Navigation Links
Scripps Research scientists create vaccine against heroin high
Date:7/20/2011

such as cocaine, methamphetamine, and nicotine. Human clinical trials are under way for the cocaine and nicotine vaccines.

Attempts by other researchers over the past four decades to create a clinically viable heroin vaccine, however, have fallen short, in part due to the fact that heroin is an elusive target metabolized into multiple substances each producing psychoactive effects.

An Innovative Approach

To overcome this problem, in the new study the Scripps Research team used a "dynamic" approach, targeting not only heroin itself, but also the chemical it quickly degrades into, 6-acetylmorphine (6AM), and morphine.

"Heroin is lipophilic and is rapidly degraded to 6AM," said G. Neil Stowe, a research associate in Janda's laboratory who is first author of the new study. "Both readily cross the blood-brain barrier and gain access to the opioid receptors in the brain."

The researchers linked a heroin-like hapten (a small molecule that elicits an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with Alum, an adjuvant (vaccine additive), to create a vaccine "cocktail." This mixture slowly degraded in the body, exposing the immune system to different psychoactive metabolites of heroin such as 6AM and morphine.

"Critically, the vaccine produces antibodies to a constantly changing drug target," said Stowe. "Such an approach has never before been engaged with drug-of-abuse vaccines."

To compare the results of a non-dynamic approach, the team also prepared a vaccine simply targeting morphine, a substance related to heroin. Both vaccines were then injected into rats and the effects were examined in Koob's laboratory.

Promising Results

The results showed that the rats rapidly generated robust polyclonal antibodies in response to the dynamic heroin vaccine.

In addition, the study found that addicted rats were less likely to "self-admini
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists solve mystery of nerve disease genes
2. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
3. Scripps study finds plastic in 9 percent of garbage patch fishes
4. Scripps Research Institute Scientist Knighted by Italian Republic
5. Scripps Research team sheds new light on how blood clots form
6. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
7. Scripps Research scientist wins $1.9 million grant to study malaria
8. Scripps Research scientists find way to block stress-related cell death
9. Scripps Research scientists find key mechanism in transition to alcohol dependence
10. Scripps Research scientists create new genetic model of premature aging diseases
11. Scripps Research scientists identify mechanism of long-term memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... be cheerful, happy-go-lucky characters, so you might expect that ... , In fact some dogs are distinctly more pessimistic ... , "This research is exciting because it measures ... non-invasively. It offers researchers and dog owners an insight ... said Dr Melissa Starling, from the Faculty of Veterinary ...
(Date:9/18/2014)... it that when people are too stressed they are ... the Brain Mind Institute (BMI) at EPFL have just ... between chronic stress and the loss of social skills ... attacks a synaptic regulatory molecule in the brain. This ... Communications . , Carmen Sandi,s team went to ...
(Date:9/17/2014)... health care to reproductive technologies, the justice and ... of people to identify key issues, articulate their ... find the most defensible ways forward. But what ... societal conversations?, The Hastings Center and the Presidential ... teamed up to publish a series of essays ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... Now, researchers at Yonsei University in Seoul, Republic of ... a layer of silver ions that can prevent growth ... Salmonella typhimurium and Campylobacter jejuni . The ... be particularly useful for applications in disaster recovery and ...
... is killing fishers in the southern Sierra Nevada, according ... scientists from the U.S. Forest Service,s Pacific Southwest Research ... Berkeley, and the Integral Ecology Research Center. ... team documented that rodenticides were being found in the ...
... 27, 2013 /PRNewswire-iReach/ -- Industry leader in healthcare ... to improve the family waiting room experience.  While ... the company now offers a customizable multilingual whiteboard ... preference.  Over 3o languages are currently available, with ...
Cached Biology News:Spinning up antibacterial silver on glass 2Illegal marijuana grows threaten fishers in the southern Sierra Nevada 2PatientStream announces the industry's first Multilingual family waiting room board 2PatientStream announces the industry's first Multilingual family waiting room board 3
(Date:9/19/2014)... , September 19, 2014 ... and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition ... Chromatography Columns"  report to their offering.  ... market is one of the fastest-growing segments in ... $1.2 billion in 2013, and expected to reach ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
(Date:9/18/2014)... Austin, TX (PRWEB) September 18, 2014 ... of integrated urological and interventional radiology products and ... (also known as cryotherapy and cryoablation) versus external ... Mid-Atlantic Section of the American Urological Association (MAAUA) ... , "Comparing Relative Effectiveness of Cryosurgery and ...
(Date:9/18/2014)... Sept. 18, 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 ... Acid Industry" and "2014 Deep Research Report on ... its research database. Photo - ... Report on Global and China Acetic Acid Industry" ... China and Global Acetic ...
Breaking Biology Technology:Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4
... consulting firm ,based in Draper, UT, named Epic Systems ... Report Card. The study, which included 200 vendors, was ... and clinicians representing over 4,000 healthcare facilities. , ,KLAS ... information technology (HIT) vendors and releases its Top 20 ...
... game makers , ,Eau Claire, WI-- Silicon ... Graphics of Wilsonville, Ore., to offer improved custom ... spectrum. , ,The business collaboration is meant to speed ... additional manufacturing operations due to undetected errors in very ...
... intranet infrastructure helped Cisco Systems - the ... explosive growth in the late '80s ad early '90s. ... has come from careful expansion of the company's product ... Marquette University Business Leaders Forum Breakfast. , ...
Cached Biology Technology:Silicon Logic Teams Up to Save Money 2Cisco Chairman Praises University Research 2Cisco Chairman Praises University Research 3
Mouse HAI-1 Ectodomain MAb (Clone 199732)...
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
IEX-1 S/L (H-20)...
Mouse monoclonal [1.T.4] to WAVE 1 ( Abpromise for all tested applications). Antigen: His6 fusion protein corresponding to full-length rat WAVE1. Entrez Gene ID: 8936...
Biology Products: