Navigation Links
Skin cancer study uncovers new tumor suppressor gene
Date:3/29/2009

National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cancer and many other types of cancer.

The NIH analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that code for matrix metalloproteinase (MMP) enzymes. The findings lay the foundation for more individualized cancer treatment strategies where MMP and other key enzymes play a functional role in tumor growth and spread of the disease.

Tumor suppressor genes encode proteins that normally serve as a brake on cell growth. When such genes are mutated, the brake may be lifted, resulting in the runaway cell growth known as cancer. In contrast, oncogenes are genes that encode proteins involved in normal cell growth. When such genes are mutated, they also may cause cancer, but they do so by activating growth-promoting signals. Cancer therapies that target oncogenes usually seek to block or reduce their action, while those aimed at tumor suppressor genes seek to restore or increase their action.

The new study may help to explain the disappointing performance of drugs designed to treat cancer by blocking MMP enzymes. Because members of the MMP gene family were thought to be oncogenes and many tumors express high levels of MMP enzymes, researchers have spent decades pursuing MMPs as promising targets for cancer therapies. However, when MMP inhibitors were tested in people with a wide range of cancers, the drugs failed to slow -- and in some cases even sped up -- tumor growth.

Now, it turns out that one of the most often mutated MMP genes in melanoma is not an oncogene at all. In its study, the team led by researchers from the National Human Genome Research Institute (NHGRI) found that MMP-8 actual
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Getting down to cancer basics
2. Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. New drug agent knocks out multiple enzymes in cancer pathway
5. Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
6. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
7. Research yields potential target for cancer, wound healing and fibrosis
8. Lab-on-a-chip homes in on how cancer cells break free
9. TGens Dr. Von Hoff wins award for cancer research
10. Researchers identify genetic markers for aggressive head and neck cancer
11. Cancer: Another step towards medication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... U.S. cities that have seen an increase in so-called ... closures, overwhelmed storm drains and compromised infrastructure--are on the ... , This nuisance flooding, caused by rising sea levels, ... and 925 percent since the 1960s. , The report, ... the United States, also finds Annapolis and Baltimore, Maryland, ...
(Date:7/28/2014)... There is no cure for Alzheimer,s disease and other ... step closer to finding treatment. , University of Washington ... stop the harmful changes of the body,s normal proteins ... as Alzheimer,s, Parkinson,s, heart disease, Type 2 diabetes and ... as they shift from their normal state into an ...
(Date:7/28/2014)... findings of a new study suggest two ways to effectively ... as well in obese women, compared to women of a ... one-size-fits-all method, researchers say, but as the population has increased ... works for obese women. Studies have consistently found that obesity ... which may in turn affect how well the pill prevents ...
Breaking Biology News(10 mins):NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3New protein structure could help treat Alzheimer's, related diseases 2New protein structure could help treat Alzheimer's, related diseases 3Strategies identified to improve oral contraceptive success with obese women 2
... among the authors of a new paper that describes ... when and how to use an environmental strategy known ... assistant professors of biology, and Alejandro Camacho, associate professor ... that produced the paper, which appears in this week,s ...
... are several risk factors for the development of Alzheimer,s ... of studies linking these risk factors with Vitamin D ... Journal of Alzheimer,s Disease (May 2009) by ... Health Research Center (SUNARC) suggests that further investigation of ...
... wounded during combat, surgeons must focus on reducing infection ... improve the repair and regeneration processes are being developed ... not being moved quickly enough into military trauma centers. ... for Advanced Bioengineering for Soldier Survivability want to change ...
Cached Biology News:Notre Dame researchers describe new tool for evaluating 'managed relocations' 2Notre Dame researchers describe new tool for evaluating 'managed relocations' 3Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia? 2New center at Georgia Tech aims to improve recovery of soldiers with severe injuries 2New center at Georgia Tech aims to improve recovery of soldiers with severe injuries 3
(Date:7/28/2014)... 28, 2014 “2014 Deep ... Industry” is a professional and in-depth research ... The report introduces Lubricant basic information, including ... structure and industry overview. This research covers ... market as well as global industry analysis ...
(Date:7/28/2014)... , July 28, 2014 ... report  "Microbial Identification Market by Products (Consumables, Instruments, Services), ... Beverages), End User (Detection, Characterization) - Global ... Microbial Identification Market is estimated at $896.5 ... reach $1,194.1 Million by 2019, growing at ...
(Date:7/28/2014)... July 28, 2014 It’s a hard truth: ... benefits to further their post-secondary education are failing to obtain ... released this year. And according to an analysis by ... is veteran students’ uninformed choice of college majors, which leads ... of the study: Some 51.7 percent of post-9/11 veterans using ...
(Date:7/28/2014)... 2014 The National Model Aviation Museum, ... is pleased to announce that it has been granted ... the United States Air Force. , The certification is ... concluded this spring with an on-site inspection by Sarah ... , The National Museum of the United States ...
Breaking Biology Technology:Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 2Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 3Lubricant Market & Adhesion Promoter Industry (Globa, China) Analysis Now Available at DeepResearchReports.com 4Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2
... tumor,s vulnerability yields durable responses in Phase I/II ... ... 21 Systems Medicine, LLC (SM),a wholly-owned subsidiary of Cell Therapeutics, ... phase I trial,combining cisplatin with brostallicin in patients with solid tumors ...
... Nov. 21 Syngenta and the Royal,Society of Chemistry ... to help promote the economic and social development of,the ... continent,is being established initially in Kenya. Its purpose is ... to achieve greater levels of,innovation and scientific development., ...
... paper to be published Nov. 22 in the online ... of Wisconsin-Madison researchers reports the genetic reprogramming of human ... cells., The finding is not only a critical scientific ... landscape of stem cell biology as human embryos may ...
Cached Biology Technology:Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 2Brostallicin Trial Data Demonstrates Encouraging Anti-tumor Activity in Patients With Chemotherapy-Resistant Cancers 3Syngenta and The Royal Society of Chemistry Launch African Science Initiative 2Syngenta and The Royal Society of Chemistry Launch African Science Initiative 3UW-Madison scientists guide human skin cells to embryonic state 2UW-Madison scientists guide human skin cells to embryonic state 3
... H3 (Lys 4) Immunogen: ... ...RT[ Ac K]Q... in which [ Ac ... human histone H3 Accession ... Weight: Mr ~17kDa ...
Blank Calibration Particles, 3.0-3.4 mu m 5 ml...
b-Catenin (pSer675), phospho-specific...
BDFastImmune? IFN-gamma /CD69/CD4/CD3 Storage Temperature: Refrigerate(2 to 8C)...
Biology Products: