Navigation Links
Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
Date:7/19/2012

JUPITER, FL, July 19, 2012 A new study by scientists on the Florida campus of The Scripps Research Institute shows, in cell culture, a natural compound can virtually eliminate human immunodeficiency virus (HIV) in infected cells. The compound defines a novel class of HIV anti-viral drugs endowed with the capacity to repress viral replication in acutely and chronically infected cells.

The HIV/AIDS pandemic continues to affect 34 million individuals worldwide, including more than 3 million children, according to the World Health Organization. Current treatment involves the use of several antiretroviral drugs, termed Highly Active Antiretroviral Therapy (HAART), which can extend the life expectancy of HIV-positive individuals and decrease viral load without, however, eradicating the virus.

"We know that there are reservoirs of HIV that aren't being eliminated by current treatment and that keep replenishing the infection," said Susana Valente, a Scripps Research biologist who led the study. "Viral production from these cellular reservoirs that harbor an integrated viral genome is not affected by current antiretroviral drugs, which only stop novel rounds of infection. The compound in the current study virtually eliminates all viral replication from already-infected cells where HIV hides."

The new study, published in the July 20, 2012 issue of the journal Cell Host and Microbe, focused on a medically promising compound known as Cortistatin A. This natural product was isolated in 2006 from a marine sponge, Corticium simplex, discovered more than 100 years ago. In 2008, Scripps Research chemist Phil Baran and his team won the global race to synthesize the compound, presenting an efficient and economical method.

In the new study, Valente and her colleagues collaborated with the Baran lab, using a synthetic version of the compound, didehydro-Cortistatin A, to study the compound's effect on two strains of HIV. The strains
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research Institute wins $77 million to develop AIDS vaccine center
2. Scripps Florida scientists identify critical quality control for cell growth
3. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
4. Scripps Research Institute announces five-year research collaboration with Bristol-Myers Squibb
5. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
6. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
7. Plastic trash altering ocean habitats, Scripps study shows
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
10. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
11. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
(Date:9/22/2014)... may be at greater risk for stress-related diseases ... according to a new study by Brandeis University. ... trigger biological responses similar to the effects of ... is an important part of our body,s healing ... life-threatening diseases. , In a recently published ...
(Date:9/22/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... mobile commerce market, issues the following corporate shareholder update ... Letter from the CEO : ... funding and joined the NASDAQ to support ramping of ... biometric and authentication products and services. This strategic achievement positions ...
(Date:9/21/2014)... Assembly events focussed on ways to save and improve ... Canada, funded by the Government of Canada, today announced ... address this challenge. , The novel approaches include: , ... in garment factories to express, pasteurize and store breast ... to child illnesses, and lowering baby formula expense , ...
Breaking Biology News(10 mins):Obesity and stress pack a double hit for health 2NXT-ID Issues Shareholder Corporate Update 2NXT-ID Issues Shareholder Corporate Update 3NXT-ID Issues Shareholder Corporate Update 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 2Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 3Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 4Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 5Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 6Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 7Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 8Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 9Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 10Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 11Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 12Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 13Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 14Canada funds 22 innovative projects to help save 'Every Woman, Every Child' 15
... WEST LAFAYETTE, Ind. - Fast-food restaurants can supersize French fries ... supersize a type of apple. Peter Hirst, a Purdue ... some Gala apple trees causes some apples to grow much ... in the current issue of the Journal of Experimental ...
... decrease viral infection rates among phytoplankton and enhance the ... carbon is transferred from the atmosphere to the deep ... findings, published in the Journal of Theoretical Biology ... tackling global warming. Tiny free-floating algae called phytoplankton ...
... to treat rheumatoid arthritis also reduces the damage a stroke ... findings from a clinical trial of stroke patients. The results ... the drug anakinra,s use as an effective therapy for victims ... her team,s latest research into both the causes of brain ...
Cached Biology News:Apples grow larger when cells don't divide, study shows 2Nutrients, viruses and the biological carbon pump 2New hope for victims of stroke 2
(Date:9/20/2014)... 20, 2014 MediVet America ... a groundbreaking surgery at the specialized Wolvega Horse Clinic. ... digital flexor tendon was ruptured 90% and her deep ... is a death sentence for a horse. , The ... cell treatments . This revolutionary regenerative option for ...
(Date:9/19/2014)... yields to disease risks, the biological characteristics people care ... as for heightthe textbook example of a complex traitattributes ... by multiple genetic and environmental influences, making it challenging ... genes, geneticists typically mate two individuals that differ in ... mouseand then study their descendents, looking for genes that ...
(Date:9/19/2014)... to move data would consume much less power ... as chips, transistor counts rise. , Of the ... emitters, modulators, and detectors emitters are the ... optical chips is molybdenum disulfide (MoS2), which has ... atom-thick layer. Other experimental on-chip light emitters have ...
(Date:9/19/2014)... , Sept. 19, 2014  An entire month is ... inherited neuropathies – Charcot-Marie-Tooth disease (CMT) – a debilitating ... causing extreme muscle atrophy, weakness, and foot and hand ... and millions worldwide. CMT is a progressive disease, and ... legs, requiring mobility devices such as leg braces, wheelchairs ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... this time (actually it was April rather than May), we ... broke all the meeting records: total attendance, foreign attendance, total ... it, it was broken. But even new records are made ... about? Well, the BIO Annual International Convention , being ...
... on multiple flanks. Google , the Internet utility and search-engine ... 2007, according to Hitwise , is drawing out entrepreneurs and ... slay the giant. One intriguing possibility is evident in the buzz ... about a merger or other sharing of capabilities, according to the ...
... Merge Technologies reported a net loss of $10.1 million, or ... double the net loss of $4.9 million, or $0.15 per share, ... loss was well below the $27.0 million, or $0.80 per share ... continuing difficulties for a company that is trying to emerge from ...
Cached Biology Technology:Olympics of biotechnology has international flavor 2Olympics of biotechnology has international flavor 3Olympics of biotechnology has international flavor 4Olympics of biotechnology has international flavor 5Outflanking the Google, Yahoo, MSN juggernaut 2Outflanking the Google, Yahoo, MSN juggernaut 3Outflanking the Google, Yahoo, MSN juggernaut 4Outflanking the Google, Yahoo, MSN juggernaut 5Outflanking the Google, Yahoo, MSN juggernaut 6
MHC. Sections include: the isolation and functional properties of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecu...
Supplemental reagent for annexin V assay....
Large-fragment, single-stranded carrier DNA of the highest quality, perfectly suited for all types of yeast transformation....
Qa-1 (L-12)...
Biology Products: