Navigation Links
Scripps Research scientists create new genetic model of premature aging diseases
Date:4/29/2011

JUPITER, FL, April 28, 2011 Working with a group of national and international researchers, scientists from the Florida campus of The Scripps Research Institute have developed a new genetic model of premature aging disorders that could shed light on these rare conditions in humans and provide a novel platform for large-scale screening of compounds to combat these and other age-related diseases.

In the new study, which was published this month in the open-access publication PLoS ONE, the scientists found a way to use zebrafish (Danio rerio) to model two rare human genetic disorders: Hutchinson-Gilford Progeria Syndrome and laminopathies.

"This is a robust model system of human aging that corresponds directly to the human genes involved in these diseases," said Scripps Florida Assistant Professor Shuji Kishi, who led the study. "This model is ready now and can be used to screen and develop chemical compounds to treat these and other age-related diseases."

Kishi noted that zebrafish, which display an array of signs of aging resembling those in humans, have emerged over the past decade as a powerful system to study diseases associated with aging and development.

Hutchinson-Gilford Progeria Syndrome is a rare disease that causes symptoms of advanced aging such as cardiovascular problems, hair loss, and distressed skin in young children. The laminopathies are a cluster of at least 13 different genetic disorders, whose symptoms range from muscular dystrophy to premature aging. They are grouped together because they are all caused by mutations in the genes that encode proteins of the nuclear membrane, the double-hulled envelope that surrounds the cell nucleus.

The gene associated with both progeria and laminopathies is the lamin A gene (LMNA), which presumably is also involved in the normal process of human aging, although the underlying mechanisms of the process are still relatively unknown.

In the new re
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/11/2014)... CHICAGO , Nov. 11, 2014  Forensicon, Inc., ... eDiscovery firm, is pleased to announce the promotion of ... to Director of Digital Forensics. In Schiff,s new role ... out the team of digital forensics examiners and provide ... Photo - http://photos.prnewswire.com/prnh/20141110/157719 ...
(Date:11/7/2014)... Researchers led by Dr. Debra Auguste, associate professor, ... at The City College of New York, have ... treatment for one of the most aggressive forms ... (TNBCs) have a high mortality rate owing to ... effective therapeutic options. However, Professor Auguste,s team, discovered ...
(Date:11/7/2014)... , November 6, 2014 Leading ... for better mobile security revolutionizing online transactions.  Companies in focus ... Holdings Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... ), eBay Inc. (NASDAQ: EBAY ) and MasterCard ... NXTD and NXTDW), a biometric authentication company focused on ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... molecules of membranes, also known as phospholipids, are composed of ... The molecules form a bilayer in the membrane, with all ... hanging in a zip-like interlay position. Biomembranes are ... cell is constantly creating new phospholipids that have to align ...
... JUPITER, FL, January 29, 2013 While the wooly musk ox ... it hot, or at least warm. In fact, their preferred optimum ... Scientists have known that a type of brain cell circuit helps ... their temperature preferences. What has been a mystery is whether or ...
... Trees in the continental U.S. could send out new spring ... than they did before global temperatures started to rise, according ... changes could lead to changes in the composition of northeastern ... up carbon dioxide. Trees play an important role in ...
Cached Biology News:Pathway for membrane building blocks 2Scripps Research Institute study shows how brain cells shape temperature preferences 2Spring may come earlier to North American forests 2Spring may come earlier to North American forests 3
(Date:11/21/2014)... , Nov. 21, 2014   TRU-D SmartUVC LLC ... their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS ... from Nov. 23 to 26 at Stand 23. ... United Kingdom,s largest infection-related event of ... societies to one of the leading events of its type ...
(Date:11/21/2014)... 2014 Offering a complete line of ... Balance promotion . The Sartorius Entris Balance is the ... accuracy, and easy-to-maintain balance entry level balance. , The ... designed to help customer’s bridge the gap between a ... is very durable. Sartorius is the second biggest balance ...
(Date:11/21/2014)... November 20, 2014 The ... policy research organization representing leading California academic institutions, ... PwC US today released a report ... sciences industry growth. The trend shows a 4 ... 2015 California Biomedical Industry Report indicates that, ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... government-mandated change as a result of the Sarbanes-Oxley ... reporting and companies to continually evaluate their financial ... as to the technology requirements and information technology ... any technology; however, it is difficult to envision ...
... Wednesday it will support American Musical Supplys (AMS) ... chain execution solutions. AMS , a supplier ... distribution network next year and develop business-to-business sales ... vision products. , ,AMS was driven to ...
... Act went info effect Jan. 1 and, although its enforceability ... to come. , ,CAN-SPAM (controlling the assault of non-solicited pornography ... reduce the flow of unsolicited e-mail (SPAM). According to the ... , , Clearly label commercial e-mail as advertising , Use ...
Cached Biology Technology:Technology Implications of Sarbanes-Oxley 2Technology Implications of Sarbanes-Oxley 3CAN-SPAM: Wheres the Meat? 2
... Zyagen tissue microarrays are derived from frozen ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... coated slides. Sections are large (3-5mm in ...
... Opticon real-time PCR detection system uses a ... (450-495 nm) and a photomultiplier tube for ... is built on an DNA Engine thermal ... feature. This item includes the thermal cycler, ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... are highly sensitive laser confocal systems designed ... advanced scanners that meet your expectations, differentiating ... and optimizing the signal on the bottom ... the range for increased sensitivity. Results with ...
Biology Products: