Navigation Links
Sex chromosome shocker: The 'female' X a key contributor to sperm production
Date:7/21/2013

CAMBRIDGE, Mass. -- Painstaking new analysis of the genetic sequence of the X chromosomelong perceived as the "female" counterpart to the male-associated Y chromosomereveals that large portions of the X have evolved to play a specialized role in sperm production.

This surprising finding, reported by Whitehead Institute scientists in a paper published online this week in the journal Nature Genetics, is paired with another unexpected outcome: despite its reputation as the most stable chromosome of the genome, the X has actually been undergoing relatively swift change. Taken together, these results suggest that it's time to reexamine the biological and medical importance of the X chromosome.

"We view this as the double life of the X chromosome," says Whitehead Institute Director David Page, whose lab conducted this latest research.

"The X is the most famous, most intensely studied chromosome in all of human genetics. And the story of the X has been the story of X-linked recessive diseases, such as color blindness, hemophilia, and Duchenne's muscular dystrophy," Page adds. "But there's another side to the X, a side that is rapidly evolving and seems to be attuned to the reproductive needs of males."

Page's lab, best known for its pioneering investigations of the Y chromosome, embarked on a rigorous comparison of the mouse and human X chromosomes, in part to test the longstanding biological tenet that the gene content of X chromosomes is conserved and shared across mammals. However, to render such a comparison valid, the lab had to upgrade the human X reference sequence, which was originally assembled as a mosaic of sequences from the X chromosomes of at least 16 people. This composite left the reference with errors and gaps that fail to capture so-called ampliconic regions containing segments of nucleotides that are virtually identical. Such near-complete identity prevents recognition of tiny but important differences.'/>"/>

Contact: Matt Fearer
fearer@wi.mit.edu
617-452-4630
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New therapy for fragile X chromosome syndrome discovered
2. Clues to chromosome crossovers
3. A closer look at chromosomes
4. NYU biologists identify proteins vital to chromosome segregation
5. Chromosome anchors organize DNA during cell division
6. From Mediterranean coasts to Tatra Mountains and beyond: Plant chromosome number variation
7. Extra chromosome 21 removed from Down syndrome cell line
8. Western aspen trees commonly carry extra set of chromosomes
9. Study of fruit fly chromosomes improves understanding of evolution and fertility
10. Men can rest easy - sex chromosomes are here to stay
11. Discovery reveals chromosomes organize into yarns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... the environmental effects of moorland burning is published today ... with the aim of relieving tensions on both sides ... EMBER (Effects of Moorland Burning on the Ecohydrology of ... moorland, which is practised predominantly to support red grouse ... peat hydrology, peat chemistry and physical properties, river water ...
(Date:9/30/2014)... have in common? Unlike most eukaryotic multicellular organisms ... these organisms are all polyploid, meaning they have three ... 3 and 4 sets of chromosomes, respectively, and strawberries ... fact most plant species are polyploid. Polyploidy, or genome ... only recently, with the development of molecular tools, has ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
Breaking Biology News(10 mins):Grouse moor burning causes widespread environmental changes 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... image of fossil gliding reptile Mecistrotrachelos apeoros. Curved foot ... of a previously unknown, 220 million-year-old long-necked, gliding reptile ... an industrial-size CT scanner at Penn State's Center for ... small creatures are now known. , The new ...
... at the University of Missouri-Columbia are studying the status ... in the state during the 18th and 19th centuries, ... the late 19th century. The results of the MU ... Conservation to help manage Missouri’s black bear population. , ...
... enough to keep an avian marriage together for the Nazca ... the coast of Ecuador. , Many Nazca booby females switch ... Forest University study scheduled for publication in the journal Proceedings ... , This is surprising because there is an advantage to ...
Cached Biology News:CT scan reveals ancient long-necked gliding reptile 2MU researchers to study the status of black bears in Missouri 2Study investigates 'divorce' among Galapagos seabirds 2
(Date:10/1/2014)... Oct. 1, 2014  Discovery Laboratories, Inc. (Nasdaq: ... awarded a Phase II Small Business Innovation Research ... from the National Institute of Allergy and Infectious ... (NIH) to support the development of the Company,s ... countermeasure to mitigate acute and chronic/late-phase radiation-induced lung ...
(Date:10/1/2014)... , Oct. 1, 2014  Spherix Incorporated (Nasdaq: ... fostering and monetization of intellectual property, announced today ... VTech and Uniden in the U.S. District Court ... has been rescheduled for November 10, ... 2, 2014.  The Court Order setting the Markman ...
(Date:10/1/2014)... (PRWEB) September 30, 2014 The participants ... designs, but to spending their own time adjusting, tweaking ... their complex designs were ready for judging. , “I ... design firm thought leader. “The entries showed a ... the physical characteristics of the print medium and the ...
(Date:10/1/2014)... Washington, USA (PRWEB) September 30, 2014 ... yet efficient arrangements that have evolved in nature over ... biomimetic and bioinspired materials for applications in biophotonics ... Biomedical Optics . The journal is published by SPIE, ... SPIE Digital Library. Several of the peer-reviewed articles are ...
Breaking Biology Technology:Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives SBIR Grant Valued up to $3.0 Million to Support Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3Markman Hearing Date for VTech and Uniden Litigation Now Set for November 10, 2014 2Array Architects Challenges Staff to Create with 3D Printer 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3
... Conference Call to be held on May 15, 2008 ... 8:00 am ... April 29 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ), ... and marketing biopharmaceutical,products, today announced that it will release ...
... real steps towards building a microscopic device that can ... Writing in the peer-reviewed publication, International Journal of Nanomanufacturing ... a nanoassembler. , In his 1986 book, The Engines ... aim of nanotechnology - to create an assembler, a ...
... Emisphere,Technologies, Inc. (Nasdaq: EMIS ) announced that ... the NASDAQ Stock Market (the "NASDAQ Letter"),advising that, ... Company,s,market value of listed securities had been below ... NASDAQ Global Market pursuant to,NASDAQ Marketplace Rule 4450(b)(1)(A). ...
Cached Biology Technology:3SBio Inc. Schedules 2008 First Quarter Earnings Release on Wednesday, May 14, 2008 2Are nanobots on their way? 2Are nanobots on their way? 3Emisphere Reports Receipt of Notification from NASDAQ Regarding Non-Compliance with Continued Listing Requirements 2Emisphere Reports Receipt of Notification from NASDAQ Regarding Non-Compliance with Continued Listing Requirements 3
For microscopy...
... that enables fully automated hybridization of microarrays ... has been designed to offer researchers improved ... to perform a wide range of applications. ... range 485C; denaturations of up to 99C. ...
... microarray slide processing offering reproducibility, reliability ... to miniaturization, automation and massive parallel ... tool with many applications in both ... range from gene expression profiling, gene ...
... The user-friendly Eppendorf Thermomixer R offers ... that require shaking, heating, and cooling. ... expanded its application and temperature control ... each accommodate 24 micro test tubes, ...
Biology Products: