Navigation Links
Scripps Research team uncovers chemical basis for extra 'quality control' in protein production
Date:12/9/2009

LA JOLLA, CA December 9, 2009 Even small errors made by cells during protein production can have profound disease effects, and nature has developed ways to uncover these mistakes and correct them. Though in the case of one essential protein building blockthe amino acid alaninenature has been extra careful, developing not one, but two checkpoints in her effort to make sure that this component is used correctly.

Now, scientists at The Scripps Research Institute have discovered the chemical basis for why these extraordinary efforts are necessary. The work was published in the December 10, 2009 issue of the prestigious journal Nature.

"What is shown here with the 'serine paradox' is just the tip of the iceberg," said senior author Paul Schimmel, who is the Ernest and Jean Hahn Professor and Chair of Molecular Biology and Chemistry and a member of The Skaggs Institute for Chemical Biology at Scripps Research. "In the coming years, there will be an increasing awareness of the role of mistranslation in human diseases and of how nature has struggled to find solutions to attenuate mistranslation and its consequences."

Spelling with Amino Acids and Proofreading for Errors

As letters of the alphabet spell out words, when amino acids are linked to one another in a particular order they "spell out" proteins. When amino acids are put in the wrong order, "spelling errors" (mistranslations) occur, often with devastating consequences for the health of the organism.

Normally, small RNA molecules, called transfer RNAs (tRNAs), transport specific amino acids to the ribosomes, the protein factories of cells, so that amino acids can be added to their correct place in a growing chain. At the beginning of this process, 20 tRNA enzymes, one for each of the 20 common amino acids, select the proper amino acid to be transported by a tRNA and join them together.

However, as Senior Research Associate Min Guo of the Schi
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps research scientists find new link between insulin and core body temperature
2. Scripps-led study shows ocean health plays vital role in coral reef recovery
3. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
4. Scripps studies offer new picture of Lake Tahoes earthquake potential
5. Scripps scientists help decode mysterious green glow of the sea
6. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
7. Scripps research scientists watch as individual alpha-synuclein proteins change shape
8. Scripps research team identifies key molecules that inhibit viral production
9. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Scripps scientists develop first examples of RNA that replicates itself indefinitely
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... of native animal species for food or commercial food ... factor in the decline of many species of primates ... that more than half of the species being consumed ... "By surveying not only the meat made available for ... the forest by hunters and brought to villages for ...
(Date:7/24/2014)... of 3.5 billion years of evolutionary trial and error, ... it may be reaching a tipping point. , In ... data published in Science , an international team ... animals is contributing to what appears to be the ... event. , Since 1500, more than 320 terrestrial vertebrates ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... human evolution follows a progressive trajectory is one of ... is often expressed in popular media by showing cavemen ... a notable exception). But is this assumption correct? ... In a paper published in the ...
... stop the spread of a deadly fungus that is threatening ... a new mathematical model. , White-nose syndrome, which is estimated ... year period, is probably caused by a newly discovered cold-adapted ... WNS is passed from bat to bat and concludes that ...
... and warms the world,s oceans with carbon emissions, the harder ... That,s the blunt message from a major new study ... and global warming will combine with local impacts like overfishing ... when they are struggling to survive. Modelling by a ...
Cached Biology News:Earliest humans not so different from us, research suggests 2Earliest humans not so different from us, research suggests 3Culling can't control deadly bat disease 2Acid oceans demand greater reef care 2
(Date:7/25/2014)... Muncie, IN (PRWEB) July 25, 2014 ... Administration (FAA) has granted a 60-day extension for the ... of the Special Rule for Model Aircraft established by ... Act of 2012. The 60-day extension establishes the new ... the United States Department of Transportation/FAA notice published in ...
(Date:7/24/2014)... Calabasas, CA (PRWEB) July 24, 2014 ... advancing the Global Supply Chain of the biotech ... annual SCM Innovation Awards, brought to you by ... premiere global organization of supply chain management professionals ... be given to stakeholders of the Biotech industry ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
(Date:7/24/2014)... prefer to settle into equilibriuma state of unchanging ... realm of non-equilibrium conditions where new possibilities lie. ... phases, such as temperature fluctuations, freezing and melting, ... their body temperature, airplanes to fly, and the ... But even though these conditions exist naturally and ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... System provides tightly regulated control of exogenous ... capable of repeated on/off expression kinetics. This ... highly specific interaction between the GenoStat Ligand ... Gene expression levels are easily manipulated higher ...
... added in Dec 2005 , Quantitative ... Detection from as little as 25 pg ... available for hundreds of mammalian miRNAs , ... , Ideal for validating expression profiling ...
Recommend to use at up to 5000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.)...
... Molecular Weight Markers, 37 kBq, 1 uCi. ... determination of the sample on Western blots.The ... band migration in the gel and on ... version without Rainbow-labeling is 0.37-3.7 MBq/mg (10-100 ...
Biology Products: