Navigation Links
Scripps Research scientists find way to block stress-related cell death
Date:6/2/2011

Scientists from the Florida campus of The Scripps Research Institute have uncovered a potentially important new therapeutic target that could prevent stress-related cell death, a characteristic of neurodegenerative diseases such as Parkinson's, as well as heart attack and stroke.

In the study, published recently in the journal ACS Chemical Biology, the scientists showed they could disrupt a specific interaction of a critical enzyme that would prevent cell death without harming other important enzyme functions.

The enzyme in question is c-jun-N-terminal kinase (JNK), pronounced "junk," which has been implicated in many processes in the body's response to stresses, such as oxidative stress, protein misfolding, and metabolic disorder. JNK also plays an important role in nerve cell survival and has become a target for drugs to treat neurodegenerative disorders such as Parkinson's disease.

In recent studies, JNK has been found to migrate to the mitochondriathe part of the cell that generates chemical energy and that is involved in cell growth and death. That migration, coupled with JNK activation, is associated with a number of serious health issues, including apoptosis or programmed cell death, liver damage, neuronal cell death, stroke and heart attack.

"Activated JNK migrates to the mitochondria in reaction to a stress signal," said Philip LoGrasso, professor in the Department of Molecular Therapeutics and senior director for drug discovery at Scripps Florida who led the study. "Once there, it amplifies the effects of reactive oxygen species that cause significant damage to the cell. We developed a small peptide that intervenes in JNK migration and blocks those harmful effectsspecifically cell death."

LoGrasso noted that the team was able to block JNK mitochondrial interaction without harming any other important enzyme processes, such as JNK's impact on gene expression. These findings, LoGrasso said, suggest t
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find key mechanism in transition to alcohol dependence
2. Scripps Research scientists create new genetic model of premature aging diseases
3. Scripps Research scientists identify mechanism of long-term memory
4. Scripps Research scientists uncover new DNA role in modifying gene function
5. Scripps Research scientists find dual switch regulates fat formation
6. Common chaperone protein found to work in surprising way, say Scripps Research scientists
7. Dr. Daniel Von Hoff presented with top genomics award from Scripps
8. Scripps Research team discovers new details about medically important protein family
9. Scripps Research scientists develop new test for pluripotent stem cells
10. Scripps Research scientists create cell assembly line
11. Scripps oceanography researchers discover arctic blooms occurring earlier
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... Aug. 6, 2015  Today, U.S. Congressman ... Crossmatch ™ to learn firsthand how Silicon Valley ... Crossmatch is a world leader in multi-factor identity ... are helping federal agencies and commercial organizations achieve ... "The vast majority of network breaches ...
(Date:8/5/2015)... CHICAGO , August 5, 2015 ... Identity & Access Management Market by Software, Services, Vertical (BFSI, ... Chemical/Pharma), & Geography - Global Forecast to 2020", published ... Access Management Market globally into various segments. The global ... in 2014 to $546.2 Million by 2019, at a ...
(Date:8/4/2015)... DUBLIN , Aug. 04, 2015 /PRNewswire/ ... ( http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition ... Component (Hardware, Software, and Service), Sub-Segment (Computer ... Cloud Forensics), Tool Types, Service, Vertical and ... report to their offering. By ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2
... ITHACA, N.Y. - A new study of maize has ... the genome. New techniques may allow breeders and researchers to ... new varieties that were not easily possible before. Publishing ... researchers, whose senior and first author are at Cornell, have ...
... COLLEGE PARK, Md.-John Fisher, associate professor in the Fischell ... the 2009 Bioscience Research and Technology Review Day with ... other types of tissue for implantation. Fisher,s technology ... minute pitch by faculty members and graduate students at ...
... the first time, scientists have successfully used a method called ... for a mendelian disorder. Mendelian disorders, such as ... one or more mutations in a single gene, typically a ... code for proteins taken together are called the exome. The ...
Cached Biology News:New map of variation in maize genetics holds promise for developing new varieties 2Bioreactor for bone tissue engineering wins professor venture fair 2Bioreactor for bone tissue engineering wins professor venture fair 3Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome 2Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome 3
(Date:9/3/2015)... Sept. 3, 2015  StemProtein LLC, a leading ... spinout of Stemedica Cell Technologies Inc., announced today ... as CEO of StemProtein. Silberg will help advance ... preserving Stem Cell Factors (SCFs), a significant consumer ... the pharmaceutical and biopharmaceutical industries with substantial executive ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... non-invasive hydration monitoring wearable early 2016. , The device, called the Halo ... proprietary optical and electrical sensing technology. These sensors track trending interstitial fluid levels ...
(Date:9/2/2015)... 2, 2015 Research and Markets ... of Jain PharmaBiotech,s new report "Nanobiotechnology ... offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... and Companies" to their offering. ... based on technologies and applications. The report starts ... for estimation of markets. Technologies include array comparative ...
Breaking Biology Technology:StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2
... Investigating programmed cell death , Wei-ping Yang ... ,Stratagene , The apoptotic response is a complex ... of genes that interact with and respond to ... ,sets that are specific for genes ...
... pathway activation , Li Xu Tim Sanchez ... Stratagenes PathDetect in vivo signal transduction pathway,reporting systems ... activation of signal,transduction pathways. To expand the utility ... and pFA-Elk1 plasmids with new, improved fusion,trans-activator plasmids. ...
... with TKB1 competent cells , David ... for Molecular Biology and Biotechnology, McMaster University,Ontario, ... bacteria are used to affinity purify,cellular proteins, ... on,the ErbB2/Neu receptor tyrosine kinase (RTK). This ...
Cached Biology Technology:RT-PCR Primers for the Study of Apoptosis 2RT-PCR Primers for the Study of Apoptosis 3RT-PCR Primers for the Study of Apoptosis 4RT-PCR Primers for the Study of Apoptosis 5RT-PCR Primers for the Study of Apoptosis 6RT-PCR Primers for the Study of Apoptosis 7Improved Vectors for PathDetect Trans-Reporting Systems 2Improved Vectors for PathDetect Trans-Reporting Systems 3Improved Vectors for PathDetect Trans-Reporting Systems 4Improved Vectors for PathDetect Trans-Reporting Systems 5TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins 2TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins 3TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins 4TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins 5
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Gap junction protein, beta 2, 26kDa (connexin 26) Antigen: Peptide...
HSPBP1 Antibody...
... advanced RACE (rapid amplification of cDNA ends) ... full-length 5' and 3' cDNA ends. The ... Reverse Transcriptase (RT) for improved amplification of ... complex mRNA. The RNase H portion of ...
Biology Products: