Navigation Links
Several common differentially expressed genes between Kashin-Beck disease and Keshan disease
Date:9/14/2013

KD patients are similar, for example, most patients live in remote rural areas and the areas of awful transportation, have a meager income, and a simply diet. There is little research conducted to compare KBD and KD gene expression profiles. Therefore, the two diseases may have a further relationship at the molecular biology level.

In this study, the Agilent Human 1A Oligo microarray was used to compare gene expression profiles of peripheral blood mononuclear cells (PBMCs) between KBD or KD patients and healthy controls, and identified the common genes differentially expressed in both diseases groups. One hundred and thirty-six differentially expressed genes (53 up-regulated and 83 down-regulated) were identified between KBD and normal controls. Moreover, comparing KD and normal controls, 3310 differentially expressed genes (3154 up-regulated and 156 down-regulated) were identified. Comparing all identified differentially expressed genes, 16 genes showed differential expression in both diseases, including nine with synchronous and seven with asynchronous expression. These 16 genes were subdivided into 11 categories, namely metabolism, cytochrome enzymes, transcription-related, G-protein-related, receptor, cytokine factor, ion channel transport protein, signal transduction, hematopoietic related, interleukin, and immune-related.

The distribution of KBD and KD is in the similar geographical regions, although the clinical presentations and target pathological focus are not same. The common differentially expressed genes identified in both KBD and KD could be helpful to identify the potential mechanisms of the different organ lesions, caused by similar environmental risk factors, selenium deficiency. These findings make a great contribution towards clarifying the etiology and pathogenesis of KBD and KD.

The discovery of these common differentially expressed genes of KBD and KD was a collaborative effort involving many researchers from different institute
'/>"/>

Contact: GUO Xiong
guox@mail.xjtu.edu.cn
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Birds evolved ultraviolet vision several times
3. Single protein targeted as the root biological cause of several childhood psychiatric disorders
4. NASA satellite sees several western US fires blazing
5. UCLA researchers invent portable device for common kidney tests
6. Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows
7. Common autism supplement affects endocrine system
8. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
9. MacaInfo.org Offers In-Depth Answers the 20 Most Common Questions People Have about Maca
10. Toward broad-spectrum antiviral drugs for common cold and other infections
11. Complex genetic architectures: Some common symptoms of trisomy 21
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... a small, icy moon of Uranus, is one of ... solar system. Despite its relatively small size, Miranda appears ... resulted in the formation of at least three remarkable ... , These coronae are visible in Miranda,s southern ... across. Arden corona, the largest, has ridges and troughs ...
(Date:9/18/2014)... that can operate inside the bore of an MRI ... biomedical research partnership program at Brigham and Women,s Hospital ... robot, in conjunction with real-time MRI images, can make ... less discomforting for the patient. The novel system also ... greater precision. , Developed by a team of robotics ...
(Date:9/18/2014)... Station ever starts a "frequent flyers" program, fruit flies ... orbiting laboratory has hosted increasing numbers of fruit fly ... space station in April, and another is scheduled launch ... planned to launch in December. , Fruit flies are ... and in space. Model organisms can reveal the basis ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... with dogs and using the latest in imaging software and ... heart specialists have developed a fast and accurate means of ... the coronary arteries. Researchers say it took them less ... echocardiograms currently used to find early warning of vessels more ...
... approach, researchers at Children's Hospital Boston have demonstrated that ... a heart attack and protect the heart from scarring. ... a natural inhibitor of cell division with a naturally ... Together, these two agents enabled heart-muscle cells to multiply ...
... Researchers at the Salk Institute for Biological Studies in collaboration ... took a high resolution "action shot" of a protein switch ... nervous system. Their findings, published in the Dec. 8 issue ... design of small molecule inhibitors to control that switch, a ...
Cached Biology News:Fast test for low blood flow in dogs detects early heart trouble 2Fast test for low blood flow in dogs detects early heart trouble 3Fast test for low blood flow in dogs detects early heart trouble 4Rescuing injured hearts by enhancing regeneration 2Rescuing injured hearts by enhancing regeneration 3Detailed 3-D image catches a key regulator of neural stem cell differentiation in action 2Detailed 3-D image catches a key regulator of neural stem cell differentiation in action 3
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review ... PharmaBoardroom.com for free download , looks beyond ... economy in 2009, and the austerity measures that followed, to ... times of trouble. "Despite the crisis, ... and the general conditions to invest are favorable to the ...
(Date:9/18/2014)... 2014 About POCT ... a clinical laboratory. It helps in making fast ... and medication. POCT is gaining popularity due to ... such as diabetes, heart disease, and obesity. It ... standardized to minimize errors during the diagnosis of ...
(Date:9/18/2014)... HARBOR, Mich. , Sept. 18, 2014  Health Enhancement ... biotech firm investigating early-stage algae bioactive compounds and metabolic processes, ... to the company,s board of directors. Ms. Nola E. ... and investment advisor joined the board effective September 17, 2014. ... Ms. Masterson agree to join our board," states Andrew ...
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3POCT Market in China 2014-2018 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... , New GeneConnection discovery microarrays provide more than 4,000 unique,human cDNA sequences ... a series of human cDNA microarrays on , ... which are based on the technology published by Schena et , ... monitoring RNA expression levels , of genes. ...
... with standardized clones , , Rebecca L. ... Wynne Vilma Nioko ,Leonardo DeLeon SanDEe Soares ... Spencer Stevens Chris Hansen Brian Schilling ,Phenogenex ... a single dual- expression vector. These clones eliminate the ...
... fast and easy detection of mycoplasma,contamination , ... Staggs ,Genetic Applications LLC , Heinz Miller ,Stratagene , ... potency of transfection reagents. 1 Cells must be ... ,transfection reagent and ...
Cached Biology Technology:Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 2Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 3Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and,Discover New Genes 4Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression,Vector 2Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression,Vector 3Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression,Vector 4Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression,Vector 5Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression,Vector 6Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 2Mycoplasma Contamination Reduces the Effect of Lipid-Mediated Transfection,of Mammalian Cells 3
... is the most advanced thermal cycler ever ... performance, the Dyad also boasts graphical programming ... navigation via touch pad or mouse. ... economically expanded to a four-bay system with ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... that made the original Gene Pulser apparatus and ... has been applied in the Gene Pulser II ... design of the Gene Pulser II system has ... has the widest range of settings to target ...
... Experion Pro260 reagents and supplies, for ... supplies sufficient to perform protein analysis ... automated electrophoresis system. Supplied are 3 ... microliters Pro260 stain, 60 microliters Pro260 ...
Biology Products: