Navigation Links
Scripps physicians call for change in cancer tissue handling
Date:1/4/2013

SAN DIEGO Genetic sequencing technology is altering the way cancer is diagnosed and treated, but traditional specimen handling methods threaten to slow that progress.

That's the message delivered this week in a column appearing in the Journal of the American Medical Association (JAMA) by Scripps Clinic physicians Eric Topol, Kelly Bethel and Laura Goetz.

Dr. Topol is a cardiologist who serves as chief academic officer of Scripps Health and director of the Scripps Translational Science Institute (STSI), leading Scripps' genomic medicine research efforts. Dr. Bethel is a pathologist, and Dr. Goetz is a general surgeon and a researcher at STSI.

"Deciding how best to obtain (tumor) samples and how best to process them for whole genome or exome sequencing is a pivotal yet unresolved issue with several layers of complexity," the doctors wrote. "As the new clinical applicability of genomics emerges at a fairly rapid rate, the field of pathology will arrive at a tipping point for a fundamental change in how cancer specimens are handled."

Currently, tumor tissue obtained through a biopsy is fixed in formalin, a mixture of formaldehyde and water, and embedded in paraffin for microscopic viewing. However, because the chemical mixture damages DNA, sequencing tissue processed in this way can be difficult, if not impossible.

A better alternative is to also routinely freeze a portion of the specimen, which retains the tissue's genetic coding while preserving it for future analysis. In order to have enough tissue to freeze, larger or additional biopsy samples may be required, especially when using minimally invasive needle biopsy procedures.

"We need to completely rethink the way we have collected and stored cancer tissue samples for decades," said Dr. Topol, "It's becoming increasingly clear that obtaining an accurate map of a tumor's DNA can be the key to determining the specific mutations that are driving
'/>"/>

Contact: Keith Darce
darce.keith@scrippshealth.org
858-678-7121
Scripps Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... Calif. , March 12, 2015 WHEN:Tuesday, ... Complimentary Registration here: http://bit.ly/1G7Os0L . SPEAKERS: , ... Aravind SeshagiriPhoto - http://photos.prnewswire.com/prnh/20150311/181111 ... order to compete in several different markets and ... is currently witnessing an uptrend. ...
(Date:3/10/2015)... 10, 2015   Tute Genomics , pioneer in ... by next-generation sequencing company PrimBio Research Institute ... targeted gene panel interpretation. PrimBio, a certified ... most current technologies to support the work of experts ... offers two types of exome sequencing services: 1) Targeted ...
(Date:3/2/2015)... 2, 2015 Synaptics Inc. (NASDAQ: ... interface solutions, today announced a new implementation of ... enable rapid and secure transactions and reliable identification ... is a turnkey solution providing mouse and keyboard ... integrate fingerprint ID solutions into their product offerings, ...
Breaking Biology News(10 mins):Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 2PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 3Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3
... Soybean production has continued to increase in the Northeast ... the crop and many experienced growers planting alongside corn crops. ... with a corn planter in 30-inch rows instead of 7.5-inch ... a Cornell University scientist, investigated the response of two soybean ...
... L. Boren announced today that OU is establishing an ... expertise to benefit Oklahoma and the nation, including emerging ... led by a national expert, who will be appointed ... million gift from Corix, a multi-utility infrastructure company, which ...
... grant totaling $2.2 million shows how the University of ... using technology to advance the cutting-edge field of personalized ... their genetic make-up. The grant also highlights the ... Institute (CCTSI) to bring scientific discoveries to the bedside ...
Cached Biology News:OU establishes a new water and sustainability institute 2OU establishes a new water and sustainability institute 3Personalizing medicine 2Personalizing medicine 3
(Date:4/1/2015)... 01, 2015 National recruitment firm ... of Brad Allen as Head of Sales at Optimal ... system market. , Allen brings over 20 years ... at a number of companies including Dell Services Healthcare, ... experience were a perfect fit for accomplishing the goals ...
(Date:3/31/2015)... 2015 Eastern Kentucky University is ... bachelor’s of criminal justice degree programs by Nonprofitcollegesonline.com. ... inspiring ideas and high quality educational opportunities,” Editor ... University. We are confident that students will find ... is the site’s first “Students before Profits” list, ...
(Date:3/31/2015)... 2015   Mapi expands Pharmacovigilance and ... and global Risk Management strength with the expanded ... acquisition . Pharmacovigilance and ... global team that includes physicians, pharmacists, and numerous ... in navigating complex safety requirements throughout the product ...
(Date:3/31/2015)... 31, 2015 Today, Cryos International, the ... of their U.S. facilities and inventory from New York ... of experience, Cryos’ relocation is a reflection of their ... to Orlando was completed during the first weekend of ... taking place on April 6. The new facility in ...
Breaking Biology Technology:Slone Partners Fills Head of Sales at Optimal Medicine 2EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2
... decades X-ray crystallography has been fundamental in the development ... the structure and function of many biological molecules, including ... However, in order to obtain good data, large ... to grow. There also is the problem that ...
... SOUTH SAN FRANCISCO, Calif., Feb. 21, 2012 Onyx Pharmaceuticals, Inc. ... at four investor conferences in February and March. ... 2012 Citi Global Healthcare Conference on Monday, February 27, 2012 at ... Cowen and Company 32nd Annual Health Care Conference Onyx ...
... Inc. (Nasdaq: CDXS ), a developer of ... chemicals, and pharmaceutical intermediates, today announced that Peter Strumph, ... Jefferies Global Clean Technology Conference, to be held in ... 1:45 p.m. ET. A live webcast and replay will ...
Cached Biology Technology:Scientists learn how to 'out run damage' with imaging technique 2Onyx Pharmaceuticals to Present at Upcoming Investor Conferences 2
...
Anti-VDAC (Voltage-Dependent Anion Channel) AVOID FREEZE/THAW CYCLES. Recognizes the porin 31HL protein. Corresponds to mAb 1 in the literature....
This spacer is required to use the Miniature FRENCH Pressure Cell (FA-003) with the Laboratory Press....
... Amplification Grade digests single- ... oligodeoxyribonucleotides. The specific activity ... I Amplification Grade is ... for absence of RNase ...
Biology Products: