Navigation Links
Short stretches of piRNA evaluate cells' genetic history
Date:6/29/2012

As scientists have added to a growing list of types of RNA molecules with roles that go beyond conveying the genetic code, they have found the short strands known as Piwi-interacting RNAs (piRNAs) particularly perplexing. New work from Howard Hughes Medical Institute (HHMI) scientists suggests those abundant molecules may be part of the cell's search engine, capable of querying the entire history of a cell's genetic past.

Organisms contain thousands of piRNA molecules, strands of 26 to 31 nucleotides encoded all over the genome. In two studies published online June 25, 2012, in the journal Cell, HHMI investigator Craig Mello of the University of Massachusetts Medical School has discovered that piRNAs may be responsible for detecting foreign RNAsuch as that carried by viruses -- relying on a complex search mechanism to reveal whether an invader is foreign based on prior gene activity.

"piRNAs are found in all animals and some of their functions in some organisms have been explained," says Mello. "But overall they've been a very mysterious category of molecule."

Some piRNAs have sequences that match up identically to genes elsewhere in the genome, suggesting that they bind and regulate those genes. But most have no perfect genetic match. Mello and his team focused their attention on the more puzzling piRNAs -- those that had no obvious targets.

In the worm Caenorhabditis elegans, the scientists unexpectedly found that foreign genes that they inserted into the genome were sometimes silenced and sometimes not. When they genetically modified the worm to lack the Piwi protein, the silencing no longer worked.

When the researchers probed which sequences piRNAs tended to shut down, they found that if a cell has ever turned on a gene in the past, the piRNA system will recognize it as a "self" gene and allow it to be expressed. But if it hasn't been active in the organism before, the piRNA will set the silencing mechanism into act
'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Reed Elsevier Environmental Challenge shortlists 2012 projects
2. New product to replace fishmeal could help prevent global food shortage
3. Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
4. The long, err, short of it
5. New report evaluates progress of Everglades Restoration Plan
6. Ultrasound idea: Prototype NIST/CU bioreactor evaluates engineered tissue while creating it
7. Regulation of telomerase in stem cells and cancer cells
8. Blood-brain barrier building blocks forged from human stem cells
9. Bringing down the cost of fuel cells
10. Cells to Civilizations: The Principles of Change That Shape Life
11. Research could help track stem cells in the body
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... , March 2, 2015   Neurotechnology , ... today introduced the SentiGaze Software Development Kit ... create applications that use off-the-shelf webcams to track eye ... gazes at a monitor. Heatmaps can be used for ... effectiveness of online advertising. The SDK can also be ...
(Date:2/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/sxwl43/global_2d_gesture ) ... 2D Gesture Recognition Market 2015-2019" report to ... the Global 2D Gesture Recognition market to grow ... 2014-2019 The increased demand for gesture-enabled ... the major trends in the market. The growing ...
(Date:2/13/2015)... Feb. 13, 2015 ACT Genomics Co., ... aims to transform cancer genomic information into precision ... company has raised US$ 8 million in the its ... Taipei, Taiwan , ACT Genomics ... With the aim to implement next generation sequencing ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2ACT Genomics Raises $8 Million in its First Private Funding Round 2
... include understanding new evidence for rock pulverization by catastrophic ... examples of active arc-continent collision in Taiwan; discovery and ... Earth, located in Japan; the puzzling record of the ... last 500 million years; and a possible refutation of ...
... the tropical fish known as swordtail characins have flag-like sex ... fishing rod would. What,s more, a study reported online on ... publication, shows just what any good fly-fisherman would know: Lures ... often eat. For some characins in the study, that means ...
... . , It is not unusual for babies to ... of the heart in the embryo is a process which is ... Planck Institute for Heart and Lung Research in Bad Nauheim have ... regulating the function of stem cells in the heart. As a ...
Cached Biology News:Pulverized rocks, coral reefs, seawater chemistry, and continental collisions 2Pulverized rocks, coral reefs, seawater chemistry, and continental collisions 3Pulverized rocks, coral reefs, seawater chemistry, and continental collisions 4Male sex ornaments are fishing lures, literally 2Finished heart switches stem cells off 2Finished heart switches stem cells off 3
(Date:3/5/2015)... , Mar. 05, 2015 Research and Markets ... the "Mature Biotech Outlook 2015: New Therapy Ventures ... offering. All biotech companies - Gilead ... in past year, have given a positive return and ... have been able to select therapy/niche indication where the ...
(Date:3/5/2015)... (PRWEB) March 05, 2015 The next ... have received the CE mark (European) approval. The CE ... Free Trade Association (EFTA) and the European Union. Following ... now been granted to implants supplied by the Turkey-based ... conditions. , Osimplant's Cervical Expandable Bladed HA PEEK ...
(Date:3/4/2015)... -- In an article published and posted online today, ... review the clinical aspects of diseases caused by 5 ... article, "Clinical Management of Potential Bioterrorism-Related Conditions," was published ... New England Journal of Medicine . ... Tom Inglesby—review the clinical management of conditions resulting from ...
(Date:3/4/2015)... March 04, 2015 USDM Life ... the life sciences industry, hired David Blewitt ... Cloud Compliance Services and Solutions at USDM Life ... based applications while maintaining compliance with government regulations worldwide. ... been an accomplished life sciences regulatory and IS compliance ...
Breaking Biology Technology:Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 3Latest Clinical Information On Bioterrorism Threats 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 2USDM Life Sciences Names David Blewitt VP of Cloud Compliance for Regulated Life Sciences 3
... crowd who is proud to announce their compulsive habit of ... job classifieds. , ,Don't get me wrong. I don't spend ... communication skills" and the ever popular "outstanding communication skills." I ... it happens to be my first day on a new ...
... Milwaukee Rockwell Automation Inc. has increased ... 22.5 cents per share, up from 16.5 cents, ... Nosbusch said the change reflected strong earnings and ... ,Rockwell makes control and automation systems for industrial ...
... building relationships that will carry into your personal and professional ... on networking just for your employer. , ,The relationships you ... with you from job to job. Treat every relationship you ... will find it valuable to have some of these people ...
Cached Biology Technology:Is IT leadership a position or an attitude? 2Is IT leadership a position or an attitude? 3Networking for your employer is great for building your personal Rolodex 2Networking for your employer is great for building your personal Rolodex 3
...
... PCR specificity *High PCR specificity ... with unique QIAGEN PCR Buffer ... by the stringent built-in hot start ... Mix and simple reaction setup at ...
... Nuclear matrix proteins (NMPs) make up the internal ... with such functions as DNA replication, RNA synthesis, ... has been shown to be highly insoluble ... cell death releases soluble nuclear matrix proteins that ...
Request Info...
Biology Products: