Navigation Links
Skin cancer study uncovers new tumor suppressor gene
Date:3/29/2009

e tumor samples. Nearly one-quarter of the tumors analyzed had at least one MMP gene mutation. Some mutations were found in as few as 3 percent of tumors, while more than 6 percent of tumors had mutations in MMP-8 and more than 7 percent had mutations in MMP-27, which codes for an enzyme very similar to MMP-8.

"We often talk about cancer as though it is one disease, and cancers do have many common denominators. But when we look at the DNA level, we see that different cancers have different genetic profiles, and so do different patients who have the same cancer," said the study's senior author, Yardena Samuels, Ph.D., an investigator in the Cancer Genetics Branch of the NHGRI's Division of Intramural Research.

Dr. Samuels and her collaborators followed up their DNA sequencing work with cell and animal studies to see whether MMP-8 mutations affect enzyme function. Strikingly, the researchers showed that five of the mutations reduced activity of the MMP-8 enzyme. The researchers next studied whether MMP-8 mutations promote activities related to cancer. Indeed, cells with MMP-8 mutations showed increased ability to multiply outside the constraints of normal cells, a hallmark of cancer development known as anchorage-independent growth. Likewise, cells with MMP-8 mutations had a greater ability to migrate -- a key aspect of cancer metastasis -- than normal cells.

The researchers found that mice injected with cells expressing normal MMP-8 did not develop skin ulcers, which are one of the most important measures of cancer aggression in melanoma. In contrast, mice injected with cells expressing mutated MMP-8 went on to develop ulcerations and metastases in their lungs.


'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Getting down to cancer basics
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. New drug agent knocks out multiple enzymes in cancer pathway
5. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
6. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
7. Research yields potential target for cancer, wound healing and fibrosis
8. Lab-on-a-chip homes in on how cancer cells break free
9. TGens Dr. Von Hoff wins award for cancer research
10. Researchers identify genetic markers for aggressive head and neck cancer
11. Cancer: Another step towards medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... therapeutics present unique challenges when it comes to ... harm. New consensus guidelines for toxicity testing that ... characteristics of these novel biopharmaceuticals are presented in ... from Mary Ann Liebert, Inc. publishers . ... Nucleic Acid Therapeutics website until November 30, ...
(Date:10/30/2014)... Biological membranes are mainly composed of lipid bilayers. ... ions onto lipid membranes helps clarify functional processes ... a quantitative description of the equilibria between lipid ... Zbigniew Figaszewski from the University of Bialystok, Poland, ... findings, just published in EPJ E . ...
(Date:10/29/2014)... as a consequence of chemotherapy will benefit from a ... technology that prevents hair loss. , The research is ... scalp cooling manufacturing company, Paxman Coolers, of Fenay Bridge, ... University of Huddersfield. , The research will be led ... in the pharmacology of cancer treatment, which he will ...
Breaking Biology News(10 mins):New guidelines for reproductive & developmental toxicity testing of oligonucleotide drugs 2Ion adsorption matter in biology 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2
... When North Carolina,s "Laura,s Law" was signed by Governor ... in the last year to pass progressive DUI legislation that ... cars to required—and enforced—sobriety for the most dangerous drivers on ... movement, as state lawmakers look at incorporating required 24/7 alcohol ...
... Calif., Oct. 18, 2011 DigitalPersona, ... and endpoint protection solutions, today launched a new ... the growing market of battery-powered mobile identification devices. ... of fingerprint modules and readers make high-efficiency, standards-compliant ...
... the first time have identified and mapped the chemical structure ... kill or inhibit the growth of reef-building coral. Chemicals ... been shown to harm coral, suggesting that competition with these ... and lack of recovery of coral reefs. Seaweed ...
Cached Biology News:Are Alcohol Anklets the New Ignition Interlock? 2Are Alcohol Anklets the New Ignition Interlock? 3Are Alcohol Anklets the New Ignition Interlock? 4DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 2DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 3DigitalPersona Goes Mobile with New U.are.U 5100 Fingerprint Sensors for Battery-Powered Mobile ID Devices 4Study identifies molecules used by certain species of seaweed to harm corals 2Study identifies molecules used by certain species of seaweed to harm corals 3Study identifies molecules used by certain species of seaweed to harm corals 4
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), ... present a company overview at the Nomura Biotechnology Conference on ... Boston, MA. A live webcast ... Media" section of the Company,s website, www.isispharm.com .  A ... hours and will be archived for a limited time. ...
(Date:10/30/2014)... RIDGE, N.J. , Oct. 30, 2014  Regado ... that it will hold a conference call and live ... a.m. EST to discuss its third quarter 2014 financial ... the conference call by dialing (888) 347-1165 for domestic ... call will be webcast live under the investor relations ...
(Date:10/30/2014)... 29, 2014) – The severe flooding that devastated a ... less destructive if the bridges, roads and other infrastructure ... study from the University of Colorado Denver. , "People ... said Jimmy Kim, PhD, associate professor of structural engineering ... Science and lead author the study. "There is an ...
(Date:10/27/2014)... 27, 2014 The new research ... (High & Medium), Sub-type (Primary & Secondary), and ... & Transportation & Power Generation) - Trends and ... market with analysis and forecasting of the market ... Tables with 52 Figures spread through 146 Pages ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2CU Denver study says upgrading infrastructure could reduce flood damage 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... ... users to easily find and schedule an appointment for a local health screening, learn ... with the company via Facebook, Twitter, and YouTube. The health screening company’s ... ...
... passed as fact among historians, journalists and politicians, and has ... the U.S. Congress: British forces used chemical weapons on Iraqis ... has never been fully squared with the historical record, says ... Douglas,s research, forthcoming in the December issue of The ...
... of death from roadside bombs to freeway crashes. Traumatic injury, ... 44, often overwhelms the body,s natural blood-clotting process. In ... by Erin Lavik, a new Case Western Reserve University biomedical ... built synthetic platelets that show promise in halting internal and ...
Cached Biology Technology:Website Redesign Enhances Global Health Screening Service's Online Presence 2Website Redesign Enhances Global Health Screening Service's Online Presence 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4Researchers take the inside route to halt bleeding 2
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 81 tubes. Box dimensions: 13 x ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
Biology Products: