Navigation Links
Scripps Research scientists find key mechanism in transition to alcohol dependence
Date:5/31/2011

A team of Scripps Research Institute scientists has found a key biological mechanism underpinning the transition to alcohol dependence. This finding opens the door to the development of drugs to manage excessive alcohol consumption.

"Our focus in this study, like much of our lab's research, was to examine the role of the brain's stress system in compulsive alcohol drinking driven by the aversive aspects of alcohol withdrawal," said Scripps Research Associate Professor Marisa Roberto, Ph.D., senior author of the study.

"A major goal for this study," added Research Associate Nicholas Gilpin, Ph.D., the paper's first author, "was to determine the neural circuitry that mediates the transition to alcohol dependence."

In the new research, published in the June 1, 2011 issue of the journal Biological Psychiatry, the Scripps Research scientists demonstrated the key role of a receptor a structure that binds substances, triggering certain biological effectsfor neuropeptide Y in a part of the brain known as the central amygdala. The amygdala, a group of nuclei deep within the medial temporal lobes, performs an important role in the processing and memory of emotional reactions.

"We've known for quite some time that neuropeptide Y is an endogenous [naturally occurring] anti-stress agent," says Markus Heilig, clinical director of the National Institute of Alcohol Abuse and Alcoholism (NIAAA). "We've also known that development of alcohol dependence gives rise to increased sensitivity to stress. This paper elegantly and logically brings these two lines of research together. It supports the idea that strengthening neuropeptide Y transmission in the amygdala would be an attractive treatment for alcoholism. The challenge remains to develop clinically useful medications based on this principle."

Discovering the Circuitry

Building on Gilpin's previous work on neuropeptide Y, in the new project, Gilpin, Roberto,
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... 19, 2014  Earlier this year Donald Spector ... and one of the most prolific inventors in the ... transmitted from Smartphones to third party agencies. Spector envisioned ... one of the earliest known patents in this area. ... the military, child care, elder care and hospital applications. ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Abnormalities in cardiac conduction, the rate at which ... are a major cause of death and disability around ... developing a new method, Electromechanical Wave Imaging (EWI), that ... activation of the heart. Based on ultrasound imaging, EWI ...
... to impair normal muscle function in rats, an ... according to Penn State researchers. "Our findings demonstrate ... and carrying excess weight," said Rudolf J. Schilder, ... Penn State College of Medicine. "We show that, ...
... Hopkins scientists have discovered how two closely related proteins ... attracting and repelling these axons as they navigate the ... to make remarkably precise connections. The discovery, reported ... that proteins belonging to the "semaphorin" family of guidance ...
Cached Biology News:Columbia engineers develop new method to diagnose heart arrhythmias 2Obesity creates wimpy rats 2Johns Hopkins scientists reveal nerve cells' navigation system 2Johns Hopkins scientists reveal nerve cells' navigation system 3
(Date:11/21/2014)... (PRWEB) November 20, 2014 BlueInGreen, ... Ozone Solutions, LLC (Pinnacle), and PCI, Inc., leading ... that they have been selected to provide a ... Fayetteville, Arkansas Paul R. Noland Wastewater Treatment. ... patented HyDOZ® gas dissolution technology, Pinnacle ...
(Date:11/21/2014)... November 21, 2014 2014 Deep ... Industryā€¯ is a professional and in-depth research report ... ferrocyanide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/21/2014)... , Nov. 20, 2014 Polaris ... been dosed in its Phase 1 trial of ... for the treatment of malignant pleural mesothelioma (MPM) ... is conducting clinical trials on ADI-PEG 20, both ... for the treatment of several other indications, including ...
(Date:11/21/2014)... , Nov. 20, 2014  Cytori Therapeutics (NASDAQ: ... Hedrick , M.D. will present live at VirtualInvestorConferences.com on December ... TIME:    11:15 am PT / 2:15 pm ET ... into your browser,s address bar: http://bit.ly/1B2KGaL ... receive event updates. This will be a ...
Breaking Biology Technology:City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... PRA International, a leading Clinical Research Organization, announces it ... Meeting April 28-30, 2009 in Orlando Florida. PRA,s Greg ... " RFP Management & Contracting with CROs to Minimize ... Drawing on his extensive experience with contracting, Mr. Guarasci ...
... 2009 edition of the,Biotechnology Industry Organization (BIO) Conference ... 18th-20th. Genopole(R) will participate in this,major event as ... Region.,Seven of Genopole(R),s innovative companies (BioQuanta, Drugabilis,GenOptics, Innavirvax, ... will, attend. , The ...
... SQNM ), today announced that it will report first ... 2009. The company will conduct a conference call and an ... on the same day., Conference Call Information:, ... callers: 1 (706) 679-9912, , , Webcast information: ...
Cached Biology Technology:PRA International Presents Key Budgeting Strategies at 18th Annual CRO Partnerships Conference 2Genopole(R) to Accompany 7 Companies and a Research lab to BIO Atlanta 2SEQUENOM to Hold First Quarter 2009 Financial Results Conference Call on April 30 2
... affinity chromatography, Affi-Prep protein A media ... remove IgG prior to analysis of ... complexes for antigen purification. Protein A ... immunoglobulins, especially IgG from mammalian species. ...
... introduce its new line of Protein Standards, ... for use in mass spectrometry, molecular biology, ... Standards are high quality purified proteins for ... by electrospray ionization mass spectrometry (ESI-MS). ...
... White solid. HYGROSCOPIC. A non-ionic ... reduced electrostatic interactions that do not interfere ... number: 8-16. Purity: ≥95% by HPLC. ... number 8 - 16, CMC 1.1 - ...
Determine relative degree of protein binding to phosphoinositides...
Biology Products: