Navigation Links
Scripps Research scientists find way to block stress-related cell death
Date:6/2/2011

Scientists from the Florida campus of The Scripps Research Institute have uncovered a potentially important new therapeutic target that could prevent stress-related cell death, a characteristic of neurodegenerative diseases such as Parkinson's, as well as heart attack and stroke.

In the study, published recently in the journal ACS Chemical Biology, the scientists showed they could disrupt a specific interaction of a critical enzyme that would prevent cell death without harming other important enzyme functions.

The enzyme in question is c-jun-N-terminal kinase (JNK), pronounced "junk," which has been implicated in many processes in the body's response to stresses, such as oxidative stress, protein misfolding, and metabolic disorder. JNK also plays an important role in nerve cell survival and has become a target for drugs to treat neurodegenerative disorders such as Parkinson's disease.

In recent studies, JNK has been found to migrate to the mitochondriathe part of the cell that generates chemical energy and that is involved in cell growth and death. That migration, coupled with JNK activation, is associated with a number of serious health issues, including apoptosis or programmed cell death, liver damage, neuronal cell death, stroke and heart attack.

"Activated JNK migrates to the mitochondria in reaction to a stress signal," said Philip LoGrasso, professor in the Department of Molecular Therapeutics and senior director for drug discovery at Scripps Florida who led the study. "Once there, it amplifies the effects of reactive oxygen species that cause significant damage to the cell. We developed a small peptide that intervenes in JNK migration and blocks those harmful effectsspecifically cell death."

LoGrasso noted that the team was able to block JNK mitochondrial interaction without harming any other important enzyme processes, such as JNK's impact on gene expression. These findings, LoGrasso said, suggest t
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find key mechanism in transition to alcohol dependence
2. Scripps Research scientists create new genetic model of premature aging diseases
3. Scripps Research scientists identify mechanism of long-term memory
4. Scripps Research scientists uncover new DNA role in modifying gene function
5. Scripps Research scientists find dual switch regulates fat formation
6. Common chaperone protein found to work in surprising way, say Scripps Research scientists
7. Dr. Daniel Von Hoff presented with top genomics award from Scripps
8. Scripps Research team discovers new details about medically important protein family
9. Scripps Research scientists develop new test for pluripotent stem cells
10. Scripps Research scientists create cell assembly line
11. Scripps oceanography researchers discover arctic blooms occurring earlier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 2015 The Sync Project™ , a ... health, today announced a collaborative partnership with Berklee,s ... center on collaboration on original research, joint course development ... the collaboration, The Sync Project and BerkleeICE are exploring ... in the 2015-2016 academic year.  The ...
(Date:5/20/2015)... Conn. , May 20, 2015 NXT-ID, ... announces that its wholly owned subsidiary, 3D-ID LLC, a ... under Team Battelle for the biometrics technology portion of ... Suite Contract from the Department of the Army. ... recognition products developed for government, law enforcement and security ...
(Date:5/19/2015)... -- Technology is rapidly advancing, outpacing enterprises, ability to secure ... and their management are soon to be rendered obsolete ... as those developed by the FIDO Alliance™. With the ... BYOD, COPE, IoT, and mobile payments, the interconnected online ... In response to the call for seamless, secure, ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... last few decades in old-growth forests of the western United ... is regional warming, according to a U.S. Geological Survey-led (USGS) ... The study found that the increase in dying trees has ... variety of forest types, at all elevations, in trees of ...
... Medical System researchers have discovered there are differing taste ... for future smoking-cessation products. "We learned some ... postdoctoral fellow of the Duke Department of Neurobiology. "This ... taste pathways activated by nicotine, and how these pathways ...
... researchers have identified a cellular mechanism that could someday ... Stephen Helfand and Nicola Neretti and others adds another ... biology, molecular biology, cell biology and biochemistry, first discovered ... the Indy ("I,m Not Dead Yet") gene that can ...
Cached Biology News:Tree deaths have doubled across the western US 2Nicotine activates more than just the brain's pleasure pathways 2Scientists unlock possible aging secret in genetically altered fruit fly 2
(Date:5/20/2015)... 2015  Marc Tessier-Lavigne, president of The Rockefeller ... million from The Marie-Josée and Henry R. Kravis ... that will be the centerpiece of the University,s ... R. Kravis Research Building, two stories high, will ... three city blocks following the shoreline of the ...
(Date:5/20/2015)... 2015 Research and Markets ( ... "Bone Morphogenetic Proteins Market (Types : rhBMP-2 ... Oral - Maxillofacial) - Global Industry Analysis, Size, ... report to their offering. The ... on the types of recombinant BMPs, applications, and ...
(Date:5/20/2015)... May 20, 2015  HOSTING, the leading provider ... it is an official partner of the ... Cooperative Members Services Program. This unique collaboration ... cloud services and best practices derived from ... and service providers, enabling member healthcare organizations ...
(Date:5/20/2015)... The Honey Bee Health Coalition applauded the announcement ... Honey Bees and other Pollinators and the accompanying Pollinator ... Pollinator Health Task Force. The Strategy represents a ... and other pollinators that support billions of dollars annually ... goals for pollinator health that underscore the importance of ...
Breaking Biology Technology:The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4Global Bone Morphogenetic Proteins Market Industry Analysis 2014 - 2022 2HOSTING Named Partner of the CHIME Cooperative Member Services Program 2HOSTING Named Partner of the CHIME Cooperative Member Services Program 3Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 2Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 3Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 4Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 5Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 6Honey Bee Health Coalition Ready to Provide Leadership in Implementing National Pollinator Health Strategy 7
... use, reliability and ... convenience, ... availability of easypod(R), the first of its kind,automated device in the ... [somatropin (rDNA origin) for,injection], the company,s treatment for growth hormone deficiency. ...
... proteins in their natural environment and interactions inside ... advanced microscopy technique called cryo-electron tomography, researchers from ... proteins responsible for cell-cell contacts for the first ... publish the first 3D image of human skin ...
... (NYSE: SGP ) was honored by Scrip ... industry awards: Large Pharma Company,of the Year, Management ... Year for,Fred Hassan, Schering-Plough chairman and CEO., ... and achievement,within the pharmaceutical and biotech industries. Scrip ...
Cached Biology Technology:Video and Photo: EMD Serono Launches easypod(R), New Electronic Growth Hormone Injection Device 2Video and Photo: EMD Serono Launches easypod(R), New Electronic Growth Hormone Injection Device 3Video and Photo: EMD Serono Launches easypod(R), New Electronic Growth Hormone Injection Device 4The closest look ever at native human tissue 2Schering-Plough Wins Three of Scrip's Top Pharma Industry Awards 2
... Reagents are complete ready-to-use reagents for the ... is specifically formulated for the isolation of ... is specifically formulated for the isolation of ... with DNAzol Reagents can be used for ...
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Apoptosis Detection Systems and Reagents...
Apoptosis Detection Systems and Reagents...
Biology Products: