Navigation Links
Skin cancer study uncovers new tumor suppressor gene
Date:3/29/2009

National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cancer and many other types of cancer.

The NIH analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that code for matrix metalloproteinase (MMP) enzymes. The findings lay the foundation for more individualized cancer treatment strategies where MMP and other key enzymes play a functional role in tumor growth and spread of the disease.

Tumor suppressor genes encode proteins that normally serve as a brake on cell growth. When such genes are mutated, the brake may be lifted, resulting in the runaway cell growth known as cancer. In contrast, oncogenes are genes that encode proteins involved in normal cell growth. When such genes are mutated, they also may cause cancer, but they do so by activating growth-promoting signals. Cancer therapies that target oncogenes usually seek to block or reduce their action, while those aimed at tumor suppressor genes seek to restore or increase their action.

The new study may help to explain the disappointing performance of drugs designed to treat cancer by blocking MMP enzymes. Because members of the MMP gene family were thought to be oncogenes and many tumors express high levels of MMP enzymes, researchers have spent decades pursuing MMPs as promising targets for cancer therapies. However, when MMP inhibitors were tested in people with a wide range of cancers, the drugs failed to slow -- and in some cases even sped up -- tumor growth.

Now, it turns out that one of the most often mutated MMP genes in melanoma is not an oncogene at all. In its study, the team led by researchers from the National Human Genome Research Institute (NHGRI) found that MMP-8 actual
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Getting down to cancer basics
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. New drug agent knocks out multiple enzymes in cancer pathway
5. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
6. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
7. Research yields potential target for cancer, wound healing and fibrosis
8. Lab-on-a-chip homes in on how cancer cells break free
9. TGens Dr. Von Hoff wins award for cancer research
10. Researchers identify genetic markers for aggressive head and neck cancer
11. Cancer: Another step towards medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
(Date:6/25/2015)... , June 25, 2015  TAKE Solutions Ltd., ... patent by the United States Patent and Trademark Office ... This process leverages TAKE Solutions, Clinical Accelerators to reduce ... 50% (when compared to standardization without the accelerators), thus ... At the heart of the ...
(Date:6/24/2015)... 24, 2015 This report provides market analysis ... six years. It contains an analysis of the drivers, ... their impact from the short, medium, and long term ... industry, market, and technology trends that currently, prevail in ... concerned authorities to efficiently manage the increasing marine traffic ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4TAKE Solutions Awarded Patent By USPTO 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2
... new species of bird in Gabon, Africa, that was, ... were published in the international science journal Zootaxa today, ... (Stiphrornis pyrrholaemus) was named by the scientists for its ... inches in length and average 18 grams in weight. ...
... A new systematic analysis of the relationship between ... of trends in cancer gene expression. The research, ... Genome Biology, describes how cancers can be divided ... Isaac S Kohane from Children,s Hospital Boston ...
... 14 L-1 Identity,Solutions, Inc. (NYSE: ID ), ... that it closed its tender offer for all of ... and completed its,acquisition of Digimarc,s ID systems business., ... expired at,5:00 p.m. (ET) on August 13, 2008. Through ...
Cached Biology News:Smithsonian scientists discover new bird species 2Smithsonian scientists discover new bird species 3Cancer signatures uncovered 2L-1 Identity Solutions Completes Acquisition of the ID Systems Business from Digimarc Corporation 2L-1 Identity Solutions Completes Acquisition of the ID Systems Business from Digimarc Corporation 3
(Date:7/7/2015)... , July 7, 2015 Genes in ... grades 7-12, is landing at New England Biolabs® ... a day of scientific exploration and celebration, on ... a partnership between Boeing®, The Center for Advancement ... miniPCR™, asked students to design an experiment to ...
(Date:7/7/2015)... , July 7, 2015  In the farthest reaches ... of the Matsés tribe came together in a quest ... extinction. The gathering, held in May in a remote ... Brazil , concluded over two years work ... Medicine Encyclopedia ever written by an Amazonian tribe. The ...
(Date:7/7/2015)... ... 07, 2015 , ... The global aptamers market is expected ... a CAGR of 17.89% between 2015 and 2020. The aptamer type segments included ... applications, the report is segmented into diagnostics, therapeutics development, R&D, and other applications. ...
(Date:7/6/2015)... Washington, USA, and CARDIFF, UK (PRWEB) , ... ... ... used in ophthalmology and other medical fields holds potential to reveal how blood ... treatments and reduce stroke-induced damage to the brain. , A new article published ...
Breaking Biology Technology:Genes in Space finalists attend laboratory workshop and celebration at New England Biolabs' headquarters 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 2Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 3Amazonian Tribe Creates First Encyclopedia of Indigenous Medicine 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 2Reducing Stroke Damage May be Next Application for OCT Technology Now Widely Used in Eye and Vision Healthcare 3
... March 28, 2012  Regado Biosciences, Inc., a privately held ... control agents, announced that David J. Mazzo, PhD, President ... 11th Annual Healthcare Conference at 10 a.m. EDT on ... in New York City. The presentation will ...
... little dry ice and a simple industrial process cheaply ... Case Western Reserve University report. Graphene, which ... in pencils, has been hailed as the most important ... than copper, heat better than any material known, are ...
... March 26, 2012 Aviir, a biotechnology company dedicated ... tests and Guard A Heart, a non-profit foundation committed ... Storyland, a Red Carpet Charity Extravaganza in Hollywood on ... whimsical Dr. Seuss theme, as homage to the children ...
Cached Biology Technology:Regado Biosciences, Inc. to Present at Needham & Company's 11th Annual Healthcare Conference in New York, NY 2Regado Biosciences, Inc. to Present at Needham & Company's 11th Annual Healthcare Conference in New York, NY 3Simple, cheap way to mass-produce graphene nanosheets 2Aviir Diagnostics Laboratory in Collaboration with Cause;ology Sponsors "Storyland," a Red Carpet Charity Extravaganza in Hollywood 2Aviir Diagnostics Laboratory in Collaboration with Cause;ology Sponsors "Storyland," a Red Carpet Charity Extravaganza in Hollywood 3
... Methylated Protein Molecular Weight Markers, 37 kBq, ... molecular weight determination of the sample on ... monitoring of band migration in the gel ... the [14C] version without Rainbow-labeling is 0.37-3.7 ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
... Blunt TOPO PCR Cloning ... designed for cloning and ... PCR products. The pCR4Blunt-TOPO ... Cloning and greater than ...
... 1 EA. Ultrospec 6300 pro ... of the Pharmacopoeia in terms of instrument ... of being able to be used for ... and excellent scanning capability., *Press to read ...
Biology Products: