Navigation Links
Scripps Research scientists identify mechanism of long-term memory
Date:4/13/2011

JUPITER, FL, April 13, 2011 Using advanced imaging technology, scientists from the Florida campus of The Scripps Research Institute have identified a change in chemical influx into a specific set of neurons in the common fruit fly that is fundamental to long-term memory.

The study was published in the April 13, 2011 issue of The Journal of Neuroscience.

"In studying fruit flies' learning and long-term memory storage, we observed an increase in calcium influx into a specific set of brain neurons in normal fruit flies that was absent in 26 different mutants known to impair long-term memory,," said Ron Davis, chair of the Scripps Research Department of Neuroscience, who led the study. "This logical conclusion is that this increase, which we call a memory trace, is a signature component of long-term memory."

The memory trace in question is an increased influx of calcium into a set of neurons after long-term memory forms in a part of the insect brain known as mushroom bodies, a pair of oversized lobes known to mediate learning and memory, particularly the memories of smell. They have been compared to the hippocampus, a site of memory formation in humans.

Increases in calcium influx also occur with learning in other animal models, Davis said, and it seems highly likely a similar correlation exists in humans.

Measuring Memory Traces

To measure the changes in the Drosophila neurons, Davis and his colleagues used functional optical imaging, an advanced technology that his laboratory helped pioneer for the study of learning and memory. Using protein sensors that become fluorescent when calcium levels are increased, the team was able to highlight changes in the levels of calcium influx into the mushroom body neurons in response to odor learning. These observed memory traces occur in parallel with behavioral changes.

Interestingly, these memory traces occur only with spaced conditioning where
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... But on the remote UK overseas territory of Ascension ... is undergoing something of a renaissance. , Writing in ... the University of Exeter and Ascension Island Government Conservation ... at the remote South Atlantic outpost has increased by ... the 1970s. As many as 24,000 nests are now ...
(Date:7/29/2014)... research from scientists at the University of Kent has ... cells are regulated a breakthrough that could have ... team from Kent,s School of Biosciences uncovered the mechanism ... cells known as actin filaments are ,fine-tuned, ... actin filaments appear to completely stable, providing a framework ...
(Date:7/29/2014)... rare disease it affects 1 in 100,000 people ... wall. While its cause remains unknown, a new study by ... University of Bonn in Germany and other European institutions confirms ... The study, published on 6 July in Nature Genetics ... , When we swallow, a sphincter in the lower esophagus ...
Breaking Biology News(10 mins):Major turtle nesting beaches protected in 1 of the UK's far flung overseas territories 2Mysterious esophagus disease is autoimmune after all 2
... CHICAGO, Ill. (March 29, 2011)A medical device developed by ... a new paradigm for the detection, diagnosis and monitoring ... the Society of Interventional Radiology,s 36th Annual Scientific Meeting ... trauma is detected, identified and located using a simple ...
... global economy depends on marine transportation. But in addition ... stowaways that can cause huge problems for the environment ... will facilitate accurate screening of vessels for dangerous species ... in the journal Environmental Science & Technology . ...
... A novel supercomputing resource created by researchers at the ... San Diego, is allowing scientists to study evolutionary relationships ... times and without having to understand how to ... new resource, called the CIPRES (Cyberinfrastructure for Phylogenetic RESearch) ...
Cached Biology News:New device uses submarine technology to diagnose stroke quickly 2New device uses submarine technology to diagnose stroke quickly 3Smithsonian scientists help block ship-borne bioinvaders before they dock 2Smithsonian scientists help block ship-borne bioinvaders before they dock 3SDSC's CIPRES Gateway provides window to the past -- and fast 2SDSC's CIPRES Gateway provides window to the past -- and fast 3
(Date:7/29/2014)... Hill, South Carolina (PRWEB) July 29, 2014 ... with teams of people where cell phone masts or other ... iPhones up to 100 feet away without the need for ... to target longer ranges. , The new app has launched ... of US homes are at very high risk of being ...
(Date:7/29/2014)...  United Therapeutics Corporation (NASDAQ: ... for the second quarter ended June 30, 2014. ... our medicines are reaching increasing numbers of ... said Martine Rothblatt, Ph.D., United Therapeutics, Chairman ... this quarter of our extended-release tablet called ...
(Date:7/29/2014)... The first product launch from start-up Hurley Research ... What sets Droidles completely apart from other stand alone ... to communicate, share code with each other and evolve ... invention is the system,” said Hurley Research founder Jay ... their own, both physically and on the internet." Remote ...
(Date:7/29/2014)... July 29, 2014 The prestigious "Discovery ... Congress was recently awarded to Juliana Hillis and Kaylie ... for their project, “From an Egg, Everything: America’s First ... final entries for the National History Day program during ... historians and educators in Washington, D.C. , The growing ...
Breaking Biology Technology:DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3
... Epitomics, Inc. today announced that The Michael J. ... company to distribute a panel of LRRK2 monoclonal antibodies ... parties. Under a special arrangement the antibodies are being ... community to help advance LRRK2 therapeutic development efforts. The ...
... BASEL, Switzerland, Sept. 17 /PRNewswire-FirstCall/ - Neuro-Biotech Corp. (PINKSHEETS: ... Poulin as President and CEO. Mr Barry ... the Company,s direction during the summer of 2010, I ... in order to facilitate the transition process, and now ...
... 2010 bluebird bio (formerly Genetix Pharmaceuticals Inc.) an ... for severe genetic disorders, today announced publication in the ... data highlighting positive results of LentiGlobin gene therapy treatment ... disorder that is one of the most frequent inherited ...
Cached Biology Technology:Epitomics, Inc. Announces Worldwide Availability of LRRK2 Antibodies Developed in Partnership With The Michael J. Fox Foundation 2Mr Claude Poulin nominated as President and CEO of Neuro-Biotech Corp. 2Nature publishes results of gene therapy treatment in phase 1/2 beta-thalassemia study 2Nature publishes results of gene therapy treatment in phase 1/2 beta-thalassemia study 3
Bovine Brain Microvascular Endothelial Cells (BBMVEC) (>500,000 cells)...
The improved design and new mechanical solutions of Finnpipette Focus Multichannel Plus improves accuracy and precision.In these low volume multichannel pipettes, the super blow-out function ensures ...
... solution. Cleaves a-(1-3)- and ... and glycoproteins. It is particularly efficient for ... pH must be neutral or above, for ... Unit Definition: One unit will hydrolyze ...
... is specific for human cardiac troponin subunit T, ... signals responsible for contraction of cardiac muscle. It ... in human cells. It also cross-reacts with human ... Antigen: Highly purified human cardiac troponin ...
Biology Products: