Navigation Links
Several common differentially expressed genes between Kashin-Beck disease and Keshan disease
Date:9/14/2013

KD patients are similar, for example, most patients live in remote rural areas and the areas of awful transportation, have a meager income, and a simply diet. There is little research conducted to compare KBD and KD gene expression profiles. Therefore, the two diseases may have a further relationship at the molecular biology level.

In this study, the Agilent Human 1A Oligo microarray was used to compare gene expression profiles of peripheral blood mononuclear cells (PBMCs) between KBD or KD patients and healthy controls, and identified the common genes differentially expressed in both diseases groups. One hundred and thirty-six differentially expressed genes (53 up-regulated and 83 down-regulated) were identified between KBD and normal controls. Moreover, comparing KD and normal controls, 3310 differentially expressed genes (3154 up-regulated and 156 down-regulated) were identified. Comparing all identified differentially expressed genes, 16 genes showed differential expression in both diseases, including nine with synchronous and seven with asynchronous expression. These 16 genes were subdivided into 11 categories, namely metabolism, cytochrome enzymes, transcription-related, G-protein-related, receptor, cytokine factor, ion channel transport protein, signal transduction, hematopoietic related, interleukin, and immune-related.

The distribution of KBD and KD is in the similar geographical regions, although the clinical presentations and target pathological focus are not same. The common differentially expressed genes identified in both KBD and KD could be helpful to identify the potential mechanisms of the different organ lesions, caused by similar environmental risk factors, selenium deficiency. These findings make a great contribution towards clarifying the etiology and pathogenesis of KBD and KD.

The discovery of these common differentially expressed genes of KBD and KD was a collaborative effort involving many researchers from different institute
'/>"/>

Contact: GUO Xiong
guox@mail.xjtu.edu.cn
Science China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
2. Birds evolved ultraviolet vision several times
3. Single protein targeted as the root biological cause of several childhood psychiatric disorders
4. NASA satellite sees several western US fires blazing
5. UCLA researchers invent portable device for common kidney tests
6. Trust in leaders, sense of belonging stir people to safeguard common goods, analysis shows
7. Common autism supplement affects endocrine system
8. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
9. MacaInfo.org Offers In-Depth Answers the 20 Most Common Questions People Have about Maca
10. Toward broad-spectrum antiviral drugs for common cold and other infections
11. Complex genetic architectures: Some common symptoms of trisomy 21
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... 2014   News Highlights: ... develop The Partners Data Lake, an agile data ... Lake will allow researcher and clinicians to explore ... the lives of patients , The Partners ... across the Partners system, breaking down physical barriers ...
(Date:11/15/2014)... YORK , Nov. 13, 2014  While we may ... technology Doctor McCoy used in "Star Trek" to gain instant ... tools designed to work with smartphones and tablets for monitoring ... of the healthcare world. This may seem a tad Orwellian ... ready to adopt some of these technological opportunities into their ...
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
Breaking Biology News(10 mins):Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Study finds laundry detergent pods, serious poisoning risk for children 2
... - In the July issue of Biomaterials , ... Florida (UCF) report on the first lab-grown motor nerves ... in the human body. The model system will ... such as diabetic neuropathy and later, possibly multiple sclerosis ...
... (BOSTON) July 21, 2009 - A menace to ... the World Organisation for Animal Health (OIE) has declared ... cattle-killing disease that threatened its food supply and its ... July 25, 2009. A team from Tufts University,s ...
... , This release is available in German ... enriching samples, then separating, identifying, and counting the bacteria. This ... arrival of the sample in the laboratory. Tests that work ... being precise and error-free, are thus high on the wish ...
Cached Biology News:Researchers design first model motor nerve system that's insulated and organized like the human body 2Ethiopian government celebrates rinderpest eradication 2Ethiopian government celebrates rinderpest eradication 3Reveal the enemy 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... , , Collaboration to Create Optimized Antibodies ... Cancer , MISSISSAUGA, ON, Dec. 10 /PRNewswire-FirstCall/ - YM ... results of a collaborative program between YM and the ... Institute (NRC-BRI). Utilizing YM,s IntelliMab(TM) technology, the program is ...
... challenges miniaturizing transistors, the key active components in nearly ... or switch electronic signals. Now, ... and Applied Science, Purdue University and IBM have successfully ... transistors. These nanowires which ...
... - Sirius Genomics, a developer of pharmacogenomic diagnostics, announced today ... Officer, replacing Dr. Brad Popovich. , "We want to thank ... the last four years. Brad has taken the Company from ... of time. Brad has also managed to recruit one of ...
Cached Biology Technology:YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 2YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 3YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 4YM BIOSCIENCES AND THE NATIONAL RESEARCH COUNCIL OF CANADA BIOTECHNOLOGY RESEARCH INSTITUTE (NRC-BRI) PRODUCE NEW BREAST CANCER DRUG CANDIDATES 5New silicon-germanium nanowires could lead to smaller, more powerful electronic devices 2New silicon-germanium nanowires could lead to smaller, more powerful electronic devices 3Sirius Genomics Announces Change in Leadership 2
A component of the Acridinium protein labeling kit....
... Acridinium NHS ester can ... and nucleic acids. The covalently ... produce chemiluminescence in the presence ... ester-labeled proteins can be used ...
... cytometry accessible to anyone in the lab. Novice ... to Guavas on-demand microcapillary flow cytometry systems ... surprisingly affordable, very compact, and nicely equipped with ... EasyCyte Mini has all of the functionality of ...
... real-time PCR detection system holds 48 x 0.2 ml ... LEDs independently excites fluorescence (470-500 nm) for each well, ... (523-543 nm and 540-700 nm). This item is a ... cycler. System dimensions are 18 x 32 x 33 ...
Biology Products: