Navigation Links
Scripps Research scientists create vaccine against heroin high
Date:7/20/2011

such as cocaine, methamphetamine, and nicotine. Human clinical trials are under way for the cocaine and nicotine vaccines.

Attempts by other researchers over the past four decades to create a clinically viable heroin vaccine, however, have fallen short, in part due to the fact that heroin is an elusive target metabolized into multiple substances each producing psychoactive effects.

An Innovative Approach

To overcome this problem, in the new study the Scripps Research team used a "dynamic" approach, targeting not only heroin itself, but also the chemical it quickly degrades into, 6-acetylmorphine (6AM), and morphine.

"Heroin is lipophilic and is rapidly degraded to 6AM," said G. Neil Stowe, a research associate in Janda's laboratory who is first author of the new study. "Both readily cross the blood-brain barrier and gain access to the opioid receptors in the brain."

The researchers linked a heroin-like hapten (a small molecule that elicits an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with Alum, an adjuvant (vaccine additive), to create a vaccine "cocktail." This mixture slowly degraded in the body, exposing the immune system to different psychoactive metabolites of heroin such as 6AM and morphine.

"Critically, the vaccine produces antibodies to a constantly changing drug target," said Stowe. "Such an approach has never before been engaged with drug-of-abuse vaccines."

To compare the results of a non-dynamic approach, the team also prepared a vaccine simply targeting morphine, a substance related to heroin. Both vaccines were then injected into rats and the effects were examined in Koob's laboratory.

Promising Results

The results showed that the rats rapidly generated robust polyclonal antibodies in response to the dynamic heroin vaccine.

In addition, the study found that addicted rats were less likely to "self-admini
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists solve mystery of nerve disease genes
2. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
3. Scripps study finds plastic in 9 percent of garbage patch fishes
4. Scripps Research Institute Scientist Knighted by Italian Republic
5. Scripps Research team sheds new light on how blood clots form
6. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
7. Scripps Research scientist wins $1.9 million grant to study malaria
8. Scripps Research scientists find way to block stress-related cell death
9. Scripps Research scientists find key mechanism in transition to alcohol dependence
10. Scripps Research scientists create new genetic model of premature aging diseases
11. Scripps Research scientists identify mechanism of long-term memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/12/2015)... , June 12, 2015  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... its patent to electronically capture, analyze and identify ... facial recognition methods. This system can: ... by an enrollment and subsequent sign-on process is ...
(Date:6/9/2015)... -- Research and Markets  ( http://www.researchandmarkets.com/research/xsgs2s/gesture ) has ... & Touchless Sensing Market by Technology (Touch-based & ... (Biometric & Sanitary Equipment) & by Geography - ... offering. The total gesture recognition and ... 23.55 Billion by 2020 at a high CAGR ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... gene responsible for controlling a first key step in the ... the journal Nature tomorrow (Thursday 27 October 2005). , The ... place once a sperm enters an egg, giving it a ... animals. , The absence or mutation of this gene in ...
... to last year's groundbreaking toxicological study on water-soluble ... and Environmental Nanotechnology (CBEN) find that water-soluble carbon ... Moreover, the research finds that nanotubes, like buckyballs, ... , The findings come from the first toxicological ...
... the University of California, San Diego that appears in the ... of the species Uca crenulata may check out 100 or ... on a mate. , “As far as I know, no ... as the California fiddler crab,?said Catherine deRivera, who conducted the ...
Cached Biology News:Scientists unpick genetics of first 15 minutes of life 2Modifications render carbon nanotubes nontoxic 2Modifications render carbon nanotubes nontoxic 3Biologist Discovers What May Be World’s ‘Pickiest?Mates 2Biologist Discovers What May Be World’s ‘Pickiest?Mates 3
(Date:7/1/2015)... ... July 01, 2015 , ... NEMA 4 (IP66) ... CTI’ new Medical Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. ... device that will increase healthcare worker safety and reduce financial costs. , CTI ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... take part in the first half of “Integrative Biotechnology,” an applied biotechnology course ... in summer 2014, this course combines students from both universities and is taught ...
(Date:6/30/2015)... WASHINGTON , June 30, 2015  NASA astronaut ... launch next month on his first mission to the ... interviews from 8 to 9 a.m. EDT Tuesday, July 7. ... Center in Star City, Russia . The ... on NASA Television highlighting his mission training. To ...
(Date:6/30/2015)... ... June 30, 2015 , ... ... provide new insights on mechanics of fecal microbiota transplantation in C. difficile patients. ... the microbiome of patients undergoing fecal microbiota transplantation (FMT) as a treatment for ...
Breaking Biology Technology:Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2Rivier University and Beijing City University Academic and Cultural Exchanges Begin 2NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3
... Canary Foundation, a,nonprofit organization that funds research in early ... Sam Gambhir, has,been elected as a new member of ... one of the highest honors in the fields of ... National Academy of,Sciences, serves as adviser to the nation ...
... MOUNTAIN VIEW, Calif., Oct. 21 An ... difficult to treat allures clinicians,to the approach of ... potential, stem cell therapies are believed to treat ... at a fast pace; however,both adult and embryonic ...
... Findings confirm that NanoBio,s nanoemulsion technology is effective when ... used in therapeutic applications and vaccines, ... announced,today that it will present compelling new data in ... preclinical development programs,in onychomycosis, herpes labialis, cystic fibrosis and ...
Cached Biology Technology:Canary Foundation's Dr. Sanjiv Sam Gambhir Elected to the National Academies Institute of Medicine 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 2Innovation and Strong Therapeutic Potential Seen in Adult Stem Cells, According to Frost & Sullivan 3NanoBio to Announce Key Clinical and Preclinical Data in Nine Presentations at ICAAC/IDSA 2008 2
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Designed for flow cytometric applications intended to identify...
MOUSE ANTI RAT RT1Bu Immunogen: Rat thymocyte membrane glycoproteins...
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
Biology Products: