Navigation Links
Shades of 1918? New study compares avian flu with a notorious killer from the past
Date:2/10/2009

"Basically, when you injure type II pneumocytes as opposed to type I, you impair the ability of lung tissue to repair itself. In addition, when type II are infected, they produce chemokines and cytokines, which contribute directly to the overall inflammatory response." In this way, H5N1 delivers a devastating one-two punch to the host's ability to recover from the infectious siege. The researchers observed that within 24 hours, H5N1 had caused severe bronchiolar and alveolar lesions in lung tissue.

H5N1's penchant for infecting type II rather than type I pneumocytes is due to the receptor preference found in avian viruses as opposed to human viruses, (including the 1918 ressortants used in the study), which primarily attack type I cells in the lung.

H5N1's attack on type II pneumocytes was sustained, from the point of initial infection through the 7 days of the study, as seen in figure 2. Examination of lung tissue showed widespread, prolonged replication of viruses and associated tissue destruction. "The fact that the infection of type II pneumocytes was so protracted directly contributed to the damage we saw," notes Baskin.

Another aspect of lung function debilitated by H5N1 involves the loss of surfactants, produced by type II pneumocytes and responsible for pliability of lung tissue. Without such surfactants, breathing becomes impossible.

The final act

A further critical finding of the study is that H5N1, having swamped the innate immune response, turns its attention next to the body's adaptive response, specifically, dendritic cells whose job it is to phagocytize protein components from the virus and present these to T cells, either locally or at the lymph nodes that drain the lungs. Normally, through this process, specific antibodies are then produced to combat the viral infection. Tissue sampling for the H5N1 found a notable absence of these dendritic cells, suggesting they were destroyed during the infection proce
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. International study identifies gene variants associated with early heart attack
2. Genetic study shows direct link between vitamin D and MS susceptibility gene
3. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
4. Molecule that suppresses immune response under study in type 1 diabetes
5. UNC study: Tinkering with the circadian clock can suppress cancer growth
6. Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
7. Results of the third school nutrition dietary assessment study published
8. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
9. Study finds rescue course of antenatal steroids improves outcome in premature babies
10. Brain structure assists in immune response, according to Penn vet study
11. Study finds MRSA in Midwestern swine, workers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shades of 1918? New study compares avian flu with a notorious killer from the past
(Date:10/29/2014)... number of chemicals from household and industrial products are ... bodies. But for most of them, scientists have yet ... taken the first step toward doing that by estimating ... new method is published in the ACS journal ... and colleagues note that the risks to human health ...
(Date:10/29/2014)... in German . ... and Peter Schlögelhofer at the Max F. Perutz Laboratories ... University of Vienna dived into the process of meiosis ... display an inversion of the standard meiotic phases. The ... Nature Communications . , Meiosis is the two-step ...
(Date:10/29/2014)... all organisms in the living world compete with ... strongly in how much they invest into their ... eager to get access to high-quality resources, while ... use of the lower-quality resources that are left ... in animal and human societies seems to fluctuate ...
Breaking Biology News(10 mins):Meiotic cell division 'the other way round' 2Evolution of competitiveness 2Evolution of competitiveness 3
... used in California,s Central Valley, one of the world,s ... frog species miles from farmland. Writing in Environmental ... Pacific Tree Fogs in remote mountain areas, including national ... pesticides by the elements. California,s Central Valley is ...
... 25, 2013 The following statement is being issued by Robbins Geller ... Pacific Biosciences Securities Litigation SUPERIOR COURT OF THE ... IN RE PACIFIC BIOSCIENCES OF CALIFORNIA ... CIV509210 SUMMARY NOTICE OF PROPOSED SETTLEMENT OF CLASS ACTION Hon. Marie ...
... researchers have developed a computer-aided method that uses ... rapid advances toward personalized health care, disease management ... V. Chawla and his doctoral student, Darcy A. ... Recommendation Engine (CARE) for personalized disease risk predictions ...
Cached Biology News:Pesticides contaminate frogs from Californian National Parks 2Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 2Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 3Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 4Notre Dame researchers develop system that uses a big data approach to personalized healthcare 2
(Date:10/30/2014)...  Regado Biosciences, Inc. (Nasdaq: RGDO ), ... and live audio webcast on Thursday, November 6, 2014, ... 2014 financial results. Interested participants and investors ... for domestic callers or (412) 902-4276 for international callers. ... investor relations section of the Regado website at ...
(Date:10/27/2014)... 27, 2014 The new research ... (High & Medium), Sub-type (Primary & Secondary), and ... & Transportation & Power Generation) - Trends and ... market with analysis and forecasting of the market ... Tables with 52 Figures spread through 146 Pages ...
(Date:10/27/2014)... 2014 The “Molecular Diagnostic Market ... Technology (PCR, INAAT, DNA Sequencing), End User (Hospital, ... - Global Forecast to 2018” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
(Date:10/27/2014)... Mass. , Oct. 27, 2014 ... "Company"), a worldwide leader in the development and ... the life sciences research market, today announced that ... presented a novel, accurate, highly reproducible, and robust ... – routine high-throughput protein analysis on small needle ...
Breaking Biology Technology:Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5
... EXTON, Pa., June 2, 2011 Morphotek®, Inc., a ... commenced a multi-center, phase II study of MORAb-004 for ... MORAb-004, a potentially first-in-class monoclonal antibody that specifically binds ... therapy comparing its safety and therapeutic activity at two ...
... a medical explanation for why exercise is good for the ... that started in Dr. Ian Phillips, lab at Keck Graduate ... 29 that keeps hearts healthy even under intense exercise. ... of why exercise is good for you," said Phillips, KGI,s ...
... (NASDAQ: SQNM ), a life sciences company ... its subsidiary Sequenom Center for Molecular Medicine® (Sequenom CMM) ... Valley Bank’s San Diego-based team. Sequenom will use proceeds ... of new products and other near term growth initiatives. ...
Cached Biology Technology:Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3Scientists Discover Gene Regulator That Helps Hearts Through Exercise 2Sequenom Enters Into New $30.0 Million Credit Facility 2Sequenom Enters Into New $30.0 Million Credit Facility 3Sequenom Enters Into New $30.0 Million Credit Facility 4
This antibody detects an ~25 kDa band, corresponding to the expected molecular mass of Rab3A, on immunoblots. The antibody specificity is confirmed in peptide inhibition immunoblotting studies....
... reactive against the complex IV assembly factor SURF1. ... cultured cells. SURF1 is an important assembly factor ... participate in the folding of subunit II and ... SURF1, particularly ones that result in an absence ...
100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
Biology Products: