Navigation Links
Scripps Research scientists reveal key mechanism governing nicotine addiction
Date:1/30/2011

ay isn't functioning properly, you simply take more. Our data may explain recent human data showing that individuals with genetic variation in the α5 nicotinic receptor subunit are far more vulnerable to the addictive properties of nicotine, and far more likely to develop smoking-associated diseases such as lung cancer and chronic obstructive pulmonary disease."

A Previously Unknown Pathway Inhibits Motivation

Tobacco smoking is one of the leading causes of death worldwide, with more than five million people dying each year as a result of it, according to statistics cited in the study. Smoking is considered the cause of more than 90 percent of lung cancer deaths. Scientists have established that a tendency towards smoking can be inherited more than 60 percent of the risk of becoming addicted to nicotine can be laid at the door of genetic factors.

Nicotine is the major addictive component of tobacco smoke, and nicotine acts in the brain by stimulating proteins called nicotinic acetylcholine receptors (nAChRs). These nAChRs are made up of different types of subunits, one of which is the α5 subunitthe focus of the new study.

In their experiments, the Scripps Research scientists set out to determine the role of nAChRs-containing α5 subunits (α5* nAChRs) in regulating nicotine consumption.

First, the team assessed the addictive properties of nicotine in genetically altered mice lacking α5* nAChRs. The results showed that when these "knockout" mice were given access to high doses of nicotine, they consumed much larger quantities than normal mice. Next, to determine if the subunit was responsible for the sudden shift in appetite for nicotine, the scientists used a virus that "rescued" the expression of α5* nAChRs only in the medial habenula and areas of the brain into which it projects. The results showed the nicotine consumption patterns of the knockout mice returned to a normal range. <
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team creates new synthetic compound with HIV-fighting promise
2. Scripps Research and Vanderbilt to launch joint institute
3. Scripps Research chemist devises new method to quantify protein changes
4. Scripps Research scientists identify key interaction in hepatitis C virus
5. Scripps Research scientist uncovers switch controlling protein production
6. Scripps Research scientists show prions mutate and adapt to host environment
7. Scripps scientists see the light in bizarre bioluminescent snail
8. Scripps Research scientists redefine the role of plasma cells in the immune system
9. Judy and J. John Goodman give $50,000 gift to Scripps Florida
10. New Scripps Florida scientist awarded pair of unconventional grants
11. Scripps Research scientists identify new mechanism regulating daily biological rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and Markets ... "Biometrics - A Global Market Overview" report to ... biometrics technology is to ensure that an individual is who ... technology may make use of a person,s unique physical characteristics, ...
(Date:1/22/2015)... , Jan. 13, 2015 Technology Showcase, Hall E ... identity authentication solutions, today announced it will showcase its EyeLock ... developed by the Department of Energy,s Oak Ridge National ... Auto Show . EyeLock,s iris identity authentication technology is being ...
(Date:1/22/2015)... and POINT ROBERTS, Washington , January 20, ... leading sectors including technology and tech stocks, releases video from ... master pickpocket and security consultant Apollo Robbins . ... talks about the Wocket™ biometric smart wallet, a product of ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... BAR HARBOR − Famous for their sluggishness, turtles have ... evolution and place on the evolutionary tree. For decades, ... genetics have disagreed about whether turtles are more closely ... two scientists from the Mount Desert Island Biological Laboratory ...
... a herd of gazelles and a fluffy mass of ... the population dynamics of such prey animals as gazelles ... relationship between cloud systems, rain and tiny floating particles ... among other things, how human-produced aerosols affect rainfall patterns. ...
... A new analysis has found that many doctors report ... cancer counseling and testing services to their female patients. ... journal of the American Cancer Society, the study indicates ... high-risk women and discourage them for average-risk women. ...
Cached Biology News:Discovery places turtles next to lizards on family tree 2Eat, prey, rain 2Mismatch between cancer genetics counseling and testing guidelines and physician practices 2
(Date:2/27/2015)... BOSTON , Feb. 27, 2015   PureTech ... identifying, inventing and commercializing disruptive products and technologies in ... Christopher Viehbacher , former CEO and Member of the ... Directors.  "It,s has been a pleasure ... very excited that we will be working together more ...
(Date:2/26/2015)... 26, 2015 On behalf of biotech client ... Wilentz, Goldman & Spitzer, P.A. (Wilentz) secured a ... Genewiz Inc. in excess of $10 million. The jury ... secrets, and that it improperly hired one or more ... motions for judgment notwithstanding the verdict, a new trial, ...
(Date:2/26/2015)... Feb. 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... sciences company that develops and commercializes proprietary technologies and ... and operational results for the fiscal first quarter ended ... are in Canadian dollars (CAD), unless otherwise stated. ... win new business from our existing customers and add ...
(Date:2/26/2015)... Feb. 26, 2015   Regulus Therapeutics Inc . ... the discovery and development of innovative medicines targeting microRNAs, ... President and Chief Executive Officer of Regulus, will present ... th Annual Healthcare Conference on Wednesday, March 4, ... held at the Boston Marriott Copley Place.  ...
Breaking Biology Technology:Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 4Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3
... 30, 2012  The formation of a new Contract Research ... will focus on providing customized clinical research and consulting ... device and diagnostic companies.  The Company was formed by ... Ventures, LLC. According to Hale, "Agility,s mission ...
...  Today, leading events organizer UBM Live announced ... developments and opportunities across a broad spectrum of  India,s ... as InformexUSA, North America,s leading networking event for buyers ... conjunction with the UBM team in India, InformexINDIA will ...
... is slowly becoming reality. Over the past five years ... that enable invisibility cloaks perhaps not yet concealing ... detection by microwaves or sound waves. A University of ... to understand invisibility and extend its possible applications. The ...
Cached Biology Technology:Agility Clinical, Inc., a Specialty Contract Research Organization is Formed 2Informex Returns To India In 2012 2Informex Returns To India In 2012 3Mathematicians can conjure matter waves inside an invisible hat 2
alpha-N-Catenin Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Bovine Endometrium Epithelial Cells (BEnEpC) (>500,000 cells)...
... Darkroom is designed for imaging of chemiluminescent, ... systems offer direct control for users who ... by hand , A range of high ... for all fluorescent and chemiluminescent applications ...
... smooth muscle cell specific protein, is reported to ... such as intestine, lung and uterus. It shares ... alpha expression has been reported in most tissues ... visceral forms. It is also reported to be ...
Biology Products: