Navigation Links
Skin cancer study uncovers new tumor suppressor gene
Date:3/29/2009

ly serves as a tumor suppressor gene in melanoma. Consequently, in the estimated 6 percent of melanoma patients whose tumors harbor a mutated MMP-8 gene or related tumor suppressor(s), it may not be wise to block all MMPs. The study suggests that a better approach may be to look for drugs that restore or increase MMP-8 function or for drugs that block only those MMPs that are truly oncogenes.

"This research is an illustrative proof of concept that shows the value of genomic strategies for understanding cancer and possible therapies," said NHGRI Scientific Director Eric Green, M.D., Ph.D. "It is gratifying to see that genomic technologies are guiding scientific discovery, advancing cancer research, especially melanoma research."

Melanoma is the most serious form of skin cancer. In the United States and many other nations, melanoma is becoming more common every year. A major cause is thought to be overexposure to the sun. The ultraviolet radiation in sunlight can damage DNA and lead to cancer-causing genetic changes within skin cells.

MMP enzymes help the body to break down and recycle proteins, playing a crucial role in the process of remodeling skin after sunburns, cuts or other injuries. The MMP gene family has been associated with tumor growth in a variety of cancers, including breast, colon and melanoma.

To explore the role of MMP genes in melanoma, the NHGRI researchers studied a bank of tumor and blood samples collected from 79 patients with aggressive melanoma by collaborator Steven Rosenberg, M.D., Ph.D., chief of surgery at the National Cancer Institute (NCI). Specifically, they compared the sequence of MMP genes in tumors and normal DNA from the same patients, looking for mutations in all 23 members of the MMP gene family.

The researchers identified 28 different mutations in eight MMP genes in the melanoma tumors studied. These mutations were found to be distributed in different frequencies and patterns among th
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Getting down to cancer basics
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. New drug agent knocks out multiple enzymes in cancer pathway
5. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
6. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
7. Research yields potential target for cancer, wound healing and fibrosis
8. Lab-on-a-chip homes in on how cancer cells break free
9. TGens Dr. Von Hoff wins award for cancer research
10. Researchers identify genetic markers for aggressive head and neck cancer
11. Cancer: Another step towards medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Institute for Biologically Inspired Engineering at Harvard University ... be commercialized by a newly formed private company ... personalized medicine products. The announcement follows ... Technology Development (OTD) and the start-up Emulate Inc., ... human Organs-on-Chips platform. , "This is a ...
(Date:7/27/2014)... the asteroid strike that wiped them out if it ... scientists say. , A fresh study using up-to-date fossil ... build a new narrative of the prehistoric creatures, demise, ... in the few million years before a 10km-wide asteroid ... upheaval. This included extensive volcanic activity, changing sea levels ...
(Date:7/27/2014)... potential for global climate change to cut food supplies. ... the interactions between increasing temperature and air pollution ... , A new study involving researchers at MIT shows ... policymakers need to take both warming and air pollution ... looked in detail at global production of four leading ...
Breaking Biology News(10 mins):Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 2Wyss Institute's technology translation engine launches 'Organs-on-Chips' company 3Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... Compared to European Americans, African Americans are four to five ... of African Americans with kidney failure have an increased risk ... a role in this skewed risk between races. Previous studies ... a role. The APOL1 gene creates a protein that is ...
... SAN FRANCISCO, Oct. 13, 2011 -- The tiny phytoplankton ... outsized role in drawing carbon from the atmosphere and sequestering ... as ocean water becomes warmer and more acidic, according to ... study published this week in the journal Global Change Biology, ...
... is a master builder. Using a bottom-up approach, nature ... materials, like diamonds, silicon and even table salt. In ... upon the type and arrangement of atoms within the ... University scientists has learned how to top nature by ...
Cached Biology News:Better ways to predict kidney disease risk for African Americans 2Better ways to predict kidney disease risk for African Americans 3Researchers explore plankton's shifting role in deep sea carbon storage 2Researchers explore plankton's shifting role in deep sea carbon storage 3Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3
(Date:7/28/2014)... , July 28, 2014 /PRNewswire/ -   JOLT ... group of companies to join its growing portfolio of ... of Toronto,s JOLT accelerator, and ... on the roster. Since its launch ... have successfully raised  $7.5M of financing. Now at 23 ...
(Date:7/28/2014)... St Louis, MO (PRWEB) July 28, 2014 ... tools, software, and services that bring the power of ... for the inaugural Appistry Pipeline Challenge . ... Callum Bell, president of the National Center for Genome ... Children’s Mercy Hospitals and Clinics of Kansas City. Rounding ...
(Date:7/28/2014)... , July 28, 2014 Research and Markets ... Size Analysis Market 2014-2018" report to their offering. ... size analysis is a technique used to determine the size ... liquid. It is crucial to analyze the size of particles ... particle size analysis is performed to determine the behavior and ...
(Date:7/25/2014)... of bacteria live in each person,s digestive tract. Scientists ... and stave off harmful infections, but their role in ... shed light on the role of these bacteria, a ... Alm recently tracked fluctuations in the bacterial populations of ... described in the July 25 issue of the journal ...
Breaking Biology Technology:JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 2JOLT Announces the Next 6 Startups to Join its Summer 2014 Cohort 3Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... Thomson Reuters announced today the publication of a white ... in entering the Japanese generic drug market. , ... opportunities and strategies for success," notes that a combination ... aging population and wide-ranging government initiatives to reduce healthcare ...
... ROCKVILLE, Md., Oct. 1 Novavax, Inc. (Nasdaq: ... to the board,s corporate governance, compensation and finance committees, replacing ... member James Tananbaum who is retiring from the board. ... and immunology products companies and joined the Novavax board in ...
... BC, Oct. 1 /PRNewswire-FirstCall/ - avVaa World Health Care ... manufacturer and distributor of nationally branded therapeutic, natural skin ... launching their second test run of Neuroskin(R) Psoriasis Relief ... avVaa World Health Care Products will launch a two ...
Cached Biology Technology:Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 3Novavax Announces Board of Director Changes 2Novavax Announces Board of Director Changes 3avVaa World Health Care Products Inc. Announces Second DRTV Test Week 2avVaa World Health Care Products Inc. Announces Second DRTV Test Week 3
Human BMP 2 Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
Biology Products: