Navigation Links
Single gene lets bacteria jump from host to host
Date:2/1/2009

sh's menu.

But how did a single species of bacteria come to terms with such different hosts?

Working in the UW-Madison laboratory of microbiologist Ned Ruby, Mandel and his colleagues scoured the genomes of the two different strains of V. fischeri and found that most of the bacterium's genetic architecture was conserved over the course of millions of years of evolutionary history, but with a key difference: The strain that colonizes the squid has a regulatory gene that controls other genes that lay down a biofilm that allows the microbe to colonize the animal's light organ.

"During squid colonization, this regulatory gene turns on a suite of genes that allow bacteria to colonize the squid through mucus produced by the animal," Mandel explains. "The mucus is the pathway to the light organ, but it also helps keep out the bad guys."

Both strains of bacteria, Mandel explains, have the same genes that produce the biofilms the bacterium needs to get established in its host. But the regulatory gene that sets the other biofilm genes in motion is absent in the strain that lives in the pinecone fish, the animal scientists believe was first colonized by V. fischeri before it moved in to the squid light organ when the squid family came onto the scene in the Pacific Ocean at least 30 million years ago.

"The regulatory gene entered the bacterium's lineage and allowed it to expand its host range into the squid," according to Mandel. "The bottom-line message of the paper is that bacteria can shift host range by modifying their capabilities with small regulatory changes."

The regulatory gene acquired by the bacterium, notes Ruby, is essentially a switch the organism uses to activate a set of genes that had been residing quietly in the V. fischeri genome. Such mechanisms, he says, are very likely at play in many other species of bacteria, including those that infect humans and cause illness.

"This is going to inform a qu
'/>"/>

Contact: Mark J. Mandel
mmandel@wisc.edu
608-262-5550
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
2. Single-largest biodiversity survey says primary rainforest is irreplaceable
3. New technique captures chemical reactions in a single living cell at unprecedented resolution
4. Gene study supports single main migration across Bering Strait
5. Baumann lab identifies elusive telomere RNA subunit in single cell model
6. Ebola virus disarmed by excising a single gene
7. Blue-eyed humans have a single, common ancestor
8. Rice scientists make breakthrough in single-molecule sensing
9. Single-celled bacterium works 24-7
10. RevGenUK, a single-stop shop for use in functional genomics
11. Researchers observe spontaneous ratcheting of single ribosome molecules
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... recent Yokahama IPCC meeting painted a stark warning on ... which has a greenhouse effect 32 times that of ... shown that humic substances act as fully regenerable electron ... are held in wetlands instead of being released to ... system is disrupted it may enter into a vicious ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
(Date:4/17/2014)... uncovered a new way the immune system may fight ... to use immune cells to treat illness. , The ... immunological equivalent of "neighborhood police" specialized squads of ... instead of an entire city, the body. , Scientists ... have shown that the liver, skin and uterus each ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2Rapid and accurate mRNA detection in plant tissues 2Some immune cells defend only 1 organ 2
... presented the 2013 Gustav O. Lienhard Award to Steven ... have helped save millions from premature, smoking-related deaths. ... as well as his work to improve end-of-life care. ... award to a dedicated champion of health for Americans ...
... -- Carnegie Mellon University President Subra Suresh has been ... making him the only current university president to be ... National Academy is among the highest professional distinctions accorded ... membership honors those who have made outstanding contributions to ...
... WASHINGTON -- The Institute of Medicine of the National Academies ... Clayton for their outstanding service today at the IOM,s 43rd ... Medal, awarded to an IOM member for distinguished service over ... on the Quality of Health Care in America, which produced ...
Cached Biology News:Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicine's 2013 Lienhard Award 2Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicine's 2013 Lienhard Award 3Leader of smoking cessation and tobacco prevention efforts receives Institute of Medicine's 2013 Lienhard Award 4Carnegie Mellon President Subra Suresh elected to Institute of Medicine 2Institute of Medicine honors members for outstanding service 2Institute of Medicine honors members for outstanding service 3
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
(Date:1/14/2014)... January 14, 2014 Date: Friday, April 11, ... Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... organization solely dedicated to finding a cure for hepatitis B ... will host its annual Crystal Ball on Friday, April 11 ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... SAN DIEGO, April 9, 2012 ADVENTRX Pharmaceuticals, Inc. ... establishment of a Regulatory Advisory Board (RAB). The RAB ... Company management in its interactions with the U.S. Food ... JD, who is rendering legal advice to Company management, ...
... wholly owned subsidiary of British company Innovative Carbon Limited today ... 10th April to 13th. , Graphene, a sheet of carbon ... wonder material. First isolated at Manchester University in 2004, ... race has been on to produce it commercially. To ...
... 2012  Albright Stonebridge Group (ASG), a global strategy ... senior advisors – Hakan Akbas, Steven Bipes, Brian ... leading ASG,s commercial activities and advising clients on ... clients of ASG,s Brazil practice as they look ...
Cached Biology Technology:ADVENTRX Announces Establishment of Regulatory Advisory Board 2ADVENTRX Announces Establishment of Regulatory Advisory Board 3ADVENTRX Announces Establishment of Regulatory Advisory Board 4ADVENTRX Announces Establishment of Regulatory Advisory Board 5ADVENTRX Announces Establishment of Regulatory Advisory Board 6UK company to demonstrate their commercially effective graphene production process 2Experts Strengthen Albright Stonebridge Group's Global Reach 2Experts Strengthen Albright Stonebridge Group's Global Reach 3
... Development, Pharmaceutical Development, Physician Owned Labs, Drugs of Abuse, and Industrial Testing applications. Analyzer ... ... ... ...
... OS X provides the most highly integrated ... analysis and molecular biology data management available ... Suite you can store manage view analyze ... molecular biology data all within one integrated ...
... determinations for petroleum-based applications. Multiple solvents can be used, such as water, benzene, formamide, nitrobenzene, ... ... ... ...
rat Leptin...
Biology Products: