Navigation Links
Sex chromosome shocker: The 'female' X a key contributor to sperm production
Date:7/21/2013

p>

To set the sequence straight, the lab turned to the unique sequencing method Page had developed with collaborators at Washington University in St. Louis to help navigate the structural complexities of the Y chromosome. As Page reported roughly a decade ago, the Y contains several regions of large palindromesareas of mirror-imaged genetic sequences. Such regions defy elucidation via conventional sequencing approaches, which simply cannot detect extremely subtle genetic differences found hidden among the "mirrors." In response, Page and colleagues devised what is known as SHIMS (single-haplotype iterative mapping and sequencing) to establish a definitive reference DNA sequence of the Y chromosome.

Using SHIMS, the lab greatly improved the human X reference sequence, accurately assembling three large amplicons, identifying previously unknown palindromes, and ultimately shortening the entire length of the sequence by eliminating four major gaps. These important updates will now be incorporated into the reference sequence of the human X for use by the greater scientific community.

Upgraded reference in hand, the lab discovered that, as might have been expected, the mouse and human X chromosomes have nearly 95% of their X-linked, single-copy genes in common. Almost all of these genes are expressed in both sexes. Strikingly, however, the lab identified approximately 340 genes that are not shared between the two species. Fittingly, most of these genes reside in ampliconic regions of the X and appear to have been acquired independently during the 80 million years since mouse and human diverged from a common ancestor. Expression analyses revealed that these genes are active almost exclusively in testicular germ cells, where, at a minimum, they likely contribute to sperm production. Further exploration of these X-ampliconic regions and their associated genes is warranted.

"This is a collection of genes that has largely eluded medical genet
'/>"/>

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New therapy for fragile X chromosome syndrome discovered
2. Clues to chromosome crossovers
3. A closer look at chromosomes
4. NYU biologists identify proteins vital to chromosome segregation
5. Chromosome anchors organize DNA during cell division
6. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
7. Extra chromosome 21 removed from Down syndrome cell line
8. Western aspen trees commonly carry extra set of chromosomes
9. Study of fruit fly chromosomes improves understanding of evolution and fertility
10. Men can rest easy - sex chromosomes are here to stay
11. Discovery reveals chromosomes organize into yarns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... Israel , May 6, 2015 LifeBEAM, ... most established helmet producer, announced today that they will ... Helmet, the world,s first bio-sensing cycling helmet and the ... released in two new colors in order to give ... the product. In addition, LifeBEAM and Lazer announced their ...
(Date:4/27/2015)... 27, 2015  For more than four decades, AUVSI,s ... been the premier worldwide event for the unmanned land, ... must-attend event for any local, national, or trade news ... commercial markets and current applications of unmanned technologies. The ... projected $48 billion industry, and how it will soon ...
(Date:4/27/2015)... Fla. , Apr. 27, 2015 Profile ... access control and security systems is pleased to announce ... company as a consultant and member of its scientific ... is widely known as a thought leader in technology-enhanced ... Learning Technology Group, and has published studies and books ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... as the lungs of the planet, inhales carbon dioxide as ... to grow parts that eventually fall to the ground to ... Until recently people believed much of the rain ... deep in the ocean. University of Washington research showed a ...
... novel vaccine study from South Dakota State University (SDSU) will ... American Association of Pharmaceutical Scientists, (AAPS) National Biotechnology Conference (NBC). ... 22 at the Sheraton San Diego Hotel and Marina. ... the immune system to fight against a pathogen that causes ...
... women of European descent inherit common foot disorders, such as ... claw toe. Findings from the Framingham Foot Studythe first to ... Arthritis Care & Research , a journal published by Wiley ... Previous studies show that as many as 60% of ...
Cached Biology News:Amazon River exhales virtually all carbon taken up by rain forest 2Amazon River exhales virtually all carbon taken up by rain forest 3Germ-fighting vaccine system makes great strides in delivery 2Blame your parents for bunion woes 2
(Date:5/28/2015)... 2015 DryLet, LLC a biotechnology ... such as animal waste reduction, bioremediation, wastewater treatment, ... wastewater treatment plants and restaurant kitchen settings, announced ... Expo, June 3-5 in Des Moines, Iowa. , ... Wall Street Journal article because of its industry-leading ...
(Date:5/28/2015)... May 28, 2015 BioNorth Texas ... and representing the life sciences industry in northern ... Directors meeting at The Foundry in Dallas on ... organization brought together a broad spectrum of biotech ... the organization's early successes in partnering with key ...
(Date:5/28/2015)... May 28, 2015  PDS Biotechnology Corp. announces ... treatment targeting HPV-16, has generated strong T-cell responses ... pre-cervical cancer is treated by surgical removal of ... effective non-surgical alternative. Results show that it primes ... recognize, target, and kill precancerous and cancerous cells ...
(Date:5/28/2015)... May 28, 2015 RXi Pharmaceuticals Corporation (NASDAQ: ... and developing innovative therapeutics, primarily in the areas of ... public offering of 26 million units at a price ... proceeds of approximately $10.4 million. Each unit consists of ... overallotment purchase right to purchase 0.50 of a share ...
Breaking Biology Technology:DryLet to Showcase Patented ManureMagicâ„¢ at the 2015 World Pork Expo, June 3-5 in Des Moines, Iowa 2BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3
... of Wisconsin-Madison , justified or otherwise, is that its ... It has world-class scientists and well-developed mechanisms for turning ... of that commercialization takes place within a half-hour drive ... check the figures for per capita wages, unemployment and ...
... the fourth in a series of articles on developing start-up companies ... Madison, Wis. - In my last column for Stage 3, ... In the meantime, I received a thoughtful response about the ... column, dated November 17, 2006, discussed naming the entity. ...
... David Wittwer as CEO of TDS Telecom , , Madison, ... era of leadership at TDS Telecom , as Dave Wittwer ... the company announced. , ,Wittwer, 45, will become president and CEO ... TDS Metrocom . , ,He will be taking ...
Cached Biology Technology:Entrepreneurship grant will build strong foundation 2Entrepreneurship grant will build strong foundation 3Entrepreneurship grant will build strong foundation 4Early Stage, Step 4: Cautionary trademark tales 2Early Stage, Step 4: Cautionary trademark tales 3
C/EBPalpha Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Mouse monoclonal [GB3] to Kalinin ( Abpromise for all tested applications). entrezGeneID: 3918 SwissProtID: Q13753...
Rabbit polyclonal to VEZT ( Abpromise for all tested applications). Antigen: Full length human VEZT conjugated to GST Entrez Gene ID: 55591 Swiss Protein ID: Q9HBM0...
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: