Navigation Links
Scripps Research scientist wins $1.9 million grant to study malaria
Date:6/9/2011

A scientist from The Scripps Research Institute has won a four-year, $1.9 million grant from the National Institutes of Health to better understand the parasite that causes malaria, laying the groundwork to develop better drugs to combat the widespread and deadly disease.

"Many antimalarial drugs alleviate symptoms, but do not necessarily result in a complete cure because some malaria parasites are able to persist asymptomatically in the liver for months or years," said Scripps Research Professor Elizabeth Winzeler, who is principal investigator for the new grant. "We hope to find new targets that are critical to the liver stages as well as the blood stages with the long-term aim of designing better drugs."

A Complicated Lifecycle

Malaria is a nasty and often fatal disease, affecting about 250 million people every year in Africa, Asia, and the Americas, according to the World Health Organization (WHO). Each year, more than 1 million people die of malaria, mostly children under the age of five. While significant strides had been made in curtailing the disease, for the last two decades malaria, has again been on the rise due to the emergence of drug-resistant parasites.

The parasite Plasmodium, which causes malaria, has a complicated lifecycle in two hostsmosquitoes and humans (or other vertebrate). When a malaria-infected mosquito feeds on a person, the parasite enters the human body. Within 30 minutes, the parasite has infected liver cells, where it remains anywhere from eight days to several months without causing noticeable symptoms.

When this period is over, however, the parasite (now in a different form) leaves the liver and enters red blood cells, where it grows and multiplies. When the infected red blood cells eventually burst, the parasite and Plasmodium toxins are released into the bloodstream, and the person feels sick. Symptoms include fever, chills, headache, and other flulike symptoms; in severe
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Scripps Research scientists find way to block stress-related cell death
2. Scripps Research scientists find key mechanism in transition to alcohol dependence
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Scripps Research scientists identify mechanism of long-term memory
5. Scripps Research scientists uncover new DNA role in modifying gene function
6. Scripps Research scientists find dual switch regulates fat formation
7. Common chaperone protein found to work in surprising way, say Scripps Research scientists
8. Dr. Daniel Von Hoff presented with top genomics award from Scripps
9. Scripps Research team discovers new details about medically important protein family
10. Scripps Research scientists develop new test for pluripotent stem cells
11. Scripps Research scientists create cell assembly line
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... University of Adelaide shows that weight gain and increased ... linked to a higher IQ at early school age. , The ... analysed data from more than 13,800 children who were born full-term. ... , show that babies who put on 40% of their birthweight ... by the time they were six years of age, compared with ...
(Date:6/17/2013)... food may turn out to be just as important as ... St. Michael,s Hospital. , The study, led by Dr. ... between poor eating habits in kids ages three to five ... putting them at risk for cardiovascular disease later in life. ... Association Journal today. , "We know that eating ...
(Date:6/17/2013)... delay early onset of puberty in girls, a new ... The Endocrine Society,s 95th Annual Meeting in San Francisco. ... of 10 and 14. Boys undergo these changes later, ... puberty is diagnosed in girls when sexual development begins ... diagnosed when these changes occur before age 9. , ...
Breaking Biology News(10 mins):IQ link to baby's weight gain in first month 2Poor eating behaviors may put preschoolers at risk for later health problems 2Vitamin D supplementation may delay precocious puberty in girls 2
... Contrary to popular belief, the biodiversity of a tropical ... to support local household livelihoods, according to a new ... But biodiversity and resource use are most likely to ... that receive inputs from local forest users or local ...
... The Pancreatic Cancer Action Network and the American ... Ph.D., and E. Scott Seeley, M.D., Ph.D., the 2011 ... grants, each totaling $600,000 over five years, will be ... held April 2-6. "Because of the poor prognoses ...
... of their survival, and it is precisely those born at ... out to the ocean area which enjoy optimum growth. These ... conclusions of biologist Naroa Aldanondo in a thesis drawn up ... Country (UPV/EHU). Dr Aldanondo investigated patterns of growth and ...
Cached Biology News:Surprise! Biodiversity and resource use may co-exist in tropical forests 2Surprise! Biodiversity and resource use may co-exist in tropical forests 3Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 2Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 3Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 4Shift of young anchovy from the estuary to the sea may be important for recruitment 2Shift of young anchovy from the estuary to the sea may be important for recruitment 3
(Date:6/18/2013)... , June 18, 2013  regulated information — Global ... Klauk today announced the launch of a new ... ones. The Pledge empowers the ... stand and make a personal commitment to demand more: ... health care team and additional partial-onset seizure control.  More ...
(Date:6/18/2013)... -- Techne Corporation (NASDAQ: TECH ) (Techne) ... 100% ownership of Bionostics Holdings Limited and its ... global leader in the development, manufacture and distribution ... of in vitro diagnostic (IVD) devices ... and blood gas testing.  Biosnostics has strategic supply ...
(Date:6/18/2013)... As a leading provider of telehealth ... release of their infographic - " 8 New ... goal was to leverage an information graphic to ... 3.0 and mHealth.The infographic features a list of ... the fitness industry in unimaginable ways; turning science ...
(Date:6/18/2013)... Woburn, MA (PRWEB) June 18, 2013 ... of an automated system for rapid bacterial strain ... M.B.A., has joined the company as Vice President ... and integration for the company’s RESOLUTION™ Microbial ... which includes the benchtop instrument, pathogen-specific assay kits, ...
Breaking Biology Technology:Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 2Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 3Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 4Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 5Professional Golfer Jeff Klauk Tees Off New Pledge Campaign for People Living with Epilepsy 6Techne Corporation Announces Acquisition Agreement 2Techne Corporation Announces Acquisition Agreement 3Techne Corporation Announces Acquisition Agreement 4Techne Corporation Announces Acquisition Agreement 5MeMD, Inc Releases Infographic Featuring the Top Eight Technologies that are Revolutionizing Health and Fitness Today 2PathoGenetix Hires Technology Development VP for Resolution Microbial Genotyping System 2PathoGenetix Hires Technology Development VP for Resolution Microbial Genotyping System 3
... ... is breaking new ground in medical imaging, satellite imaging and defense imaging. The breakthrough ... taken from different cameras, of varying scale, in different modalities, at different distances, with ... ...
... , , TIRAT CARMEL, ... team at the University Children,s Hospital Zurich has completed a ... ultrasound surgery (MRgFUS) for the treatment of neuropathic pain. Ten ... deep brain ablation surgery (central lateral thalamotomy) with transcranial MRgFUS ...
... Medical Center have discovered a novel gene responsible for heart ... adults with dilated cardiomyopathy (DCM). Mutations in the ANKRD1 ... of chronic heart failure in young people and the most ... encodes a protein that plays a role in the structure ...
Cached Biology Technology:Powerful Image Registration and Recognition Software Unveiled for Medical, Satellite, and Defense Imaging Industries 2Powerful Image Registration and Recognition Software Unveiled for Medical, Satellite, and Defense Imaging Industries 3A Swiss Team Uses Transcranial MR-Guided Focused Ultrasound to Treat Patients With Functional Brain Disorders 2A Swiss Team Uses Transcranial MR-Guided Focused Ultrasound to Treat Patients With Functional Brain Disorders 3Novel gene found for dilated cardiomyopathy 2
Rad51, N-terminal...
Rabbit polyclonal to WWOX8 ( Abpromise for all tested applications). entrezGeneID: 51741 SwissProtID: Q9NZC7-8...
Goat polyclonal to T7 tag (Agarose) Immunogen: Goats were immunized with MASMTGGQQMG (T7) conjugated to KLH.After multiple immunizations in Freund's adjuvant, serum was collected....
Rabbit polyclonal to Olfactory Receptor LS189744 ( Abpromise for all tested applications)....
Biology Products: