Navigation Links
Scripps Research scientist wins $1.9 million grant to study malaria
Date:6/9/2011

A scientist from The Scripps Research Institute has won a four-year, $1.9 million grant from the National Institutes of Health to better understand the parasite that causes malaria, laying the groundwork to develop better drugs to combat the widespread and deadly disease.

"Many antimalarial drugs alleviate symptoms, but do not necessarily result in a complete cure because some malaria parasites are able to persist asymptomatically in the liver for months or years," said Scripps Research Professor Elizabeth Winzeler, who is principal investigator for the new grant. "We hope to find new targets that are critical to the liver stages as well as the blood stages with the long-term aim of designing better drugs."

A Complicated Lifecycle

Malaria is a nasty and often fatal disease, affecting about 250 million people every year in Africa, Asia, and the Americas, according to the World Health Organization (WHO). Each year, more than 1 million people die of malaria, mostly children under the age of five. While significant strides had been made in curtailing the disease, for the last two decades malaria, has again been on the rise due to the emergence of drug-resistant parasites.

The parasite Plasmodium, which causes malaria, has a complicated lifecycle in two hostsmosquitoes and humans (or other vertebrate). When a malaria-infected mosquito feeds on a person, the parasite enters the human body. Within 30 minutes, the parasite has infected liver cells, where it remains anywhere from eight days to several months without causing noticeable symptoms.

When this period is over, however, the parasite (now in a different form) leaves the liver and enters red blood cells, where it grows and multiplies. When the infected red blood cells eventually burst, the parasite and Plasmodium toxins are released into the bloodstream, and the person feels sick. Symptoms include fever, chills, headache, and other flulike symptoms; in severe
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find way to block stress-related cell death
2. Scripps Research scientists find key mechanism in transition to alcohol dependence
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Scripps Research scientists identify mechanism of long-term memory
5. Scripps Research scientists uncover new DNA role in modifying gene function
6. Scripps Research scientists find dual switch regulates fat formation
7. Common chaperone protein found to work in surprising way, say Scripps Research scientists
8. Dr. Daniel Von Hoff presented with top genomics award from Scripps
9. Scripps Research team discovers new details about medically important protein family
10. Scripps Research scientists develop new test for pluripotent stem cells
11. Scripps Research scientists create cell assembly line
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... Between 16 and 20 ... innovations in biometric identification at the CeBIT exhibition ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) , ... at the forefront: the company,s all new BiometricGate ... Germany . BiometricGate is the first ...
(Date:3/11/2015)... , Mar. 11, 2015 Research and Markets ... of the "Access Control Market by Product, Application ... 2020" report to their offering. , ... expected to reach $10.4 billion by 2020, with an ... market report covers the products types such as contact ...
(Date:3/10/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce ... been named the "Number One Best Tech Gift ... Modern ( http://www.rethinkmodern.com/ ) is a web magazine focused ... that have a unique function or design.  ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... Ice Age bones indicate that humans in Ohio hunted or ... curator of archaeology at The Cleveland Museum of Natural History, ... 2012 online issue of the journal World Archaeology . ... 1998 in the collections of the Firelands Historical Society Museum ...
... University biologists have found that specific types of RNA polymerase ... differ in function based on variation in the parts -- ... machines. The new findings on the synthesis and function ... lead author Craig Pikaard discovered over a decade ago -- ...
... Probing the largely unexplored question of what characteristics ... that by mimicking nature, a robotic fish can transform ... series of experiments, researchers from Polytechnic Institute of New ... animal behavior, including learning how robots might someday steer ...
Cached Biology News:Research reveals first evidence of hunting by prehistoric Ohioans 2IU biologists offer clearer picture of how protein machine systems tweak gene expression 2What makes a robot fish attractive? (Hint: It's in the moves) 2
(Date:3/26/2015)... 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ... advanced testing solutions for the detection of foodborne ... three months and full year ended December 31, ... for the quarter ended December 31, 2014 was ... quarter of 2013 and $1.5 million for the ...
(Date:3/26/2015)...  BioNano Genomics, Inc., the leader in genome mapping, ... chief commercial officer. Salyer has more than 20 years ... life sciences. At BioNano, Salyer will oversee the commercialization ... to assemble a comprehensive view of complex genomes to ... institutions located in the United States ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 ReliantHeart, Inc., ... and Transonic, a supplier of precision transit-time flow measurement ... will greatly improve the efficiency of the HeartAssist5® ... LVAD patients to experience greater mobility and peace of ... the miniature flow board, will draw 1/6th of the ...
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
Breaking Biology Technology:Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 2Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 3Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 4Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 5Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 6Roka Bioscience Reports Fourth Quarter and Full Year 2014 Financial Results 7BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 2BioNano Genomics Appoints Terry Salyer as Chief Commercial Officer 3LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3
... Inc. (Nasdaq: BIOD ) today reported financial results ... Third Quarter Operating Highlights During Biodel,s third ... completed Phase 1 testing of two new ultra-rapid-acting formulations of ... supported investigators at Oregon Health and Sciences University who have ...
... 4, 2011 Vermillion, Inc. (NASDAQ: ... for the second quarter ended June 30, 2011. Key milestones we ... Performance of an estimated 3,920 OVA1® tests during ... 3,200-3,500 tests and representing volume growth of 27% over the ...
... carbon nanofiber-filled coatings devised by researchers from the National ... University outperformed conventional flame retardants used in the polyurethane ... 160 percent and perhaps by as much as 1,130 ... journal Polymer ,* suggest that significant fire-safety advantages ...
Cached Biology Technology:Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 2Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 3Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 4Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 5Biodel Reports Third Quarter Fiscal Year 2011 Financial Results 6Vermillion Reports Results for the Second Quarter 2011 2Vermillion Reports Results for the Second Quarter 2011 3Vermillion Reports Results for the Second Quarter 2011 4Vermillion Reports Results for the Second Quarter 2011 5Vermillion Reports Results for the Second Quarter 2011 6Vermillion Reports Results for the Second Quarter 2011 7Novel coatings show great promise as flame retardants in polyurethane foam 2
... RQ1 RNase-Free DNase is a ... single-stranded or double-stranded DNA to produce ... for use in applications where maintaining ... RQ1 DNase is qualified for use ...
... Wild Type Liquid. In 100 mM ... µM EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW ... a monomeric protein of 765 amino acids encoded ... of both positive and negative supercoiled DNAs without ...
Request Info...
... III digests duplex DNA in a 3'-> ... or nick, producing stretches of single-stranded DNA. ... Exonuclease III proceeds at a uniform rate ... rate of exonucleolytic excision of deoxyribonucleotides by ...
Biology Products: