Navigation Links
Signaling pathway linked to fetal alcohol risk
Date:2/20/2013

Fetal alcohol syndrome is the leading preventable cause of developmental disorders in developed countries. And fetal alcohol spectrum disorder (FASD), a range of alcohol-related birth defects that includes fetal alcohol syndrome, is thought to affect as many as 1 in 100 children born in the United States.

Any amount of alcohol consumed by the mother during pregnancy poses a risk of FASD, a condition that can include the distinct pattern of facial features and growth retardation associated with fetal alcohol syndrome as well as intellectual disabilities, speech and language delays, and poor social skills. But drinking can have radically different outcomes for different women and their babies. While twin studies have suggested a genetic component to susceptibility to FASD, researchers have had little success identifying who is at greatest risk or what genes are at play.

Research from Harvard Medical School and Veterans Affairs Boston Healthcare System sheds new light on this question, identifying for the first time a signaling pathway that might determine genetic susceptibility for the development of FASD. The study was published online Feb. 18 in the journal Proceedings of the National Academy of Sciences.

"Our work points to candidate genes for FASD susceptibility and identifies a path for the rational development of drugs that prevent ethanol neurotoxicity," said Michael Charness, chief of staff at VA Boston Healthcare System and HMS professor of neurology. "And importantly, identifying those mothers whose fetuses are most at risk could help providers better target intensive efforts at reducing drinking during pregnancy."

The discovery also solves a riddle that had intrigued Charness and other researchers for nearly two decades. In 1996, Charness and colleagues discovered that alcohol disrupted the work of a human protein critical to fetal neural developmenta major clue to the biological processes of FASD. The protein
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. FASEB SRC announces conference: TGF-β Superfamily: Signaling in Development & Disease
2. FASEB SRC announces conference registration open for: NAD Metabolism & Signaling
3. FASEB SRC announces conference registration open for: Histone Deacetylases, Sirtuins, and Reversible Acetylation in Signaling and Disease
4. Waste removal in worms reveals new mechanism to regulate calcium signaling
5. Cholesterol helps regulate key signaling proteins in the cell
6. Researchers describe new molecular interactions behind the inhibition of TGF beta-signaling
7. Ion selectivity in neuronal signaling channels evolved twice in animals
8. Scientists tie DNA repair to key cell signaling network
9. To drive infections, a hijacking virus mimics a cells signaling system
10. Pathway for membrane building blocks
11. Thomas Jefferson University researchers discover new pathways that drive metastatic prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Norwegian explorer Roald Amundsen reached the South Pole in ... arrived long before any human. , Using data from ... the Antarctic continent, including the South Pole, a group ... (DRI) in Reno, Nevada, created the most accurate and ... southernmost continent. The new record, described in an article ...
(Date:7/28/2014)... ago, MIT professor John Essigmann and colleagues from the University ... They thought if they could induce the virus to mutate ... out a strategy that our immune system uses against ... which caused HIV to mutate at an enhanced rate, as ... in a small clinical trial reported in 2011. In a ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3
... bred to age too quickly seemed to have sipped from ... Pittsburgh School of Medicine injected them with stem cell-like progenitor ... of becoming infirm and dying early as untreated mice did, ... lived two to three times longer than expected, according to ...
... new study shows that deep brain stimulation (DBS) is ... patients with either unipolar major depressive disorder (MDD) or ... Online First by Archives of General Psychiatry , ... led by Helen S. Mayberg, MD, professor in the ...
... Millbrook, N.Y. -- On January 2nd, WAMC Northeast Public Radio ... new radio show called Earth Wise: A look at our ... among radio listeners, with a focus on raising awareness about ... segments will air Monday through Friday at 11:10 AM and ...
Cached Biology News:Pitt: A shot of young stem cells made rapidly aging mice live longer and healthier 2Deep brain stimulation shows promising results for unipolar and bipolar depression 2Deep brain stimulation shows promising results for unipolar and bipolar depression 3Cary Institute and WAMC debut new environment radio show 2
(Date:7/28/2014)... 28, 2014   Propeller Health , the FDA-cleared ... hire of Brad Towle as Senior Vice ... for driving the company,s sales growth, customer acquisition and ... and specifically his past role in the development of ... at this pivotal time in the industry," said ...
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... release its second quarter 2014 financial results at the ... 2014. A live conference call and webcast will be hosted ... day. Interested investors and others may participate ... +1 212-231-2900 (international), conference ID#21728775. A replay of the webcast ...
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market Outlook ... Canada Endoscopy Visualization Systems market. The report provides ... units) and average prices (in US dollars) within ... Endoscopy Visualization Systems and Low-End Endoscopy Visualization Systems. ... , The report also provides company shares and ...
(Date:7/25/2014)... by researchers from the University of Leicester has ... unlocking the potential to create new materials using ... been published in the prestigious academic journal ... technique to examine in rich detail the structure ... containing an acetylene molecule and a single helium ...
Breaking Biology Technology:Propeller Health Hires Brad Towle as Senior Vice President of Business and Client Development 2InterMune to Release Second Quarter Financial Results on August 6 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... Approves Class Action Settlement, NORCROSS, Ga., ... ), the global leader in providing automated ... today that the,Securities and Exchange Commission (SEC) ... previously-disclosed investigation into certain,activities involving the company,s ...
... Educational Grants to Support the 25th Biennial Cornea Research Conference ... ... Meeting -, TAMPA, Fla., Sept. 28 ... of the advancement of ocular innovation through its,contributions of unrestricted educational ...
... FDA and Leading Pharmaceutical Companies Slated to ... ... (OTC Bulletin Board: PHST), a leading provider of software and,strategic services for ... Pharsight(R) Knowledgebase,Server(TM) (PKS(TM)) User Group Meeting on October 3 and 4, 2007 ...
Cached Biology Technology:Immucor Settles SEC Investigation 2Sirion Therapeutics Supports Ophthalmic Education 2Pharsight Hosts Fourth Annual PKS User Group Meeting 2Pharsight Hosts Fourth Annual PKS User Group Meeting 3
... Bruker Daltonics and Bruker BioSpins ... for metabolism studies, and analysis of ... ESI-TOF system, an optional Avance NMR ... acquisition, evaluation and statistical analysis for ...
... animal movements in a Morris Water Maze. ... a predefined sequence of trials.The Spatial Behavior line ... a video camera, frame grabber, and feature extraction ... once and up to 6 moving animals. ...
... Object Records behavior directed toward examining a novel ... a family of instruments all built around a ... and that can track two fields at once ... automatically extracts animal positions and records them, but ...
... Ultrapure ACS Reagent Grade C 19 H ... Weight: 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity ... pH 3.0 - Yellow pH ... tracking dye in agarose and acrylamide gel ...
Biology Products: