Navigation Links
Shedding light on cancer cells
Date:9/24/2009

Scientists label cells with coloured or glowing chemicals to observe how basic cellular activities differ between healthy and cancerous cells. Existing techniques for labelling cells are either too slow or too toxic to perform on live cells. Now, a study reviewed by Philip Dawson, a member of Faculty of 1000 Biology and leading authority in chemistry and cell biology, describes a novel labelling technique that uses a chemical reaction to make live cancer cells light up quickly and safely.

Researchers at Massachusetts General Hospital developed a two-step process to specifically tag cancer cells. First, chemically modified antibodies home in on cancer cells. Then a chemical reaction called cycloaddition transfers a dye onto the antibody making the cancer cells glow when viewed through a microscope.

The novel cycloaddition reaction is fast, very specific, and requires minimal manipulation of the cells. Dawson comments that, in combining antibody binding with the cycloaddition, "low signal-to-noise ratios are achieved". This new labelling technique could be used to track the location and activity of anti-cancer drugs, the location of cancer-specific proteins within the cell, or to visualize cancer cells inside a living organism.

Dawson concludes that cycloaddition will allow scientists to observe live cancer cells in the body, leading to a better understanding of cancer's basic processes.


'/>"/>

Contact: Steve Pogonowski
press@f1000.com
Faculty of 1000: Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Clemson scientists shed light on molecules in living cells
2. September Geology and GSA Today media highlights
3. Highlights from the September 2007 Journal of the American Dietetic Association
4. Genome study shines light on genetic link to height
5. Pig study sheds new light on the colonisation of Europe by early farmers
6. Researchers developing device to predict proper light exposure for human health
7. AGU journal highlights -- Sept. 6, 2007
8. IDEMA Reveals Program Highlights for DISKCON USA 2007
9. Men shed light on the mystery of human longevity, study finds
10. Zebrafish to shed light on human mitochondrial diseases
11. UT researcher sheds new light on hybrid animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)...   Neurotechnology , a provider of high-precision ... version of its fingerprint matching algorithm has achieved ... evaluation organized by NIST. The MINEX test measures ... 378 fingerprint standard template format. MINEX compliance is ... the United States and ...
(Date:11/3/2014)... study published in this month,s Proceedings of ... of a recently discovered communication molecule of the body,s ... known to limit inflammation and the current study reports ... the ability of the immune system to recognize and ... IL-37,s effect on the immune system now allows us ...
(Date:11/3/2014)... Researchers from Australia report that low birth weight and ... (OA)-related hip replacements in adulthood. Findings published in the ... & Research , indicate that low birth weight and ... arthroplasty due to OA as adults. , According ... of 25 are diagnosed with clinical OA. Symptoms of ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2
... 23, 2010) A clue to the causes of ... tiny intercellular junction that rapidly transfers information from one ... University School of Medicine, with students from the Sackler ... called APC (adenomatous polyposis coli) plays a key role ...
... viral genes protected monkeys infected with deadly Ebola or ... therapeutics were administered one hour after exposuresuggesting the approach ... hospital settings. The research, which appears in today,s ... was conducted by the U.S. Army Medical Research Institute ...
... the University of Minnesota Academic Health Center have identified two ... for HIV. The two drugs, decitabine and gemcitabine ... therapy were found to eliminate HIV infection in the ... death an outcome researchers dubbed "lethal mutagenesis." This ...
Cached Biology News:Researchers connect APC protein to autism and mental retardation 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 3U of M researchers identify 2 FDA approved drugs that may fight HIV 2
(Date:11/21/2014)... The November 2014 issue of BioTechniques ( ... journal featuring the following articles:, , ... in the retina , DNA from fingermarks ... chromogenic substrates in zebrafish , Re-use of ... , Nuclear LC3-positive puncta in stressed cells ...
(Date:11/21/2014)... 2014 Why did Stephen Hawking become ... so instantly recognizable? Why have they become icons to ... author Hilton Ratcliffe seeks out the answers to those ... to do with science. In " Stephen Hawking Smoked ... 21, 2014), Ratcliffe puts it plainly: , “It ...
(Date:11/21/2014)... Texas (PRWEB) November 21, 2014 ... is a professional and in-depth research report on ... including its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... macroeconomic environment & economic situation analysis. The report ...
(Date:11/21/2014)... 20, 2014 /CNW/ - Aequus Pharmaceuticals Inc. (the ... it has closed a brokered private placement offering ... C$3.7 million.  Cormark Securities Inc. and Clarus Securities ... Offering for a syndicate of agents that also ... (collectively the "Agents"). Concurrently with the Brokered Offering, ...
Breaking Biology Technology:BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3
... International,Corporation (Nasdaq: PRXL ) will release Second Quarter ... after the close of the,stock market. The announcement will ... on the PR Newswire website at, http://www.prnewswire.com ., ... at 10:00 a.m. ET,on Thursday, January 24, 2008 to ...
... update on QuatRx clinical development programs, including review of positive ... ... ANN ARBOR, Mich., Jan. 4 QuatRx Pharmaceuticals Company,today announced ... a presenter at the 26th Annual JP Morgan Healthcare,Conference on Tuesday, ...
... BOSTON, Jan. 4 Follica Inc., a privately ... (male and female pattern hair,loss caused by androgens ... follicle disorders, today announced a $5.5 million Series ... existing,investors PureTech Ventures participated. The funding is expected ...
Cached Biology Technology:PAREXEL Announces Date of Second Quarter Fiscal Year 2008 Earnings Release and Conference Call 2QuatRx Pharmaceuticals to Present at 26th Annual JP Morgan Healthcare Conference 2Follica Raises $5.5 M To Advance New Treatment for Androgenetic Alopecia Into the Clinic 2Follica Raises $5.5 M To Advance New Treatment for Androgenetic Alopecia Into the Clinic 3
... that will help protect your PCR runs ... work area prior to use, reducing the ... Containment features reduce the chance of airborne ... for a clear view, an acid-resistant black ...
...
... glass slide in this set of ... in triplicate, for a total of ... proteins as internal control. Antibodies belonging ... angiogenesis, apoptosis, cell cycle progression, signal ...
...
Biology Products: