Navigation Links
Shining light on neurodegenerative pathway
Date:9/18/2013

University of Adelaide researchers have identified a likely molecular pathway that causes a group of untreatable neurodegenerative diseases, including Huntington's disease and Lou Gehrig's disease.

The group of about 20 diseases, which show overlapping symptoms that typically include nerve cell death, share a similar genetic mutation mechanism ‒ but how this form of mutation causes these diseases has remained a mystery.

"Despite the genes for some of these diseases having been identified 20 years ago, we still haven't understood the underlying mechanisms that lead to people developing clinical symptoms," says Professor Robert Richards, Head of Genetics in the University's School of Molecular and Biomedical Sciences.

"By uncovering the molecular pathway for these diseases, we now expect to be able to define targets for intervention and so come up with potential therapies. Ultimately this will help sufferers to reduce the amount of nerve cell degeneration or slow its progression."

In an article published in Frontiers in Molecular Neuroscience, Professor Richards and colleagues describe their innovative theory and new evidence for the key role of RNA in the development of the diseases. RNA is a large molecule in the cell that copies genetic code from the cell's DNA and translates it into the proteins that drive biological functions.

People with these diseases all have expanded numbers of copies of particular sequences of the 'nucleotide bases' which make up DNA.

"In most cases people with these diseases have increased numbers of repeat sequences in their RNA," says Professor Richards. "The disease develops when people have too many copies of the repeat sequence. Above a certain threshold, the more copies they have the earlier the disease develops and the more severe the symptoms. The current gap in knowledge is why having these expanded repeat sequences of genes in the RNA translates into actual
'/>"/>

Contact: Robert Richards
robert.richards@adelaide.edu.au
61-422-007-867
University of Adelaide
Source:Eurekalert

Page: 1 2

Related biology news :

1. Recent highlights in Molecular Biology and Evolution
2. Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting
3. Research highlights from ICAAC meeting
4. Survey highlights barriers to interdisciplinary environmental science
5. Rutgers study: Worms may shed light on human ability to handle chronic stress
6. AGU journal highlights -- Aug. 13, 2013
7. Family matters: Evolutionary relationships among species of magic mushrooms shed light on fungi
8. Montana State University researchers highlight bears use of Banff highway crossings
9. Light that moves and molds gels
10. Study highlights possible new approach to prostate cancer treatment
11. Controlling genes with light
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... synchrotron source that emits over a wide part of ... is currently being built in Lund, Sweden. The MAX ... the team putting together its component parts in a ... circumference of just a few hundred metres. Nevertheless, if ... new class of experiments that require source brightness and ...
(Date:10/31/2014)... steps involved in programmed cell death, offering new targets ... neurodegenerative diseases. , The research teams from the ... the three-dimensional structure of a key cell death protein ... it causes cell death. Their studies were published in ... Proceedings of the National Academy of Sciences . ...
(Date:10/30/2014)... a $1.04 million grant from the U.S. Army ... osteoarthritis using a patient,s own stem cells, spurred ... polymers., Liping Tang, a bioengineering professor and interim ... is primarily focused on helping soldiers who are ... if we inject microscaffolding that we,ve developed into ...
Breaking Biology News(10 mins):A new generation of storage -- ring 2A matter of life and death: Cell death proteins key to fighting disease 2UTA researcher uses microscaffolding injections to mend cartilage, prevent osteoarthritis 2
... available in French . , A new ... University reveals that ghrelin - a stomach hormone, acts on ... food related cues and eating for pleasure. This study, ... critical to advance understanding and treating obesity, a condition affecting ...
... There are two ways in which cooperation is the theme ... Mary Anne Alliegro, scientists at the Marine Biological Laboratorys (MBL) ... the papers acknowledgements, where the Alliegros thank those who helped ... State University (LSU) in New Orleans and their lives ...
... N.Y., May 5 bioMETRX Inc., (OTC,Bulletin Board: ... products, today announced that it has closed an ... group of previous angel,accredited investors., "We have ... team.,The company has demonstrated to us the ability ...
Cached Biology News:Hunger hormone: Makes food more attractive 2The cooperative view: New evidence suggests a symbiogenetic origin for the centrosome 2bioMETRX, Inc. Closes Angel Round of Funding 2
(Date:10/31/2014)... Following the successful launch of On ... to introduce its new product and demonstrate its potential ... Launched in September, Formedix On Demand Services is the ... automation tools. For the first time, these market-leading tools ... introducing Formations – a revolutionary new token-based payment system ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)...  Ardelyx, Inc. (NASDAQ: ARDX ), ... and metabolic diseases, today announced that it will ... November 6, 2014. Following the announcement, the Ardelyx ... and webcast at 4:30pm ET to review the ... The live webcast can be accessed ...
(Date:10/30/2014)... (PRWEB) October 30, 2014 Rancho ... that they have manually curated public data source ... profit customers. the data is now available for ... and unifies public and internal data sources for their ... knowledge out of the data that becomes more easily ...
Breaking Biology Technology:Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2Rancho BioSciences Manually Curated TCGA Data Sets Available 2
... CRANBURY, N.J., Feb. 18, 2011 Palatin Technologies, Inc. (NYSE ... and webcast on February 24, 2011 at 11:00 a.m. Eastern ... results and plans for its programs under development.   ... Call / Webcast Q2 Fiscal Year 2011 Conference Call-Live ...
... have heard of virtual keyboards controlled by thought, brain-powered ... be downright tiring, a fact that prevents the technology ... among others. Professor Jos del R. Milln and his ... in Switzerland have a solution: engineer the system so ...
... Pharmaceuticals, Inc. (Nasdaq: SVNT ) today announced that ... at the Citi 2011 Global Healthcare Conference on Tuesday, March ... be held at the New York Hilton in New York, ... can be accessed through the investor relations section of the ...
Cached Biology Technology:Taking brain-computer interfaces to the next phase 2
... APAgene kits are designed to rapidly ... using our patented APA Technology. ... at an extraordinarily competitive price. All ... kit. The Locator Kit can be ...
Recommended for supporting the growth of anchorage-dependent cells including human and mouse stromal cells, mesenchymal cells and cell lines....
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
Biology Products: