ... ArrayScript engineered M-MLV RT, engineered to maximize , ... cRNA synthesis powered by , ...
... More thermostable than AMV RT and M-MLV RT , ... Highly sensitive enzyme for RT-PCR applications , ... G/C content , ... AMV RT, Ambion's HIV RT synthesizes cDNA from single-stranded , ...
... Probe & Marker Kit , ... , small RNAs , Prepare high specific activity RNA ... small RNA probes , , Contains ... DNA and RNA positive controls , The new <A , ...
Cached Biology Technology:RNA Amplification Just Got Better: MessageAmp II 2RNA Amplification Just Got Better: MessageAmp II 3RNA Amplification Just Got Better: MessageAmp II 4RNA Amplification Just Got Better: MessageAmp II 5Recombinant HIV Reverse Transcriptase 2Rapidly Prepare Probes and Markers for Small RNA Analysis 2Rapidly Prepare Probes and Markers for Small RNA Analysis 3Rapidly Prepare Probes and Markers for Small RNA Analysis 4
From formula-fed bovine calves Sterile, Cell culture tested...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
... may be carried out using this high ... System control and data processing is provided ... The elegant, powerful and very easy to use ... and 2000., The supplied automatic sample injector has ...
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
Biology Products: