Navigation Links
Single gene controls development of many forms of polycystic disease
Date:6/19/2011

New Haven, Conn. A single gene is central in the development of several forms of polycystic kidney and liver disease, Yale School of Medicine researchers report in the June 19 issue of Nature Genetics.

The findings suggest manipulating activity of PKD1, the gene causing the most common form of polycystic kidney disease, may prove beneficial in reducing cysts in both liver and kidney.

"We found that these conditions are not the result of an all or nothing phenomenon," said Stefan Somlo, the C.N.H. Long Professor of Medicine and Genetics and Chief, Section of Nephrology and senior author of the study. "The less PKD1 is expressed, the more cysts develop. Conversely, expressing more PKD1 can slow the process."

The most common form of this condition is called autosomal dominant polycystic kidney disease (ADPKD), a condition passed on to children from one parent affected with the disease that is found in 600,000 people in the United States alone. Two genes, PKD1 and PKD2, are responsible for the onset of this condition.

PKD patients also develop cysts of the liver and Somlo and colleagues had previously identified families with identical cysts found only in the liver. They found two different genes were responsible for this related condition.

The researchers wanted to know how liver-only polycystic disease was related to ADPKD. In a series of experiments using both genetically engineered mouse models and biochemical studies, they found that the activity of only one of the four genes, PKD1, controlled cyst formation in the other forms of the disease. Experiments in mice showed that modulating dosage of PKD1 could slow disease progression.

"The data suggest the exciting possibility that targeting the activity of PKD1 may be beneficial for treatment of isolated polycystic liver disease, childhood recessive polycystic kidney disease and even a subset of adult ADPKD," said Somlo.

Yale is a leader in th
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Single GFP-expressing cell is basis of living laser device
2. Improving health assessments with a single cell
3. Scientists observe single gene activity in living cells
4. Species unique to single island should not be rare there
5. 3-D tracking of single molecules inside cells
6. Type 2 diabetes linked to single gene mutation in 1 in 10 patients
7. Single-cell marine predators unique survival mechanisms revealed: UBC research
8. Research shows single-patient rooms reduce hospital infections in ICU
9. Single cell studies identify coactivator role in fat cell maturation
10. Iowa State, Ames Lab researcher develops new way to study single biological molecules
11. Single parenthood doesnt pay off for plants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Single gene controls development of many forms of polycystic disease
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... about the way our bodies are assembled during early ... they are supposed to become a nerve or a ... correct place and alignment? Researchers at the University of ... a new study, UM researchers describe the signaling systems ... at the head-trunk region. Their discovery may have important ...
(Date:11/4/2014)... Lithuania , Nov. 4, 2014   ... technologies, today announced that the latest version of ... in the Ongoing MINEX evaluation organized ... of fingerprint algorithms using the INCITS 378 fingerprint ... mandatory requirement in public tenders in ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2The inside story: How the brain and skull stay together 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3
... Although a recent study suggests that women with normal ... and older may wait up to 15 years for a ... Journal of Bone and Mineral Research (JBMR) cautions that ... Viewpoints allow experts to provide a new perspective on research. ...
... scientists have been awarded $3.1 million by the National ... of Health, to study and develop several new compounds ... without the unwanted side effects common with opiate drugs, ... Bohn, an associate professor in the Department of Molecular ...
... Ridge National Laboratory,s Jaguar supercomputer has completed the ... it among the most powerful scientific computing systems ... upgrade was completed earlier this month. The testing ... dynamics, high-temperature superconductivity, nuclear fusion, and combustion. ...
Cached Biology News:Osteoporosis experts urge bone density testing more frequently for women at risk 2Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments 2ORNL completes first phase of Titan supercomputer transition 2
(Date:11/22/2014)... 21, 2014 Prominent academics, leaders ... gather on December 3rd at Genetic Rx, a ... GeneticRx will take place at the Joseph B. ... will discuss the present and future of genetic ... and gene editing—as well as the treatment of ...
(Date:11/22/2014)... 22, 2014 The “Chiral Chromatography ... by Material (Metal, Glass, Plastic), by Application [GC, ... - Forecast to 2018” analyses and studies the ... North America, Europe, Asia, and Rest of the ... 15 figures spread through 135 pages and in-depth ...
(Date:11/21/2014)... November 21, 2014 , ...   Mariano Rodríguez es elegid vicepresidente senior ... KLOX está en marcha para comenzar de forma rápida ... heridas de reciente aprobación en Europa   , ... complace al anunciar los siguientes nombramientos: Todd ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short ... Side” published as a tribute to his mentor ... Short Story” category of the 2014 USA Best ... of USA Book News, said this year’s contest yielded ... Simon & Schuster, Penguin, John Wiley & Sons, Houghton ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4
... I wrote on an article on "The Final Death Knell ... on the walls of the demise of Searle due to ... Searle facilities in Chicago. Since then, the Searle name has ... another article I wrote on May 16, 2005, titled " ...
... Madison Area Technical College's Network Security Specialist ... and other threats to computer systems and data, has earned ... National Security Systems . , ,It is only one of ... high-level certification. MATC had to match its curriculum precisely to ...
... attract the presence of major pharmaceutical companies from out ... own environment, said a panel assembled Monday night by ... building the future today in Wisconsin has to do ... CEO Irene Hrusovsky. , ,Woody Hydrick, a senior consultant ...
Cached Biology Technology:Searle spirit lives on in Chicago as alumni celebrate at former home 2Searle spirit lives on in Chicago as alumni celebrate at former home 3Searle spirit lives on in Chicago as alumni celebrate at former home 4Searle spirit lives on in Chicago as alumni celebrate at former home 5Panel stresses drawing outside biotech firms to state 2
UGT1A7 (E-15)...
... nucleofection of optimized cell lines in combination ... nucleofection parameters. Nucleofector Kits are only functional ... cell lines can be transfected with this ... given in brackets in percent (Efficiency [%] ...
... Fluorescein 6-Fam, Hex, Tet Cy3, Cy5, ... Tamra Black Hole Quenchers Molecular Beacons* ... Tamra, Joe 3 Dabcyl Dabcyl*Licensed ... York Double labelled probes are purified either ...
... Protein Phosphatase ( l-PPase) ... phosphatase with activity towards ... tyrosine residues. It is ... of the ORF221 open ...
Biology Products: