Navigation Links
Signaling pathway linked to fetal alcohol risk
Date:2/20/2013

Fetal alcohol syndrome is the leading preventable cause of developmental disorders in developed countries. And fetal alcohol spectrum disorder (FASD), a range of alcohol-related birth defects that includes fetal alcohol syndrome, is thought to affect as many as 1 in 100 children born in the United States.

Any amount of alcohol consumed by the mother during pregnancy poses a risk of FASD, a condition that can include the distinct pattern of facial features and growth retardation associated with fetal alcohol syndrome as well as intellectual disabilities, speech and language delays, and poor social skills. But drinking can have radically different outcomes for different women and their babies. While twin studies have suggested a genetic component to susceptibility to FASD, researchers have had little success identifying who is at greatest risk or what genes are at play.

Research from Harvard Medical School and Veterans Affairs Boston Healthcare System sheds new light on this question, identifying for the first time a signaling pathway that might determine genetic susceptibility for the development of FASD. The study was published online Feb. 18 in the journal Proceedings of the National Academy of Sciences.

"Our work points to candidate genes for FASD susceptibility and identifies a path for the rational development of drugs that prevent ethanol neurotoxicity," said Michael Charness, chief of staff at VA Boston Healthcare System and HMS professor of neurology. "And importantly, identifying those mothers whose fetuses are most at risk could help providers better target intensive efforts at reducing drinking during pregnancy."

The discovery also solves a riddle that had intrigued Charness and other researchers for nearly two decades. In 1996, Charness and colleagues discovered that alcohol disrupted the work of a human protein critical to fetal neural developmenta major clue to the biological processes of FASD. The protein
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FASEB SRC announces conference: TGF-β Superfamily: Signaling in Development & Disease
2. FASEB SRC announces conference registration open for: NAD Metabolism & Signaling
3. FASEB SRC announces conference registration open for: Histone Deacetylases, Sirtuins, and Reversible Acetylation in Signaling and Disease
4. Waste removal in worms reveals new mechanism to regulate calcium signaling
5. Cholesterol helps regulate key signaling proteins in the cell
6. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
7. Ion selectivity in neuronal signaling channels evolved twice in animals
8. Scientists tie DNA repair to key cell signaling network
9. To drive infections, a hijacking virus mimics a cells signaling system
10. Pathway for membrane building blocks
11. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)...  Continuing its 167-year history of offering the Best, ... The Eye Scanning Password Authenticator , a device that ... websites or sensitive data. Employing the same ... the device has a small camera that scans and ... converting them into an encrypted ID that cannot be ...
(Date:3/10/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ... biometric authentication company focused on the growing mobile ... has been named the "Number One Best Tech ... Rethink Modern ( http://www.rethinkmodern.com/ ) is a web ... and lifestyle that have a unique function or design.  ...
(Date:3/3/2015)... LAKE FOREST, Calif. , March 3, ... ("Company"), the leading provider of advanced cryogenic ... serving markets including immunotherapies, stem cells, cell ... health, and reproductive medicine, today announced the ... Hutchinson Cancer Research Centers, ("Fred Hutch") ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3
, This press release is available in spanish . Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing Testing, ,...
... Humans are conducting massive experiments on ecosystems around ... species, boosting nutrient concentrations, and altering climates. On ... give the Jane Block Distinguished Lecture in Conservation Biology ... will discuss how our ability to assess these impacts ...
... Department,s National Renewable Energy Laboratory (NREL) recently recognized ... the past year during its Intellectual Property & ... active licenses covering the spectrum of renewable energy ... research and development agreements with industry partners, the ...
Cached Biology News:Public lecture at UC Riverside to discuss challenges in assessing human impact on ecosystems 2NREL staff recognized for breakthrough technologies 2
(Date:3/25/2015)... 2015 Having added two International locations ... of 2014, ITRA Global proudly announced recently the organization’s ... Representative Alliance, based in the United States, is one ... occupiers of commercial real estate. , Saltwood International ... Poland that exclusively advises occupiers of office space, ensuring ...
(Date:3/25/2015)... and the HAGUE, Netherlands , March ... of LES Stimulation therapy for chronic gastro-esophageal reflux disease ... Surgery [ Surgery . 2015; 157(3):556-567 ], ... minimally-invasive therapy. The study included 25 ... 11 years and taking prescribed daily proton pump inhibitor ...
(Date:3/25/2015)... 2015 /CNW/ - The Gairdner Foundation is pleased ... Awards, recognizing some of the most significant medical ... Among the world,s most esteemed medical research prizes, ... provide a $100,000 (CDN) prize to each scientist for their ... research and innovation across the country, inspiring the ...
(Date:3/25/2015)... FDNA®, the pioneer in computer-aided ... Face2Gene, allowing geneticists around the globe to access ... mobile devices. Face2Gene® facilitates detection of facial dysmorphic features ... and up-to-date genetic references. The date of the release ... in Salt Lake City, UT , ...
Breaking Biology Technology:International Organization Expands its Global Reach to Warsaw, Poland 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 2EndoStim LES Stimulation therapy demonstrates long term safety and efficacy results in treating reflux patients 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 22015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 32015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 42015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 52015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 62015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 72015 Canada Gairdner Awards Honour Top Medical Discoveries Around The World 8FDNA Releases a Multi-Platform Version of Face2Gene, a Genetic Search and Reference Solution at ACMG 2015 2
... The Madison-area technology business community has received a ... associate vice chancellor with the University of California at ... not with its resources or industry, but with cultural ... California, billions of dollars have been invested over the ...
... writing my book, I found it helpful to attend ... entrepreneurs, venture capitalists, and corporate lawyers. In my experience, ... piece of the entrepreneurial puzzle, and gave me insights ... following list of seminars, classes, and financial services organizations ...
... trade mission to Japan is building interest in possible ... experiences abroad in a conference call Monday morning. , ... several Wisconsin representatives, Doyle has been speaking at biotechnology ... spent much of today telling people about the value ...
Cached Biology Technology:San Diego success stories become a challenge for the Midwest 2San Diego success stories become a challenge for the Midwest 3San Diego success stories become a challenge for the Midwest 4Starting a high-tech company? Here uFFFDs help 2Starting a high-tech company? Here uFFFDs help 3Starting a high-tech company? Here uFFFDs help 4Starting a high-tech company? Here uFFFDs help 5Doyle builds bridges and hopes for deals in Japan 2Doyle builds bridges and hopes for deals in Japan 3
... Clone/PAD: 3B8A10. Immunogen: ... the C-terminal region of ... Specific for the human ... Human (positive control: 293 ...
...
...
... The versatile Zymo-Spin I-96 Plate can be ... manifolds for the large-scale (i.e., 96-well) purification ... polypropylene construction and unique silica-based matrix make ... g DNA or RNA in = 10 ...
Biology Products: