Navigation Links
Shades of 1918? New study compares avian flu with a notorious killer from the past
Date:2/10/2009

gton. Using this strategy, respiratory tissue was analyzed with high-throughput technologies of functional genomics, proteomics and transcriptomics to measure gene expression and regulation in fine-grained detail. Such techniques have opened a new window onto the genetic underpinnings of infectious disease.

A large number of these genes code for cytokines and chemokinesimmunomodulating agents which include interleukins, interferons and other factors involved with the host's innate inflammatory response to infection. The result of this overwhelming transcription induction, shown graphically in figure 1, is a "cytokine storm" often leading to acute respiratory distress syndrome in the viral host, while proving entirely ineffective in blunting prodigious replication of the H5N1 virus.

Respiratory tissues sampled on days 1, 2 4 and 7 post-infection were subjected to pathological, viral and microarray analysis. Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the group's measurements of Tissue Culture Infectious Dose or TCID over the course of H5N1's infection, "the take home message is that for H5N1 there is hardly any viable tissue left to infect by day 7, yet there is still very strong viral replication." Further, despite the broad and sustained upregulation of inflammatory genes, they were of no use in limiting the H5N1 infection.

While the new study found that the 1918 ressortant strains and H5N1 each attacked specialized respiratory cells called pneumocytes, the 1918 chimaraes showed preference for so-called type I pneumocytes, responsible for air exchange in the lungs. In contrast, H5N1 characteristically infects the more numerous type II pneumocytes, a critical distinction, as Dr. Baskin explains:
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. International study identifies gene variants associated with early heart attack
2. Genetic study shows direct link between vitamin D and MS susceptibility gene
3. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
4. Molecule that suppresses immune response under study in type 1 diabetes
5. UNC study: Tinkering with the circadian clock can suppress cancer growth
6. Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
7. Results of the third school nutrition dietary assessment study published
8. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
9. Study finds rescue course of antenatal steroids improves outcome in premature babies
10. Brain structure assists in immune response, according to Penn vet study
11. Study finds MRSA in Midwestern swine, workers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shades of 1918? New study compares avian flu with a notorious killer from the past
(Date:4/27/2015)... more than four decades, AUVSI,s Unmanned Systems ... event for the unmanned land, sea, and air industries. ... local, national, or trade news organization interested in gathering ... applications of unmanned technologies. The conference will explore the ... and how it will soon impact the lives of ...
(Date:4/20/2015)... April 20, 2015 The announcement ... Glenbeigh Records Management (GRM), Ireland,s ... Islamic Bank. Having built up an impressive track record of ... leading player within the records management sector in ... double is GCC staffbase and employ a further eight staff ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... say "shade grown, please" when you order your morning ... under a canopy of multiple tree species, not only ... also maintain genetic diversity of native tree species and ... The finding comes from a study published by ...
... bone marrow that can continuously make red and white ... Michigan lab. This development could lead to ... defects and a continuous supply of blood for transfusions. ... mimics the tissues supporting bone marrow in the body, ...
... Dec. 22, 2008 NYU Langone Medical Center scientists and ... Calif., have discovered an unexpected cause for the fatal seizures ... central nervous system, according to a study published in the ... of thinking about how the human immune system responds to ...
Cached Biology News:Shade coffee benefits more than birds 2Shade coffee benefits more than birds 3Biomedical researchers create artificial human bone marrow in a test tube 2Peering inside the skull of a mouse to solve meningitis mystery 2Peering inside the skull of a mouse to solve meningitis mystery 3
(Date:5/29/2015)... New Columbia, Pa. (PRWEB) May 29, 2015 ... approached Thermal Product Solutions with a request to ... uniformly remove excess moisture from prescription medications being ... a custom solution that includes a robotic gantry, ... precisely positions and dries trays of 3D-printed pills ...
(Date:5/29/2015)... RESEARCH TRIANGLE PARK, N.C. , May 29, 2015 ... today that Roger Jeffs , Ph.D., President and Co-Chief ... update on the company,s business at the Jefferies 2015 Global ... The presentation and the immediately following Q&A session ... AM Eastern Time, and can be accessed via a live ...
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Markets and Companies"  to their offering.  ... disease remains a challenge in management. With ... in the seven major markets of the ...
(Date:5/28/2015)... May 27, 2015 Research and ... of Jain PharmaBiotech,s new report "Nanobiotechnology ... offering. An increasing use of ... is anticipated. Nanotechnology will be applied at ... formulations for optimal delivery to diagnostic applications ...
Breaking Biology Technology:New industrial oven with “pill pushing” robotic gantry precisely removes excess moisture from 3D-printed pharmaceuticals 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3
... , ... Web Service Available Immediately to Researchers Worldwide,Free/Full NGS-based Runs Available to First Registrants ... Westborough, MA (PRWEB) ... and easy-to-use ChIP-Seq workflow solution available immediately as a web cloud service ...
... Corporation, a spinal and orthopaedic implant and instrument company ... the launch of four new product offerings. The ... Valeo(®) C VBR, Valeo(®) Concise Cervical Plating System and ... American Spine Society (NASS) prepares to meet in San ...
... Nov. 10 Genoptix, Inc. (Nasdaq: GXDX ), a ... the Lazard Capital Management 6th Annual Healthcare Conference at The ... 2009. , Genoptix,s EVP and CFO, Doug Schuling, ... beginning at approximately 11:25 a.m. EST. He will provide ...
Cached Biology Technology:GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 2GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 3GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 4Amedica Announces New Product Offering 2Genoptix Announces Participation at Lazard Capital Management 6th Annual Healthcare Conference 2
...
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
...
... Shakers combine high durability and capacity ... of use. The patented triple-counterbalanced heavy-duty ... to run at high speed with ... temperature range is delivered with tight ...
Biology Products: