Navigation Links
Scripps Research scientists identify mechanism of long-term memory
Date:4/13/2011

JUPITER, FL, April 13, 2011 Using advanced imaging technology, scientists from the Florida campus of The Scripps Research Institute have identified a change in chemical influx into a specific set of neurons in the common fruit fly that is fundamental to long-term memory.

The study was published in the April 13, 2011 issue of The Journal of Neuroscience.

"In studying fruit flies' learning and long-term memory storage, we observed an increase in calcium influx into a specific set of brain neurons in normal fruit flies that was absent in 26 different mutants known to impair long-term memory,," said Ron Davis, chair of the Scripps Research Department of Neuroscience, who led the study. "This logical conclusion is that this increase, which we call a memory trace, is a signature component of long-term memory."

The memory trace in question is an increased influx of calcium into a set of neurons after long-term memory forms in a part of the insect brain known as mushroom bodies, a pair of oversized lobes known to mediate learning and memory, particularly the memories of smell. They have been compared to the hippocampus, a site of memory formation in humans.

Increases in calcium influx also occur with learning in other animal models, Davis said, and it seems highly likely a similar correlation exists in humans.

Measuring Memory Traces

To measure the changes in the Drosophila neurons, Davis and his colleagues used functional optical imaging, an advanced technology that his laboratory helped pioneer for the study of learning and memory. Using protein sensors that become fluorescent when calcium levels are increased, the team was able to highlight changes in the levels of calcium influx into the mushroom body neurons in response to odor learning. These observed memory traces occur in parallel with behavioral changes.

Interestingly, these memory traces occur only with spaced conditioning where
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small ... Brands report showed that planet-wide, transactions at merchants on the ... the total number of credit, debit, and prepaid cards reached ... were victims of fraudulent card usage in 2012, and credit ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:1/22/2015)... 22, 2015 Infinisource has launched its new NXG series ... The G2 sets a higher standard for collecting attendance and ... solution. With plug-and-play installation, touch screen interface and seamless connection ... robust time collection solution for the small to mid-size employer. ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2Infinisource's NXG series sets new time clock standard 2
... even though they do not actually touch your skin are ... student Yu Mike Chi,s dissertation. This technology and the ... team the top spot in the UC San Diego Entrepreneur ... and $15K in legal services. Engineers and physicians are ...
... lot of large particles of dust and pollen in the ... directly to greater precipitation in clouds, Colorado State University atmospheric ... of ice crystals necessary to form precipitation in clouds is ... atmosphere, according to a study by Paul DeMott and Anthony ...
... journal Genetics suggests that mutant maize have ... throughout its various organs More than 40 years ... seeing colors this time, in maize, and the ... State University have identified new genes in maize which ...
Cached Biology News:Wireless sensor startup wins UC San Diego $80K Entrepreneur Challenge 2Wireless sensor startup wins UC San Diego $80K Entrepreneur Challenge 3Amount of dust, pollen matters for cloud precipitation, climate change 2Amount of dust, pollen matters for cloud precipitation, climate change 3'Psychedelic' maize may help increase crop and biofuel yields 2
(Date:1/22/2015)... 2015 Crystal Diagnostics (CDx) Xpress System, a ... received AOAC-PTM Certifications for the six non-O157 Shiga toxin-producing E. ... referred to as STEC or the “Big-6”) as well as ... (cfu) per 325 g of raw ground beef and raw ...
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics ... from a new partner. STT-Systems has developed an ... years, with offerings in the optical-motion capture, 3D scanning, and ... measurement unit), iSen, is opening eyes around the world. With ...
(Date:1/22/2015)... Controlled Substance Compliance Services (CSCS), a project ... the legal requirements around using controlled substances in pharmaceutical ... As their international operations expand and become increasingly complex, ... as a result of the first phase of the ...
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... with breakthroughs to highlight, royalty, and the possibility record-setting attendance ... 2007 , and perhaps no geographic region is more eager ... story is the news that Quincy Bioscience , a ... treatment of strokes. , ,The highlight of the conference's first ...
... primary burdens facing a patent applicant before the ... requirement that the claimed invention is not obvious under ... defense raised in patent infringement cases. Yet, overcoming obviousness ... lawsuits, was relatively routine. This changed last week when ...
... Kevin Hayden, secretary of the Wisconsin Department ... president and chief administrative officer for Dean Health ... advance the use of health information technology, particularly ... promote health IT adoption. , ,His 23-year career in ...
Cached Biology Technology:BIO 2007: Wisconsin makes its presence felt 2BIO 2007: Wisconsin makes its presence felt 3BIO 2007: Wisconsin makes its presence felt 4High court sends message on patent obviousness 2High court sends message on patent obviousness 3High court sends message on patent obviousness 4DHC 2007: Hayden says technology creates magic moment for healthcare delivery 2DHC 2007: Hayden says technology creates magic moment for healthcare delivery 3DHC 2007: Hayden says technology creates magic moment for healthcare delivery 4
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Collected at a certified USDA establishment located within the United States. All final processing is done by Quad Five employees....
... MasterAmp™ Taq DNA Polymerase is a ... aquaticus. Having optimal activity at temperatures ... thermostable enzyme used for PCR and ... purpose. The enzyme has an intrinsic ...
... Adept CE 4100 high pressure dual piston pump ... added flexibility and utra low drift. The ... photodiode array detection and provides superior stability. ... method development and for monitoring to the highest ...
Biology Products: