Navigation Links
Shifting the balance between good fat and bad fat
Date:1/4/2013

LA JOLLA, Calif., January 4, 2013 In many cases, obesity is caused by more than just overeating and a lack of exercise. Something in the body goes haywire, causing it to store more fat and burn less energy. But what is it? Researchers at Sanford-Burnham Medical Research Institute have a new theorya protein called p62. According to a study the team published in the Journal of Clinical Investigation, when p62 is missing in fat tissue, the body's metabolic balance shiftsinhibiting "good" brown fat, while favoring "bad" white fat. These findings indicate that p62 might make a promising target for new therapies aimed at curbing obesity.

"Without p62 you're making lots of fat but not burning energy, and the body thinks it needs to store energy," said Jorge Moscat, Ph.D., Sanford-Burnham professor. "It's a double whammy." Moscat led the study with collaborators at Helmholtz Zentrum Mnchen in Germany and the University of Cincinnati.

p62 and obesity

Moscat's team had previously produced mice that completely lack the p62 protein everywhere in their bodies. As a result, the animals were obese. They also had metabolic syndrome. In other words, as compared to mice with p62, mice lacking p62 weighed more, expended less energy, had diabetes and had a hyper-inflammatory response that's characteristic of obesity.

While those results showed that the lack of p62 leads to obesity, "we didn't know which tissue was responsible for these effects, because p62 was missing in all of them," Moscat said.

Some researchers believe that muscle tissue, where energy is expended, controls obesity. Others suspect the liver is a key player, or that the brain's appetite control center is most responsible for obesity.

But then there's fat itselfboth white fat and brown fat. White fat is the type we think of as unwanted body fat. Brown fat, on the other hand, is beneficial because it burns calories. Many researchers now b
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. New menhaden study will help identify balance between fishing and preserving Bay forage fish
2. Decoding the secrets of balance
3. Researchers find mechanism that gives plants balance
4. Increasing water scarcity in Californias Bay-Delta will necessitate trade-offs; hard decisions needed to balance various environmental risks
5. New study documents the natural relationship between CO2 concentrations and sea level
6. Ironing out the link between H. pylori infection and gastric cancer
7. The findings between DNMs and autism provides global view of mutability on human diseases
8. Dark Ages scourge enlightens modern struggle between man and microbes
9. Multiple sclerosis immune exchange between brain and blood is uncovered
10. Researchers study links between conflict and fisheries in East Africa
11. Mongolia and the Altai Mountains: Origins of genetic blending between Europeans and Asians
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shifting the balance between good fat and bad fat
(Date:8/21/2014)... new study of American singles found that during ... highest orgasm rates. On average, men experience orgasm ... orientation making little difference. For women, however, orgasm ... orgasm 62.9 percent of the time during sex ... varies with women,s sexual orientation, with lesbian women ...
(Date:8/21/2014)... darkness use a previously unknown process for harvesting energy ... by a Penn State University scientist has discovered. The ... improving plant growth, harvesting energy from the Sun, and ... Erie and other lakes worldwide. A paper describing the ... Express edition of the journal Science on ...
(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... study reports for the first time that a less-virulent strain ... The research appears in the October 1 issue of ... the species barrier is an important step in the development ... focused on the ability of highly pathogenic strains, such as ...
... Two peas in a pod may not be so friendly when ... plant, once separated may treat the former conjoined twin as an ... looking at how plants determine who is a competitor when competing ... researcher in plant ecology. "There is no reason for roots to ...
... become increasingly concerned by the problem of "super-bugs" - ... is well known that a high rate of antibiotic ... resistant bacteria. But for some antibiotics, an even more ... of researchers in the open access international medical journal ...
Cached Biology News:Less virulent strains of avian influenza can infect humans 2Plants discriminate between self and non self 2Agricultural antibiotic use contributes to 'super-bugs' in humans 2
(Date:8/20/2014)... lessons often have it that American Indians largely were ... pox, influenza and tuberculosis brought to the New World ... about 20 million people lived in the Americas shortly ... were killed by European diseases., But new research led ... and Johannes Krause of the University of Tubingen in ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 High ... and apply the most complete climate and Earth ... demanding climate change issues. , Eight national laboratories, ... with the National Center for Atmospheric Research, four ... new effort. Other participating national laboratories include Argonne, ...
(Date:8/20/2014)... The 6th Annual Arrowhead Personalized ... October 29-30 in San Francisco, CA. This year’s conference ... researchers and clinicians focused on addressing and solving the ... the twelve years since the sequencing of the human ... with pharmacogenetic information in the label and molecular diagnostics ...
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
Breaking Biology Technology:Unusual discovery leads to fascinating tuberculosis theory 2Unusual discovery leads to fascinating tuberculosis theory 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2'Tickling' your ear could be good for your heart 2
... IDRI (Infectious Disease Research,Institute) announced it has granted ... exclusive license in Latin America and a,non-exclusive license ... two of IDRI,s lead,vaccine antigen candidates for the ... IDRI will provide technical assistance to the Instituto,Butantan ...
... UNION CITY, Calif., Jan. 22 Abaxis, Inc. (Nasdaq: ... analysis systems, has scheduled a conference call to discuss its ... ended December 31, 2008. The call will be at 4:15 ... 356-5706 or (706) 643-0580 to access the conference call, or ...
... - illumin8 Combines Scientific Content ... With Intelligent Web Search Technology to,Address Complex Technology ... Elsevier, the world,s leading ... today announced the European availability of,illumin8 ( http://www.illumin8.com ...
Cached Biology Technology:IDRI Collaborates with the Brazilian Butantan Institute To Develop Novel Vaccines Against Leishmaniasis 2IDRI Collaborates with the Brazilian Butantan Institute To Develop Novel Vaccines Against Leishmaniasis 3Abaxis to Report Third Quarter Fiscal 2009 Financial Results Thursday, January 29, 2009 2Elsevier Introduces Breakthrough Technology Intelligence Solution for Accelerating R&D and Innovation in Europe 2Elsevier Introduces Breakthrough Technology Intelligence Solution for Accelerating R&D and Innovation in Europe 3Elsevier Introduces Breakthrough Technology Intelligence Solution for Accelerating R&D and Innovation in Europe 4
The VersArray hybridization chamber is used for manual (coverslip) hybridization of microarrays. The chamber accommodates 2 slides and is watertight to allow incubation of slides in a water bath. Dim...
... state-of-the-art separation system using the asymmetric flow ... integrates easily with Wyatts multi-angle light scattering ... as the Optilab DSP. The combined system ... of the particles/molecules separated by the AFFF ...
Monoclonal antibodies conjugated with rhodamine...
... Moticam 2300 camera (MC2300) attaches to virtually ... trinocular port. Included in the standard package, ... software offers quick and accurate image capture, ... for examination or documentation purposes. The MC2300s ...
Biology Products: