Navigation Links
Skin care: new research into scar-free healing
Date:1/20/2008

New research from the University of Bristol shows that by suppressing one of the genes that normally switches on in wound cells, wounds can heal faster and reduce scarring. This has major implications not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery.

When skin is damaged a blood clot forms and cells underneath the wound start to repair the damage, leading to scarring. Scarring is a natural part of tissue repair and is most obvious where skin has healed after a cut or burn. It ranges from trivial (a grazed knee) to chronic (diabetic leg ulcers) and is not limited to the skin. All tissues scar as they repair; for example, alcohol-induced liver damage leads to fibrosis and liver failure, and after most abdominal surgeries scars can often lead to major complications.

Tissue damage triggers an inflammatory response by white cells to protect skin from infection by killing microbes. The same white cells guide the production of layers of collagen. These layers of collagen help the wound heal but they stand out from the surrounding skin and result in scarring. Research by Professor Paul Martin and colleagues at the University of Bristol shows that osteopontin (OPN) is one of the genes that triggers scarring and that applying a gel, which suppresses OPN to the wound, can accelerate healing and reduces scarring. It does this in part by increasing the regeneration of blood vessels around the wound and speeding up tissue reconstruction.

The findings will be published by the Journal of Experimental Medicine on 26 January in a paper entitled Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring. The paper is available online now.

Speaking of the discovery, Professor Martin said: White blood cells (macrophages), and the chemical signals (PDGF) delivered to the wound cells, and osteopontin itself ar
'/>"/>

Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
University of Bristol
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood ... for quite a while. Hypertension – the medical term for ... in the early 1800s, and the inflatable cuff that,s used ... That doesn,t, however, mean there,s nothing new about hypertension, its ... some long-held beliefs about the condition and the best ways ...
(Date:12/10/2014)... 2014  Valencell, a leader in performance biometric data ... demand from its licensees for highly accurate, clinically validated ... solely coming from fitness and health sectors, but first ... wearable is only as useful as the biometric data ... driver in long-term mass consumer adoption of wearable products," ...
(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... its eruption in early June, several NASA satellites have captured ... Chilean Volcano called Puyehue-Cordn Caulle and have tracked it around ... FLICKR image gallery that shows the progression of the plume ... Complex includes the Puyehue volcano, the Cordn Caulle rift zone ...
... 15, 2011 A first of its kind combination ... Oak Ridge National Laboratory is providing a close-up look ... a major component of plant cell walls, aggregates to ... cellulosic ethanol. The exact shape and structure of the ...
... mutations that add up over time could create an evolutionary ... traits, researchers from the University of Pittsburgh and the University ... in the Proceedings of the National Academy of Sciences ... DNA known as transcriptional enhancerswhich determine the when, where, and ...
Cached Biology News:NASA satellite gallery shows Chilean volcano plume moving around the world 2NASA satellite gallery shows Chilean volcano plume moving around the world 3ORNL neutrons, simulations reveal details of bioenergy barrier 2Leaky genes put evolution on the fast track, Pitt and UW-Madison researchers find 2
(Date:12/19/2014)... Dec. 18, 2014  Decision Resources Group finds that ... market will grow moderately through 2023 as the aging ... awareness of dental biomaterials all spur procedure volumes. Growth ... China and India ... procedures within reach for a larger proportion of the ...
(Date:12/19/2014)... Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage ... pain, announced the results of its annual general meeting ... transformational year in Relmada,s history and it set the ... Sergio Traversa , chief executive officer of Relmada. ... financial, human resource and clinical development objectives that position ...
(Date:12/17/2014)... 2014 “Never say, ‘I cannot ... Marburg’s Department of Physics, advises young women pursuing ... released SPIE Women in Optics 18-month planner ... to ask questions.” , In the annual planner, ... occupations ranging from university professor and laboratory researcher ...
(Date:12/17/2014)... December 17, 2014 Once more, EMAAR ... a larger packaged waste water treatment plant to phase ... Economic City (KAEC). Two years ago Bioshaft successfully supplied ... Development, serving two residential towers with an occupancy of ... a quarter million gallons per day and was signed ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... of graphite, a piece of Scotch tape and a silicon ... just one atom thick -- but strong enough to contain ... unlike your average party balloon -- or even a thick, ... impermeable to even nimble helium atoms. , The research, by ...
... KNDL ), a,leading, global full-service clinical research organization, ... PharmD, will,participate in the annual UBS Global Life ... Grand Hyatt New York, Park Avenue at Grand,Central, ... is,scheduled for Wednesday, September 24 at 9:30 a.m. ...
... Audio Webcast Thursday, September 25, 2008, SAN DIEGO, ... announced today that Kevin Gorman, President and Chief,Executive Officer ... Life Sciences Conference at the Grand Hyatt in New ... 25, 2008 at 10:00,a.m. Eastern Time (ET) /7:00 a.m. ...
Cached Biology Technology:CU scientists create world's thinnest balloon -- just one atom thick 2Neurocrine Biosciences to Present at the UBS Global Life Sciences Conference 2
... Affinity Life Sciences can provide custom microplate coating using ... washes a variety of plate formats. We can also accommodate ... volume range of 0.5-320 L):, , ... 96 well microplate, ...
...
... the first biological reagent that ... and not just by inhibiting ... anti-mycoplasma agent that can be ... directly. The cytotoxicity of Mynox ...
Mynox is intended for research use only. Mynox is used for the elimination of Mycoplasma and Acholeplasma in cell and virus cultures, and other biologicals....
Biology Products: