Navigation Links
Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
Date:1/12/2010

LA JOLLA, CAJanuary 12, 2010In 1993 researchers discovered a chemical compound in a sponge off Palau, an island nation in the Pacific Ocean, that has shown anticancer, antibacterial, and antifungal pharmaceutical promise. But that wasn't its greatest allure, at least not for chemists.

This compound, called Palau'amine, is so chemically complex that finding a way to produce it in the laboratory became the most hotly pursued synthetic chemistry goal in modern history. Groups around the globe dedicated millions to the challenge, but it is a team of scientists from The Scripps Research Institute that has finally completed the quest.

Anonymous reviewers of the team's paper describing the achievement, which will be published as the cover article of an upcoming edition of the international journal Angewandte Chemie, called the work variously "a masterpiece," "spectacular," "a landmark," and "a spectacular synthetic achievement including unprecedented and previously 'unthinkable' transformations."

An Exquisite Target

Synthesizing Palau'amine is a daunting task because of two main features. First, it has a molecular framework with inner connections so bizarre that chemists have been taught in graduate school that they can't exist in nature. The most striking feature is a combination of two carbon rings sprinkled with nitrogen atoms that bond in a way that puts phenomenal strain on the molecule.

"It's so contorted that you wouldn't expect it to be possible," says Scripps Research chemist Phil Baran, Ph.D., who led the team that made the breakthrough.

To add to the fun, Palau'amine is exceedingly fragile. For instance it falls apart if exposed to the wrong pH level. All told, developing a synthesis method proved to be the chemical equivalent of a treasure hunt through booby-trapped terrain where one false move sends the quarry up in smoke.

Baran's lab had been working on the Palau'amine challenge
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
2. Scripps research team develops technique to determine ethnic origin of stem cell lines
3. Scripps Research scientists crack mystery of proteins dual function
4. Scripps Research team uncovers chemical basis for extra quality control in protein production
5. Scripps research scientists find new link between insulin and core body temperature
6. Scripps-led study shows ocean health plays vital role in coral reef recovery
7. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
8. Scripps studies offer new picture of Lake Tahoes earthquake potential
9. Scripps scientists help decode mysterious green glow of the sea
10. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
11. Scripps research scientists watch as individual alpha-synuclein proteins change shape
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... A new study shows that legume plants regulate ... cytokininssignaling molecules that are transmitted through the plant ... the number of bacteria-holding nodules in the roots. ... the National Institute for Basic Biology, the Graduate ... Center for Sustainable Resource Science in Japan. ...
(Date:9/18/2014)... located deep in the primitive brainstem has revealed how ... Harvard School of Medicine and the University at Buffalo ... the second "sleep node" identified in the mammalian brain ... to produce deep sleep. , Published online in August ... fully half of all of the brain,s sleep-promoting activity ...
(Date:9/18/2014)... robotic system that can operate inside the bore of ... of a biomedical research partnership program at Brigham and ... if the robot, in conjunction with real-time MRI images, ... costly, and less discomforting for the patient. The novel ... therapies with greater precision. , Developed by a team ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... is available in French . Quebec ... Nova Scotia Agricultural College, have discovered what causes Christmas tree ... of Christmas trees in homes. The authors presented their findings ... . The researchers have identified a plant hormoneethyleneresponsible for ...
... California, San Diego developed an explanation for why some ... brains of people with Alzheimer,s disease. These insights, published ... 21, come from detailed models of brain energy metabolism ... San Diego Jacobs School of Engineering. The ...
... whales that sink down to the seafloor provide a ... Previous research suggested that such "whale falls" were homes ... sinking five whale carcasses in Monterey Canyon, researchers from ... most of the animals at these sites were not ...
Cached Biology News:Researchers discover a way to delay Christmas tree needle loss 2Metabolism models may explain why Alzheimer's disease kills some neuron types first 2Metabolism models may explain why Alzheimer's disease kills some neuron types first 3Fleshing out the life histories of dead whales 2Fleshing out the life histories of dead whales 3Fleshing out the life histories of dead whales 4
(Date:9/21/2014)... first time, scientists have discovered how to produce ultra-thin ... stiffness greater than that of today,s strongest nanotubes and ... team led by John V. Badding, a professor of ... the 21 September 2014 issue of the journal ... view, our discovery is intriguing because the threads we ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 ... urological and interventional radiology products and services, has ... subsidiary with Clinicon Corporation for its ... HealthTronics’ portfolio of minimally invasive, mobile, surgical technology—offering ... , Under the agreement, HealthTronics will make available ...
(Date:9/19/2014)... From crop yields to disease risks, the biological characteristics ... traits." Just as for heightthe textbook example of a ... are shaped by multiple genetic and environmental influences, making ... down such genes, geneticists typically mate two individuals that ... a small mouseand then study their descendents, looking for ...
(Date:9/19/2014)... Follow us on LinkedIn ... the world has attracted diverse players including academic ... The early years of nanotechnology development was dominated ... the high risks involved, which deterred private and ... evolving technology have been growing over the years, ...
Breaking Biology Technology:Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4
... ROCKVILLE, Md., Dec. 9 EntreMed, Inc.,(Nasdaq: ... for the treatment of cancer and inflammatory diseases, ... study of ENMD-2076 in refractory,multiple myeloma patients. The ... Melvin and Bren Simon Cancer Center, Indianapolis, ...
... selected as the most promising biotech start-up company at ... which uses a proprietary process to convert wastewater from ... animal feed, was given top honors out of 22 ... capitalists: one from the sponsoring Colorado law firm of ...
... XTL,Biopharmaceuticals Ltd. (Nasdaq: XTLB ; TASE: ... the failure of the Bicifadine Phase 2b,clinical trial. The ... of its workforce. The remaining employees will be,responsible ... into XTL, or,for assisting in the liquidation and/or disposition ...
Cached Biology Technology:EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma 2EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma 3EntreMed Initiates ENMD-2076 Clinical Trial in Multiple Myeloma 4Oberon FMR Wins Top Prize at BioWest 2008 Venture Showcase Competition 2Oberon FMR Wins Top Prize at BioWest 2008 Venture Showcase Competition 3Oberon FMR Wins Top Prize at BioWest 2008 Venture Showcase Competition 4Oberon FMR Wins Top Prize at BioWest 2008 Venture Showcase Competition 5
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
... Stand-96 is designed for paramagnetic bead precipitation ... ml PCR plates with no additional accessories. ... in a standard SBS 96-well microplate footprint. ... magnets guarantees easy and fast (as little ...
... circular clear acrylic chamber for complete visibility ... features microprocessor operation for precise mixing capability. ... Carousel rotates at 11 rpm; manufactured ... , Bottle Capacity - four 35 ...
Biology Products: