Navigation Links
Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
Date:9/9/2013

he study, led by GIS Executive Director Prof Ng Huck Hui, establishes an initial connection between splicing and pluripotency in hESCs and contributes to the comprehensive understanding of the nature of hESCs. Besides its role in hESCs, SON was previously found to be involved in the development of leukemia and influenza virus infection.

Prof Ng Huck Hui said, "Maintenance and differentiation of human embryonic stem cells are governed by an intricate network that comprises diverse cellular processes. In the past, we had been focusing primarily on transcriptional regulation. In our new study, it is clear that splicing contributes to the unique cellular state of hESCs and this can be explained in part through the function of a protein known as SON. SON regulates the precise splicing of specific transcripts which are important for pluripotency. A systematic dissection of the different pathways required for maintenance of pluripotency can eventually guide us in engineering novel cellular states in the laboratory."

"In this new manuscript in Nature Cell Biology, Ng Huck Hui and his colleagues continue to cement their position at the forefront of pluripotency research worldwide," said Dr Alan Colman, the former Executive Director of the Singapore Stem Cell Consortium. "The distinctive feature of human embryonic stem cells is their ability to either self renew or alternatively, given the right conditions, to differentiate into all the cell types that comprise the adult body. In previous work, the team had uncovered a number of unique transcription factors that mediate the maintenance of pluripotency via binding to genomic DNA. In this latest publication, they reveal a novel mechanism where SON, a protein localized to nuclear speckles, regulates the proper splicing of transcripts encoding pluripotency regulators such as OCT4, PRDM14, E4F1 and MED24, and ensures cell survival and maintenance of pluripotency in hESC (and by extrapolation, presumably hu
'/>"/>

Contact: Winnie Lim
limcp2@gis.a-star.edu.sg
65-680-88013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
2. NUS launches new book on Singapores rainforests and new free digital nature archive
3. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
4. National Heart Centre Singapore develops worlds first human heart cell model
5. First in the world - Singapore scientists discover genes responsible for cornea blindness
6. Singapore research team identifies new drug target in deadly form of leukemia
7. Less haze in Singapore as the cause becomes clearer and more complex
8. Physiotherapy in Singapore Clinic Urbanrehab Pte Ltd Announces the Opening of an Additional Location
9. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
10. Queens scientists seek vaccine for Pseudomonas infection
11. Scientists produce eye structures from human blood-derived stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... is enough to prevent Type 2 diabetes, don,t get your ... of The FASEB Journal , suggests that ... diabetes. This study compared genetically identical twins-one heavier and one ... metabolites, including those related to Type 2 diabetes, were found ... suggest that the onset of this type of diabetes is ...
(Date:9/2/2014)... published in the September issue of The ... novel strategy to diagnose the leading cause of ... damage has occurred. This advance involves quantifying the ... endothelium of retinal vessels. Using new probes developed ... early molecular development of diabetic retinopathy. , "My ...
(Date:9/2/2014)... as perching birds, that migrate by night tend to ... to reach their destinations. This seasonal difference in flight ... short migratory flights, says researcher Cecilia Nilsson of Lund ... and Sociobiology . , Nilsson, in a group ... to measure over three years the speed by which ...
Breaking Biology News(10 mins):What you eat and not just the number of calories, is a significant factor in diabetes risk 2Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2Migrating birds sprint in spring, but take things easy in autumn 2
... new study finds that Caribbean seaweeds are far better competitors ... this triumph is bad news for Caribbean coral reefs. ... the living corals that build reefs and contribute startling white ... environment but in fact a battle is constantly waged between ...
... Obama has made cyber security an integral issue when ... ensure that the U.S. remains on the cutting edge, ... will convene a gathering of the nation,s top minds ... issues affecting the economy and United States, national security. ...
... Smith, Ph.D., Wellcome Trust Principal Research Fellow and ... Fellow of Emmanuel College, Cambridge, has been bestowed ... Award, recognizing exemplary leadership in the international microbiological ... University of Virginia, says Smith is "internationally recognized ...
Cached Biology News:Jim Demitrieus, CEO of EyeLock, Invited to White House Cyber Security Event 2Jim Demitrieus, CEO of EyeLock, Invited to White House Cyber Security Event 3The American Society for Microbiology honors Geoffrey L. Smith 2
(Date:9/2/2014)... 2, 2014  Technology Applications International Corporation (the "Company" ... subsidiary Renuell Int,l, Inc. has signed an additional exclusive ... ("NASA") at the Johnson Space Center in ... tapplic.com/houstonphotos/ Charles J. ... to announce our latest, exclusive agreement with NASA. In ...
(Date:9/2/2014)... 2014 /PRNewswire/ - Oncothyreon Inc. (Nasdaq: ONTY ) announced ... Executive Officer, will present at the Rodman & Renshaw 16 ... York on Tuesday, Sept. 9, 2014 at 2:05 ... of the presentation will be accessible by visiting the Oncothyreon ... About Oncothyreon Oncothyreon is ...
(Date:9/2/2014)... Massachusetts , September 2, 2014 ... to BioData,s research and lab management services  ... management service, is pleased to announce the appointment of ... Culot most recently served as VP Marketing and Business ... life science research and clinical applications. Previously, ...
(Date:8/31/2014)... 31, 2014 Wockhardt Limited today announces a ... Anti-Infective research when two of its drugs, WCK 771 ... Product (QIDP) status from U.S. Food & Drug Administration ... against pathogens which have a high degree of unmet ... for Disease Control (a top U.S. government health and ...
Breaking Biology Technology:Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3Louis Culot Appointed as BioData's CEO 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3
... /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. ("Angiotech") (NASDAQ: ... and medical device company, today announced that ... (the "Tender Offer"),for its outstanding Senior Floating ... "First Priority Notes"), and its outstanding 7.75% ...
... breadth of experience and business expertise, SCOTTSDALE, ... technology company that markets the Provant(R) Wound Therapy,System, ... its Board of,Directors. The two new directors are ... and Charles "Chuck" S. Lunden, a principal with,Bederson ...
... ... the job done, NEWARK, N.J., Aug. 22 BioNeutral announced ... its,Ogiene(TM) FE technology to bring 10,000 mobile homes into full compliance,so ... in need,of biohazard-free housing., Dr. Andy Kielbania, Chief Scientist at ...
Cached Biology Technology:Angiotech Announces Extension of the Expiration Date of its Tender Offer for Senior Floating Rate Notes Due 2013 and 7.75% Senior Subordinated Notes Due 2014 2Angiotech Announces Extension of the Expiration Date of its Tender Offer for Senior Floating Rate Notes Due 2013 and 7.75% Senior Subordinated Notes Due 2014 3Angiotech Announces Extension of the Expiration Date of its Tender Offer for Senior Floating Rate Notes Due 2013 and 7.75% Senior Subordinated Notes Due 2014 4Angiotech Announces Extension of the Expiration Date of its Tender Offer for Senior Floating Rate Notes Due 2013 and 7.75% Senior Subordinated Notes Due 2014 5Regenesis Biomedical Announces Additions to Board of Directors 2BioNeutral Signs Agreement With a Non-profit for Long-Term Removal of Formaldehyde to Save 10,000 Mobile Homes in Louisiana 2
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
...
...
Biology Products: