Navigation Links
Sex chromosome shocker: The 'female' X a key contributor to sperm production
Date:7/21/2013

CAMBRIDGE, Mass. -- Painstaking new analysis of the genetic sequence of the X chromosomelong perceived as the "female" counterpart to the male-associated Y chromosomereveals that large portions of the X have evolved to play a specialized role in sperm production.

This surprising finding, reported by Whitehead Institute scientists in a paper published online this week in the journal Nature Genetics, is paired with another unexpected outcome: despite its reputation as the most stable chromosome of the genome, the X has actually been undergoing relatively swift change. Taken together, these results suggest that it's time to reexamine the biological and medical importance of the X chromosome.

"We view this as the double life of the X chromosome," says Whitehead Institute Director David Page, whose lab conducted this latest research.

"The X is the most famous, most intensely studied chromosome in all of human genetics. And the story of the X has been the story of X-linked recessive diseases, such as color blindness, hemophilia, and Duchenne's muscular dystrophy," Page adds. "But there's another side to the X, a side that is rapidly evolving and seems to be attuned to the reproductive needs of males."

Page's lab, best known for its pioneering investigations of the Y chromosome, embarked on a rigorous comparison of the mouse and human X chromosomes, in part to test the longstanding biological tenet that the gene content of X chromosomes is conserved and shared across mammals. However, to render such a comparison valid, the lab had to upgrade the human X reference sequence, which was originally assembled as a mosaic of sequences from the X chromosomes of at least 16 people. This composite left the reference with errors and gaps that fail to capture so-called ampliconic regions containing segments of nucleotides that are virtually identical. Such near-complete identity prevents recognition of tiny but important differences.'/>"/>

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New therapy for fragile X chromosome syndrome discovered
2. Clues to chromosome crossovers
3. A closer look at chromosomes
4. NYU biologists identify proteins vital to chromosome segregation
5. Chromosome anchors organize DNA during cell division
6. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
7. Extra chromosome 21 removed from Down syndrome cell line
8. Western aspen trees commonly carry extra set of chromosomes
9. Study of fruit fly chromosomes improves understanding of evolution and fertility
10. Men can rest easy - sex chromosomes are here to stay
11. Discovery reveals chromosomes organize into yarns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
(Date:10/15/2014)... virus is spreading rapidly and to an unexpected extent. ... the past and the virus shows a new disease ... before. For this reason, the German National Academy of ... and Engineering, and the Union of the German Academies ... the Ebola epidemic today. , In the statement the ...
(Date:10/14/2014)... N.C. – Like discriminating thieves, prostate cancer tumors scavenge ... the body. But such avarice may be a fatal ... a way to kill prostate cancer cells by delivering ... selectively destroys the diseased cells brimming with the mineral, ... uses two drugs already commercially available for other uses, ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Prostate cancer's penchant for copper may be a fatal flaw 2
... PennsylvaniaOn Tuesday, August 3rd, as part of the ... a team of scientists will discuss the environmental ... Home to some of the most diverse habitats ... being permanently altered by mountaintop removal and valley ...
... elected ten new Fellows of the Society for 2010. ... one or more of the following: research, teaching, extension, ... Entomology 2010 -- ESA,s Annual Meeting -- which will ... Dr. Gary J. Blomquist received his B.S. degree in ...
... Stellwagen Bank National Marine Sanctuary, such as halibut and ... ago, according to a new NOAA report released today ... National Marine Sanctuaries Conservation Series report, "Stellwagen Bank Marine ... sanctuary that are resilient, but have suffered declines in ...
Cached Biology News:Ecologists to discuss impacts of mountaintop mining at special ESA symposium 2Ecologists to discuss impacts of mountaintop mining at special ESA symposium 3Entomological Society of America names 2010 Fellows 2Entomological Society of America names 2010 Fellows 3Entomological Society of America names 2010 Fellows 4Entomological Society of America names 2010 Fellows 5Entomological Society of America names 2010 Fellows 6Entomological Society of America names 2010 Fellows 7Entomological Society of America names 2010 Fellows 8Entomological Society of America names 2010 Fellows 9Top predators and biodiversity historically pressured in Stellwagen Bank National Marine Sanctuary 2
(Date:10/20/2014)... Oct. 20, 2014  GenVec, Inc. (NASDAQ: GNVC ... , Ph.D., from its board of directors effective on October ... 2003, and served as its chairman from June 2006 to ... Nominating and Corporate Governance and Audit Committees of the board.  ... a decade of dedicated service to GenVec, and its stockholders," ...
(Date:10/20/2014)... October 20, 2014 Earle ... LLC, announced today that Ellen Teplitzky, an experienced ... for the pharmaceutical industry, has joined the firm ... its legal services practice. NDA Partners provides ... witness and testimony, to top law firms and ...
(Date:10/19/2014)... October 20, 2014 OCTOBER ... Meeting (ABIM). ABIM will take place ... information about ABIM 2014 is now available ... Delegates representing companies and organizations from all ... obtain information on the latest products and ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Discovery and Validation of New Biomarker Panels , ... Medicine, Incorporated (RBM), the world,s leading multiplexed biomarker ... most comprehensive collection of quantitative immunoassays for use ... and diagnostic development. The new service, DiscoveryMAP(TM) v ...
... ... NC and will include additional stability storage space, additional retain sample storage, and a ... ... worldwide provider of long-term and short term storage of stability samples, sample management, and ...
... Oclaro, Inc. (Nasdaq: OCLR ) has ... biomedical and analytical instrumentation markets. Oclaro filters are used ... and analytical applications, including clinical diagnostics, drug discovery, gene ... from the Oclaro filter portfolio are on display at ...
Cached Biology Technology:Rules-Based Medicine, Inc. Launches DiscoveryMAP(TM) Service for Drug and Diagnostic Development 2Rules-Based Medicine, Inc. Launches DiscoveryMAP(TM) Service for Drug and Diagnostic Development 3Precision Stability Storage Announces Upcoming Expansion 2Precision Stability Storage Announces Upcoming Expansion 3Oclaro(TM) Hits Milestone With Clarity(TM) Fluorescence Filters 2Oclaro(TM) Hits Milestone With Clarity(TM) Fluorescence Filters 3