Navigation Links
Scripps physicians call for change in cancer tissue handling
Date:1/4/2013

SAN DIEGO Genetic sequencing technology is altering the way cancer is diagnosed and treated, but traditional specimen handling methods threaten to slow that progress.

That's the message delivered this week in a column appearing in the Journal of the American Medical Association (JAMA) by Scripps Clinic physicians Eric Topol, Kelly Bethel and Laura Goetz.

Dr. Topol is a cardiologist who serves as chief academic officer of Scripps Health and director of the Scripps Translational Science Institute (STSI), leading Scripps' genomic medicine research efforts. Dr. Bethel is a pathologist, and Dr. Goetz is a general surgeon and a researcher at STSI.

"Deciding how best to obtain (tumor) samples and how best to process them for whole genome or exome sequencing is a pivotal yet unresolved issue with several layers of complexity," the doctors wrote. "As the new clinical applicability of genomics emerges at a fairly rapid rate, the field of pathology will arrive at a tipping point for a fundamental change in how cancer specimens are handled."

Currently, tumor tissue obtained through a biopsy is fixed in formalin, a mixture of formaldehyde and water, and embedded in paraffin for microscopic viewing. However, because the chemical mixture damages DNA, sequencing tissue processed in this way can be difficult, if not impossible.

A better alternative is to also routinely freeze a portion of the specimen, which retains the tissue's genetic coding while preserving it for future analysis. In order to have enough tissue to freeze, larger or additional biopsy samples may be required, especially when using minimally invasive needle biopsy procedures.

"We need to completely rethink the way we have collected and stored cancer tissue samples for decades," said Dr. Topol, "It's becoming increasingly clear that obtaining an accurate map of a tumor's DNA can be the key to determining the specific mutations that are driving
'/>"/>

Contact: Keith Darce
darce.keith@scrippshealth.org
858-678-7121
Scripps Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... YORK , June 24, 2015 The ... rate. The major drivers for the market include growth ... number of new drug launches. Over the years, the ... increased. Between 2001 and 2010, the FDA approved 225 ... according to WIPO, Europe accounted ...
(Date:6/24/2015)... , June 22, 2015 ... the addition of the "Huawei Ascend Mate ... report to their offering. Huawei,s technological ... the opposite direction than Apple,s and Samsung,s one. ... sensor developed by Fingerprint Cards, a main actor ...
(Date:6/23/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/vq2k2f/bodyworn ... "Body-Worn Temperature Sensors Market - Global Industry Analysis, ... 2020" report to their offering. ... body-worn temperature sensors market. The global body-worn temperature ... of types, care setting, patient demographic, applications and ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... brain, but they also leave behind in the bloodstream a ... the future to direct better treatment for schizophrenia and other ... study is among the first to use metabolomics -- the ... processes -- to look at a psychiatric disease and its ...
... Research Institute on Addictions (RIA) is investigating the “brain’s ... stress, stress-related behavior and anxiety. , A five-year, $1.7 ... is supporting this investigation. , “It is widely ... use and abuse marijuana is to relieve stress,?according to ...
... generators (dopaminergics) in brain cells has produced improvement in ... tests carried out with monkeys by the Navarra University ... at the Hospital and at the other Navarra University-based ... , The results have been published in the latest ...
Cached Biology News:Chemical maps hint at drug's effects on schizophrenia 2Chemical maps hint at drug's effects on schizophrenia 3Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys 2Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys 3
(Date:7/1/2015)... BANGALORE, India , July 1, 2015 ... that uses next generation sequencing technology to empower cancer ... Storrer as chief executive officer. In his expanded ... responsible for all strategy, business expansion and worldwide operations ... served as Strand,s chairman and CEO since its founding ...
(Date:7/1/2015)... , July 1, 2015  Axovant Sciences ... focused on the treatment of dementia, today announced ... on July 22 at 5:45 p.m. EDT following ... Alzheimer,s Association International Conference 2015 (AAIC). ... , Dr. Lawrence Friedhoff , ...
(Date:7/1/2015)... ... ... A newly launched business plan contest will ask startup companies from around the ... R&D. The Pistoia Alliance President’s Startup Challenge 2015 will see small and medium enterprises ... mentorship from a senior industry figure drawn from the Pistoia Alliance membership. , The ...
(Date:7/1/2015)... ... , ... Apex Therapeutics announced today that company CEO, David Broecker provided a ... The presentation took place on Tuesday, June 16 and provided an update on the ... the treatment of pancreatic cancer. A copy of the company overview can be ...
Breaking Biology Technology:Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2
... AMN Healthcare Services,Inc. (NYSE: AHS ), the ... its quarterly conference call to discuss second quarter,results on ... The,company expects to issue an earnings news release also ... Time., A live webcast of the call can ...
... Management and New Leaf Venture Partners Commit To Purchase ... Subsidiary of $200 to $300 Million ... to Reduce Angiotech Debt, VANCOUVER, July 7 /PRNewswire-FirstCall/ ... a global specialty pharmaceutical and,medical device company, today announced ...
... July 4 ,Shire Limited (LSE:SHP, NASDAQ: SHPGY), the global ... 31 July 2008, Results press release will ... 07:00 EDT Investor meeting and conference call time: ... Analyst meeting and conference call:, Angus Russell, Chief ...
Cached Biology Technology:AMN Healthcare Services to Host 2008 Second Quarter Earnings Conference Call on Wednesday, August 6, 2008 2Angiotech to Establish Separate Operating and Royalty Businesses 2Angiotech to Establish Separate Operating and Royalty Businesses 3Angiotech to Establish Separate Operating and Royalty Businesses 4Angiotech to Establish Separate Operating and Royalty Businesses 5Angiotech to Establish Separate Operating and Royalty Businesses 6Angiotech to Establish Separate Operating and Royalty Businesses 7Angiotech to Establish Separate Operating and Royalty Businesses 8Angiotech to Establish Separate Operating and Royalty Businesses 9Angiotech to Establish Separate Operating and Royalty Businesses 10Angiotech to Establish Separate Operating and Royalty Businesses 11Angiotech to Establish Separate Operating and Royalty Businesses 12Angiotech to Establish Separate Operating and Royalty Businesses 13Angiotech to Establish Separate Operating and Royalty Businesses 14Shire Ltd - Second Quarter 2008 Results Date Notification - 31 July 2008 2
Request Info...
2 ml SmartScan Racks...
Leptin Receptor Polyclonal Ab 100 ug purified rabbit anti-mouse Leptin Receptor. Tested in Western blotting....
... The EC135-90 is a compact, highly versatile ... volts and 500 milliamps, this power supply is ... gels as well as all types of small ... in constant voltage or constant current with a ...
Biology Products: