Navigation Links
Skin care: new research into scar-free healing
Date:1/20/2008

New research from the University of Bristol shows that by suppressing one of the genes that normally switches on in wound cells, wounds can heal faster and reduce scarring. This has major implications not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery.

When skin is damaged a blood clot forms and cells underneath the wound start to repair the damage, leading to scarring. Scarring is a natural part of tissue repair and is most obvious where skin has healed after a cut or burn. It ranges from trivial (a grazed knee) to chronic (diabetic leg ulcers) and is not limited to the skin. All tissues scar as they repair; for example, alcohol-induced liver damage leads to fibrosis and liver failure, and after most abdominal surgeries scars can often lead to major complications.

Tissue damage triggers an inflammatory response by white cells to protect skin from infection by killing microbes. The same white cells guide the production of layers of collagen. These layers of collagen help the wound heal but they stand out from the surrounding skin and result in scarring. Research by Professor Paul Martin and colleagues at the University of Bristol shows that osteopontin (OPN) is one of the genes that triggers scarring and that applying a gel, which suppresses OPN to the wound, can accelerate healing and reduces scarring. It does this in part by increasing the regeneration of blood vessels around the wound and speeding up tissue reconstruction.

The findings will be published by the Journal of Experimental Medicine on 26 January in a paper entitled Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. The paper is available online now.

Speaking of the discovery, Professor Martin said: White blood cells (macrophages), and the chemical signals (PDGF) delivered to the wound cells, and osteopontin itself ar
'/>"/>

Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market and creator ... campaign for Q4 2015. The new marketing campaign is ... of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ... a leader in retail driven marketing and brand awareness ...
(Date:8/12/2015)... , August 12, 2015 ... of mobile payment innovation and advanced biometrics technology is ... the way consumers rely on using their credit cards, ... reinventing the future for payment services led by companies ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ), ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... it, bread that contains critical nutrients could help combat ... of a group of Johns Hopkins University undergraduate students ... so that it yields beta carotene, the orange substance ... turns into vitamin A. The students, project ...
... likely, you would be disgusted if confronted with a ... worms. Or a particularly bloody wound. Or a horribly ... disgust you feel may lend important insight into your ... scientists closely measured people,s physiological reactions as they looked ...
... -- Low levels of a brain protein that regulates gene ... disorder, a complex and sometimes disabling psychiatric disease. As reported ... journal of The International Society for Bipolar Disorders, levels of ... of the brain in postmortem samples from patients with bipolar ...
Cached Biology News:Students coax yeast cells to add vitamins to bread 2Students coax yeast cells to add vitamins to bread 3Students coax yeast cells to add vitamins to bread 4That's gross!: Study uncovers physiological nature of disgust in politics 2Gene regulatory protein is reduced in bipolar disorder 2Gene regulatory protein is reduced in bipolar disorder 3
(Date:8/31/2015)... FL (PRWEB) , ... August 31, 2015 , ... ... bring together the world's most successful food and beverage processors, equipment manufacturers and ... competencies in product inspection and industrial weighing and formulation for manufacturers of bakery ...
(Date:8/31/2015)... ... August 31, 2015 , ... Proove Biosciences, Inc. is a finalist for ... High Tech Awards. , Now in its 22nd year, this premier awards event celebrates ... across the nation and around the world. The OC Tech Alliance will announce all ...
(Date:8/28/2015)... Aug. 28, 2015 Research ... of the "Global & USA BioSimilar Market Analysis ... The highly awaited US Biosimilar market will be initiated ... biologic, Zarxio. How will the global market react? Will ... that biosimilars could save the US economy up to ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... studies at the International Spine Intervention Society’ s 23rd Annual Scientific ... August 1st, 2015. With a focus on evidence-based research and clinical application, the ...
Breaking Biology Technology:METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 2Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 3Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 4Global & USA BioSimilar Market Analysis Report 2015-2021 2Global & USA BioSimilar Market Analysis Report 2015-2021 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4
... , SAN DIEGO, Calif., INDIANAPOLIS, Ind., and CAMBRIDGE, ... ), Eli Lilly and Company (NYSE: LLY ) and Alkermes, ... 20 studies at the 45th Annual Meeting of the European Association for ... 29 to Oct. 2. The companies will present the latest research findings ...
... ... million round of funding. Participating investors included CTTV Investments LLC, the venture capital ... , ... Francisco, CA (PRWEB) September 24, 2009 -- LS9, Inc., the Renewable Petroleum Company™, today ...
... , , PHILADELPHIA and LONDON, ... -- researchers likely to be in contention for Nobel honors -- in anticipation ... be announced from October 5-12. , , Thomson Reuters ... Nobel Prize winners. , , Each year, data ...
Cached Biology Technology:Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 2Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 3Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 4Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 5Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 6Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 7LS9 Secures $25 Million in Latest Round of Funding 2LS9 Secures $25 Million in Latest Round of Funding 3Thomson Reuters Predicts Nobel Laureates 2Thomson Reuters Predicts Nobel Laureates 3Thomson Reuters Predicts Nobel Laureates 4Thomson Reuters Predicts Nobel Laureates 5Thomson Reuters Predicts Nobel Laureates 6
... Complete kit for stabilizing 1.5mg of purified ... optimised for the stabilization of aqueous RNA ... methods such as guanidine, phenol/chloroform, silica, oligo ... StabMRT Kits contain all the necessary components ...
... stabilizing 50g of purified RNA samples for RT-PCR ... all of the advantages and applications you expect ... RNA can be used for enzymatic applications such ... been optimised for the stabilization of aqueous RNA ...
Blasticidin resistance gene (bsr), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Biology Products: