Navigation Links
Scripps Research team uncovers chemical basis for extra 'quality control' in protein production
Date:12/9/2009

LA JOLLA, CA December 9, 2009 Even small errors made by cells during protein production can have profound disease effects, and nature has developed ways to uncover these mistakes and correct them. Though in the case of one essential protein building blockthe amino acid alaninenature has been extra careful, developing not one, but two checkpoints in her effort to make sure that this component is used correctly.

Now, scientists at The Scripps Research Institute have discovered the chemical basis for why these extraordinary efforts are necessary. The work was published in the December 10, 2009 issue of the prestigious journal Nature.

"What is shown here with the 'serine paradox' is just the tip of the iceberg," said senior author Paul Schimmel, who is the Ernest and Jean Hahn Professor and Chair of Molecular Biology and Chemistry and a member of The Skaggs Institute for Chemical Biology at Scripps Research. "In the coming years, there will be an increasing awareness of the role of mistranslation in human diseases and of how nature has struggled to find solutions to attenuate mistranslation and its consequences."

Spelling with Amino Acids and Proofreading for Errors

As letters of the alphabet spell out words, when amino acids are linked to one another in a particular order they "spell out" proteins. When amino acids are put in the wrong order, "spelling errors" (mistranslations) occur, often with devastating consequences for the health of the organism.

Normally, small RNA molecules, called transfer RNAs (tRNAs), transport specific amino acids to the ribosomes, the protein factories of cells, so that amino acids can be added to their correct place in a growing chain. At the beginning of this process, 20 tRNA enzymes, one for each of the 20 common amino acids, select the proper amino acid to be transported by a tRNA and join them together.

However, as Senior Research Associate Min Guo of the Schi
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps research scientists find new link between insulin and core body temperature
2. Scripps-led study shows ocean health plays vital role in coral reef recovery
3. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
4. Scripps studies offer new picture of Lake Tahoes earthquake potential
5. Scripps scientists help decode mysterious green glow of the sea
6. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
7. Scripps research scientists watch as individual alpha-synuclein proteins change shape
8. Scripps research team identifies key molecules that inhibit viral production
9. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Scripps scientists develop first examples of RNA that replicates itself indefinitely
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... is available in German . ... sperms every day in order to reproduce? And why are ... topic of the latest issue of the research journal ... evolutionary biologist Steven Ramm from Bielefeld University Bielefeld has compiled ... not unusual for a female to copulate with several males ...
(Date:10/16/2014)... war on the human body. Battles are won, ... pancreatic cancer, this stalemate—known as tumor dormancy—can last ... a phenomena that is poorly understood. , ... of Salvatore Torquato, a Professor of Chemistry at ... tumor dormancy and the switch to a malignant ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Sperm wars 2Modeling tumor dormancy 2
... A new grant from the National Institute of Biomedical ... of Health (NIH), will provide funding for University of ... novel bioreactor system that will control mechano-electrochemical environment for ... properties of engineered tissues. The two-year, $735,000 grant will ...
... Il. A key statistic that consumer groups and ... national rankings can be misleading, researchers report in a new ... number above 1.0 indicates a hospital had more deaths than ... were fewer than the expected number of deaths. The ...
... Aquaculture, once a fledgling industry, now accounts for 50 percent ... by an international team of researchers. And while the industry ... significant strain on marine resources by consuming large amounts of ... authors conclude. Their findings are published in the Sept. 7 ...
Cached Biology News:University of Miami receives NIH grant to support novel technology for tissue engineering 2Treating bone loss in breast cancer survivors 2Half of the fish consumed globally is now raised on farms, study finds 2Half of the fish consumed globally is now raised on farms, study finds 3
(Date:10/25/2014)... (PRWEB) October 24, 2014 This ... PHA, PBS, Starch Based Plastics, Regenerated Cellulose, PCL), ... Global Trends and Forecasts to 2019”, defines and ... analysis and forecast of its global volume and ... 54 Figures spread through 178 Slides and in-depth ...
(Date:10/25/2014)... Oramed Pharmaceuticals Inc. (NASDAQCM: ORMP) ... the development of oral drug delivery systems, announced today ... present at FireRock Capital,s Micro-Cap Conference. ... Tuesday, October 28, 2014 ,Time: 9:15am EST ,Location: The ... , About The FireRock Conference  ...
(Date:10/25/2014)... ... the addition of the  "The Global Market ... Nanomaterials "  report to their offering.  ... graphene are the strongest, lightest and most ... performance-per-weight greater than any other material. In ...
(Date:10/22/2014)... The North American crystal oscillator market report defines ... and forecast of revenue. This market was valued at ... $623.6 million by 2018, at a CAGR of 3.3% ... of the North American crystal oscillator market report, to ... also provides a glimpse of the segmentation of the ...
Breaking Biology Technology:Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4Oramed to Present at the FireRock Annual Micro-Cap Conference 2Oramed to Present at the FireRock Annual Micro-Cap Conference 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4
... and biochemistry at The University of Texas at Austin, ... with Professor William Moerner of Stanford University. , The ... Tamir, was given to the two scientists for their ... and imaging. , The $100,000 prize will be presented ...
... service revenue of $238.7 million grows 32% year-over-year, - Operating ... - Backlog increases 41% ... - Net quarterly book-to-burn ratio equates ... PRXL ) today announced its financial results for the,second quarter ended ...
... of Family Cord Blood Banks, LOS ANGELES, ... of California Cryobank, today announced that its co-founder ... appointed to the Department,of Health and Human Services, ... on Blood Stem Cell Transplantation,(ACBSCT). Through his appointment, ...
Cached Biology Technology:PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 2PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 3PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 4PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 5PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 6PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 7PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 8PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 9PAREXEL Reports Second Quarter Fiscal Year 2008 Financial Results 10Dr. Charles A. Sims of California Cryobank's Family Cord Blood Services Named to National Stem Cell Advisory Council 2Dr. Charles A. Sims of California Cryobank's Family Cord Blood Services Named to National Stem Cell Advisory Council 3
ANTI GELSOLIN...
...
... is intended for the derivation of ... in serum-free conditions. ... Clonal Grade Medium Basal Medium ... Trypsin Solution Gelatin Solution Complete Freezing ...
Template and primers for preparation of internal control spots...
Biology Products: