Navigation Links
Shades of 1918? New study compares avian flu with a notorious killer from the past
Date:2/10/2009

gton. Using this strategy, respiratory tissue was analyzed with high-throughput technologies of functional genomics, proteomics and transcriptomics to measure gene expression and regulation in fine-grained detail. Such techniques have opened a new window onto the genetic underpinnings of infectious disease.

A large number of these genes code for cytokines and chemokinesimmunomodulating agents which include interleukins, interferons and other factors involved with the host's innate inflammatory response to infection. The result of this overwhelming transcription induction, shown graphically in figure 1, is a "cytokine storm" often leading to acute respiratory distress syndrome in the viral host, while proving entirely ineffective in blunting prodigious replication of the H5N1 virus.

Respiratory tissues sampled on days 1, 2 4 and 7 post-infection were subjected to pathological, viral and microarray analysis. Although the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the group's measurements of Tissue Culture Infectious Dose or TCID over the course of H5N1's infection, "the take home message is that for H5N1 there is hardly any viable tissue left to infect by day 7, yet there is still very strong viral replication." Further, despite the broad and sustained upregulation of inflammatory genes, they were of no use in limiting the H5N1 infection.

While the new study found that the 1918 ressortant strains and H5N1 each attacked specialized respiratory cells called pneumocytes, the 1918 chimaraes showed preference for so-called type I pneumocytes, responsible for air exchange in the lungs. In contrast, H5N1 characteristically infects the more numerous type II pneumocytes, a critical distinction, as Dr. Baskin explains:
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. International study identifies gene variants associated with early heart attack
2. Genetic study shows direct link between vitamin D and MS susceptibility gene
3. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
4. Molecule that suppresses immune response under study in type 1 diabetes
5. UNC study: Tinkering with the circadian clock can suppress cancer growth
6. Small male chimps use politics, rather than aggression, to lead the pack, U of Minnesota study says
7. Results of the third school nutrition dietary assessment study published
8. TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug
9. Study finds rescue course of antenatal steroids improves outcome in premature babies
10. Brain structure assists in immune response, according to Penn vet study
11. Study finds MRSA in Midwestern swine, workers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Shades of 1918? New study compares avian flu with a notorious killer from the past
(Date:11/4/2014)... (Nov. 4, 2014) – A majority of Madagascar,s 101 ... could have serious consequences for the rainforests they call ... the positive impacts lemurs can have on rainforest tree ... disappearance could have on the region,s rich biodiversity. , ... fruits eaten by lemurs. Lemurs in turn disperse ...
(Date:11/3/2014)... DUBLIN , Nov. 3, 2014 Research ... report "Cell Therapy - Technologies, Markets and Companies" ... evaluates cell therapy technologies and methods, which have already started ... Hematopoietic stem cell transplantation is replacing the old fashioned bone ... described. Cell therapy is bound to become a part of ...
(Date:11/3/2014)... 3, 2014  NeuroSigma ® , Inc. (NeuroSigma), ... company focused on commercialization of its non-invasive ... treatment of neurological and neuropsychiatric disorders, announced today ... issued a Notice of Allowance for Mexican Patent ... by NeuroSigma and the Regents of the University ...
Breaking Biology News(10 mins):Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... unusual symbiosis between tiny single-celled algae and highly specialized ... ecosystems, fertilizing the oceans by taking nitrogen from the ... organisms can use. Details of the symbiosis, ... , emerged from the investigation of a mysterious nitrogen-fixing ...
... development of new biocomposites based on the transformation ... for the construction sector. These innovative materials will ... BIocomposiTEs), a European Commission FP7 collaborative project co-participated ... (FI), EMPA (CH), EXERGY (UK), VERTECH (FR), ...
... pregnant makes a huge difference in the health of her ... ate before pregnancy might be important too. According to a ... Journal , what a group of female mice atebefore ... her offspring. These DNA alterations, called "epigenetic" changes, drastically affected ...
Cached Biology News:Unusual symbiosis discovered in marine microorganisms 2Unusual symbiosis discovered in marine microorganisms 3Unusual symbiosis discovered in marine microorganisms 4TECNALIA leads research to develop new biocomposites based on wheat straw and recycled paper 2A mother’s nutrition--before pregnancy--may alter the function of her children’s genes 2
(Date:11/21/2014)... 20, 2014 The report, ... Oligos, Enzymes, Cloning kits), Technology (Bioinformatics, Nanotechnology, ... Pharmaceuticals, Biomaterials, Bioremediation) - Global Forecast to ... drivers, threats, opportunities, and challenges. , Browse ... spread through 185 pages and in-depth TOC ...
(Date:11/21/2014)... Why did Stephen Hawking become so famous? ... recognizable? Why have they become icons to rival film ... Ratcliffe seeks out the answers to those questions, and ... with science. In " Stephen Hawking Smoked My Socks ... Ratcliffe puts it plainly: , “It is profoundly ...
(Date:11/21/2014)... Polaris Group announced today that the ... 1 trial of ADI-PEG 20 in combination with ... pleural mesothelioma (MPM) and non-squamous non-small cell lung ... ADI-PEG 20, both as monotherapy and in combination ... other indications, including breast cancer, melanomas, ovarian cancer, ...
(Date:11/21/2014)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced results ... 2014.  Biorem,s complete 2014 third quarter financial statements and MD&A have ... ended September 30, , Nine-months ended September ... 2014 , 2013 , 2014 , ... , 6,715 , 14,476 Gross profit , ...
Breaking Biology Technology:Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... of siRNAs targeting , key ... cells. To identify genes involved in a given cellular process, , ... distinct response profiles such as ... Inc., who pioneered the field of High Content , ...
... , Up to 50X more activity and 350% greater ... Removes trace quantities of , DNA ... RNase-free and recombinant in , ... lower in RNase activity than bovine pancreas , ...
... ... fastest, easiest, and most consistent method for PAGE purification of small , ... which was designed for the visualization of small nucleic acids, the flashPAGE ... of RNA , and DNA. , ...
Cached Biology Technology:Using Validated siRNAs in Functional Genomic Assays 2Using Validated siRNAs in Functional Genomic Assays 3TURBO DNase: Hyperactive, Salt Tolerant DNase 2TURBO DNase: Hyperactive, Salt Tolerant DNase 3TURBO DNase: Hyperactive, Salt Tolerant DNase 4TURBO DNase: Hyperactive, Salt Tolerant DNase 5Ultra-Fast Purification of Small Nucleic Acids 2Ultra-Fast Purification of Small Nucleic Acids 3Ultra-Fast Purification of Small Nucleic Acids 4Ultra-Fast Purification of Small Nucleic Acids 5
Includes PROTEAN II xi Basic unit and IPG conversion kit PROTEAN II XL Cell, wide format, Compatible with ReadyStrip IPG Strips 1.0 mm 165-3188 1.5 mm 165-3189 2.0 mm 165-3190...
F40 piston seals are supplied as 2 seals with a seal tool to service one F40 pump of a BioLogic DuoFlow workstation....
...
... an intelligent full microplate washer with a 96 ... instrument gives you the best of two worlds ... , Performance ,Separate wash and aspiration ... A dispense precision of better than 2% CV ...
Biology Products: