Navigation Links
Scripps Research scientist wins $1.9 million grant to study malaria
Date:6/9/2011

A scientist from The Scripps Research Institute has won a four-year, $1.9 million grant from the National Institutes of Health to better understand the parasite that causes malaria, laying the groundwork to develop better drugs to combat the widespread and deadly disease.

"Many antimalarial drugs alleviate symptoms, but do not necessarily result in a complete cure because some malaria parasites are able to persist asymptomatically in the liver for months or years," said Scripps Research Professor Elizabeth Winzeler, who is principal investigator for the new grant. "We hope to find new targets that are critical to the liver stages as well as the blood stages with the long-term aim of designing better drugs."

A Complicated Lifecycle

Malaria is a nasty and often fatal disease, affecting about 250 million people every year in Africa, Asia, and the Americas, according to the World Health Organization (WHO). Each year, more than 1 million people die of malaria, mostly children under the age of five. While significant strides had been made in curtailing the disease, for the last two decades malaria, has again been on the rise due to the emergence of drug-resistant parasites.

The parasite Plasmodium, which causes malaria, has a complicated lifecycle in two hostsmosquitoes and humans (or other vertebrate). When a malaria-infected mosquito feeds on a person, the parasite enters the human body. Within 30 minutes, the parasite has infected liver cells, where it remains anywhere from eight days to several months without causing noticeable symptoms.

When this period is over, however, the parasite (now in a different form) leaves the liver and enters red blood cells, where it grows and multiplies. When the infected red blood cells eventually burst, the parasite and Plasmodium toxins are released into the bloodstream, and the person feels sick. Symptoms include fever, chills, headache, and other flulike symptoms; in severe
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find way to block stress-related cell death
2. Scripps Research scientists find key mechanism in transition to alcohol dependence
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Scripps Research scientists identify mechanism of long-term memory
5. Scripps Research scientists uncover new DNA role in modifying gene function
6. Scripps Research scientists find dual switch regulates fat formation
7. Common chaperone protein found to work in surprising way, say Scripps Research scientists
8. Dr. Daniel Von Hoff presented with top genomics award from Scripps
9. Scripps Research team discovers new details about medically important protein family
10. Scripps Research scientists develop new test for pluripotent stem cells
11. Scripps Research scientists create cell assembly line
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ... long-held beliefs about the condition and the best ways to ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an ... connective tissue that enhances care coordination among social service ... client-level information; earned a second $1 million grant from ... seniors aging in community and; will be recognized as ... th 4-6p. CIE San Diego today ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... Editor : A 0.1 change over 200 years? I'd like to ... as with the last article, don't panic just yet! Still, if ... big... It takes a lot of acid to change its pH, ... in the U.K. sounds the alarm about the world's oceans. "If ...
... the Tulane National Primate Research Center has for the ... a vaginal gel protect the animals against an HIV-like ... that inhibit the processes by which HIV attaches to ... effective and practical way to prevent HIV transmission in ...
... Analysis of a key protein in different subtypes of ... drug amantadine in H5N1 occurs worldwide, but is especially ... to the antiviral drug amantadine is spreading more rapidly ... Asia than in North America, according to the study ...
Cached Biology News:Oceans turning to acid from rise in CO2 2Vaginal gel may provide a new approach to HIV prevention 2Drug resistant avian influenza viruses more common in Southeast Asia than North America 2Drug resistant avian influenza viruses more common in Southeast Asia than North America 3Drug resistant avian influenza viruses more common in Southeast Asia than North America 4
(Date:12/19/2014)... CA (PRWEB) December 18, 2014 With ... limited time special on Sartorius Biohit products . ... on mLINE pipettes, Picus Electronic Pipette Trade-in Program, and ... Health and Safety officers around the world. They are ... pipetting. Other features include:, ,     Full volume ...
(Date:12/19/2014)... Dec. 18, 2014 Egenix, Inc. is pleased to ... Chairman of the Board, to succeed Donald Fresne ; ... will continue as a member of the Board.  In recognition ... to the company over almost twenty years, the Board designated ... of Directors has established a Search Committee to find a ...
(Date:12/19/2014)... YORK , Dec. 18, 2014 Relmada ... therapies for the treatment of chronic pain, announced the ... today. "This was a transformational year in ... promising future for our company," said Sergio Traversa ... year, we have executed on key financial, human resource ...
(Date:12/17/2014)... 2014 Based on the revenues ... imaging market is dominated by four major players ... market. These players include GE Healthcare (U.K.), Siemens ... , Full Report Copy at http://www.marketsandmarkets.com/Market-Reports/surgical-imaging-market-210534462.html ... can be attributed to its strong product portfolio, ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 2Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 3Global Refurbished Surgical Imaging Market by Product & Application is Estimated to Reach $1.25 Billion by 2019 - New Research Report by MarketsandMarkets 4
... YORK, Oct. 10 To mark 50 years ... Foundation,(PDF) will present an authoritative round-up of the ... Thursday, October 11 and Friday, October,12. The jam-packed ... latest news in Parkinson,s science and quality,of life ...
... 10 Microtest has announced the,availability of a ... Partnering With a Contract Lab." In manufacturing ... many levels, from raw materials to processing. This,contamination ... testing,program is essential to ensure the biological product ...
... RALEIGH, N.C., Oct. 10 Campbell Alliance, the leading,management ... announced that the firm was recognized as one of ... area of North Carolina by the,Triangle Business Journal, ranking ... firm at the Triangle Business Journal,s annual Best,Places to ...
Cached Biology Technology:The Parkinson's Disease Foundation Commemorates its 50th Anniversary with Special Scientific Symposium on Parkinson's Disease 2The Parkinson's Disease Foundation Commemorates its 50th Anniversary with Special Scientific Symposium on Parkinson's Disease 3Microtest Offers Free White Paper: 'Virus Testing for Biological Products: Partnering With a Contract Lab' 2Campbell Alliance Named 'Best Place to Work' by Triangle Business Journal 2
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Fully adjustable mixing angle, Variable speed, Digital ... a number of different sized tubes, Spillage ... cultures, keeping biological samples in suspension and ... be used in incubators up to 60C ...
... 2 real-time PCR detection system uses a ... (470-505 nm) and two photomultiplier tubes for ... Opticon 2 system is built on an ... thermal gradient feature. This item includes the ...
Biology Products: