Navigation Links
Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
Date:9/9/2013

09 Sept 2013 - Scientists at A*STAR's Genome Institute of Singapore (GIS), in collaboration with their counterparts from Canada, Hong Kong and US, have discovered a protein mediator SON plays a critical role in the health and proper functioning of human embryonic stem cells (hESCs). This finding was reported on 8th September 2013 in the advanced online issue of the prestigious science journal Nature Cell Biology.

Correct expression of genes is essential for a cell to stay alive and to perform other cellular and physiological functions. During gene expression, DNA is first converted into RNA transcript and then some parts of it are removed while others are joined before the trimmed RNA transcript can be translated into proteins. This process of cutting and joining different pieces of RNA is called splicing, and the proteins that mediate splicing are known as splicing factors. Mutations in splicing factors can cause diseases such as myotonic dystrophy and cancer. Even though hESCs have been studied extensively over the last decade due to their potential to differentiate into cell-types of potential clinical applications, little is known about the role that splicing plays in the regulation of pluripotency in these cells.

Scientists at the GIS followed their previous study on a genome-wide investigation of gene functions in hESCs, which was published in Nature [Chia et al. 2010. 468(7321):316-20], and found that splicing factors, such as the protein known as SON, are key regulators of hESC maintenance.

SON was discovered to be essential for converting differentiated cells into pluripotent stem cells . In addition, SON promotes correct splicing of a particular group of RNAs, including those coding for essential hESC regulators, and thereby helps hESCs to survive in an undifferentiated state. Moreover, the authors showed that silencing of SON induced new transcript isoforms that seemed to be non-functional in hESCs.

T
'/>"/>

Contact: Winnie Lim
limcp2@gis.a-star.edu.sg
65-680-88013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
2. NUS launches new book on Singapores rainforests and new free digital nature archive
3. Singapore scientists find genes associated with glaucoma, a major cause of eye blindness
4. National Heart Centre Singapore develops worlds first human heart cell model
5. First in the world - Singapore scientists discover genes responsible for cornea blindness
6. Singapore research team identifies new drug target in deadly form of leukemia
7. Less haze in Singapore as the cause becomes clearer and more complex
8. Physiotherapy in Singapore Clinic Urbanrehab Pte Ltd Announces the Opening of an Additional Location
9. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
10. Queens scientists seek vaccine for Pseudomonas infection
11. Scientists produce eye structures from human blood-derived stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... MOUNTAIN VIEW, Calif. , Nov. 20, 2014 /PRNewswire/ ... for higher driver efficiency are piloting the North American ... the number of accidents growing, gesture recognition systems that ... will make a mark in the industry. ... of the Automotive Gesture Recognition Market in ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a ... that its U.are.U ® fingerprint readers have been ... in Central Mexico . The bakery ... to eliminate payroll issues caused by employees clocking in ... the U.are.U fingerprint readers, Montparnasse relied on paper timecards ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... men have surgery to remove a cancerous prostate gland, up ... have an erection because of damage to a critical nerve ... Northwestern University Feinberg School of Medicine shows the damaged nerve ... hedgehog delivered via a nanofiber gel. The study, ...
... PASADENA, Calif.East Africa,s Turkana Basin has been a hot savanna ... period of time during which early hominids evolved in this ... California Institute of Technology (Caltech). These findings may shed light ... lose most of our body hair, develop a more slender ...
... Ariz. The evolution of computer systems has freed us ... finger flicking, intuitive and easy to learn computer manipulations that ... to iPads. But little is known about the long-term stresses ... Now, a team of researchers led by Kanav Kahol ...
Cached Biology News:Protein could heal erectile dysfunction after cancer surgery 2Protein could heal erectile dysfunction after cancer surgery 3East-African human ancestors lived in hot environments, says Caltech-led team 2East-African human ancestors lived in hot environments, says Caltech-led team 3Project focuses on physical stresses caused by multi-touch electronic devices 2Project focuses on physical stresses caused by multi-touch electronic devices 3
(Date:11/22/2014)... LONDON , Nov. 21, 2014  The element ... in emerging diseases, i.e., they strike without warning. Until ... advance warning of a viral outbreak, resulting in suboptimal ... to Ebola currently. Photo - ... surprise has now been removed because virus gene structural ...
(Date:11/21/2014)... November 20, 2014 Offering a complete ... Sartorius Entris Balance promotion . The Sartorius Entris Balance ... durable, high accuracy, and easy-to-maintain balance entry level balance. ... It was designed to help customer’s bridge the gap ... balance that is very durable. Sartorius is the second ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 BlueInGreen, ... Ozone Solutions, LLC (Pinnacle), and PCI, Inc., leading ... that they have been selected to provide a ... Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... patented HyDOZ® gas dissolution technology, Pinnacle ...
(Date:11/21/2014)... VANCOUVER , Nov. 20, 2014 /CNW/ - ... pleased to announce that it has closed a ... special warrants for approximately C$3.7 million.  Cormark Securities ... agents in the Brokered Offering for a syndicate ... and PI Financial Corp. (collectively the "Agents"). Concurrently ...
Breaking Biology Technology:Viruses' Advantage of Surprise is Lost 2Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3
... Systems , an Experian company providing marketing automation ... ,NuEdge Suite allows companies to respond to the ... multi-channel purchases and intense competition. NuEdge Suite 3.0 ... from unlimited sources of customer information, including customer ...
... you my observations on the French technology market. From Paris, ... a half days talking to technology companies in Israel. Though ... experience, as always. , ,Much of the visit was a ... Israel. Let me start by saying that even Israelis complimented ...
... Services selected BMC Software 's MAINVIEW ... of its credit card and credit application processing ... credit receivables management services and is a unit ... provides clients with technology that enhances their ability ...
Cached Biology Technology:The Search for new Global Technologies 2The Search for new Global Technologies 3
... Activins are polypeptide hormones which ... (TGF-) superfamily. The TGF- superfamily is ... factors which control many aspects of ... (1). Other members incude TGF-s, bone ...
... EZ-Spread Plating Beads Sterile plating ... for glass rods and potentially hazardous ethanol flaming, ... Two choices of ready-to-use sterile packaging: dispenser bottle ... 50 plating, Fastest and easiest way ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
... working in a regulated environment, Pipette ... calibration software that automates gravimetric pipette ... framework that meets todays regulatory compliance ... secure solution that includes a full ...
Biology Products: