Navigation Links
Scripps Research scientists identify mechanism of long-term memory
Date:4/13/2011

JUPITER, FL, April 13, 2011 Using advanced imaging technology, scientists from the Florida campus of The Scripps Research Institute have identified a change in chemical influx into a specific set of neurons in the common fruit fly that is fundamental to long-term memory.

The study was published in the April 13, 2011 issue of The Journal of Neuroscience.

"In studying fruit flies' learning and long-term memory storage, we observed an increase in calcium influx into a specific set of brain neurons in normal fruit flies that was absent in 26 different mutants known to impair long-term memory,," said Ron Davis, chair of the Scripps Research Department of Neuroscience, who led the study. "This logical conclusion is that this increase, which we call a memory trace, is a signature component of long-term memory."

The memory trace in question is an increased influx of calcium into a set of neurons after long-term memory forms in a part of the insect brain known as mushroom bodies, a pair of oversized lobes known to mediate learning and memory, particularly the memories of smell. They have been compared to the hippocampus, a site of memory formation in humans.

Increases in calcium influx also occur with learning in other animal models, Davis said, and it seems highly likely a similar correlation exists in humans.

Measuring Memory Traces

To measure the changes in the Drosophila neurons, Davis and his colleagues used functional optical imaging, an advanced technology that his laboratory helped pioneer for the study of learning and memory. Using protein sensors that become fluorescent when calcium levels are increased, the team was able to highlight changes in the levels of calcium influx into the mushroom body neurons in response to odor learning. These observed memory traces occur in parallel with behavioral changes.

Interestingly, these memory traces occur only with spaced conditioning where
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... Scientists at the University of Warwick have discovered that ... , The substance, methylglyoxal - MG, was found ... of bad cholesterol from the body. , Low ... to heart disease, with increased levels of MG being ... kidney problems. , Supported by funding from the ...
(Date:8/31/2014)... A new blood test provides a fast and ... new proof-of-concept study shows. The newly developed test ... to detect active tuberculosis in children. The test ... tests in combination with speed of a blood ... for the diagnosis of tuberculosis in children, particularly ...
(Date:8/31/2014)... bacteria C. diff , that causes diarrhoea, temperature ... at the University of Leicester. , Using a mass ... possible to identify the unique ,smell, of C. ... the condition., What is more, the Leicester team say ... the disease simply from their smell a chemical ...
Breaking Biology News(10 mins):Sugar substance 'kills' good HDL cholesterol, new research finds 2New tuberculosis blood test in children is reliable and highly specific 2Scientists develop 'electronic nose' for rapid detection of C. diff infection 2
... , The Woods Hole Research Center has released the ... associated carbon stock for the forests and woodlands of ... as the National Biomass and Carbon Dataset (NBCD), produced ... spatial resolution of 30 m. The digital raster ...
... Earth may be able to recover from rising carbon dioxide ... prehistoric event analyzed by a Purdue University-led team. When ... temperatures 56 million years ago, the Earth increased its ability ... recovery that was quicker than anticipated by many models of ...
... arid Namib Desert on the west coast of Africa, one type ... morning fog rolls in, the Stenocara gracilipes species, also known as ... lets the moisture roll down into its mouth, allowing it to ... has developed, Shreerang Chhatre wants to refine, to help the world,s ...
Cached Biology News:WHRC debuts detailed maps of forest canopy height and carbon stock for the conterminous US 2WHRC debuts detailed maps of forest canopy height and carbon stock for the conterminous US 3WHRC debuts detailed maps of forest canopy height and carbon stock for the conterminous US 4Purdue-led team studies Earth's recovery from prehistoric global warming 2Purdue-led team studies Earth's recovery from prehistoric global warming 3MIT: Development in fog harvesting process 2MIT: Development in fog harvesting process 3MIT: Development in fog harvesting process 4
(Date:8/31/2014)... Wockhardt Limited today announces a major boost ... when two of its drugs, WCK 771 and WCK ... status from U.S. Food & Drug Administration (FDA).  QIDP ... which have a high degree of unmet need in ... Control (a top U.S. government health and safety body). ...
(Date:8/31/2014)... (PRWEB) September 01, 2014 Available ... lighting needs for research and cultivation of a ... by Valoya’s proprietary LEDs with proven patented and ... ensures uncompromised light uniformity in critical applications in ... white LEDs. , “Our customers have a large ...
(Date:8/31/2014)... 2014 2014 Market Research ... professional and in-depth research report on the ... information, including Polyacrylamide definition, classification, application, and ... overview. This research covers the international market ... global industry analysis covering macroeconomic environment & ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 This ... current state of the Epoxy Hardener industry ... basic overview of the industry, including definitions, applications ... Chinese domestic market analysis are provided with a ... of the market. A comparison between the international ...
Breaking Biology Technology:U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3
Request Info...
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... The Fujifilm Life Science FLA-7000 excels at ... CBB-stained gel documentation. It features four easy-to-access ... and a filter for Imaging Plates) for ... a customizable choice of four kinds of ...
Improves spot morphology and DNA binding to the slide resulting in increased hybridization signal. ID Clarifier: Optimized spotting solution for use with SigmaScreen APS Coated Slides for Microarrays...
Biology Products: