Navigation Links
Shades of 1918? New study compares avian flu with a notorious killer from the past
Date:2/10/2009

gton. Using this strategy, respiratory tissue was analyzed with high-throughput technologies of functional genomics, proteomics and transcriptomics to measure gene expression and regulation in fine-grained detail. Such techniques have opened a new window onto the genetic underpinnings of infectious disease.

A large number of these genes code for cytokines and chemokinesimmunomodulating agents which include interleukins, interferons and other factors involved with the host's innate inflammatory response to infection. The result of this overwhelming transcription induction, shown graphically in figure 1, is a "cytokine storm" often leading to acute respiratory distress syndrome in the viral host, while proving entirely ineffective in blunting prodigious replication of the H5N1 virus.

Respiratory tissues sampled on days 1, 2 4 and 7 post-infection were subjected to pathological, viral and microarray analysis. Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the group's measurements of Tissue Culture Infectious Dose or TCID over the course of H5N1's infection, "the take home message is that for H5N1 there is hardly any viable tissue left to infect by day 7, yet there is still very strong viral replication." Further, despite the broad and sustained upregulation of inflammatory genes, they were of no use in limiting the H5N1 infection.

While the new study found that the 1918 ressortant strains and H5N1 each attacked specialized respiratory cells called pneumocytes, the 1918 chimaraes showed preference for so-called type I pneumocytes, responsible for air exchange in the lungs. In contrast, H5N1 characteristically infects the more numerous type II pneumocytes, a critical distinction, as Dr. Baskin explains:
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. International study identifies gene variants associated with early heart attack
2. Genetic study shows direct link between vitamin D and MS susceptibility gene
3. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
4. Molecule that suppresses immune response under study in type 1 diabetes
5. UNC study: Tinkering with the circadian clock can suppress cancer growth
6. Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
7. Results of the third school nutrition dietary assessment study published
8. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
9. Study finds rescue course of antenatal steroids improves outcome in premature babies
10. Brain structure assists in immune response, according to Penn vet study
11. Study finds MRSA in Midwestern swine, workers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shades of 1918? New study compares avian flu with a notorious killer from the past
(Date:7/2/2015)... 2, 2015 Fingerprint Cards has received ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... be used by smartphone manufacturers in Asia ... the communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/26/2015)... 26, 2015 ATL Technology, LLC, a top provider ... in single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Jose, Costa Rica ). This acquisition will ... with ATL Technology,s existing facility in Costa ...
(Date:6/24/2015)... , June 24, 2015 The biologics ... The major drivers for the market include growth of ... of new drug launches. Over the years, the number ... Between 2001 and 2010, the FDA approved 225 drug ... to WIPO, Europe accounted for ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... in the Southampton Centre for Biomedical Research, established ... (SUHT) and the University of Southampton, have been ... and respiratory research facilities. The funding, ... investment in NHS and university partnerships, has secured ...
... of celiac disease in women who present with unexplained ... The Journal of Reproductive Medicine, the study ... participant underwent serologic screening for celiac disease as well ... had positive serum test results were advised to seek ...
... of revising now that biologists at UC San Diego have ... According to the textbooks, chromatin, the natural state of DNA ... nucleosomes are the basic repeating unit of chromatin. When ... on a string (photo at right). But in the August ...
Cached Biology News:Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research 2Biologists' discovery may force revision of biology textbooks 2
(Date:7/7/2015)... ... July 07, 2015 , ... bioLytical Laboratories Inc. announced ... was accepted for presentation at the 8th Annual International AIDS Society (IAS) Conference ... Wednesday, July 22nd from 1:00 pm to 2:00pm Pacific Standard Time at the ...
(Date:7/7/2015)... ... , ... uBiome, the leading microbial genomics company, is offering talented researchers with ... 16S laboratory analysis. The goal is to fast-track a study with the greatest potential ... own dashboard, enabling them to view and compare the results of their study, as ...
(Date:7/7/2015)... ... July 07, 2015 , ... The Pistoia ... to innovation in life science R&D, has attracted a number of new members ... top ten pharmaceutical company joining as a Core member, and DNAnexus and Tessella ...
(Date:7/6/2015)... 6, 2015  Emdeon Inc. today announced ... agreement to acquire Altegra Health, a national ... combine data aggregation and analytics with unique ... actionable insights and improved management for value-based ... risk adjustment and quality analytics and Emdeon,s ...
Breaking Biology Technology:bioLytical to Present Findings of Early HIV Detection 2bioLytical to Present Findings of Early HIV Detection 3uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 2uBiome to Award Grant of up to $100k for Groundbreaking Microbiome Research 3Pistoia Alliance Continues to Attract New Members 2Emdeon to Acquire Altegra Health 2Emdeon to Acquire Altegra Health 3Emdeon to Acquire Altegra Health 4
... , NOVATO, Calif., Sept. 8 BioMarin Pharmaceutical Inc. ... Officer of BioMarin, will present a company update at the Morgan Stanley ... 1:35 p.m. ET. , , Interested parties ... investor section of the BioMarin website, www.BMRN.com . ...
... , SAN DIEGO, Sept. 8 eBioscience Corporation, a ... the acquisition of NatuTec GmbH, a leading distributor of high-quality biological ... , "For the past 10 years, NatuTec has ... R. Nelson, CEO of eBioscience. "The NatuTec acquisition provides eBioscience ...
... LAIYANG, China, Sept. 8 /PRNewswire-Asia-FirstCall/ -- ... a,U.S. pharmaceutical company with its principal operations in the ... for,fiscal year 2009. The Company expects to meet ... revenue and operating income of $40 to $43 million ...
Cached Biology Technology:BioMarin to Present at the Morgan Stanley Healthcare Conference 2eBioscience Corporation Acquires NatuTec GmbH 2Jiangbo Pharmaceuticals Reaffirms Guidance for Fiscal 2009 2
...
Rubeola (Measles) Antigen Preservative: No Preservatives...
One-step, microplate or cuvet, colorimetric, linear detection range 8 mg/dL to 300 mg/dL. Procedure: 5 min....
Homo sapiens jumping translocation breakpoint...
Biology Products: