Navigation Links
Single adult stem cell can self renew, repair tissue damage in live mammal
Date:12/14/2008

The first demonstration that a single adult stem cell can self-renew in a mammal was reported at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

The transplanted adult stem cell and its differentiated descendants restored lost function to mice with hind limb muscle tissue damage.

The adult stem cells used in the study, conducted at Stanford University, were isolated from a mixed population of satellite cells in the skeletal muscle of mice.

The skeletal adult muscle stem cells (MusSC), which live just under the membrane that surrounds muscle fibers, normally respond to tissue damage by giving rise to progenitor cells that become myoblasts, fusing into myofibers to repair the tissue damage.

The scientists transplanted the MusSC into special immune-suppressed "nude" mice whose muscle satellite cells had been wiped out in a hind limb by irradiation.

The mice would only be able to repair injury if the transplanted MuSC "took." The scientists, Alessandra Sacco and Helen Blau, had genetically engineered the transplanted MusSC to express Pax7 and luciferase proteins. As a result, every transplanted cell glowed under ultraviolet light and was easy to trace.

"To be able to detect the presence of the cells by bioluminescence was really a breakthrough," says Blau. "It taught us so much more. We could see how the cells were responding, and really monitor their dynamics."

Through luminescent imaging as well as quantitative and kinetic analyses, Sacco and Blau tracked each transplanted stem cell as it rapidly proliferated and engrafted its progeny into the irradiated muscle tissue.

The scientists then injured the regenerated tissue, setting off massive waves of muscle cell growth and repair, and subsequently showed that the MuSC and descendents rescued the second animal's lost muscle healing function.

After isolating the luciferase-g
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein researchers develop technique to count messages made by single genes
2. Reprogrammable cell type depends on a single gene to keep its identity
3. Salk researchers successfully reprogram keratinocytes attached to a single hair
4. A single mechanism for hypertension, insulin resistance and immune suppression
5. Study shows single insecticide application can kill 3 cockroach generations
6. Researchers observe spontaneous ratcheting of single ribosome molecules
7. RevGenUK, a single-stop shop for use in functional genomics
8. Single-celled bacterium works 24-7
9. Rice scientists make breakthrough in single-molecule sensing
10. Blue-eyed humans have a single, common ancestor
11. Ebola virus disarmed by excising a single gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)...  Analyst Report Issued by Small Cap IR. In 2011, Nilson ... transactions at merchants on the leading payment cards rose to ... debit, and prepaid cards reached 6.54 billion.  Eight million credit ... usage in 2012, and credit and debit card fraud resulted ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time clocks ... a higher standard for collecting attendance and labor data and ... installation, touch screen interface and seamless connection to cloud-based iSolved, ... solution for the small to mid-size employer. The ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season may ... Acuity Market Intelligence reports that the long anticipated floodgates ... that intensifying demand for smart phones, tablets, and wearable ... market of 2.5 billion users with nearly 4.8 billion ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Infinisource's NXG series sets new time clock standard 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... developed a computer modeling method to accurately predict how ... the complex work from an inhibitory weeks-long process to ... efficient evaluation of a nerve,s response to millions of ... accurate and capable electrodes to stimulate nerves and thereby ...
... MD, a clinician and scientific investigator in the Division ... Beth Israel Deaconess Medical Center (BIDMC) has been selected ... the Doris Duke Charitable Foundation. The three-year award, which ... and environmental factors that lead to kidney disease in ...
... its first appearance in Texas, a prehistoric crocodile thought to ... native of the Lone Star State. The switch in ... the identification of a well-preserved, narrow fossil snout that was ... The 96-million-year-old fossil from Texas is the oldest prehistoric crocodile ...
Cached Biology News:Fast prediction of axon behavior 2BIDMC scientist David J. Friedman, M.D., receives award from Doris Duke Charitable Foundation 296-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 296-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 396-million-year-old fossil suggests prehistoric crocodile Terminonaris was Texas native 4
(Date:1/23/2015)... BioPharma Inc. (NASDAQ: ARRY ) today announced ... Pharma AG to acquire worldwide rights to encorafenib (LGX818), ... agreement is conditional on the closing of transactions announced by ... are expected to close in the first half of ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces ... of office space for Shire a leading biopharmaceutical company, at ... Transwestern | RBJ,s Robert Richards , president, and ... lease for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... The laboratory information management systems market is a ... technological advancements due to factors such as rising pressure ... healthcare systems, and increasing government support for adoption of ... players in the market focus on technological advancements to ...
(Date:1/22/2015)... 2015 zFlo Motion , a US ... an exciting product from a new partner. STT-Systems ... the past 15 years, with offerings in the optical-motion capture, ... IMU system (inertial measurement unit), iSen, is opening eyes around ...
Breaking Biology Technology:Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 2Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 3Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 4Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 5Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 6Array Announces Agreement To Acquire ENCORAFENIB (LGX818) 7Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 43D Motion Capture Just Got Easy 2
... with today,s invisibility cloaks, people can,t walk through walls. ... The electrons perform this trick, called macroscopic quantum tunneling, ... of space that is normally off-limits under the laws ... of electrons collectively move through a superconducting nanowire, they ...
... Scientists from the Georgia Institute of Technology have ... "confinement controlled sublimation" technique for growing high-quality layers ... technique relies on controlling the vapor pressure of ... fabricating the material. The basic principle for ...
... 2011 MaxWest Environmental Systems, Inc. ... wastewater treatment industry, was recognized on stage yesterday at ... Meeting in New York City for its Commitment to ... selected as an exemplary approach to addressing challenges in ...
Cached Biology Technology:Scientists observe how superconducting nanowires lose resistance-free state 2Scientists observe how superconducting nanowires lose resistance-free state 3Controlling silicon evaporation allows scientists to boost graphene quality 2Controlling silicon evaporation allows scientists to boost graphene quality 3MaxWest Environmental Systems Makes Commitment to Clinton Global Initiative 2MaxWest Environmental Systems Makes Commitment to Clinton Global Initiative 3
... an aqueous-based mounting medium designed for ... Gel/Mount is especially recommended when using ... FluoroBlue. It can also be used ... fluorescein (FITC), Rhodamine (TMRITC) and Texas ...
... specifically formulated for mounting tissue specimens, cell ... with immunohistochemical methods for viewing by light ... chromogens, such as AEC, that are alcohol-soluble ... completely when slides are cover-slipped forming a ...
...
...
Biology Products: