Navigation Links
Scripps Research team sheds new light on how blood clots form
Date:6/13/2011

Scripps Research Institute scientists have discovered new elements of the blood clot-formation process. The findings could lead to better drugs for preventing heart attacks and other clot-related conditions.

The work, which was published by the Journal of Clinical Investigation in an advance, online edition June 13, 2011, helps to establish a new model of clot formation.

According to the old model, an injury to the wall of blood vessels causes smooth muscle cells to expose a clot-organizing protein called tissue factor. "In the emerging new model, tissue factor exists on the surfaces of these smooth muscle cells, as well as on circulating immune cells, but in an inactive state," said Scripps Research Professor Wolfram Ruf. "In this study, we've shown that cell-surface receptor P2X7, which was known to promote inflammation when stimulated, also plays a major role in the clot-forming process by activating tissue factor."

An Intriguing Target

To better understand clot formation, Ruf and his colleagues performed a set of experiments on cultured mouse cells and transgenic mouse models. The team's investigation began with the P2X7 receptor, because of its known role in the inflammatory response that can lead to excessive clotting in sepsis, a severe illness in which the bloodstream is overwhelmed by bacteria.

Normally, when cells are damaged, they release large quantities of energy-storage molecules known as adenosine triphosphate (ATP). Previous research had hinted that when this freed ATP encounters passing immune cells, it serves as a damage signal, stimulating the immune cells' P2X7 receptors and causing the release of "microparticles" exposing the clot-promoting tissue factor. The new study showed that ATP can affect P2X7 receptors on both immune cells and smooth muscle cells.

To confirm the significance of the P2X7 receptor in the clot-forming process, the team bred transgenic mice that lacked
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
2. Scripps Research scientist wins $1.9 million grant to study malaria
3. Scripps Research scientists find way to block stress-related cell death
4. Scripps Research scientists find key mechanism in transition to alcohol dependence
5. Scripps Research scientists create new genetic model of premature aging diseases
6. Scripps Research scientists identify mechanism of long-term memory
7. Scripps Research scientists uncover new DNA role in modifying gene function
8. Scripps Research scientists find dual switch regulates fat formation
9. Common chaperone protein found to work in surprising way, say Scripps Research scientists
10. Dr. Daniel Von Hoff presented with top genomics award from Scripps
11. Scripps Research team discovers new details about medically important protein family
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 The Nano-Bio Manufacturing ... States Air Force Research Laboratory (AFRL), has awarded ... Binghamton University to develop electronics and ... The $425,000 project, with contributions from the University ... Electronics, Inc. ( Endicott, N.Y. ), ...
(Date:7/29/2014)... the University of Bristol,s Nutrition and Behaviour Unit (NBU) ... account when planning meals. , The research, to be ... Behavior Conference (SSIB 2014) in Seattle, USA this week ... , The team was led by Professor Jeff Brunstrom, ... , As part of a Biotechnology and Biological Sciences ...
(Date:7/29/2014)... science, researchers sometimes need to get back to ... that to study the impacts of the bumphead ... ecosystems at two remote locations in the central ... and computer simulation, McCauley, an assistant professor in ... and his colleagues sought to understand whether the ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3Underwater elephants 2Underwater elephants 3
... 2010-Grass buffer strips are commonly used in crop ... encouraged through incentives, regulations or laws, and are ... subsurface filtration (under the buffer strips) is not ... of trees integrated into buffer strips with grasses. ...
... happens when something goes wrong? And why do so ... carefully following all the well-meaning advice they,ve gotten from ... more difficulty than others and there are many factors ... first week after birth. For example, being African-American, having ...
... residents of eastern deciduous forests where their bright red ... of local bird species. Native Americans have also traditionally ... the plant, and several domesticated varieties now grace contemporary ... chokeberry (Aronia) is enjoying a new claim-to-fame as a ...
Cached Biology News:How grass buffers keep agricultural herbicides at bay 2Clinical study supports benefit of breastfeeding support for obese women 2Clinical study supports benefit of breastfeeding support for obese women 3Chokeberry extract found to regulate weight gain, blood glucose, and inflammation in rats 2Chokeberry extract found to regulate weight gain, blood glucose, and inflammation in rats 3
(Date:7/30/2014)... 2014 A study presented at the ... efficacy of CSL Behring,s C1 Inhibitor (C1-INH) concentrate ... highly sensitized patients. C1-INH is a human protein ... The study shows that post-transplant treatment ... levels of complement components 3 and 4, suggesting ...
(Date:7/30/2014)... Toronto, Canada (PRWEB) July 30, 2014 ... been available in health services research for a ... an upswing in interest regarding the use of ... actual practice conditions. , By combining today’s powerful ... in the digital era, ‘big data’ holds significant ...
(Date:7/30/2014)... 30, 2014   Wyle has been ... Lifecycle Mission Support Services (FILMSS) contract awarded by ... the terms of the contract, Wyle will provide ... Field, Calif. In particular, Wyle will provide program ... projects on the International Space Station and collaborative ...
(Date:7/30/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... in Industrial Applications , the global market for industrial ... by 2018, registering a five-year compound annual growth rate ... recorded in the detergent enzyme segment with a CAGR ... has influenced almost every sector of industrial activity, ranging ...
Breaking Biology Technology:Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3
... Engineers have developed a device platform that combines electronic ... all on an ultrathin skin-like patch that mounts directly ... of a temporary tattoo. Led by researcher John ... at the University of Illinois, the researchers described their ...
... unexpected things when they look at materials at the ... true even for the most common materials, such as ... of years, researchers have observed that water spontaneously flows ... carbon nanotubes. This unexpected observation is intriguing because carbon ...
... The American College of Medical Genetics (ACMG) has ... Learning Center , which will bring online genetics education ... on-demand resource brings the latest educational programming in genetics ... the Genetics Review Course and Annual Meeting Short Courses ...
Cached Biology Technology:Smart skin: Electronics that stick and stretch like a temporary tattoo 2Smart skin: Electronics that stick and stretch like a temporary tattoo 3Caltech researchers find that disorder is key to nanotube mystery 2Caltech researchers find that disorder is key to nanotube mystery 3ACMG Announces New Online Live Learning Center: Will Bring Genetics and Genomics Education to Varied Health Professionals 2
... at the 3, 3', 4, and 4' ... an internal standard for the quantification of ... is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic ... in the plasma of normal humans or ...
Acrylamide, 500 g. Assay: > 99.9%, acrylic acid: < 0.001%. Conductivity (35%): < 2 umhos/cm.Risks: 45, 46, 48, 23, 24, 25 ; Safety Precautions: 53, 44. Category: Nucleotides & Enzymes & Biochemicals...
Direct ELISA Assay Diluent, 10 L...
Direct ELISA Assay Diluent - EDTA, 10 L...
Biology Products: